Drosophila melanogaster

226 known processes

sax (Dmel_CG1891)

saxophone

(Aliases: Brk43E,Sax,CG1891,SAX,Bkr43E,Dmel\CG1891,STK-B)

sax biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of pathway restricted smad protein phosphorylation GO:0060393 1 1.000
Human Fly
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 1 0.999
Human Fly
oocyte development GO:0048599 124 0.999
negative regulation of cellular metabolic process GO:0031324 382 0.998
Human Fly
oocyte differentiation GO:0009994 145 0.998
germ line stem cell division GO:0042078 25 0.997
negative regulation of signaling GO:0023057 219 0.997
regionalization GO:0003002 416 0.997
catabolic process GO:0009056 409 0.988
Worm Fly
axis specification GO:0009798 167 0.986
tube morphogenesis GO:0035239 191 0.986
Human Zebrafish Mouse Fly
pole plasm mrna localization GO:0019094 49 0.979
tissue morphogenesis GO:0048729 297 0.978
Human Zebrafish Mouse Fly
oocyte axis specification GO:0007309 108 0.978
taxis GO:0042330 304 0.977
Fly
regulation of cell cycle GO:0051726 291 0.973
Fly
stem cell division GO:0017145 69 0.971
segmentation GO:0035282 207 0.965
embryonic axis specification GO:0000578 107 0.963
oocyte construction GO:0007308 112 0.960
eye morphogenesis GO:0048592 260 0.956
Fly
male gamete generation GO:0048232 201 0.954
regulation of cell differentiation GO:0045595 302 0.953
negative regulation of signal transduction GO:0009968 206 0.952
enzyme linked receptor protein signaling pathway GO:0007167 179 0.949
embryonic pattern specification GO:0009880 174 0.938
regulation of localization GO:0032879 275 0.933
Human
cell maturation GO:0048469 144 0.932
negative regulation of cell communication GO:0010648 223 0.928
cell death GO:0008219 279 0.925
Human
malpighian tubule morphogenesis GO:0007443 44 0.923
Fly
organic substance catabolic process GO:1901575 308 0.921
Worm
blastoderm segmentation GO:0007350 159 0.917
positive regulation of developmental growth GO:0048639 62 0.914
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.913
Human
digestive tract development GO:0048565 149 0.910
Zebrafish Mouse Fly
regulation of phosphorylation GO:0042325 147 0.907
Human Fly
eye development GO:0001654 323 0.896
Mouse Fly
cellular catabolic process GO:0044248 372 0.896
Fly
malpighian tubule development GO:0072002 64 0.886
Fly
programmed cell death GO:0012501 257 0.877
Human
muscle structure development GO:0061061 224 0.869
Human Mouse Rat Fly
anterior posterior axis specification GO:0009948 109 0.865
compound eye development GO:0048749 307 0.861
Fly
positive regulation of rna metabolic process GO:0051254 271 0.825
Human Mouse Worm
regulation of developmental growth GO:0048638 174 0.819
tripartite regional subdivision GO:0007351 103 0.813
negative regulation of developmental process GO:0051093 201 0.811
negative regulation of autophagy GO:0010507 16 0.800
Fly
single organism cellular localization GO:1902580 180 0.798
dorsal ventral axis specification GO:0009950 66 0.795
cell division GO:0051301 248 0.787
regulation of cellular protein metabolic process GO:0032268 243 0.778
Human Fly
pathway restricted smad protein phosphorylation GO:0060389 1 0.777
Human Fly
spermatogenesis GO:0007283 200 0.775
positive regulation of cellular biosynthetic process GO:0031328 316 0.771
Human Mouse Worm
hindgut morphogenesis GO:0007442 58 0.770
Fly
developmental growth GO:0048589 280 0.759
epithelial tube morphogenesis GO:0060562 88 0.755
Human Zebrafish Mouse Fly
cell motility GO:0048870 251 0.742
Human Zebrafish Mouse Fly
biological adhesion GO:0022610 138 0.739
Human Zebrafish Worm Fly
negative regulation of cell differentiation GO:0045596 143 0.739
sensory organ morphogenesis GO:0090596 260 0.731
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.730
anterior posterior pattern specification GO:0009952 136 0.711
negative regulation of biosynthetic process GO:0009890 277 0.704
Human
cellular nitrogen compound catabolic process GO:0044270 165 0.694
positive regulation of nucleic acid templated transcription GO:1903508 266 0.689
Human Mouse Worm
maternal determination of anterior posterior axis embryo GO:0008358 74 0.684
regulation of cellular catabolic process GO:0031329 157 0.674
Fly
negative regulation of gene expression GO:0010629 387 0.666
Fly
negative regulation of rna metabolic process GO:0051253 251 0.666
protein modification process GO:0036211 438 0.659
death GO:0016265 284 0.649
Human
stem cell differentiation GO:0048863 117 0.643
regulation of catabolic process GO:0009894 170 0.627
Worm Fly
cellular macromolecule localization GO:0070727 220 0.602
Worm
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.599
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.598
Human
regulation of vesicle mediated transport GO:0060627 59 0.596
nucleobase containing compound catabolic process GO:0034655 165 0.595
regulation of mapk cascade GO:0043408 92 0.591
compound eye morphogenesis GO:0001745 249 0.589
Fly
negative regulation of cell cycle phase transition GO:1901988 103 0.584
regulation of immune system process GO:0002682 176 0.577
regulation of autophagy GO:0010506 62 0.572
Fly
regulation of cell cycle process GO:0010564 181 0.564
urogenital system development GO:0001655 72 0.561
Rat Fly
renal tubule morphogenesis GO:0061333 44 0.549
Fly
positive regulation of rna biosynthetic process GO:1902680 266 0.549
Human Mouse Worm
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.548
Human Mouse Worm
morphogenesis of an epithelium GO:0002009 276 0.534
Human Zebrafish Mouse Fly
ribose phosphate metabolic process GO:0019693 145 0.532
response to bacterium GO:0009617 198 0.530
positive regulation of transcription dna templated GO:0045893 266 0.529
Human Mouse Worm
stem cell development GO:0048864 79 0.528
regulation of embryonic development GO:0045995 68 0.515
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.509
Human Mouse Worm
cardiovascular system development GO:0072358 82 0.508
Human Zebrafish Mouse
heterocycle catabolic process GO:0046700 166 0.504
tube development GO:0035295 244 0.499
Human Zebrafish Mouse Fly
single organism membrane organization GO:0044802 93 0.496
anterior posterior axis specification embryo GO:0008595 103 0.490
cell fate specification GO:0001708 71 0.483
Fly
regulation of protein modification process GO:0031399 112 0.475
Human Fly
positive regulation of biosynthetic process GO:0009891 316 0.469
Human Mouse Worm
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.461
Human Worm
positive regulation of macromolecule metabolic process GO:0010604 405 0.457
Human Mouse Worm Fly
chemotaxis GO:0006935 249 0.446
Fly
pole plasm assembly GO:0007315 61 0.443
negative regulation of cellular component organization GO:0051129 108 0.442
Human
organophosphate metabolic process GO:0019637 195 0.433
oocyte anterior posterior axis specification GO:0007314 72 0.430
purine nucleoside metabolic process GO:0042278 127 0.426
muscle system process GO:0003012 21 0.416
cellular protein modification process GO:0006464 438 0.415
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.409
cellular response to chemical stimulus GO:0070887 199 0.406
negative regulation of response to stimulus GO:0048585 258 0.406
single organism behavior GO:0044708 391 0.404
defense response GO:0006952 300 0.391
positive regulation of multicellular organism growth GO:0040018 21 0.386
Worm
endomembrane system organization GO:0010256 119 0.385
regulation of multicellular organismal development GO:2000026 414 0.384
regulation of cellular component biogenesis GO:0044087 201 0.381
negative regulation of cellular biosynthetic process GO:0031327 277 0.381
Human
regulation of apoptotic process GO:0042981 130 0.380
Human
mapk cascade GO:0000165 107 0.373
negative regulation of catabolic process GO:0009895 36 0.371
Fly
imaginal disc pattern formation GO:0007447 91 0.370
establishment or maintenance of cell polarity GO:0007163 167 0.368
growth GO:0040007 359 0.360
regulation of transport GO:0051049 181 0.355
vesicle mediated transport GO:0016192 381 0.352
response to other organism GO:0051707 293 0.343
axonogenesis GO:0007409 290 0.340
Fly
regulation of cell proliferation GO:0042127 163 0.339
Human Mouse
ameboidal type cell migration GO:0001667 151 0.339
Human Zebrafish Mouse
morphogenesis of a branching structure GO:0001763 45 0.337
Mouse Fly
regulation of phosphorus metabolic process GO:0051174 210 0.335
Human Fly
localization of cell GO:0051674 257 0.334
Human Zebrafish Mouse Fly
cell proliferation involved in imaginal disc derived wing morphogenesis GO:0090255 2 0.334
response to alcohol GO:0097305 95 0.328
regulation of phosphate metabolic process GO:0019220 210 0.327
Human Fly
negative regulation of multicellular organismal process GO:0051241 142 0.324
Human
intracellular transport GO:0046907 228 0.322
oocyte dorsal ventral axis specification GO:0007310 34 0.315
carbohydrate derivative catabolic process GO:1901136 118 0.313
dorsal ventral pattern formation GO:0009953 133 0.313
regulation of mitotic cell cycle GO:0007346 190 0.299
Fly
protein targeting GO:0006605 64 0.297
purine ribonucleotide metabolic process GO:0009150 145 0.297
synaptic growth at neuromuscular junction GO:0051124 119 0.296
cell adhesion GO:0007155 136 0.295
Human Zebrafish Worm Fly
multicellular organism growth GO:0035264 46 0.293
Worm
digestive system development GO:0055123 149 0.285
Zebrafish Mouse Fly
regulation of reproductive process GO:2000241 54 0.282
regulation of immune response GO:0050776 118 0.277
ras protein signal transduction GO:0007265 88 0.276
hindgut development GO:0061525 58 0.276
Fly
chorion containing eggshell formation GO:0007304 105 0.276
small gtpase mediated signal transduction GO:0007264 88 0.275
developmental growth involved in morphogenesis GO:0060560 65 0.266
Fly
apoptotic process GO:0006915 159 0.257
Human
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.247
Human
neuron projection guidance GO:0097485 241 0.247
Fly
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.246
regulation of centriole replication GO:0046599 2 0.242
dna replication GO:0006260 48 0.240
regulation of protein catabolic process GO:0042176 55 0.238
Worm
cytoplasmic transport GO:0016482 130 0.237
negative regulation of transcription dna templated GO:0045892 237 0.234
ribonucleotide metabolic process GO:0009259 145 0.234
positive regulation of response to stimulus GO:0048584 323 0.233
Human Mouse Fly
phosphorylation GO:0016310 294 0.229
immune system process GO:0002376 347 0.229
negative regulation of cell proliferation GO:0008285 69 0.228
Human Mouse
negative regulation of mapk cascade GO:0043409 23 0.227
response to growth factor GO:0070848 31 0.227
oocyte morphogenesis GO:0048601 3 0.226
meiotic cell cycle GO:0051321 171 0.225
endodermal cell differentiation GO:0035987 3 0.221
Fly
positive regulation of nervous system development GO:0051962 69 0.220
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded GO:0008071 1 0.220
axon guidance GO:0007411 233 0.218
Fly
response to abiotic stimulus GO:0009628 341 0.218
Fly
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.218
protein localization GO:0008104 284 0.215
Worm
establishment of protein localization GO:0045184 163 0.214
eye antennal disc development GO:0035214 60 0.213
Fly
regulation of growth GO:0040008 233 0.212
negative regulation of programmed cell death GO:0043069 72 0.212
Human
regulation of anatomical structure morphogenesis GO:0022603 242 0.212
Mouse Worm
cellular response to endogenous stimulus GO:0071495 80 0.209
autophagy GO:0006914 108 0.206
Fly
regulation of defense response GO:0031347 102 0.204
negative regulation of cellular catabolic process GO:0031330 34 0.201
Fly
intracellular signal transduction GO:0035556 300 0.201
Rat
negative regulation of cell cycle process GO:0010948 109 0.200
carbohydrate derivative metabolic process GO:1901135 217 0.200
regulation of response to stress GO:0080134 200 0.194
regulation of multicellular organism growth GO:0040014 40 0.194
Worm
negative regulation of phosphorylation GO:0042326 35 0.192
regulation of purine nucleotide catabolic process GO:0033121 48 0.191
organonitrogen compound catabolic process GO:1901565 128 0.190
mitotic cell cycle phase transition GO:0044772 138 0.185
Human
dendrite regeneration GO:0031104 2 0.185
regulation of intracellular signal transduction GO:1902531 236 0.184
wing disc pattern formation GO:0035222 66 0.184
purine nucleotide metabolic process GO:0006163 146 0.182
wing disc anterior posterior pattern formation GO:0048100 5 0.180
Fly
organic substance transport GO:0071702 257 0.175
response to radiation GO:0009314 155 0.175
Fly
synaptic vesicle endocytosis GO:0048488 28 0.174
regulation of catalytic activity GO:0050790 185 0.172
forebrain development GO:0030900 2 0.169
Zebrafish
single organism intracellular transport GO:1902582 207 0.169
embryonic hindgut morphogenesis GO:0048619 48 0.165
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.165
protein transport GO:0015031 155 0.164
aromatic compound catabolic process GO:0019439 166 0.159
head development GO:0060322 135 0.159
Zebrafish Fly
positive regulation of protein metabolic process GO:0051247 128 0.158
Human Worm Fly
central nervous system development GO:0007417 201 0.158
Zebrafish Fly
regulation of programmed cell death GO:0043067 152 0.157
Human
regulation of gtpase activity GO:0043087 44 0.152
regulation of protein localization GO:0032880 76 0.151
cell elongation involved in imaginal disc derived wing morphogenesis GO:0090254 5 0.150
Fly
response to red or far red light GO:0009639 2 0.150
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.149
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.147
regulation of pole plasm oskar mrna localization GO:0007317 27 0.145
neuroblast proliferation GO:0007405 74 0.144
Fly
protein phosphorylation GO:0006468 169 0.144
single organism catabolic process GO:0044712 228 0.144
negative regulation of protein metabolic process GO:0051248 85 0.139
heart development GO:0007507 82 0.137
Human Zebrafish Mouse
regulation of cell proliferation involved in compound eye morphogenesis GO:2000495 2 0.136
regulation of organelle organization GO:0033043 196 0.136
wing disc morphogenesis GO:0007472 344 0.134
peptidyl amino acid modification GO:0018193 105 0.133
Human
developmental maturation GO:0021700 172 0.132
single organism biosynthetic process GO:0044711 206 0.131
negative regulation of cell cycle GO:0045786 116 0.131
purine nucleoside catabolic process GO:0006152 112 0.130
cellular macromolecule catabolic process GO:0044265 136 0.129
negative regulation of mitotic cell cycle GO:0045930 109 0.128
multicellular organismal aging GO:0010259 140 0.127
Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.125
positive regulation of cell communication GO:0010647 250 0.125
Human Mouse Fly
cell proliferation GO:0008283 299 0.122
Human Mouse Fly
regulation of cell cycle phase transition GO:1901987 130 0.118
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.117
membrane organization GO:0061024 112 0.116
signal transduction by phosphorylation GO:0023014 107 0.116
Rat
regulation of molecular function GO:0065009 217 0.115
brain development GO:0007420 120 0.115
Zebrafish Fly
oocyte fate commitment GO:0048600 2 0.114
regulation of cell cycle g1 s phase transition GO:1902806 23 0.113
peptidyl threonine phosphorylation GO:0018107 2 0.111
Human
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 4 0.111
ribonucleoside metabolic process GO:0009119 127 0.111
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.110
cellular response to organic substance GO:0071310 132 0.110
regulation of response to external stimulus GO:0032101 115 0.108
pole plasm rna localization GO:0007316 52 0.108
anterior posterior pattern specification imaginal disc GO:0007448 16 0.106
regulation of cell development GO:0060284 215 0.105
negative regulation of growth GO:0045926 84 0.105
Human
ribonucleotide catabolic process GO:0009261 109 0.104
cell cycle phase transition GO:0044770 140 0.103
Human
negative regulation of terminal cell fate specification open tracheal system GO:0035155 2 0.101
response to organic substance GO:0010033 284 0.101
positive regulation of cellular component organization GO:0051130 156 0.100
meiotic spindle checkpoint GO:0044779 1 0.100
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.100
detection of virus GO:0009597 1 0.100
regulation of mitotic cell cycle phase transition GO:1901990 130 0.100
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 2 0.100
learning or memory GO:0007611 141 0.098
regulation of cellular localization GO:0060341 136 0.096
regulation of protein transport GO:0051223 57 0.095
regulation of map kinase activity GO:0043405 17 0.095
compound eye photoreceptor cell differentiation GO:0001751 140 0.094
positive regulation of nucleotide metabolic process GO:0045981 55 0.092
positive regulation of cellular catabolic process GO:0031331 95 0.092
branching morphogenesis of an epithelial tube GO:0048754 45 0.092
Mouse Fly
negative regulation of intracellular signal transduction GO:1902532 57 0.091
regulation of intracellular protein transport GO:0033157 46 0.091
nucleotide metabolic process GO:0009117 161 0.089
endodermal cell fate commitment GO:0001711 3 0.089
Fly
cell cycle g1 s phase transition GO:0044843 31 0.088
Human
innate immune response GO:0045087 144 0.088
nucleoside phosphate catabolic process GO:1901292 110 0.087
positive regulation of signal transduction GO:0009967 223 0.086
Human Mouse Fly
digestive tract morphogenesis GO:0048546 127 0.086
Zebrafish Mouse Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.086
Human Zebrafish Mouse Worm Fly
synaptic transmission GO:0007268 288 0.085
regulation of multi organism process GO:0043900 131 0.084
regulation of neural precursor cell proliferation GO:2000177 35 0.084
determination of ventral identity GO:0048264 1 0.083
Zebrafish
regulation of protein phosphorylation GO:0001932 64 0.082
Human Fly
oocyte microtubule cytoskeleton organization GO:0016325 35 0.082
regulation of cellular amine metabolic process GO:0033238 3 0.080
positive regulation of molecular function GO:0044093 136 0.080
regulation of post embryonic development GO:0048580 10 0.080
regulation of small gtpase mediated signal transduction GO:0051056 93 0.080
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.078
purine nucleoside triphosphate catabolic process GO:0009146 108 0.077
homeostatic process GO:0042592 199 0.077
regulation of ras protein signal transduction GO:0046578 93 0.076
regulation of nucleotide metabolic process GO:0006140 62 0.076
endoderm formation GO:0001706 3 0.075
Fly
specification of segmental identity antennal segment GO:0007383 2 0.075
organic cyclic compound catabolic process GO:1901361 168 0.075
secretion GO:0046903 109 0.074
regulation of dna metabolic process GO:0051052 34 0.073
Human
pole plasm oskar mrna localization GO:0045451 46 0.073
synapse organization GO:0050808 196 0.072
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.071
muscle organ development GO:0007517 127 0.071
Rat Fly
regulation of hydrolase activity GO:0051336 97 0.068
positive regulation of transcription involved in g2 m transition of mitotic cell cycle GO:0090282 1 0.068
immune response GO:0006955 246 0.067
cell migration GO:0016477 238 0.066
Human Zebrafish Mouse Fly
negative regulation of molecular function GO:0044092 51 0.066
positive regulation of chromatin silencing at telomere GO:0031940 2 0.066
axon development GO:0061564 297 0.066
Fly
negative regulation of dna templated transcription initiation GO:2000143 1 0.066
nucleotide catabolic process GO:0009166 109 0.065
meiotic nuclear division GO:0007126 151 0.065
positive regulation of catabolic process GO:0009896 105 0.064
Worm
anterior posterior axis specification follicular epithelium GO:0030714 2 0.064
meiotic nuclear envelope disassembly GO:0051078 2 0.064
positive regulation of multicellular organismal process GO:0051240 143 0.064
dorsal closure leading edge cell differentiation GO:0046663 2 0.062
gliogenesis GO:0042063 80 0.062
imaginal disc derived appendage development GO:0048737 399 0.061
regulation of cell shape GO:0008360 113 0.061
determination of dorsal ventral asymmetry GO:0048262 3 0.061
Human Zebrafish
macromolecule catabolic process GO:0009057 161 0.060
Worm
rna catabolic process GO:0006401 37 0.059
regulation of dna binding GO:0051101 10 0.059
stem cell proliferation GO:0072089 88 0.059
Fly
morphogenesis of a branching epithelium GO:0061138 45 0.059
Mouse Fly
renal tubule development GO:0061326 64 0.057
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.056
Human Mouse Worm
negative regulation of phosphate metabolic process GO:0045936 45 0.056
negative regulation of apoptotic process GO:0043066 63 0.056
Human
response to red light GO:0010114 2 0.055
body morphogenesis GO:0010171 2 0.055
Worm
positive regulation of signaling GO:0023056 243 0.055
Human Mouse Fly
respiratory system development GO:0060541 213 0.054
Fly
organelle assembly GO:0070925 198 0.054
positive regulation of stem cell differentiation GO:2000738 3 0.054
regulation of synapse structure and activity GO:0050803 128 0.053
intracellular protein transport GO:0006886 104 0.053
regulation of ran gtpase activity GO:0032316 1 0.053
renal system development GO:0072001 72 0.053
Fly
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.053
compound eye photoreceptor development GO:0042051 78 0.051
detection of stimulus GO:0051606 156 0.051
positive regulation of gene expression GO:0010628 290 0.051
Human Mouse Worm
positive regulation of nucleotide catabolic process GO:0030813 46 0.049
dorsal vessel heart proper cell fate commitment GO:0035053 2 0.049
unidimensional cell growth GO:0009826 15 0.049
Fly
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 6 0.049
positive regulation of protein kinase activity GO:0045860 25 0.048
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.048
determination of adult lifespan GO:0008340 137 0.048
Fly
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0017055 1 0.048
ribonucleoside triphosphate metabolic process GO:0009199 119 0.047
specification of symmetry GO:0009799 13 0.047
Human Zebrafish Mouse
organelle inheritance GO:0048308 2 0.047
cellular response to growth factor stimulus GO:0071363 30 0.047
nuclear transport GO:0051169 72 0.047
negative regulation of mrna 3 end processing GO:0031441 3 0.046
establishment or maintenance of polarity of larval imaginal disc epithelium GO:0016336 3 0.046
mrna catabolic process GO:0006402 33 0.045
negative regulation of activin receptor signaling pathway GO:0032926 1 0.045
Human
positive regulation of phosphate metabolic process GO:0045937 139 0.045
Human Fly
defense response to other organism GO:0098542 225 0.045
regulation of nucleotide catabolic process GO:0030811 48 0.045
regulation of synaptic transmission GO:0050804 69 0.045
establishment of localization in cell GO:0051649 402 0.045
skeletal muscle organ development GO:0060538 48 0.044
Rat
guanosine containing compound metabolic process GO:1901068 74 0.044
secretion by cell GO:0032940 101 0.044
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 9 0.044
Human Mouse Fly
purine containing compound metabolic process GO:0072521 155 0.044
dna templated transcriptional start site selection GO:0001173 1 0.043
establishment of protein localization to plasma membrane GO:0090002 9 0.043
positive regulation of retrograde axon cargo transport GO:2001019 7 0.042
gastrulation GO:0007369 70 0.042
Zebrafish Mouse Fly
negative regulation of cell development GO:0010721 62 0.042
cell substrate adhesion GO:0031589 10 0.042
Human
cognition GO:0050890 141 0.042
ectodermal placode formation GO:0060788 4 0.041
imaginal disc derived wing morphogenesis GO:0007476 337 0.041
positive regulation of cellular protein metabolic process GO:0032270 118 0.040
Human Fly
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.040
ribonucleoside catabolic process GO:0042454 112 0.040
release of cytoplasmic sequestered nf kappab GO:0008588 1 0.040
positive regulation of phosphorus metabolic process GO:0010562 139 0.040
Human Fly
establishment of tissue polarity GO:0007164 87 0.039
asymmetric neuroblast division resulting in ganglion mother cell formation GO:0055060 2 0.039
eye photoreceptor cell differentiation GO:0001754 145 0.039
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.038
circulatory system development GO:0072359 82 0.038
Human Zebrafish Mouse
positive regulation of gtp catabolic process GO:0033126 43 0.037
synaptic vesicle budding from presynaptic membrane GO:0016185 1 0.037
chromosome organization GO:0051276 360 0.037
cell morphogenesis involved in malpighian tubule morphogenesis GO:0061336 1 0.037
connective tissue development GO:0061448 3 0.037
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 152 0.037
Mouse Fly
small molecule metabolic process GO:0044281 305 0.037
eye antennal disc morphogenesis GO:0007455 34 0.037
Fly
posttranscriptional regulation of gene expression GO:0010608 145 0.036
anterior head segmentation GO:0035288 3 0.036
meiotic dna repair synthesis GO:0000711 3 0.036
camera type eye development GO:0043010 4 0.036
Mouse
regulation of protein kinase activity GO:0045859 51 0.036
histone mrna catabolic process GO:0071044 0 0.035
centripetally migrating follicle cell migration GO:0060269 1 0.035
open tracheal system development GO:0007424 204 0.035
Fly
activation of protein kinase activity GO:0032147 12 0.035
mesenchymal cell differentiation GO:0048762 1 0.035
Mouse
trichome morphogenesis GO:0010090 3 0.034
negative regulation of protein modification process GO:0031400 29 0.034
regulation of hematopoietic stem cell differentiation GO:1902036 1 0.034
male meiosis GO:0007140 52 0.034
protein targeting to nucleus GO:0044744 51 0.034
immune response activating signal transduction GO:0002757 2 0.034
nucleoside catabolic process GO:0009164 112 0.034
oocyte maturation GO:0001556 3 0.034
stress activated protein kinase signaling cascade GO:0031098 55 0.033
purine nucleoside triphosphate metabolic process GO:0009144 119 0.033
regulation of rna export from nucleus GO:0046831 3 0.033
appendage morphogenesis GO:0035107 397 0.033
organelle localization GO:0051640 148 0.033
adult behavior GO:0030534 137 0.033
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.033
meiotic sister chromatid cohesion centromeric GO:0051754 2 0.033
positive regulation of kinase activity GO:0033674 25 0.032
epithelial cell migration open tracheal system GO:0007427 32 0.032
positive regulation of mapk cascade GO:0043410 63 0.032
magnesium ion homeostasis GO:0010960 1 0.032
regulation of membrane potential GO:0042391 35 0.031
regulation of synapse assembly GO:0051963 94 0.031
positive regulation of immune system process GO:0002684 68 0.031
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051436 2 0.031
dna integration GO:0015074 1 0.031
regulation of meiotic cell cycle GO:0051445 9 0.031
regulation of organ morphogenesis GO:2000027 78 0.030
neuromuscular synaptic transmission GO:0007274 67 0.030
Fly
regulation of cell death GO:0010941 173 0.030
Human
response to fungus GO:0009620 50 0.030
Worm
anterior region determination GO:0007355 1 0.029
actin filament organization GO:0007015 126 0.029

sax disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.337
disease of anatomical entity DOID:7 0 0.100
Human
musculoskeletal system disease DOID:17 0 0.100
Human
thyroid carcinoma DOID:3963 0 0.093
endocrine gland cancer DOID:170 0 0.093
thyroid cancer DOID:1781 0 0.093
cancer DOID:162 0 0.093
organ system cancer DOID:0050686 0 0.093
follicular thyroid carcinoma DOID:3962 0 0.093
large intestine cancer DOID:5672 0 0.067
colon cancer DOID:219 0 0.067
gastrointestinal system cancer DOID:3119 0 0.067
intestinal cancer DOID:10155 0 0.067
colorectal cancer DOID:9256 0 0.067
organ system benign neoplasm DOID:0060085 0 0.057
pilomatrixoma DOID:5374 0 0.057
hair follicle neoplasm DOID:5375 0 0.057
benign neoplasm DOID:0060072 0 0.057
skin benign neoplasm DOID:3165 0 0.057
integumentary system benign neoplasm DOID:0060121 0 0.057
hajdu cheney syndrome DOID:2736 0 0.057
leopard syndrome DOID:14291 0 0.049
artery disease DOID:0050828 0 0.044
vascular disease DOID:178 0 0.044
cardiovascular system disease DOID:1287 0 0.044
aortic disease DOID:520 0 0.044
disease of metabolism DOID:0014667 0 0.038
hemochromatosis DOID:2352 0 0.038
inherited metabolic disorder DOID:655 0 0.038
metal metabolism disorder DOID:896 0 0.038
costello syndrome DOID:0050469 0 0.034
aortic valve stenosis DOID:1712 0 0.032
heart disease DOID:114 0 0.032
heart valve disease DOID:4079 0 0.032
aortic valve disease DOID:62 0 0.032
nervous system benign neoplasm DOID:0060115 0 0.032