Drosophila melanogaster

159 known processes

Mnn1 (Dmel_CG13778)

Menin 1

(Aliases: Menin1,mnn1,MEN1,CG13778,Dmel\CG13778,menin,CG33266)

Mnn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 223 0.715
protein modification process GO:0036211 438 0.483
Mouse
cellular catabolic process GO:0044248 372 0.412
chromosome organization GO:0051276 360 0.387
Mouse
multicellular organismal aging GO:0010259 140 0.356
positive regulation of rna biosynthetic process GO:1902680 266 0.296
Mouse
negative regulation of rna metabolic process GO:0051253 251 0.291
Mouse
regulation of response to stress GO:0080134 200 0.286
negative regulation of mitotic cell cycle GO:0045930 109 0.282
aging GO:0007568 143 0.273
negative regulation of cell cycle process GO:0010948 109 0.264
compound eye development GO:0048749 307 0.254
negative regulation of cell cycle GO:0045786 116 0.243
positive regulation of macromolecule metabolic process GO:0010604 405 0.243
Mouse
programmed cell death GO:0012501 257 0.241
Mouse
immune system process GO:0002376 347 0.234
Mouse
phosphorylation GO:0016310 294 0.212
regulation of phosphorylation GO:0042325 147 0.202
negative regulation of cell cycle phase transition GO:1901988 103 0.199
negative regulation of biosynthetic process GO:0009890 277 0.197
Mouse
positive regulation of rna metabolic process GO:0051254 271 0.184
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.180
Mouse
negative regulation of response to stimulus GO:0048585 258 0.175
negative regulation of cellular metabolic process GO:0031324 382 0.162
negative regulation of cellular biosynthetic process GO:0031327 277 0.161
Mouse
regulation of organelle organization GO:0033043 196 0.146
Mouse
regulation of cell cycle process GO:0010564 181 0.141
homeostatic process GO:0042592 199 0.132
Mouse
germarium derived egg chamber formation GO:0007293 101 0.131
response to abiotic stimulus GO:0009628 341 0.129
hemopoiesis GO:0030097 46 0.124
Mouse
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.122
Mouse
dna metabolic process GO:0006259 227 0.117
dna recombination GO:0006310 32 0.116
regulation of developmental pigmentation GO:0048070 24 0.114
dna replication GO:0006260 48 0.109
actin cytoskeleton organization GO:0030036 206 0.103
response to starvation GO:0042594 97 0.102
gene silencing GO:0016458 138 0.100
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.099
Mouse
regulation of immune system process GO:0002682 176 0.099
positive regulation of nucleic acid templated transcription GO:1903508 266 0.097
Mouse
regulation of phosphorus metabolic process GO:0051174 210 0.095
response to oxygen containing compound GO:1901700 200 0.091
regulation of molecular function GO:0065009 217 0.089
Mouse
regulation of protein metabolic process GO:0051246 256 0.088
Mouse
positive regulation of gene expression GO:0010628 290 0.087
Mouse
single organism catabolic process GO:0044712 228 0.087
regulation of cellular protein metabolic process GO:0032268 243 0.085
Mouse
cellular protein modification process GO:0006464 438 0.085
Mouse
response to uv GO:0009411 24 0.084
body morphogenesis GO:0010171 2 0.084
amine metabolic process GO:0009308 12 0.082
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.082
Mouse
regulation of cellular response to stress GO:0080135 89 0.082
proteolysis GO:0006508 192 0.081
Mouse
response to alcohol GO:0097305 95 0.078
negative regulation of chromosome organization GO:2001251 19 0.077
nucleobase containing compound catabolic process GO:0034655 165 0.076
response to light stimulus GO:0009416 124 0.076
cellular amine metabolic process GO:0044106 12 0.074
negative regulation of nucleic acid templated transcription GO:1903507 240 0.073
Mouse
dna damage checkpoint GO:0000077 78 0.073
negative regulation of gene expression GO:0010629 387 0.073
Mouse
single organism behavior GO:0044708 391 0.070
protein phosphorylation GO:0006468 169 0.069
compound eye morphogenesis GO:0001745 249 0.069
regulation of cellular ketone metabolic process GO:0010565 3 0.065
determination of adult lifespan GO:0008340 137 0.065
regulation of protein kinase activity GO:0045859 51 0.065
dorsal closure GO:0007391 79 0.064
establishment of localization in cell GO:0051649 402 0.064
regulation of protein modification process GO:0031399 112 0.063
Mouse
regulation of chromatin organization GO:1902275 32 0.061
Mouse
regulation of multi organism process GO:0043900 131 0.061
negative regulation of cell communication GO:0010648 223 0.061
purine ribonucleotide catabolic process GO:0009154 109 0.060
regulation of intracellular signal transduction GO:1902531 236 0.060
regulation of mitotic cell cycle GO:0007346 190 0.059
endocytosis GO:0006897 310 0.057
chromosome segregation GO:0007059 157 0.057
organonitrogen compound metabolic process GO:1901564 318 0.056
positive regulation of response to stimulus GO:0048584 323 0.056
negative regulation of gene expression epigenetic GO:0045814 77 0.055
internal protein amino acid acetylation GO:0006475 38 0.054
death GO:0016265 284 0.054
Mouse
apoptotic process GO:0006915 159 0.054
Mouse
stem cell proliferation GO:0072089 88 0.054
single organism intracellular transport GO:1902582 207 0.053
protein transport GO:0015031 155 0.053
small molecule metabolic process GO:0044281 305 0.052
intrinsic apoptotic signaling pathway GO:0097193 16 0.052
single organism cellular localization GO:1902580 180 0.052
cellular response to oxygen containing compound GO:1901701 79 0.051
regulation of phosphate metabolic process GO:0019220 210 0.051
double strand break repair via homologous recombination GO:0000724 13 0.050
negative regulation of transcription dna templated GO:0045892 237 0.049
Mouse
connective tissue development GO:0061448 3 0.049
cellular response to starvation GO:0009267 61 0.049
regulation of epithelial cell proliferation GO:0050678 4 0.049
negative regulation of signaling GO:0023057 219 0.048
protein modification by small protein conjugation or removal GO:0070647 106 0.048
recombinational repair GO:0000725 13 0.048
organic substance catabolic process GO:1901575 308 0.047
glycosyl compound metabolic process GO:1901657 127 0.046
regulation of cellular amine metabolic process GO:0033238 3 0.046
embryonic morphogenesis GO:0048598 206 0.046
Mouse
cell division GO:0051301 248 0.044
Mouse
negative regulation of cell death GO:0060548 81 0.044
purine nucleoside catabolic process GO:0006152 112 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.044
Mouse
negative regulation of rna biosynthetic process GO:1902679 240 0.044
Mouse
regulation of defense response GO:0031347 102 0.044
intracellular protein transport GO:0006886 104 0.043
dna repair GO:0006281 54 0.043
covalent chromatin modification GO:0016569 106 0.043
Mouse
regulation of cell death GO:0010941 173 0.043
Mouse
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.042
signal transduction by phosphorylation GO:0023014 107 0.042
cell death GO:0008219 279 0.042
Mouse
cell proliferation GO:0008283 299 0.041
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.041
Mouse
nucleotide metabolic process GO:0009117 161 0.041
dna synthesis involved in dna repair GO:0000731 5 0.041
ribonucleoside triphosphate metabolic process GO:0009199 119 0.041
apoptotic signaling pathway GO:0097190 27 0.040
aromatic compound catabolic process GO:0019439 166 0.040
imaginal disc derived wing morphogenesis GO:0007476 337 0.040
purine ribonucleotide metabolic process GO:0009150 145 0.040
regulation of catabolic process GO:0009894 170 0.040
regulation of cell cycle phase transition GO:1901987 130 0.040
glycosyl compound catabolic process GO:1901658 112 0.039
response to organic substance GO:0010033 284 0.039
purine nucleotide catabolic process GO:0006195 109 0.039
hemocyte differentiation GO:0042386 38 0.039
response to radiation GO:0009314 155 0.038
positive regulation of transcription dna templated GO:0045893 266 0.038
Mouse
intracellular signal transduction GO:0035556 300 0.037
establishment of protein localization GO:0045184 163 0.037
catabolic process GO:0009056 409 0.036
cellular response to radiation GO:0071478 52 0.036
protein localization to nucleus GO:0034504 55 0.036
regulation of gene silencing GO:0060968 63 0.036
purine ribonucleoside metabolic process GO:0046128 127 0.035
eye development GO:0001654 323 0.035
regulation of cellular amino acid metabolic process GO:0006521 0 0.035
protein modification by small protein conjugation GO:0032446 79 0.035
negative regulation of cellular protein metabolic process GO:0032269 85 0.034
regulation of multicellular organismal development GO:2000026 414 0.034
regulation of programmed cell death GO:0043067 152 0.034
Mouse
stress activated mapk cascade GO:0051403 52 0.033
chromatin modification GO:0016568 147 0.033
Mouse
purine containing compound metabolic process GO:0072521 155 0.033
chromatin organization GO:0006325 207 0.033
Mouse
double strand break repair via synthesis dependent strand annealing GO:0045003 6 0.032
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.032
heterocycle catabolic process GO:0046700 166 0.032
regulation of catalytic activity GO:0050790 185 0.032
Mouse
axis specification GO:0009798 167 0.032
wing disc morphogenesis GO:0007472 344 0.031
response to organonitrogen compound GO:0010243 75 0.031
peptidyl amino acid modification GO:0018193 105 0.031
positive regulation of catabolic process GO:0009896 105 0.031
regulation of lipid storage GO:0010883 22 0.031
mitotic cell cycle checkpoint GO:0007093 88 0.031
carbohydrate derivative metabolic process GO:1901135 217 0.031
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.030
purine nucleotide metabolic process GO:0006163 146 0.030
negative regulation of apoptotic process GO:0043066 63 0.030
mitotic spindle organization GO:0007052 220 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.030
Mouse
positive regulation of cell communication GO:0010647 250 0.029
adult behavior GO:0030534 137 0.029
dna double strand break processing GO:0000729 3 0.029
stem cell differentiation GO:0048863 117 0.029
nucleoside phosphate catabolic process GO:1901292 110 0.029
nucleotide excision repair GO:0006289 8 0.029
positive regulation of programmed cell death GO:0043068 62 0.029
Mouse
tissue morphogenesis GO:0048729 297 0.029
ribonucleoside catabolic process GO:0042454 112 0.028
cellular response to organic substance GO:0071310 132 0.028
activation of cysteine type endopeptidase activity GO:0097202 17 0.028
nucleoside triphosphate catabolic process GO:0009143 108 0.028
macromolecule catabolic process GO:0009057 161 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.028
Mouse
regulation of mitotic cell cycle phase transition GO:1901990 130 0.027
cell cycle phase transition GO:0044770 140 0.027
response to nitrogen compound GO:1901698 90 0.027
cellular protein catabolic process GO:0044257 83 0.027
response to paraquat GO:1901562 4 0.027
nucleobase containing small molecule metabolic process GO:0055086 174 0.027
histone acetylation GO:0016573 38 0.027
establishment of protein localization to organelle GO:0072594 62 0.027
organelle fission GO:0048285 340 0.027
atp metabolic process GO:0046034 49 0.027
organophosphate metabolic process GO:0019637 195 0.027
organic cyclic compound catabolic process GO:1901361 168 0.026
regulation of transferase activity GO:0051338 58 0.026
response to endogenous stimulus GO:0009719 119 0.026
nucleoside catabolic process GO:0009164 112 0.026
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.026
negative regulation of phosphorylation GO:0042326 35 0.026
negative regulation of molecular function GO:0044092 51 0.026
organonitrogen compound catabolic process GO:1901565 128 0.025
positive regulation of cellular catabolic process GO:0031331 95 0.025
response to other organism GO:0051707 293 0.025
male gamete generation GO:0048232 201 0.025
nucleoside triphosphate metabolic process GO:0009141 120 0.025
stress activated protein kinase signaling cascade GO:0031098 55 0.024
positive regulation of immune system process GO:0002684 68 0.024
nucleoside phosphate metabolic process GO:0006753 162 0.024
response to ionizing radiation GO:0010212 32 0.024
signal transduction in response to dna damage GO:0042770 3 0.024
secretion by cell GO:0032940 101 0.024
protein maturation GO:0051604 71 0.024
vesicle mediated transport GO:0016192 381 0.024
organic substance transport GO:0071702 257 0.023
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.023
Mouse
positive regulation of catalytic activity GO:0043085 118 0.023
Mouse
cellular response to endogenous stimulus GO:0071495 80 0.023
meiosis i GO:0007127 59 0.023
cytoplasmic transport GO:0016482 130 0.022
regulation of apoptotic process GO:0042981 130 0.022
Mouse
positive regulation of molecular function GO:0044093 136 0.022
Mouse
regulation of cell cycle GO:0051726 291 0.022
dorsal ventral pattern formation GO:0009953 133 0.022
ribonucleotide metabolic process GO:0009259 145 0.022
lysosomal transport GO:0007041 13 0.022
cell activation GO:0001775 9 0.022
regulation of protein transport GO:0051223 57 0.022
histone modification GO:0016570 106 0.022
Mouse
transcription from rna polymerase ii promoter GO:0006366 368 0.022
Mouse
positive regulation of intracellular signal transduction GO:1902533 116 0.021
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 6 0.021
purine nucleoside metabolic process GO:0042278 127 0.021
carbohydrate derivative catabolic process GO:1901136 118 0.021
regulation of protein phosphorylation GO:0001932 64 0.021
anterograde axon cargo transport GO:0008089 6 0.021
nucleoside metabolic process GO:0009116 127 0.021
anatomical structure homeostasis GO:0060249 97 0.021
photoreceptor cell development GO:0042461 96 0.020
developmental programmed cell death GO:0010623 138 0.020
modification dependent protein catabolic process GO:0019941 78 0.020
purine containing compound catabolic process GO:0072523 112 0.020
regulation of localization GO:0032879 275 0.020
positive regulation of biosynthetic process GO:0009891 316 0.020
Mouse
camera type eye development GO:0043010 4 0.019
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
regulation of response to dna damage stimulus GO:2001020 23 0.019
negative regulation of developmental process GO:0051093 201 0.019
Mouse
nuclear division GO:0000280 332 0.019
regulation of immune effector process GO:0002697 52 0.019
regulation of cellular catabolic process GO:0031329 157 0.019
cellular macromolecule catabolic process GO:0044265 136 0.019
cuticle development GO:0042335 86 0.018
gastrulation GO:0007369 70 0.018
regulation of transport GO:0051049 181 0.018
secretion GO:0046903 109 0.018
cellular response to nutrient levels GO:0031669 62 0.018
dorsal ventral axis specification GO:0009950 66 0.018
regulation of chromosome organization GO:0033044 64 0.018
Mouse
regulation of cellular component biogenesis GO:0044087 201 0.018
phagocytosis GO:0006909 215 0.018
regulation of proteolysis GO:0030162 87 0.018
Mouse
autophagy GO:0006914 108 0.018
establishment or maintenance of cell polarity GO:0007163 167 0.018
negative regulation of protein metabolic process GO:0051248 85 0.018
regulation of phosphatase activity GO:0010921 3 0.018
positive regulation of cell differentiation GO:0045597 64 0.018
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.017
cellular macromolecular complex assembly GO:0034622 153 0.017
nuclear transport GO:0051169 72 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.017
morphogenesis of an epithelium GO:0002009 276 0.017
regulation of cell cycle g1 s phase transition GO:1902806 23 0.017
pigmentation GO:0043473 75 0.017
purine nucleoside triphosphate catabolic process GO:0009146 108 0.017
protein localization to organelle GO:0033365 82 0.017
morphogenesis of follicular epithelium GO:0016333 36 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
positive regulation of mapk cascade GO:0043410 63 0.017
mitotic cell cycle phase transition GO:0044772 138 0.017
imaginal disc fusion GO:0046528 19 0.017
cellular response to external stimulus GO:0071496 66 0.016
regionalization GO:0003002 416 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.016
regulation of response to biotic stimulus GO:0002831 63 0.016
regulation of cell differentiation GO:0045595 302 0.016
Mouse
protein processing GO:0016485 68 0.016
meiotic cell cycle GO:0051321 171 0.016
negative regulation of phosphorus metabolic process GO:0010563 45 0.016
dna templated transcription elongation GO:0006354 18 0.016
protein targeting GO:0006605 64 0.016
embryonic development via the syncytial blastoderm GO:0001700 148 0.016
actin filament based process GO:0030029 220 0.016
protein ubiquitination GO:0016567 70 0.016
ribonucleoside triphosphate catabolic process GO:0009203 108 0.016
regulation of kinase activity GO:0043549 53 0.016
positive regulation of multicellular organismal process GO:0051240 143 0.015
Mouse
spindle organization GO:0007051 253 0.015
regulation of mapk cascade GO:0043408 92 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
behavioral response to ethanol GO:0048149 49 0.015
morphogenesis of embryonic epithelium GO:0016331 94 0.015
cell cycle checkpoint GO:0000075 95 0.015
purine ribonucleoside catabolic process GO:0046130 112 0.015
negative regulation of signal transduction GO:0009968 206 0.015
compound eye retinal cell programmed cell death GO:0046667 23 0.015
cellular response to chemical stimulus GO:0070887 199 0.015
single organism biosynthetic process GO:0044711 206 0.015
negative regulation of catalytic activity GO:0043086 42 0.015
positive regulation of lipid metabolic process GO:0045834 4 0.015
immune system development GO:0002520 57 0.015
Mouse
oocyte microtubule cytoskeleton organization GO:0016325 35 0.015
double strand break repair GO:0006302 26 0.015
r7 cell differentiation GO:0045466 43 0.015
protein acetylation GO:0006473 39 0.014
imaginal disc derived appendage development GO:0048737 399 0.014
positive regulation of protein catabolic process GO:0045732 34 0.014
cellular response to abiotic stimulus GO:0071214 58 0.014
regulation of stem cell proliferation GO:0072091 40 0.014
regulation of peptidase activity GO:0052547 39 0.014
Mouse
regulation of cell proliferation GO:0042127 163 0.014
Mouse
negative regulation of protein modification process GO:0031400 29 0.014
instar larval development GO:0002168 55 0.014
localization of cell GO:0051674 257 0.014
regulation of autophagy GO:0010506 62 0.014
nucleotide catabolic process GO:0009166 109 0.014
positive regulation of apoptotic process GO:0043065 47 0.014
Mouse
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.014
Mouse
regulation of cell motility GO:2000145 23 0.013
catechol containing compound biosynthetic process GO:0009713 3 0.013
neurological system process GO:0050877 358 0.013
cellular response to nitrogen compound GO:1901699 51 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.013
cell junction organization GO:0034330 57 0.013
regulation of protein localization GO:0032880 76 0.013
jnk cascade GO:0007254 50 0.013
cellular protein complex assembly GO:0043623 71 0.013
dna integrity checkpoint GO:0031570 81 0.013
cortical actin cytoskeleton organization GO:0030866 24 0.013
regulation of histone deacetylation GO:0031063 2 0.013
ras protein signal transduction GO:0007265 88 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
regulation of reproductive process GO:2000241 54 0.012
cellular response to extracellular stimulus GO:0031668 64 0.012
g2 dna damage checkpoint GO:0031572 69 0.012
regulation of locomotion GO:0040012 42 0.012
transition metal ion transport GO:0000041 16 0.012
molting cycle GO:0042303 56 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
Mouse
positive regulation of developmental process GO:0051094 143 0.012
Mouse
gastrulation involving germ band extension GO:0010004 36 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.012
response to organic cyclic compound GO:0014070 89 0.012
cellular macromolecule localization GO:0070727 220 0.012
cellular response to arsenic containing substance GO:0071243 6 0.012
mitotic dna damage checkpoint GO:0044773 74 0.012
regulation of proteasomal protein catabolic process GO:0061136 39 0.012
postreplication repair GO:0006301 2 0.012
regulation of cell morphogenesis GO:0022604 163 0.012
cellular ketone metabolic process GO:0042180 24 0.012
cellular homeostasis GO:0019725 80 0.011
retina development in camera type eye GO:0060041 4 0.011
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.011
oxidoreduction coenzyme metabolic process GO:0006733 2 0.011
protein localization GO:0008104 284 0.011
response to nutrient levels GO:0031667 114 0.011
regulation of meiosis GO:0040020 3 0.011
regulation of response to external stimulus GO:0032101 115 0.011
peptide transport GO:0015833 10 0.011
chromatin silencing GO:0006342 76 0.011
cell growth GO:0016049 108 0.011
protein catabolic process GO:0030163 101 0.011
synaptic transmission GO:0007268 288 0.011
cell maturation GO:0048469 144 0.011
regulation of cell division GO:0051302 72 0.011
Mouse
regulation of endopeptidase activity GO:0052548 36 0.011
Mouse
regulation of cellular localization GO:0060341 136 0.011
sensory organ morphogenesis GO:0090596 260 0.011
compound eye photoreceptor cell differentiation GO:0001751 140 0.010
regulation of hemocyte differentiation GO:0045610 22 0.010
gastrulation with mouth forming first GO:0001703 36 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
long term memory GO:0007616 62 0.010
oocyte dorsal ventral axis specification GO:0007310 34 0.010
ribonucleoside monophosphate metabolic process GO:0009161 51 0.010
mesenchymal cell differentiation GO:0048762 1 0.010
cellular response to ionizing radiation GO:0071479 15 0.010
positive regulation of signaling GO:0023056 243 0.010

Mnn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.049
disease of cellular proliferation DOID:14566 0 0.049
organ system cancer DOID:0050686 0 0.049
disease of anatomical entity DOID:7 0 0.034
disease of metabolism DOID:0014667 0 0.024
acquired metabolic disease DOID:0060158 0 0.024