Drosophila melanogaster

30 known processes

HBS1 (Dmel_CG1898)

CG1898 gene product from transcript CG1898-RA

(Aliases: CG1898,hbs1,Dmel\CG1898)

HBS1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of response to stimulus GO:0048584 323 0.060
regulation of protein metabolic process GO:0051246 256 0.054
chromatin modification GO:0016568 147 0.053
protein modification process GO:0036211 438 0.051
protein dna complex subunit organization GO:0071824 86 0.050
cellular protein catabolic process GO:0044257 83 0.050
histone modification GO:0016570 106 0.044
intracellular transport GO:0046907 228 0.042
positive regulation of signaling GO:0023056 243 0.041
covalent chromatin modification GO:0016569 106 0.040
chromosome organization GO:0051276 360 0.038
regulation of cellular component biogenesis GO:0044087 201 0.038
chromatin organization GO:0006325 207 0.037
small molecule metabolic process GO:0044281 305 0.037
homeostatic process GO:0042592 199 0.036
protein acetylation GO:0006473 39 0.036
organonitrogen compound metabolic process GO:1901564 318 0.036
proteolysis GO:0006508 192 0.036
response to external biotic stimulus GO:0043207 293 0.036
dna metabolic process GO:0006259 227 0.036
response to biotic stimulus GO:0009607 294 0.035
intracellular signal transduction GO:0035556 300 0.035
regionalization GO:0003002 416 0.034
positive regulation of cell communication GO:0010647 250 0.034
regulation of organelle organization GO:0033043 196 0.034
eye development GO:0001654 323 0.033
organic substance catabolic process GO:1901575 308 0.033
transcription from rna polymerase ii promoter GO:0006366 368 0.033
vesicle mediated transport GO:0016192 381 0.032
regulation of cellular catabolic process GO:0031329 157 0.031
positive regulation of cellular biosynthetic process GO:0031328 316 0.031
cellular catabolic process GO:0044248 372 0.031
ubiquitin dependent protein catabolic process GO:0006511 78 0.031
establishment of localization in cell GO:0051649 402 0.031
regulation of cell cycle GO:0051726 291 0.030
response to other organism GO:0051707 293 0.030
immune system process GO:0002376 347 0.029
eye morphogenesis GO:0048592 260 0.029
catabolic process GO:0009056 409 0.029
chromatin remodeling GO:0006338 72 0.029
protein catabolic process GO:0030163 101 0.028
actin filament based process GO:0030029 220 0.028
regulation of intracellular signal transduction GO:1902531 236 0.028
cellular macromolecule localization GO:0070727 220 0.028
macromolecule catabolic process GO:0009057 161 0.027
compound eye morphogenesis GO:0001745 249 0.026
response to lipopolysaccharide GO:0032496 4 0.026
regulation of mitotic cell cycle GO:0007346 190 0.026
regulation of proteolysis GO:0030162 87 0.026
segmentation GO:0035282 207 0.026
mitotic nuclear division GO:0007067 213 0.026
actin cytoskeleton organization GO:0030036 206 0.026
peptidyl amino acid modification GO:0018193 105 0.025
regulation of cellular ketone metabolic process GO:0010565 3 0.025
negative regulation of cell communication GO:0010648 223 0.025
regulation of protein catabolic process GO:0042176 55 0.025
positive regulation of macromolecule metabolic process GO:0010604 405 0.025
single organism intracellular transport GO:1902582 207 0.025
phagocytosis GO:0006909 215 0.025
regulation of response to stress GO:0080134 200 0.025
regulation of immune system process GO:0002682 176 0.025
actin filament organization GO:0007015 126 0.024
embryonic pattern specification GO:0009880 174 0.024
cellular macromolecule catabolic process GO:0044265 136 0.024
tripartite regional subdivision GO:0007351 103 0.024
body morphogenesis GO:0010171 2 0.024
peptidyl lysine modification GO:0018205 57 0.024
regulation of multicellular organismal development GO:2000026 414 0.024
negative regulation of gene expression GO:0010629 387 0.023
protein complex biogenesis GO:0070271 201 0.023
negative regulation of signaling GO:0023057 219 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.023
cytoplasmic transport GO:0016482 130 0.023
regulation of catabolic process GO:0009894 170 0.023
internal protein amino acid acetylation GO:0006475 38 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.023
positive regulation of protein metabolic process GO:0051247 128 0.023
cellular protein modification process GO:0006464 438 0.022
positive regulation of proteolysis GO:0045862 52 0.022
regulation of cell cycle phase transition GO:1901987 130 0.022
single organism cellular localization GO:1902580 180 0.022
axis specification GO:0009798 167 0.022
immune response GO:0006955 246 0.022
purine ribonucleotide metabolic process GO:0009150 145 0.022
transmembrane transport GO:0055085 139 0.022
regulation of cell cycle process GO:0010564 181 0.022
cell cycle phase transition GO:0044770 140 0.022
lateral inhibition GO:0046331 206 0.021
axonogenesis GO:0007409 290 0.021
endocytosis GO:0006897 310 0.021
defense response to other organism GO:0098542 225 0.021
phosphorylation GO:0016310 294 0.021
response to abiotic stimulus GO:0009628 341 0.021
wing disc morphogenesis GO:0007472 344 0.021
negative regulation of response to stimulus GO:0048585 258 0.021
growth GO:0040007 359 0.021
regulation of cell differentiation GO:0045595 302 0.021
cellular response to chemical stimulus GO:0070887 199 0.021
epithelial cell differentiation GO:0030855 322 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.021
compound eye development GO:0048749 307 0.021
organophosphate metabolic process GO:0019637 195 0.021
response to bacterium GO:0009617 198 0.020
positive regulation of signal transduction GO:0009967 223 0.020
positive regulation of cellular component organization GO:0051130 156 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.020
defense response to bacterium GO:0042742 178 0.020
oxoacid metabolic process GO:0043436 103 0.020
positive regulation of biosynthetic process GO:0009891 316 0.020
organic substance transport GO:0071702 257 0.020
modification dependent macromolecule catabolic process GO:0043632 79 0.020
regulation of mapk cascade GO:0043408 92 0.020
ribonucleoside metabolic process GO:0009119 127 0.020
cell division GO:0051301 248 0.020
anterior posterior pattern specification GO:0009952 136 0.020
regulation of phosphate metabolic process GO:0019220 210 0.020
innate immune response GO:0045087 144 0.020
nucleoside phosphate metabolic process GO:0006753 162 0.020
mitotic cell cycle phase transition GO:0044772 138 0.019
single organism biosynthetic process GO:0044711 206 0.019
positive regulation of cellular catabolic process GO:0031331 95 0.019
carboxylic acid metabolic process GO:0019752 92 0.019
imaginal disc derived wing morphogenesis GO:0007476 337 0.019
nucleoside triphosphate metabolic process GO:0009141 120 0.019
protein localization GO:0008104 284 0.019
positive regulation of molecular function GO:0044093 136 0.019
cellular homeostasis GO:0019725 80 0.019
blastoderm segmentation GO:0007350 159 0.019
regulation of mitotic cell cycle phase transition GO:1901990 130 0.019
cell cycle checkpoint GO:0000075 95 0.019
regulation of cellular amine metabolic process GO:0033238 3 0.019
nuclear division GO:0000280 332 0.019
negative regulation of cell differentiation GO:0045596 143 0.018
sensory organ morphogenesis GO:0090596 260 0.018
regulation of cellular protein metabolic process GO:0032268 243 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
cell death GO:0008219 279 0.018
protein complex assembly GO:0006461 200 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.018
pole plasm assembly GO:0007315 61 0.018
compound eye photoreceptor cell differentiation GO:0001751 140 0.018
peptidyl lysine acetylation GO:0018394 39 0.018
purine nucleotide metabolic process GO:0006163 146 0.018
axon development GO:0061564 297 0.018
oocyte differentiation GO:0009994 145 0.018
regulation of molecular function GO:0065009 217 0.018
spindle organization GO:0007051 253 0.017
imaginal disc derived appendage morphogenesis GO:0035114 395 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
organelle fission GO:0048285 340 0.017
photoreceptor cell differentiation GO:0046530 170 0.017
immune response activating signal transduction GO:0002757 2 0.017
immune response regulating signaling pathway GO:0002764 2 0.017
nucleotide metabolic process GO:0009117 161 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.017
cellular response to dna damage stimulus GO:0006974 223 0.017
anterior posterior axis specification embryo GO:0008595 103 0.017
mitotic spindle organization GO:0007052 220 0.017
forebrain development GO:0030900 2 0.017
cell motility GO:0048870 251 0.017
small gtpase mediated signal transduction GO:0007264 88 0.017
ras protein signal transduction GO:0007265 88 0.017
negative regulation of nucleic acid templated transcription GO:1903507 240 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
regulation of peptidase activity GO:0052547 39 0.017
negative regulation of developmental process GO:0051093 201 0.017
epithelial cell development GO:0002064 274 0.017
wnt signaling pathway GO:0016055 98 0.017
negative regulation of cellular biosynthetic process GO:0031327 277 0.017
imaginal disc derived appendage development GO:0048737 399 0.016
negative regulation of cellular metabolic process GO:0031324 382 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
ovarian follicle cell development GO:0030707 248 0.016
organic acid metabolic process GO:0006082 103 0.016
modification dependent protein catabolic process GO:0019941 78 0.016
positive regulation of intracellular signal transduction GO:1902533 116 0.016
taxis GO:0042330 304 0.016
negative regulation of signal transduction GO:0009968 206 0.016
posttranscriptional regulation of gene expression GO:0010608 145 0.016
appendage morphogenesis GO:0035107 397 0.016
spermatogenesis GO:0007283 200 0.016
response to organic substance GO:0010033 284 0.016
embryonic axis specification GO:0000578 107 0.016
positive regulation of apoptotic signaling pathway GO:2001235 4 0.016
camera type eye development GO:0043010 4 0.015
positive regulation of endopeptidase activity GO:0010950 26 0.015
negative regulation of multicellular organismal process GO:0051241 142 0.015
protein modification by small protein conjugation or removal GO:0070647 106 0.015
mitotic dna damage checkpoint GO:0044773 74 0.015
regulation of immune response GO:0050776 118 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
positive regulation of catabolic process GO:0009896 105 0.015
histone acetylation GO:0016573 38 0.015
cell proliferation GO:0008283 299 0.015
establishment of protein localization GO:0045184 163 0.015
negative regulation of cell cycle process GO:0010948 109 0.015
anterior posterior axis specification GO:0009948 109 0.015
g2 dna damage checkpoint GO:0031572 69 0.015
mapk cascade GO:0000165 107 0.015
developmental growth GO:0048589 280 0.015
chemotaxis GO:0006935 249 0.015
nucleoside phosphate catabolic process GO:1901292 110 0.014
nucleoside metabolic process GO:0009116 127 0.014
purine nucleoside triphosphate catabolic process GO:0009146 108 0.014
glycosyl compound metabolic process GO:1901657 127 0.014
locomotory behavior GO:0007626 176 0.014
rna processing GO:0006396 147 0.014
dephosphorylation GO:0016311 51 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.014
cellular lipid metabolic process GO:0044255 83 0.014
protein transport GO:0015031 155 0.014
purine ribonucleoside metabolic process GO:0046128 127 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
mesenchymal cell differentiation GO:0048762 1 0.014
negative regulation of cell cycle phase transition GO:1901988 103 0.014
protein acylation GO:0043543 42 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
single organism behavior GO:0044708 391 0.014
negative regulation of mitotic cell cycle GO:0045930 109 0.014
protein maturation GO:0051604 71 0.014
negative regulation of rna biosynthetic process GO:1902679 240 0.014
regulation of localization GO:0032879 275 0.014
mitotic cell cycle checkpoint GO:0007093 88 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.014
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.014
response to wounding GO:0009611 94 0.014
appendage development GO:0048736 401 0.014
aromatic compound catabolic process GO:0019439 166 0.013
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.013
neurological system process GO:0050877 358 0.013
cellular amine metabolic process GO:0044106 12 0.013
cellular protein localization GO:0034613 160 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
localization of cell GO:0051674 257 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
respiratory system development GO:0060541 213 0.013
telencephalon development GO:0021537 2 0.013
regulation of ras protein signal transduction GO:0046578 93 0.013
multicellular organismal aging GO:0010259 140 0.013
mitotic g2 m transition checkpoint GO:0044818 70 0.013
regulation of cell development GO:0060284 215 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.013
negative regulation of cell cycle GO:0045786 116 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
dorsal ventral pattern formation GO:0009953 133 0.013
cellular ketone metabolic process GO:0042180 24 0.013
positive regulation of cell motility GO:2000147 3 0.013
kidney development GO:0001822 3 0.013
tissue morphogenesis GO:0048729 297 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.013
developmental maturation GO:0021700 172 0.013
oocyte anterior posterior axis specification GO:0007314 72 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
gene silencing GO:0016458 138 0.013
ribose phosphate metabolic process GO:0019693 145 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
anatomical structure homeostasis GO:0060249 97 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
single organism catabolic process GO:0044712 228 0.012
positive regulation of cellular component biogenesis GO:0044089 80 0.012
response to oxygen containing compound GO:1901700 200 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
intracellular protein transport GO:0006886 104 0.012
jak stat cascade GO:0007259 49 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
oocyte construction GO:0007308 112 0.012
regulation of cellular localization GO:0060341 136 0.012
regulation of anatomical structure size GO:0090066 163 0.012
oocyte axis specification GO:0007309 108 0.012
wound healing GO:0042060 75 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.012
morphogenesis of an epithelium GO:0002009 276 0.012
determination of adult lifespan GO:0008340 137 0.012
proteasomal protein catabolic process GO:0010498 59 0.012
positive regulation of cell migration GO:0030335 2 0.012
regulation of epithelial cell proliferation GO:0050678 4 0.012
positive regulation of gene expression GO:0010628 290 0.012
connective tissue development GO:0061448 3 0.012
mitotic cytokinesis GO:0000281 50 0.012
purine ribonucleoside catabolic process GO:0046130 112 0.012
salivary gland development GO:0007431 162 0.012
ribonucleoside catabolic process GO:0042454 112 0.012
regulation of phosphorylation GO:0042325 147 0.012
protein processing GO:0016485 68 0.012
regulation of catalytic activity GO:0050790 185 0.012
pole plasm mrna localization GO:0019094 49 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
regulation of defense response GO:0031347 102 0.012
open tracheal system development GO:0007424 204 0.012
embryo development ending in birth or egg hatching GO:0009792 152 0.012
eye photoreceptor cell differentiation GO:0001754 145 0.012
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.012
organophosphate catabolic process GO:0046434 112 0.012
mitotic dna integrity checkpoint GO:0044774 75 0.012
regulation of cellular protein catabolic process GO:1903362 44 0.012
regulation of hydrolase activity GO:0051336 97 0.012
cell growth GO:0016049 108 0.012
purine nucleoside metabolic process GO:0042278 127 0.012
ion transport GO:0006811 145 0.011
regulation of cell death GO:0010941 173 0.011
programmed cell death GO:0012501 257 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
heterocycle catabolic process GO:0046700 166 0.011
negative regulation of biosynthetic process GO:0009890 277 0.011
humoral immune response GO:0006959 117 0.011
histone exchange GO:0043486 21 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
post embryonic appendage morphogenesis GO:0035120 385 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
regulation of wnt signaling pathway GO:0030111 68 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
neuron projection guidance GO:0097485 241 0.011
positive regulation of defense response GO:0031349 59 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
regulation of protein complex assembly GO:0043254 42 0.011
pole plasm oskar mrna localization GO:0045451 46 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
regulation of response to external stimulus GO:0032101 115 0.011
negative regulation of nervous system development GO:0051961 92 0.011
positive regulation of immune response GO:0050778 63 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
death GO:0016265 284 0.011
regulation of programmed cell death GO:0043067 152 0.011
dna integrity checkpoint GO:0031570 81 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
amine metabolic process GO:0009308 12 0.011
regulation of cellular component size GO:0032535 98 0.011
embryonic development via the syncytial blastoderm GO:0001700 148 0.011
macromolecular complex assembly GO:0065003 256 0.011
male gamete generation GO:0048232 201 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
dorsal ventral axis specification GO:0009950 66 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
negative regulation of epithelial cell proliferation GO:0050680 4 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
brain development GO:0007420 120 0.011
regulation of innate immune response GO:0045088 71 0.011
adult behavior GO:0030534 137 0.010
cellular response to hexose stimulus GO:0071331 1 0.010
nucleoside catabolic process GO:0009164 112 0.010
organophosphate biosynthetic process GO:0090407 46 0.010
intracellular protein transmembrane import GO:0044743 4 0.010
positive regulation of hydrolase activity GO:0051345 78 0.010
regulation of nervous system development GO:0051960 248 0.010
rna 3 end processing GO:0031123 45 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.010
eye photoreceptor cell development GO:0042462 81 0.010
regulation of autophagy GO:0010506 62 0.010
myotube cell development GO:0014904 3 0.010
positive regulation of rna biosynthetic process GO:1902680 266 0.010
dendrite morphogenesis GO:0048813 199 0.010
mitotic g2 dna damage checkpoint GO:0007095 69 0.010
purine nucleoside monophosphate metabolic process GO:0009126 50 0.010
cellular response to organic substance GO:0071310 132 0.010
purine ribonucleotide catabolic process GO:0009154 109 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.010
positive regulation of organelle organization GO:0010638 65 0.010
cell adhesion GO:0007155 136 0.010
spermatid development GO:0007286 98 0.010
single organism membrane organization GO:0044802 93 0.010
atp dependent chromatin remodeling GO:0043044 22 0.010
ion transmembrane transport GO:0034220 122 0.010
maternal determination of anterior posterior axis embryo GO:0008358 74 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.010
immune effector process GO:0002252 98 0.010
autophagy GO:0006914 108 0.010
mitotic sister chromatid segregation GO:0000070 87 0.010
nucleoside phosphate biosynthetic process GO:1901293 34 0.010
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.010
response to hexose GO:0009746 3 0.010

HBS1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
nervous system disease DOID:863 0 0.019
central nervous system disease DOID:331 0 0.011
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.011
sensory system disease DOID:0050155 0 0.010