Drosophila melanogaster

129 known processes

knk (Dmel_CG6217)

knickkopf

(Aliases: Dmel\CG6217,Knk,gnar,Gnarled,CG6217,l(3)85Eg)

knk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
amino sugar metabolic process GO:0006040 10 1.000
open tracheal system development GO:0007424 204 0.998
respiratory system development GO:0060541 213 0.996
glucosamine containing compound metabolic process GO:1901071 9 0.992
regulation of tube length open tracheal system GO:0035159 24 0.990
trachea morphogenesis GO:0060439 22 0.982
cuticle development GO:0042335 86 0.978
regulation of tube architecture open tracheal system GO:0035152 68 0.976
chitin metabolic process GO:0006030 7 0.975
chitin based embryonic cuticle biosynthetic process GO:0008362 16 0.966
regulation of tube size open tracheal system GO:0035151 43 0.961
regulation of tube diameter open tracheal system GO:0035158 11 0.906
branching involved in open tracheal system development GO:0060446 45 0.889
regulation of tube size GO:0035150 46 0.885
chitin based cuticle development GO:0040003 49 0.815
trachea development GO:0060438 29 0.710
terminal branching open tracheal system GO:0007430 17 0.708
regulation of tube diameter GO:0035296 14 0.639
tube morphogenesis GO:0035239 191 0.412
organonitrogen compound metabolic process GO:1901564 318 0.386
aminoglycan biosynthetic process GO:0006023 11 0.370
carbohydrate derivative biosynthetic process GO:1901137 85 0.315
embryonic morphogenesis GO:0048598 206 0.308
aminoglycan metabolic process GO:0006022 18 0.293
regulation of anatomical structure size GO:0090066 163 0.258
tube development GO:0035295 244 0.236
tissue morphogenesis GO:0048729 297 0.224
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.224
regulation of cellular protein metabolic process GO:0032268 243 0.209
morphogenesis of an epithelium GO:0002009 276 0.207
growth GO:0040007 359 0.196
morphogenesis of a branching epithelium GO:0061138 45 0.171
extracellular matrix disassembly GO:0022617 4 0.166
regulation of anatomical structure morphogenesis GO:0022603 242 0.161
positive regulation of immune response GO:0050778 63 0.151
regionalization GO:0003002 416 0.137
regulation of multicellular organismal development GO:2000026 414 0.137
dorsal trunk growth open tracheal system GO:0035001 7 0.123
embryonic pattern specification GO:0009880 174 0.122
taxis GO:0042330 304 0.119
blastoderm segmentation GO:0007350 159 0.119
embryonic epithelial tube formation GO:0001838 6 0.116
motor neuron axon guidance GO:0008045 58 0.114
epithelial cell migration open tracheal system GO:0007427 32 0.108
imaginal disc derived appendage morphogenesis GO:0035114 395 0.098
negative regulation of signal transduction GO:0009968 206 0.098
carbohydrate derivative metabolic process GO:1901135 217 0.098
molting cycle chitin based cuticle GO:0007591 56 0.096
cell motility GO:0048870 251 0.094
tracheal outgrowth open tracheal system GO:0007426 18 0.094
negative regulation of response to stimulus GO:0048585 258 0.092
oocyte development GO:0048599 124 0.092
serotonin metabolic process GO:0042428 2 0.091
regulation of localization GO:0032879 275 0.088
regulation of response to wounding GO:1903034 19 0.087
morphogenesis of a branching structure GO:0001763 45 0.087
epithelial tube formation GO:0072175 7 0.087
imaginal disc derived appendage development GO:0048737 399 0.085
localization of cell GO:0051674 257 0.085
spiracle morphogenesis open tracheal system GO:0035277 22 0.083
germ cell migration GO:0008354 43 0.081
axon development GO:0061564 297 0.080
appendage morphogenesis GO:0035107 397 0.072
developmental growth GO:0048589 280 0.071
embryo development ending in birth or egg hatching GO:0009792 152 0.070
positive regulation of macromolecule metabolic process GO:0010604 405 0.070
embryonic hindgut morphogenesis GO:0048619 48 0.069
single organism behavior GO:0044708 391 0.069
response to radiation GO:0009314 155 0.066
post embryonic appendage morphogenesis GO:0035120 385 0.064
posttranscriptional regulation of gene expression GO:0010608 145 0.063
morphogenesis of embryonic epithelium GO:0016331 94 0.063
thermotaxis GO:0043052 16 0.062
positive regulation of response to stimulus GO:0048584 323 0.061
organonitrogen compound biosynthetic process GO:1901566 117 0.060
wing disc morphogenesis GO:0007472 344 0.060
positive regulation of cell motility GO:2000147 3 0.060
small molecule metabolic process GO:0044281 305 0.058
compound eye morphogenesis GO:0001745 249 0.057
single organism biosynthetic process GO:0044711 206 0.056
segmentation GO:0035282 207 0.055
response to wounding GO:0009611 94 0.054
negative regulation of cell communication GO:0010648 223 0.054
anatomical structure homeostasis GO:0060249 97 0.053
cell cell signaling involved in cell fate commitment GO:0045168 210 0.052
regulation of immune response GO:0050776 118 0.051
camera type eye development GO:0043010 4 0.050
negative regulation of signaling GO:0023057 219 0.050
cellular ketone metabolic process GO:0042180 24 0.049
malpighian tubule morphogenesis GO:0007443 44 0.049
oxoacid metabolic process GO:0043436 103 0.048
cell migration GO:0016477 238 0.047
regulation of extracellular matrix disassembly GO:0010715 1 0.047
lipid metabolic process GO:0006629 121 0.044
regulation of response to biotic stimulus GO:0002831 63 0.044
body morphogenesis GO:0010171 2 0.043
positive regulation of cell migration GO:0030335 2 0.043
establishment or maintenance of cell polarity GO:0007163 167 0.042
regulation of molecular function GO:0065009 217 0.042
proteolysis GO:0006508 192 0.041
cell migration involved in gastrulation GO:0042074 9 0.040
regulation of nervous system development GO:0051960 248 0.038
appendage development GO:0048736 401 0.038
positive regulation of protein metabolic process GO:0051247 128 0.038
imaginal disc derived wing morphogenesis GO:0007476 337 0.038
epithelial tube morphogenesis GO:0060562 88 0.036
regulation of protein metabolic process GO:0051246 256 0.036
ameboidal type cell migration GO:0001667 151 0.035
regulation of cell adhesion GO:0030155 27 0.035
cardiac cell fate commitment GO:0060911 17 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.034
positive regulation of cellular amine metabolic process GO:0033240 0 0.034
chemotaxis GO:0006935 249 0.034
cellular amino acid metabolic process GO:0006520 61 0.032
regulation of cell morphogenesis GO:0022604 163 0.032
periodic partitioning GO:0007365 29 0.032
amino sugar biosynthetic process GO:0046349 5 0.030
regulation of humoral immune response GO:0002920 51 0.030
detection of stimulus GO:0051606 156 0.030
negative regulation of cell differentiation GO:0045596 143 0.030
intracellular signal transduction GO:0035556 300 0.029
regulation of embryonic development GO:0045995 68 0.029
wound healing GO:0042060 75 0.029
molting cycle GO:0042303 56 0.029
branch fusion open tracheal system GO:0035147 17 0.029
negative regulation of developmental process GO:0051093 201 0.028
response to organic substance GO:0010033 284 0.028
tube formation GO:0035148 21 0.028
epithelial cell differentiation GO:0030855 322 0.027
positive regulation of immune system process GO:0002684 68 0.027
neurological system process GO:0050877 358 0.027
regulation of catalytic activity GO:0050790 185 0.027
anterior posterior pattern specification GO:0009952 136 0.026
protein modification process GO:0036211 438 0.026
dorsal ventral pattern formation GO:0009953 133 0.026
renal tubule morphogenesis GO:0061333 44 0.026
regulation of extracellular matrix organization GO:1903053 4 0.026
chitin based cuticle sclerotization GO:0007593 19 0.026
regulation of organ morphogenesis GO:2000027 78 0.025
glial cell migration GO:0008347 31 0.025
hindbrain development GO:0030902 2 0.025
carboxylic acid metabolic process GO:0019752 92 0.025
response to other organism GO:0051707 293 0.025
immune response regulating signaling pathway GO:0002764 2 0.025
chemosensory behavior GO:0007635 106 0.025
positive regulation of signal transduction GO:0009967 223 0.025
defense response to other organism GO:0098542 225 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.025
epithelial cell type specification open tracheal system GO:0035153 11 0.025
positive regulation of defense response GO:0031349 59 0.024
regulation of epithelial cell migration GO:0010632 12 0.024
phagocytosis GO:0006909 215 0.024
negative regulation of notch signaling pathway GO:0045746 41 0.024
response to temperature stimulus GO:0009266 106 0.024
negative regulation of cellular protein metabolic process GO:0032269 85 0.023
regulation of defense response GO:0031347 102 0.023
negative regulation of protein metabolic process GO:0051248 85 0.023
malpighian tubule development GO:0072002 64 0.023
segment polarity determination GO:0007367 25 0.023
protein localization GO:0008104 284 0.023
stem cell development GO:0048864 79 0.023
positive regulation of cellular protein metabolic process GO:0032270 118 0.022
gland development GO:0048732 191 0.022
renal filtration cell differentiation GO:0061318 12 0.022
regulation of synapse structure and activity GO:0050803 128 0.022
positive regulation of rna biosynthetic process GO:1902680 266 0.022
stem cell differentiation GO:0048863 117 0.022
antimicrobial humoral response GO:0019730 99 0.022
carbohydrate derivative catabolic process GO:1901136 118 0.022
protein processing GO:0016485 68 0.021
ectodermal placode morphogenesis GO:0071697 4 0.021
organic acid metabolic process GO:0006082 103 0.021
salivary gland development GO:0007431 162 0.021
positive regulation of transcription dna templated GO:0045893 266 0.021
larval development GO:0002164 104 0.021
immune response activating signal transduction GO:0002757 2 0.021
extracellular structure organization GO:0043062 46 0.020
regulation of innate immune response GO:0045088 71 0.020
regulation of peptidase activity GO:0052547 39 0.020
anterior posterior axis specification embryo GO:0008595 103 0.019
regulation of multi organism process GO:0043900 131 0.019
stem cell maintenance GO:0019827 67 0.019
regulation of notch signaling pathway GO:0008593 100 0.019
hindgut morphogenesis GO:0007442 58 0.019
regulation of cell cell adhesion GO:0022407 21 0.019
protein phosphorylation GO:0006468 169 0.019
steroid catabolic process GO:0006706 1 0.019
renal tubule development GO:0061326 64 0.019
cellular amide metabolic process GO:0043603 80 0.019
protein transport GO:0015031 155 0.019
imaginal disc growth GO:0007446 37 0.019
immune response GO:0006955 246 0.019
regulation of immune system process GO:0002682 176 0.019
regulation of locomotion GO:0040012 42 0.019
epithelial cell migration GO:0010631 148 0.019
cranial nerve development GO:0021545 1 0.018
establishment of planar polarity GO:0001736 87 0.018
cellular response to chemical stimulus GO:0070887 199 0.018
connective tissue development GO:0061448 3 0.018
gliogenesis GO:0042063 80 0.018
epidermis development GO:0008544 65 0.018
positive regulation of cell adhesion GO:0045785 10 0.018
indole containing compound biosynthetic process GO:0042435 4 0.018
amino sugar catabolic process GO:0046348 3 0.018
protein maturation GO:0051604 71 0.017
regulation of cell development GO:0060284 215 0.017
nephron epithelium morphogenesis GO:0072088 3 0.017
synapse assembly GO:0007416 143 0.017
phosphorylation GO:0016310 294 0.017
regulation of protein modification process GO:0031399 112 0.017
cell growth GO:0016049 108 0.017
cellular lipid metabolic process GO:0044255 83 0.017
activation of innate immune response GO:0002218 4 0.017
positive regulation of phosphate metabolic process GO:0045937 139 0.017
chromosome organization GO:0051276 360 0.017
vesicle mediated transport GO:0016192 381 0.017
exocrine system development GO:0035272 162 0.017
negative regulation of gene expression GO:0010629 387 0.017
cellular protein modification process GO:0006464 438 0.017
regulation of neurogenesis GO:0050767 158 0.017
axonogenesis GO:0007409 290 0.017
imaginal disc derived leg morphogenesis GO:0007480 80 0.017
retina development in camera type eye GO:0060041 4 0.017
eye development GO:0001654 323 0.017
developmental induction GO:0031128 3 0.017
positive regulation of nucleic acid templated transcription GO:1903508 266 0.017
regulation of establishment of planar polarity GO:0090175 22 0.016
cellular macromolecule localization GO:0070727 220 0.016
cuticle pattern formation GO:0035017 27 0.016
negative regulation of multicellular organismal process GO:0051241 142 0.016
leg disc development GO:0035218 92 0.016
secretion by cell GO:0032940 101 0.016
dendrite morphogenesis GO:0048813 199 0.016
olfactory behavior GO:0042048 97 0.016
modification dependent macromolecule catabolic process GO:0043632 79 0.015
regulation of behavior GO:0050795 75 0.015
negative regulation of cell cycle process GO:0010948 109 0.015
branching morphogenesis of an epithelial tube GO:0048754 45 0.015
tube fusion GO:0035146 17 0.015
regulation of epithelial cell differentiation GO:0030856 4 0.015
kidney epithelium development GO:0072073 3 0.015
humoral immune response GO:0006959 117 0.015
response to external biotic stimulus GO:0043207 293 0.015
macromolecule catabolic process GO:0009057 161 0.015
negative regulation of rna metabolic process GO:0051253 251 0.015
eye pigmentation GO:0048069 43 0.015
mesenchymal cell differentiation GO:0048762 1 0.015
wnt signaling pathway GO:0016055 98 0.015
non sensory hair organization GO:0035316 47 0.015
salivary gland morphogenesis GO:0007435 145 0.015
hormone metabolic process GO:0042445 33 0.015
antimicrobial peptide production GO:0002775 46 0.015
cognition GO:0050890 141 0.015
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.014
peptide metabolic process GO:0006518 80 0.014
dendrite development GO:0016358 204 0.014
regulation of proteolysis GO:0030162 87 0.014
organic substance transport GO:0071702 257 0.014
hormone biosynthetic process GO:0042446 20 0.014
response to biotic stimulus GO:0009607 294 0.014
associative learning GO:0008306 65 0.014
aromatic amino acid family metabolic process GO:0009072 3 0.014
pole plasm assembly GO:0007315 61 0.014
epidermal cell differentiation GO:0009913 51 0.014
positive regulation of molecular function GO:0044093 136 0.014
oocyte anterior posterior axis specification GO:0007314 72 0.014
signal release GO:0023061 49 0.014
reproductive structure development GO:0048608 74 0.014
epithelium migration GO:0090132 148 0.014
organic substance catabolic process GO:1901575 308 0.014
organophosphate metabolic process GO:0019637 195 0.014
catabolic process GO:0009056 409 0.014
regulation of immune effector process GO:0002697 52 0.014
genital disc development GO:0035215 44 0.013
glandular epithelial cell differentiation GO:0002067 1 0.013
establishment of tissue polarity GO:0007164 87 0.013
positive regulation of signaling GO:0023056 243 0.013
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.013
regeneration GO:0031099 16 0.013
urogenital system development GO:0001655 72 0.013
anterior posterior axis specification GO:0009948 109 0.013
cell maturation GO:0048469 144 0.013
eye morphogenesis GO:0048592 260 0.013
endomembrane system organization GO:0010256 119 0.013
limb morphogenesis GO:0035108 1 0.013
intracellular transport GO:0046907 228 0.013
central nervous system development GO:0007417 201 0.013
response to bacterium GO:0009617 198 0.013
regulation of establishment of protein localization GO:0070201 61 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
axon extension GO:0048675 32 0.013
fibroblast growth factor receptor signaling pathway GO:0008543 10 0.013
establishment of protein localization GO:0045184 163 0.013
catechol containing compound biosynthetic process GO:0009713 3 0.013
defense response to bacterium GO:0042742 178 0.012
secondary branching open tracheal system GO:0007429 2 0.012
positive regulation of innate immune response GO:0045089 38 0.012
negative regulation of biosynthetic process GO:0009890 277 0.012
primary amino compound biosynthetic process GO:1901162 2 0.012
cellular component disassembly GO:0022411 46 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
regulation of antimicrobial humoral response GO:0002759 50 0.012
cholesterol transport GO:0030301 2 0.012
response to endogenous stimulus GO:0009719 119 0.012
neural precursor cell proliferation GO:0061351 75 0.012
lumen formation open tracheal system GO:0035149 12 0.012
multicellular organismal signaling GO:0035637 12 0.012
gonadal mesoderm development GO:0007506 8 0.012
digestive system development GO:0055123 149 0.012
response to oxygen containing compound GO:1901700 200 0.012
lateral inhibition GO:0046331 206 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
protein catabolic process GO:0030163 101 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
detection of abiotic stimulus GO:0009582 66 0.011
secretion GO:0046903 109 0.011
morphogenesis of a polarized epithelium GO:0001738 93 0.011
negative regulation of cell development GO:0010721 62 0.011
nephron development GO:0072006 3 0.011
camera type eye morphogenesis GO:0048593 2 0.011
negative regulation of transcription dna templated GO:0045892 237 0.011
translation GO:0006412 69 0.011
response to abiotic stimulus GO:0009628 341 0.011
gastrulation GO:0007369 70 0.011
striated muscle cell differentiation GO:0051146 90 0.011
extracellular matrix organization GO:0030198 32 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
defense response to gram negative bacterium GO:0050829 94 0.011
negative regulation of cellular metabolic process GO:0031324 382 0.011
cardioblast differentiation GO:0010002 20 0.011
skin development GO:0043588 65 0.011
antimicrobial peptide biosynthetic process GO:0002777 38 0.011
single organismal cell cell adhesion GO:0016337 45 0.011
tissue migration GO:0090130 155 0.011
positive regulation of cellular biosynthetic process GO:0031328 316 0.011
glial cell differentiation GO:0010001 35 0.011
regulation of cellular ketone metabolic process GO:0010565 3 0.010
muscle attachment GO:0016203 36 0.010
cuticle pigmentation GO:0048067 22 0.010
positive regulation of neurogenesis GO:0050769 41 0.010
response to organic cyclic compound GO:0014070 89 0.010
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.010
regulation of epithelial cell proliferation GO:0050678 4 0.010
regulation of map kinase activity GO:0043405 17 0.010
cellular amine metabolic process GO:0044106 12 0.010
tyrosine metabolic process GO:0006570 1 0.010
positive regulation of cell communication GO:0010647 250 0.010
central nervous system segmentation GO:0035283 5 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
mesodermal cell fate specification GO:0007501 2 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
regulation of neuron differentiation GO:0045664 103 0.010

knk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015
disease of metabolism DOID:0014667 0 0.013