Drosophila melanogaster

15 known processes

Pde9 (Dmel_CG42276)

Phosphodiesterase 9

(Aliases: Dmel_CG32648,Dmel\CG42276,CG1627,Dmel_CG3754,CG3761,CG42276,PDE9,CG3754,CG3765,CG32648)

Pde9 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
vesicle mediated transport GO:0016192 381 0.078
response to external biotic stimulus GO:0043207 293 0.076
organic acid metabolic process GO:0006082 103 0.069
neurological system process GO:0050877 358 0.067
establishment of localization in cell GO:0051649 402 0.064
regulation of localization GO:0032879 275 0.056
single organism behavior GO:0044708 391 0.052
imaginal disc derived appendage development GO:0048737 399 0.050
positive regulation of signal transduction GO:0009967 223 0.048
imaginal disc derived appendage morphogenesis GO:0035114 395 0.047
positive regulation of response to stimulus GO:0048584 323 0.046
appendage morphogenesis GO:0035107 397 0.045
protein modification process GO:0036211 438 0.044
endocytosis GO:0006897 310 0.042
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.041
neuron recognition GO:0008038 101 0.041
regulation of neurogenesis GO:0050767 158 0.040
regulation of transport GO:0051049 181 0.039
phagocytosis GO:0006909 215 0.039
axon development GO:0061564 297 0.038
innate immune response GO:0045087 144 0.037
death GO:0016265 284 0.037
adult behavior GO:0030534 137 0.036
oxoacid metabolic process GO:0043436 103 0.036
carboxylic acid metabolic process GO:0019752 92 0.036
axis specification GO:0009798 167 0.035
imaginal disc derived wing morphogenesis GO:0007476 337 0.035
small gtpase mediated signal transduction GO:0007264 88 0.035
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.035
intracellular signal transduction GO:0035556 300 0.035
cellular protein modification process GO:0006464 438 0.034
regulation of intracellular signal transduction GO:1902531 236 0.034
wing disc morphogenesis GO:0007472 344 0.034
response to biotic stimulus GO:0009607 294 0.034
mating GO:0007618 120 0.034
positive regulation of rna biosynthetic process GO:1902680 266 0.034
organonitrogen compound metabolic process GO:1901564 318 0.033
positive regulation of cell communication GO:0010647 250 0.033
positive regulation of intracellular signal transduction GO:1902533 116 0.032
regulation of molecular function GO:0065009 217 0.032
appendage development GO:0048736 401 0.032
transmembrane transport GO:0055085 139 0.031
regulation of neuron differentiation GO:0045664 103 0.031
positive regulation of biosynthetic process GO:0009891 316 0.031
small molecule metabolic process GO:0044281 305 0.031
cell death GO:0008219 279 0.030
centrosome cycle GO:0007098 137 0.030
positive regulation of macromolecule metabolic process GO:0010604 405 0.030
cellular amino acid metabolic process GO:0006520 61 0.029
defense response GO:0006952 300 0.029
cellular amine metabolic process GO:0044106 12 0.029
benzene containing compound metabolic process GO:0042537 3 0.028
response to bacterium GO:0009617 198 0.028
response to organic substance GO:0010033 284 0.028
single organism cellular localization GO:1902580 180 0.028
positive regulation of signaling GO:0023056 243 0.028
single organism intracellular transport GO:1902582 207 0.027
transcription from rna polymerase ii promoter GO:0006366 368 0.027
gland development GO:0048732 191 0.027
dendrite development GO:0016358 204 0.027
synaptic transmission GO:0007268 288 0.026
ion transport GO:0006811 145 0.026
g protein coupled receptor signaling pathway GO:0007186 136 0.026
cation transport GO:0006812 110 0.026
salivary gland morphogenesis GO:0007435 145 0.026
immune system process GO:0002376 347 0.025
microtubule organizing center organization GO:0031023 168 0.025
regulation of catalytic activity GO:0050790 185 0.025
cellular ketone metabolic process GO:0042180 24 0.025
positive regulation of phosphate metabolic process GO:0045937 139 0.025
reproductive behavior GO:0019098 122 0.025
regionalization GO:0003002 416 0.024
positive regulation of rna metabolic process GO:0051254 271 0.024
negative regulation of response to stimulus GO:0048585 258 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.024
post embryonic appendage morphogenesis GO:0035120 385 0.024
intracellular transport GO:0046907 228 0.023
regulation of protein metabolic process GO:0051246 256 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.023
regulation of phosphate metabolic process GO:0019220 210 0.023
amine metabolic process GO:0009308 12 0.023
gene silencing GO:0016458 138 0.023
organic substance transport GO:0071702 257 0.023
eye development GO:0001654 323 0.023
nuclear division GO:0000280 332 0.022
negative regulation of signaling GO:0023057 219 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
proteolysis GO:0006508 192 0.022
epithelial cell differentiation GO:0030855 322 0.022
centrosome organization GO:0051297 163 0.022
regulation of catabolic process GO:0009894 170 0.022
embryonic development via the syncytial blastoderm GO:0001700 148 0.022
response to abiotic stimulus GO:0009628 341 0.022
positive regulation of nucleic acid templated transcription GO:1903508 266 0.022
regulation of cellular amine metabolic process GO:0033238 3 0.021
defense response to bacterium GO:0042742 178 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
immune response GO:0006955 246 0.021
positive regulation of transport GO:0051050 92 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
catabolic process GO:0009056 409 0.021
regulation of cellular ketone metabolic process GO:0010565 3 0.021
forebrain development GO:0030900 2 0.021
defense response to other organism GO:0098542 225 0.020
cell cell signaling involved in cell fate commitment GO:0045168 210 0.020
positive regulation of phosphorus metabolic process GO:0010562 139 0.020
response to other organism GO:0051707 293 0.020
establishment of protein localization GO:0045184 163 0.020
cellular macromolecule localization GO:0070727 220 0.020
programmed cell death GO:0012501 257 0.020
regulation of gene expression epigenetic GO:0040029 128 0.020
phosphorylation GO:0016310 294 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
synapse assembly GO:0007416 143 0.019
l amino acid import GO:0043092 2 0.019
camera type eye development GO:0043010 4 0.019
developmental maturation GO:0021700 172 0.019
negative regulation of gene expression GO:0010629 387 0.019
positive regulation of transcription dna templated GO:0045893 266 0.019
chromosome organization GO:0051276 360 0.019
tissue death GO:0016271 102 0.019
protein localization GO:0008104 284 0.019
chemosensory behavior GO:0007635 106 0.019
regulation of ion transport GO:0043269 39 0.019
histolysis GO:0007559 102 0.019
response to oxygen containing compound GO:1901700 200 0.019
negative regulation of cellular metabolic process GO:0031324 382 0.019
sensory perception of pain GO:0019233 4 0.019
positive regulation of catalytic activity GO:0043085 118 0.018
positive regulation of phosphorylation GO:0042327 87 0.018
organelle fission GO:0048285 340 0.018
centrosome duplication GO:0051298 121 0.018
organic substance catabolic process GO:1901575 308 0.018
olfactory behavior GO:0042048 97 0.018
regulation of cell death GO:0010941 173 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
axonogenesis GO:0007409 290 0.018
negative regulation of cell communication GO:0010648 223 0.017
compound eye development GO:0048749 307 0.017
lateral inhibition GO:0046331 206 0.017
regulation of phosphorylation GO:0042325 147 0.017
epithelial cell development GO:0002064 274 0.017
locomotory behavior GO:0007626 176 0.017
organophosphate metabolic process GO:0019637 195 0.017
regulation of small gtpase mediated signal transduction GO:0051056 93 0.017
synapse organization GO:0050808 196 0.017
salivary gland cell autophagic cell death GO:0035071 83 0.017
ras protein signal transduction GO:0007265 88 0.017
regulation of organelle organization GO:0033043 196 0.017
male gamete generation GO:0048232 201 0.017
endomembrane system organization GO:0010256 119 0.017
regulation of response to stress GO:0080134 200 0.017
regulation of vesicle mediated transport GO:0060627 59 0.017
synaptic target recognition GO:0008039 45 0.017
dorsal ventral pattern formation GO:0009953 133 0.017
multi organism behavior GO:0051705 175 0.017
body morphogenesis GO:0010171 2 0.016
chromatin organization GO:0006325 207 0.016
tube development GO:0035295 244 0.016
positive regulation of gene expression GO:0010628 290 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.016
regulation of neuron projection development GO:0010975 69 0.016
sterol homeostasis GO:0055092 4 0.016
regulation of multicellular organismal development GO:2000026 414 0.016
posttranscriptional regulation of gene expression GO:0010608 145 0.016
single organism catabolic process GO:0044712 228 0.016
photoreceptor cell differentiation GO:0046530 170 0.016
developmental pigmentation GO:0048066 68 0.016
salivary gland development GO:0007431 162 0.015
positive regulation of protein metabolic process GO:0051247 128 0.015
kidney development GO:0001822 3 0.015
ion transmembrane transport GO:0034220 122 0.015
carbohydrate metabolic process GO:0005975 82 0.015
regulation of dendrite development GO:0050773 37 0.015
inter male aggressive behavior GO:0002121 60 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
regulation of cell development GO:0060284 215 0.015
positive regulation of neurogenesis GO:0050769 41 0.015
central nervous system development GO:0007417 201 0.015
cholesterol homeostasis GO:0042632 3 0.015
purine nucleotide metabolic process GO:0006163 146 0.015
sensory perception GO:0007600 196 0.015
single organism biosynthetic process GO:0044711 206 0.015
salivary gland histolysis GO:0035070 88 0.015
dendrite morphogenesis GO:0048813 199 0.015
regulation of cell differentiation GO:0045595 302 0.015
autophagic cell death GO:0048102 83 0.015
exocrine system development GO:0035272 162 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.015
single organism carbohydrate metabolic process GO:0044723 72 0.015
columnar cuboidal epithelial cell development GO:0002066 249 0.015
positive regulation of developmental process GO:0051094 143 0.015
cellular response to ethanol GO:0071361 4 0.014
spermatogenesis GO:0007283 200 0.014
neuropeptide signaling pathway GO:0007218 45 0.014
positive regulation of mapk cascade GO:0043410 63 0.014
meiotic cell cycle GO:0051321 171 0.014
regulation of ras protein signal transduction GO:0046578 93 0.014
organelle localization GO:0051640 148 0.014
enzyme linked receptor protein signaling pathway GO:0007167 179 0.014
regulation of gene silencing GO:0060968 63 0.014
cellular catabolic process GO:0044248 372 0.014
regulation of apoptotic process GO:0042981 130 0.013
negative regulation of cellular component organization GO:0051129 108 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
single organism membrane organization GO:0044802 93 0.013
regulation of synaptic transmission GO:0050804 69 0.013
cellular response to chemical stimulus GO:0070887 199 0.013
membrane organization GO:0061024 112 0.013
inorganic ion transmembrane transport GO:0098660 73 0.013
regulation of synapse structure and activity GO:0050803 128 0.013
response to lipopolysaccharide GO:0032496 4 0.013
regulation of immune system process GO:0002682 176 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
eggshell formation GO:0030703 105 0.013
positive regulation of exocytosis GO:0045921 4 0.013
cellularization GO:0007349 90 0.013
regulation of membrane potential GO:0042391 35 0.013
protein modification by small protein conjugation or removal GO:0070647 106 0.013
response to copper ion GO:0046688 4 0.013
response to wounding GO:0009611 94 0.013
detection of light stimulus GO:0009583 58 0.013
positive regulation of calcium ion transport GO:0051928 4 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
pigment metabolic process GO:0042440 84 0.013
regulation of cellular catabolic process GO:0031329 157 0.013
regulation of transferase activity GO:0051338 58 0.013
heterocycle catabolic process GO:0046700 166 0.013
synaptic vesicle transport GO:0048489 50 0.013
dorsal ventral axis specification GO:0009950 66 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
compound eye photoreceptor cell differentiation GO:0001751 140 0.013
protein phosphorylation GO:0006468 169 0.013
adult locomotory behavior GO:0008344 76 0.012
dna metabolic process GO:0006259 227 0.012
response to endogenous stimulus GO:0009719 119 0.012
eye photoreceptor cell development GO:0042462 81 0.012
positive regulation of cell death GO:0010942 69 0.012
cell maturation GO:0048469 144 0.012
regulation of protein modification process GO:0031399 112 0.012
negative regulation of signal transduction GO:0009968 206 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
protein processing GO:0016485 68 0.012
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.012
detection of stimulus GO:0051606 156 0.012
positive regulation of molecular function GO:0044093 136 0.012
lipid metabolic process GO:0006629 121 0.012
tissue morphogenesis GO:0048729 297 0.012
positive regulation of catabolic process GO:0009896 105 0.012
regulation of cell cycle phase transition GO:1901987 130 0.012
developmental programmed cell death GO:0010623 138 0.012
tube morphogenesis GO:0035239 191 0.012
cellular modified amino acid metabolic process GO:0006575 45 0.012
ovarian follicle cell development GO:0030707 248 0.012
intracellular protein transport GO:0006886 104 0.012
mapk cascade GO:0000165 107 0.012
cellular protein localization GO:0034613 160 0.012
mitotic spindle organization GO:0007052 220 0.012
regulation of programmed cell death GO:0043067 152 0.011
chemical homeostasis GO:0048878 92 0.011
telencephalon development GO:0021537 2 0.011
secretion by cell GO:0032940 101 0.011
regulation of nervous system development GO:0051960 248 0.011
establishment of organelle localization GO:0051656 122 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
regulation of sterol transport GO:0032371 1 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
androgen metabolic process GO:0008209 1 0.011
gtp catabolic process GO:0006184 72 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
compound eye morphogenesis GO:0001745 249 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
cellular response to organic substance GO:0071310 132 0.011
rna localization GO:0006403 115 0.011
secondary metabolic process GO:0019748 75 0.011
phosphatidylethanolamine metabolic process GO:0046337 1 0.011
cholesterol transport GO:0030301 2 0.011
organophosphate catabolic process GO:0046434 112 0.011
homeostatic process GO:0042592 199 0.011
regulation of gtpase activity GO:0043087 44 0.011
apoptotic process GO:0006915 159 0.011
xenobiotic catabolic process GO:0042178 1 0.011
digestive system development GO:0055123 149 0.011
ribosomal large subunit biogenesis GO:0042273 1 0.011
protein ubiquitination GO:0016567 70 0.011
digestive tract development GO:0048565 149 0.011
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
synaptic vesicle localization GO:0097479 53 0.011
response to nitrogen compound GO:1901698 90 0.011
response to radiation GO:0009314 155 0.011
phototransduction GO:0007602 52 0.011
secretion GO:0046903 109 0.011
regulation of mapk cascade GO:0043408 92 0.011
cell proliferation GO:0008283 299 0.011
kidney epithelium development GO:0072073 3 0.011
taxis GO:0042330 304 0.011
protein transport GO:0015031 155 0.011
regulation of synapse organization GO:0050807 110 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
anatomical structure homeostasis GO:0060249 97 0.010
spermatid differentiation GO:0048515 114 0.010
modification dependent protein catabolic process GO:0019941 78 0.010
respiratory system development GO:0060541 213 0.010
dna conformation change GO:0071103 105 0.010
sulfur compound metabolic process GO:0006790 59 0.010
anterior posterior pattern specification GO:0009952 136 0.010
negative regulation of protein metabolic process GO:0051248 85 0.010
oocyte construction GO:0007308 112 0.010
regulation of erk1 and erk2 cascade GO:0070372 39 0.010
negative regulation of transcription dna templated GO:0045892 237 0.010
ribonucleoside triphosphate metabolic process GO:0009199 119 0.010
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.010
regulation of lipid transport GO:0032368 3 0.010
response to glucose GO:0009749 2 0.010
nucleotide metabolic process GO:0009117 161 0.010
regulation of mitotic cell cycle GO:0007346 190 0.010

Pde9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
nervous system disease DOID:863 0 0.023
disease of metabolism DOID:0014667 0 0.019
familial hyperlipidemia DOID:1168 0 0.019
lipid metabolism disorder DOID:3146 0 0.019
inherited metabolic disorder DOID:655 0 0.019
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.013
eye disease DOID:5614 0 0.013