Drosophila melanogaster

17 known processes

Tsp (Dmel_CG11326)

Thrombospondin

(Aliases: CT31613,DTSP,CG11326,SP295,D-TSP,Dmel\CG11326,tsp)

Tsp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
muscle attachment GO:0016203 36 0.974
imaginal disc derived appendage development GO:0048737 399 0.864
regulation of epithelial cell proliferation GO:0050678 4 0.803
Human Mouse
organelle assembly GO:0070925 198 0.779
muscle structure development GO:0061061 224 0.565
imaginal disc derived appendage morphogenesis GO:0035114 395 0.356
axonogenesis GO:0007409 290 0.355
cell adhesion GO:0007155 136 0.304
muscle organ development GO:0007517 127 0.283
spermatid differentiation GO:0048515 114 0.277
actomyosin structure organization GO:0031032 56 0.275
actin filament based process GO:0030029 220 0.269
negative regulation of developmental process GO:0051093 201 0.254
Human Mouse
myofibril assembly GO:0030239 36 0.252
cell migration GO:0016477 238 0.250
Human Mouse
skeletal muscle organ development GO:0060538 48 0.243
imaginal disc derived wing morphogenesis GO:0007476 337 0.233
aging GO:0007568 143 0.218
determination of muscle attachment site GO:0016204 7 0.215
cell motility GO:0048870 251 0.215
Human Mouse
negative regulation of cell development GO:0010721 62 0.205
cell chemotaxis GO:0060326 6 0.199
Human Mouse
protein phosphorylation GO:0006468 169 0.195
Human
regulation of cellular protein metabolic process GO:0032268 243 0.186
Human
digestive tract development GO:0048565 149 0.175
regulation of cellular amino acid metabolic process GO:0006521 0 0.172
axon development GO:0061564 297 0.169
regulation of protein kinase activity GO:0045859 51 0.156
Human
neuron projection guidance GO:0097485 241 0.141
appendage development GO:0048736 401 0.140
biological adhesion GO:0022610 138 0.137
wing disc morphogenesis GO:0007472 344 0.136
regulation of cellular component biogenesis GO:0044087 201 0.134
connective tissue development GO:0061448 3 0.134
Mouse
negative regulation of cellular protein metabolic process GO:0032269 85 0.131
Human
larval development GO:0002164 104 0.129
appendage morphogenesis GO:0035107 397 0.126
cellular macromolecule localization GO:0070727 220 0.122
axon guidance GO:0007411 233 0.110
regulation of cellular amine metabolic process GO:0033238 3 0.101
posttranscriptional regulation of gene expression GO:0010608 145 0.095
Human
protein localization GO:0008104 284 0.092
regulation of transferase activity GO:0051338 58 0.091
Human
camera type eye development GO:0043010 4 0.088
regulation of cell proliferation GO:0042127 163 0.088
Human Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.086
tube morphogenesis GO:0035239 191 0.086
sarcomere organization GO:0045214 26 0.083
cellular amine metabolic process GO:0044106 12 0.080
embryonic morphogenesis GO:0048598 206 0.080
multicellular organismal aging GO:0010259 140 0.077
intracellular transport GO:0046907 228 0.075
cellular component assembly involved in morphogenesis GO:0010927 151 0.074
regulation of kinase activity GO:0043549 53 0.072
Human
striated muscle cell differentiation GO:0051146 90 0.070
spermatid development GO:0007286 98 0.069
negative regulation of cellular metabolic process GO:0031324 382 0.068
Human
localization of cell GO:0051674 257 0.066
Human Mouse
cellular response to insulin stimulus GO:0032869 28 0.063
single organism intracellular transport GO:1902582 207 0.063
taxis GO:0042330 304 0.063
Human Mouse
open tracheal system development GO:0007424 204 0.063
cytoplasmic transport GO:0016482 130 0.059
negative regulation of multicellular organismal process GO:0051241 142 0.059
Human Mouse
actin filament organization GO:0007015 126 0.059
myoblast fusion GO:0007520 43 0.058
tube development GO:0035295 244 0.058
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.057
neuron death GO:0070997 27 0.057
determination of adult lifespan GO:0008340 137 0.057
peptidyl tyrosine phosphorylation GO:0018108 24 0.056
regulation of anatomical structure size GO:0090066 163 0.055
chemotaxis GO:0006935 249 0.054
Human Mouse
mesoderm development GO:0007498 78 0.053
embryonic axis specification GO:0000578 107 0.053
endomembrane system organization GO:0010256 119 0.052
sensory organ morphogenesis GO:0090596 260 0.050
regulation of catalytic activity GO:0050790 185 0.049
Human
regulation of chemotaxis GO:0050920 12 0.048
Human Mouse
striated muscle cell development GO:0055002 50 0.048
regulation of neuron death GO:1901214 26 0.047
regulation of multicellular organism growth GO:0040014 40 0.047
tripartite regional subdivision GO:0007351 103 0.047
synapse organization GO:0050808 196 0.046
regulation of protein metabolic process GO:0051246 256 0.046
Human
cellular protein modification process GO:0006464 438 0.045
Human
glial cell migration GO:0008347 31 0.043
peptidyl tyrosine modification GO:0018212 24 0.043
morphogenesis of an epithelium GO:0002009 276 0.043
spermatogenesis GO:0007283 200 0.042
nucleocytoplasmic transport GO:0006913 72 0.041
organ growth GO:0035265 56 0.041
Mouse
regulation of cellular component movement GO:0051270 42 0.041
Human Mouse
response to monosaccharide GO:0034284 4 0.041
Human
cellular protein localization GO:0034613 160 0.040
regulation of response to external stimulus GO:0032101 115 0.040
Human Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.040
protein transport GO:0015031 155 0.040
substrate adhesion dependent cell spreading GO:0034446 2 0.040
regulation of neurogenesis GO:0050767 158 0.040
embryonic development via the syncytial blastoderm GO:0001700 148 0.039
response to peptide hormone GO:0043434 29 0.039
amine metabolic process GO:0009308 12 0.038
regulation of locomotion GO:0040012 42 0.037
Human Mouse
tissue morphogenesis GO:0048729 297 0.037
male gamete generation GO:0048232 201 0.037
negative regulation of response to stimulus GO:0048585 258 0.037
Human
motor neuron axon guidance GO:0008045 58 0.037
eye development GO:0001654 323 0.036
response to purine containing compound GO:0014074 12 0.036
circulatory system development GO:0072359 82 0.036
Human Mouse
respiratory system development GO:0060541 213 0.036
positive regulation of molecular function GO:0044093 136 0.035
Human
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.034
cellular ketone metabolic process GO:0042180 24 0.034
peptidyl amino acid modification GO:0018193 105 0.034
multicellular organismal signaling GO:0035637 12 0.034
ameboidal type cell migration GO:0001667 151 0.034
Human
cellular response to molecule of bacterial origin GO:0071219 3 0.034
phosphorylation GO:0016310 294 0.033
Human
digestive system development GO:0055123 149 0.033
regulation of multicellular organismal development GO:2000026 414 0.032
Human Mouse
body morphogenesis GO:0010171 2 0.032
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.032
negative regulation of phosphorylation GO:0042326 35 0.031
larval somatic muscle development GO:0007526 19 0.031
photoreceptor cell axon guidance GO:0072499 23 0.031
single organism cell adhesion GO:0098602 47 0.031
regulation of cell migration GO:0030334 22 0.031
Human Mouse
nuclear transport GO:0051169 72 0.030
negative regulation of transferase activity GO:0051348 18 0.030
regulation of cellular ketone metabolic process GO:0010565 3 0.030
response to ethanol GO:0045471 59 0.030
morphogenesis of a branching structure GO:0001763 45 0.030
negative regulation of epithelial cell proliferation GO:0050680 4 0.030
Human Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.030
regulation of developmental growth GO:0048638 174 0.030
response to organic substance GO:0010033 284 0.029
Human Mouse
developmental growth GO:0048589 280 0.029
Mouse
muscle cell development GO:0055001 50 0.029
mapk cascade GO:0000165 107 0.029
Human
positive regulation of transferase activity GO:0051347 26 0.029
Human
anterior posterior axis specification GO:0009948 109 0.029
regulation of reproductive process GO:2000241 54 0.029
negative regulation of gene expression GO:0010629 387 0.029
Human
establishment of protein localization GO:0045184 163 0.029
positive regulation of protein modification process GO:0031401 58 0.028
Human
metal ion transport GO:0030001 74 0.028
negative regulation of nervous system development GO:0051961 92 0.028
neuronal action potential GO:0019228 10 0.028
cellular amino acid metabolic process GO:0006520 61 0.028
apposition of dorsal and ventral imaginal disc derived wing surfaces GO:0007475 15 0.028
regulation of localization GO:0032879 275 0.027
Human Mouse
response to abiotic stimulus GO:0009628 341 0.027
endocytosis GO:0006897 310 0.027
Human
ectodermal placode morphogenesis GO:0071697 4 0.027
negative regulation of kinase activity GO:0033673 16 0.027
muscle cell differentiation GO:0042692 103 0.027
positive regulation of response to stimulus GO:0048584 323 0.027
Human Mouse
endodermal cell differentiation GO:0035987 3 0.026
regulation of cell substrate adhesion GO:0010810 2 0.026
Human Mouse
skin development GO:0043588 65 0.026
multicellular organismal homeostasis GO:0048871 41 0.026
larval visceral muscle development GO:0007523 9 0.026
somatic muscle development GO:0007525 66 0.026
regulation of mitotic cell cycle GO:0007346 190 0.025
digestive tract morphogenesis GO:0048546 127 0.025
nuclear export GO:0051168 24 0.025
chromosome segregation GO:0007059 157 0.025
positive regulation of protein phosphorylation GO:0001934 34 0.025
Human
positive regulation of catalytic activity GO:0043085 118 0.024
Human
nucleoside triphosphate catabolic process GO:0009143 108 0.024
positive regulation of developmental process GO:0051094 143 0.024
Human
anatomical structure homeostasis GO:0060249 97 0.024
cell projection assembly GO:0030031 94 0.024
protein localization to organelle GO:0033365 82 0.024
dorsal ventral pattern formation GO:0009953 133 0.024
regulation of cell adhesion GO:0030155 27 0.024
Human Mouse
regulation of notch signaling pathway GO:0008593 100 0.024
positive regulation of cellular component biogenesis GO:0044089 80 0.023
synapse assembly GO:0007416 143 0.023
regulation of neuron apoptotic process GO:0043523 16 0.022
regulation of cell differentiation GO:0045595 302 0.022
phagocytosis GO:0006909 215 0.021
Human
proteolysis GO:0006508 192 0.021
Human
negative regulation of protein metabolic process GO:0051248 85 0.021
Human
response to organonitrogen compound GO:0010243 75 0.021
specification of organ identity GO:0010092 3 0.020
peripheral nervous system development GO:0007422 52 0.020
epithelial cell proliferation GO:0050673 15 0.020
Human Mouse
positive regulation of cell death GO:0010942 69 0.020
Human
embryonic pattern specification GO:0009880 174 0.020
regulation of phosphorus metabolic process GO:0051174 210 0.020
Human
retina development in camera type eye GO:0060041 4 0.020
compound eye development GO:0048749 307 0.020
single organismal cell cell adhesion GO:0016337 45 0.020
ribonucleotide metabolic process GO:0009259 145 0.019
Human
regulation of rna splicing GO:0043484 69 0.019
positive regulation of cellular protein metabolic process GO:0032270 118 0.019
Human
cellular response to endogenous stimulus GO:0071495 80 0.019
Human Mouse
regulation of mitosis GO:0007088 56 0.019
rna processing GO:0006396 147 0.019
positive regulation of cellular component organization GO:0051130 156 0.019
positive regulation of signaling GO:0023056 243 0.019
Human Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.019
protein catabolic process GO:0030163 101 0.019
nucleoside triphosphate metabolic process GO:0009141 120 0.019
regulation of phosphorylation GO:0042325 147 0.019
Human
neural precursor cell proliferation GO:0061351 75 0.018
response to growth factor GO:0070848 31 0.018
Human Mouse
regulation of cell development GO:0060284 215 0.018
regulation of cell size GO:0008361 63 0.018
regulation of nervous system development GO:0051960 248 0.018
regulation of protein transport GO:0051223 57 0.018
negative regulation of cell proliferation GO:0008285 69 0.018
Human Mouse
protein modification process GO:0036211 438 0.017
Human
regulation of molecular function GO:0065009 217 0.017
Human
positive regulation of cell migration GO:0030335 2 0.017
Human Mouse
cellular response to peptide hormone stimulus GO:0071375 28 0.017
gastrulation GO:0007369 70 0.017
neurological system process GO:0050877 358 0.017
syncytium formation by plasma membrane fusion GO:0000768 43 0.017
regulation of neuron projection development GO:0010975 69 0.017
erbb signaling pathway GO:0038127 58 0.017
gene silencing GO:0016458 138 0.017
segmentation GO:0035282 207 0.017
regulation of map kinase activity GO:0043405 17 0.017
Human
cell junction assembly GO:0034329 42 0.016
mesoderm formation GO:0001707 21 0.016
negative regulation of neurogenesis GO:0050768 53 0.016
regulation of proteolysis GO:0030162 87 0.016
Human
carboxylic acid metabolic process GO:0019752 92 0.016
response to organophosphorus GO:0046683 2 0.016
cell junction organization GO:0034330 57 0.016
regulation of protein phosphorylation GO:0001932 64 0.016
Human
action potential GO:0001508 13 0.016
positive regulation of cell proliferation GO:0008284 47 0.016
oocyte maturation GO:0001556 3 0.016
cellular response to nitrogen compound GO:1901699 51 0.016
Mouse
nuclear import GO:0051170 51 0.016
regulation of cell motility GO:2000145 23 0.016
Human Mouse
cell proliferation GO:0008283 299 0.015
Human Mouse
vesicle mediated transport GO:0016192 381 0.015
Human
positive regulation of macromolecule metabolic process GO:0010604 405 0.015
Human
ribonucleoside metabolic process GO:0009119 127 0.015
negative regulation of protein modification process GO:0031400 29 0.015
protein targeting GO:0006605 64 0.015
negative regulation of phosphate metabolic process GO:0045936 45 0.015
positive regulation of cell motility GO:2000147 3 0.015
Human Mouse
germ band shortening GO:0007390 19 0.015
signal transduction by phosphorylation GO:0023014 107 0.015
Human
mesodermal cell migration GO:0008078 7 0.015
cell cell junction assembly GO:0007043 38 0.015
filopodium assembly GO:0046847 33 0.015
cellular response to oxygen containing compound GO:1901701 79 0.015
Mouse
actin cytoskeleton organization GO:0030036 206 0.015
neuron apoptotic process GO:0051402 17 0.015
developmental maturation GO:0021700 172 0.015
Mouse
stem cell development GO:0048864 79 0.015
golgi organization GO:0007030 66 0.014
microtubule bundle formation GO:0001578 27 0.014
cardiovascular system development GO:0072358 82 0.014
Human Mouse
regulation of cell projection organization GO:0031344 92 0.014
organelle fission GO:0048285 340 0.014
regulation of cellular component size GO:0032535 98 0.014
positive regulation of gene expression GO:0010628 290 0.014
Human
extracellular structure organization GO:0043062 46 0.014
negative regulation of catalytic activity GO:0043086 42 0.014
Human
germ line stem cell maintenance GO:0030718 50 0.014
axis elongation GO:0003401 3 0.014
response to hypoxia GO:0001666 53 0.014
response to lipopolysaccharide GO:0032496 4 0.014
sister chromatid segregation GO:0000819 92 0.014
kidney epithelium development GO:0072073 3 0.014
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.014
positive regulation of transcription factor import into nucleus GO:0042993 19 0.014
establishment of localization in cell GO:0051649 402 0.014
cell migration involved in gastrulation GO:0042074 9 0.014
response to decreased oxygen levels GO:0036293 58 0.014
transmission of nerve impulse GO:0019226 12 0.014
endoderm formation GO:0001706 3 0.014
negative regulation of molecular function GO:0044092 51 0.014
Human
gliogenesis GO:0042063 80 0.014
response to lithium ion GO:0010226 1 0.014
regulation of translation GO:0006417 56 0.013
Human
neuroblast proliferation GO:0007405 74 0.013
regulation of neuron differentiation GO:0045664 103 0.013
forebrain development GO:0030900 2 0.013
axon ensheathment GO:0008366 10 0.013
protein localization to nucleus GO:0034504 55 0.013
bmp signaling pathway GO:0030509 27 0.013
ensheathment of neurons GO:0007272 10 0.013
cell cell signaling involved in cell fate commitment GO:0045168 210 0.013
regulation of protein modification process GO:0031399 112 0.013
Human
cranial nerve development GO:0021545 1 0.013
negative regulation of signal transduction GO:0009968 206 0.013
Human
positive regulation of developmental growth GO:0048639 62 0.013
regulation of cell morphogenesis GO:0022604 163 0.013
glial cell development GO:0021782 27 0.013
outflow tract morphogenesis GO:0003151 4 0.013
Mouse
notch signaling pathway GO:0007219 120 0.013
positive regulation of protein kinase activity GO:0045860 25 0.013
Human
activation of protein kinase activity GO:0032147 12 0.012
Human
tissue homeostasis GO:0001894 36 0.012
epithelial cell migration open tracheal system GO:0007427 32 0.012
regulation of membrane potential GO:0042391 35 0.012
mitotic nuclear division GO:0007067 213 0.012
establishment of organelle localization GO:0051656 122 0.012
negative regulation of cell cycle phase transition GO:1901988 103 0.012
response to oxygen levels GO:0070482 59 0.012
nephron development GO:0072006 3 0.012
positive regulation of growth GO:0045927 75 0.012
positive regulation of kinase activity GO:0033674 25 0.012
Human
anterior posterior pattern specification GO:0009952 136 0.012
germ line cyst formation GO:0048134 44 0.012
positive regulation of cell projection organization GO:0031346 29 0.012
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.012
maintenance of location GO:0051235 73 0.012
endodermal cell fate commitment GO:0001711 3 0.012
negative regulation of cell cycle process GO:0010948 109 0.012
response to glucose GO:0009749 2 0.012
Human
camera type eye morphogenesis GO:0048593 2 0.012
positive regulation of immune system process GO:0002684 68 0.012
Human Mouse
regulation of behavior GO:0050795 75 0.012
Human Mouse
regulation of mrna metabolic process GO:1903311 72 0.012
purine containing compound catabolic process GO:0072523 112 0.012
cellular response to external stimulus GO:0071496 66 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
cell cycle arrest GO:0007050 4 0.011
Human
cell death GO:0008219 279 0.011
Human
negative regulation of cell motility GO:2000146 5 0.011
Human
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
formation of primary germ layer GO:0001704 24 0.011
negative regulation of cell cycle GO:0045786 116 0.011
Human
intracellular protein transmembrane transport GO:0065002 4 0.011
negative regulation of phosphorus metabolic process GO:0010563 45 0.011
kidney development GO:0001822 3 0.011
nuclear division GO:0000280 332 0.011
cellular response to oxygen levels GO:0071453 30 0.011
cuticle development GO:0042335 86 0.011
positive regulation of signal transduction GO:0009967 223 0.011
Human Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.011
telencephalon development GO:0021537 2 0.011
lateral inhibition GO:0046331 206 0.011
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.011
Human
purine nucleoside triphosphate catabolic process GO:0009146 108 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
Human
cell division GO:0051301 248 0.011
response to peptide GO:1901652 29 0.011
regulation of receptor activity GO:0010469 10 0.010
regulation of protein serine threonine kinase activity GO:0071900 25 0.010
Human
nucleoside metabolic process GO:0009116 127 0.010
lipid storage GO:0019915 38 0.010
intracellular protein transport GO:0006886 104 0.010
positive regulation of mapk cascade GO:0043410 63 0.010
Human
translation GO:0006412 69 0.010
Human
striated muscle myosin thick filament assembly GO:0071688 3 0.010
regulation of neural precursor cell proliferation GO:2000177 35 0.010
negative regulation of cellular biosynthetic process GO:0031327 277 0.010
negative regulation of cellular component organization GO:0051129 108 0.010
dendrite development GO:0016358 204 0.010

Tsp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.041
vascular disease DOID:178 0 0.041
cardiovascular system disease DOID:1287 0 0.041
myopathy DOID:423 0 0.022
muscular disease DOID:0080000 0 0.022
heart disease DOID:114 0 0.022
cardiomyopathy DOID:0050700 0 0.022
intrinsic cardiomyopathy DOID:0060036 0 0.022
musculoskeletal system disease DOID:17 0 0.022
muscle tissue disease DOID:66 0 0.022
large intestine cancer DOID:5672 0 0.016
gastrointestinal system cancer DOID:3119 0 0.016
intestinal cancer DOID:10155 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
colorectal cancer DOID:9256 0 0.016