Drosophila melanogaster

99 known processes

HGTX (Dmel_CG13475)

CG13475 gene product from transcript CG13475-RB

(Aliases: Nkx6,CG4745,dNkx6,CG13475,nkx6,Dmel\CG13475,Nk6)

HGTX biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
motor neuron axon guidance GO:0008045 58 0.999
neuron projection guidance GO:0097485 241 0.997
axon guidance GO:0007411 233 0.991
axon development GO:0061564 297 0.990
chemotaxis GO:0006935 249 0.982
taxis GO:0042330 304 0.978
axonogenesis GO:0007409 290 0.975
negative regulation of transcription dna templated GO:0045892 237 0.880
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.794
negative regulation of biosynthetic process GO:0009890 277 0.767
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.760
spinal cord development GO:0021510 1 0.743
negative regulation of rna metabolic process GO:0051253 251 0.739
central nervous system development GO:0007417 201 0.734
neuron recognition GO:0008038 101 0.696
negative regulation of rna biosynthetic process GO:1902679 240 0.696
regulation of nervous system development GO:0051960 248 0.648
negative regulation of gene expression GO:0010629 387 0.625
regulation of neurogenesis GO:0050767 158 0.610
negative regulation of nucleic acid templated transcription GO:1903507 240 0.603
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.595
multicellular organismal reproductive behavior GO:0033057 110 0.584
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.574
cell recognition GO:0008037 102 0.552
dendrite guidance GO:0070983 21 0.546
neuron fate commitment GO:0048663 50 0.542
positive regulation of nucleic acid templated transcription GO:1903508 266 0.524
neuron fate specification GO:0048665 12 0.502
dendrite development GO:0016358 204 0.502
regulation of neuron differentiation GO:0045664 103 0.499
synaptic transmission GO:0007268 288 0.473
transcription from rna polymerase ii promoter GO:0006366 368 0.471
myoblast proliferation GO:0051450 3 0.467
positive regulation of transcription dna templated GO:0045893 266 0.464
dendrite morphogenesis GO:0048813 199 0.462
negative regulation of cellular biosynthetic process GO:0031327 277 0.403
negative regulation of cellular metabolic process GO:0031324 382 0.403
tissue morphogenesis GO:0048729 297 0.397
negative regulation of nervous system development GO:0051961 92 0.395
reproductive behavior GO:0019098 122 0.395
cell migration GO:0016477 238 0.368
cell motility GO:0048870 251 0.357
regulation of cell differentiation GO:0045595 302 0.348
positive regulation of cellular biosynthetic process GO:0031328 316 0.327
negative regulation of neurogenesis GO:0050768 53 0.309
regulation of multicellular organismal development GO:2000026 414 0.289
muscle structure development GO:0061061 224 0.282
exocrine system development GO:0035272 162 0.277
multi organism reproductive behavior GO:0044705 121 0.275
positive regulation of macromolecule metabolic process GO:0010604 405 0.274
negative regulation of developmental growth GO:0048640 64 0.268
muscle organ development GO:0007517 127 0.261
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.260
regulation of axon extension involved in axon guidance GO:0048841 4 0.253
synaptic target recognition GO:0008039 45 0.251
regulation of dendrite morphogenesis GO:0048814 28 0.250
localization of cell GO:0051674 257 0.250
axon choice point recognition GO:0016198 26 0.248
multi multicellular organism process GO:0044706 123 0.245
circulatory system development GO:0072359 82 0.233
telencephalon development GO:0021537 2 0.231
positive regulation of gene expression GO:0010628 290 0.231
imaginal disc derived leg morphogenesis GO:0007480 80 0.226
Fly
regulation of axon guidance GO:1902667 10 0.226
cell cell signaling involved in cell fate commitment GO:0045168 210 0.225
stem cell differentiation GO:0048863 117 0.214
regulation of cell development GO:0060284 215 0.208
positive regulation of rna biosynthetic process GO:1902680 266 0.195
central nervous system neuron differentiation GO:0021953 8 0.195
salivary gland development GO:0007431 162 0.181
forebrain development GO:0030900 2 0.178
body morphogenesis GO:0010171 2 0.175
negative regulation of multicellular organismal process GO:0051241 142 0.173
regulation of cell fate commitment GO:0010453 29 0.173
cellular protein modification process GO:0006464 438 0.162
chromatin remodeling GO:0006338 72 0.152
peripheral nervous system development GO:0007422 52 0.148
sensory perception of smell GO:0007608 80 0.147
negative regulation of growth GO:0045926 84 0.146
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.144
cell proliferation GO:0008283 299 0.143
eye morphogenesis GO:0048592 260 0.141
positive regulation of biosynthetic process GO:0009891 316 0.134
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.130
regulation of cell proliferation GO:0042127 163 0.128
axon midline choice point recognition GO:0016199 26 0.127
protein modification process GO:0036211 438 0.125
regulation of axonogenesis GO:0050770 32 0.125
multi organism behavior GO:0051705 175 0.123
regulation of anatomical structure morphogenesis GO:0022603 242 0.117
neuroblast differentiation GO:0014016 29 0.116
muscle tissue morphogenesis GO:0060415 2 0.114
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.114
ameboidal type cell migration GO:0001667 151 0.113
leg disc development GO:0035218 92 0.113
Fly
skeletal muscle organ development GO:0060538 48 0.112
embryo development ending in birth or egg hatching GO:0009792 152 0.110
brain development GO:0007420 120 0.110
lateral inhibition GO:0046331 206 0.108
regulation of cell morphogenesis GO:0022604 163 0.107
detection of chemical stimulus GO:0009593 93 0.107
positive regulation of response to stimulus GO:0048584 323 0.105
Fly
regulation of neuron projection development GO:0010975 69 0.105
sensory perception of chemical stimulus GO:0007606 116 0.102
negative regulation of developmental process GO:0051093 201 0.102
cell fate specification GO:0001708 71 0.100
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.100
cell growth GO:0016049 108 0.098
synapse assembly GO:0007416 143 0.094
growth GO:0040007 359 0.092
Fly
developmental growth GO:0048589 280 0.092
Fly
skeletal muscle tissue development GO:0007519 13 0.091
gland morphogenesis GO:0022612 145 0.085
cilium organization GO:0044782 41 0.084
periodic partitioning GO:0007365 29 0.083
cell fate determination GO:0001709 91 0.082
positive regulation of nervous system development GO:0051962 69 0.082
gland development GO:0048732 191 0.081
retinal ganglion cell axon guidance GO:0031290 12 0.079
regulation of cell growth GO:0001558 43 0.079
positive regulation of rna metabolic process GO:0051254 271 0.077
compound eye photoreceptor cell differentiation GO:0001751 140 0.074
apoptotic process GO:0006915 159 0.073
camera type eye development GO:0043010 4 0.071
connective tissue development GO:0061448 3 0.070
regulation of apoptotic process GO:0042981 130 0.067
salivary gland morphogenesis GO:0007435 145 0.067
regulation of antimicrobial peptide production GO:0002784 44 0.067
regionalization GO:0003002 416 0.067
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.066
regulation of synaptic transmission GO:0050804 69 0.066
positive regulation of neurogenesis GO:0050769 41 0.065
regulation of protein modification process GO:0031399 112 0.063
neuron migration GO:0001764 5 0.063
regulation of growth GO:0040008 233 0.063
blastoderm segmentation GO:0007350 159 0.062
stem cell development GO:0048864 79 0.058
negative regulation of axon extension GO:0030517 3 0.058
response to external biotic stimulus GO:0043207 293 0.057
sensory organ morphogenesis GO:0090596 260 0.055
development of primary sexual characteristics GO:0045137 50 0.054
regulation of synapse structure and activity GO:0050803 128 0.053
positive regulation of cell differentiation GO:0045597 64 0.053
chaeta development GO:0022416 97 0.051
Fly
nucleobase containing small molecule metabolic process GO:0055086 174 0.051
histone methylation GO:0016571 40 0.050
photoreceptor cell axon guidance GO:0072499 23 0.050
striated muscle tissue development GO:0014706 27 0.049
cardiovascular system development GO:0072358 82 0.049
regulation of response to external stimulus GO:0032101 115 0.048
regulation of cellular protein metabolic process GO:0032268 243 0.047
larval development GO:0002164 104 0.046
heart development GO:0007507 82 0.046
regulation of axon extension GO:0030516 8 0.046
regulation of vesicle mediated transport GO:0060627 59 0.045
regulation of protein metabolic process GO:0051246 256 0.044
eye development GO:0001654 323 0.044
neuron death GO:0070997 27 0.044
negative regulation of response to stimulus GO:0048585 258 0.044
segment polarity determination GO:0007367 25 0.043
epithelial tube morphogenesis GO:0060562 88 0.042
neuron fate determination GO:0048664 1 0.042
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.041
cell junction organization GO:0034330 57 0.041
organonitrogen compound metabolic process GO:1901564 318 0.040
negative regulation of neuron differentiation GO:0045665 16 0.039
positive regulation of transport GO:0051050 92 0.039
negative regulation of cell communication GO:0010648 223 0.037
camera type eye morphogenesis GO:0048593 2 0.036
negative regulation of cell development GO:0010721 62 0.036
epithelial cell differentiation GO:0030855 322 0.036
negative regulation of cell differentiation GO:0045596 143 0.036
tube development GO:0035295 244 0.036
axon extension GO:0048675 32 0.035
neuroblast development GO:0014019 13 0.035
histone modification GO:0016570 106 0.034
segmentation GO:0035282 207 0.034
regulation of cell size GO:0008361 63 0.034
respiratory system development GO:0060541 213 0.033
regulation of extent of cell growth GO:0061387 8 0.033
regulation of transport GO:0051049 181 0.033
wound healing GO:0042060 75 0.033
response to organic substance GO:0010033 284 0.033
regulation of cellular component size GO:0032535 98 0.033
endocytosis GO:0006897 310 0.032
negative regulation of signal transduction GO:0009968 206 0.032
retina morphogenesis in camera type eye GO:0060042 2 0.032
mesenchymal cell development GO:0014031 1 0.031
cell maturation GO:0048469 144 0.031
axonal defasciculation GO:0007414 12 0.031
axon target recognition GO:0007412 16 0.030
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.030
detection of stimulus involved in sensory perception GO:0050906 92 0.030
embryonic heart tube development GO:0035050 22 0.030
heart morphogenesis GO:0003007 32 0.030
regulation of synapse assembly GO:0051963 94 0.029
response to wounding GO:0009611 94 0.029
cell death GO:0008219 279 0.029
organonitrogen compound biosynthetic process GO:1901566 117 0.028
muscle tissue development GO:0060537 30 0.028
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.028
death GO:0016265 284 0.028
regulation of neuron apoptotic process GO:0043523 16 0.028
cardiocyte differentiation GO:0035051 29 0.027
organelle assembly GO:0070925 198 0.027
stem cell proliferation GO:0072089 88 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.027
synapse organization GO:0050808 196 0.027
developmental pigmentation GO:0048066 68 0.027
establishment of localization in cell GO:0051649 402 0.026
purine ribonucleotide catabolic process GO:0009154 109 0.026
eye photoreceptor cell differentiation GO:0001754 145 0.026
detection of stimulus GO:0051606 156 0.026
protein alkylation GO:0008213 43 0.026
embryonic organ development GO:0048568 50 0.026
neuroepithelial cell differentiation GO:0060563 6 0.026
axon extension involved in axon guidance GO:0048846 10 0.026
formation of anatomical boundary GO:0048859 37 0.026
methylation GO:0032259 47 0.025
oviposition GO:0018991 19 0.025
negative regulation of cellular component organization GO:0051129 108 0.025
chromatin modification GO:0016568 147 0.025
regulation of cell cycle GO:0051726 291 0.025
Fly
neuroblast proliferation GO:0007405 74 0.025
male gamete generation GO:0048232 201 0.024
regulation of organelle organization GO:0033043 196 0.024
positive regulation of axonogenesis GO:0050772 2 0.024
head development GO:0060322 135 0.024
reproductive structure development GO:0048608 74 0.024
regulation of localization GO:0032879 275 0.023
developmental cell growth GO:0048588 52 0.023
regulation of neuron death GO:1901214 26 0.023
neuron projection extension GO:1990138 32 0.023
positive regulation of multi organism process GO:0043902 40 0.022
regulation of developmental growth GO:0048638 174 0.022
regulation of catalytic activity GO:0050790 185 0.022
nucleotide metabolic process GO:0009117 161 0.022
skin development GO:0043588 65 0.022
membrane organization GO:0061024 112 0.022
morphogenesis of an epithelium GO:0002009 276 0.022
regulation of neural precursor cell proliferation GO:2000177 35 0.022
negative regulation of signaling GO:0023057 219 0.021
regulation of behavior GO:0050795 75 0.021
positive regulation of cellular protein metabolic process GO:0032270 118 0.021
neurological system process GO:0050877 358 0.021
ras protein signal transduction GO:0007265 88 0.021
single organism membrane fusion GO:0044801 42 0.021
chromatin organization GO:0006325 207 0.021
dna metabolic process GO:0006259 227 0.021
single organism cell adhesion GO:0098602 47 0.021
embryonic pattern specification GO:0009880 174 0.021
cardiac cell fate commitment GO:0060911 17 0.020
sensory perception GO:0007600 196 0.020
regulation of dendrite development GO:0050773 37 0.020
peptide metabolic process GO:0006518 80 0.020
regulation of cell death GO:0010941 173 0.020
intracellular transport GO:0046907 228 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
regulation of histone modification GO:0031056 20 0.019
regulation of molecular function GO:0065009 217 0.019
positive regulation of neuron differentiation GO:0045666 26 0.019
positive regulation of cell proliferation GO:0008284 47 0.019
regulation of small gtpase mediated signal transduction GO:0051056 93 0.019
catabolic process GO:0009056 409 0.019
hindgut development GO:0061525 58 0.018
carboxylic acid metabolic process GO:0019752 92 0.018
gonad development GO:0008406 50 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
negative regulation of synapse assembly GO:0051964 39 0.018
cardioblast differentiation GO:0010002 20 0.018
immune system development GO:0002520 57 0.018
positive regulation of cellular component organization GO:0051130 156 0.018
purine ribonucleoside catabolic process GO:0046130 112 0.018
glial cell differentiation GO:0010001 35 0.018
negative regulation of cell death GO:0060548 81 0.017
phosphorylation GO:0016310 294 0.017
purine nucleoside catabolic process GO:0006152 112 0.017
regulation of chromatin modification GO:1903308 28 0.017
inositol lipid mediated signaling GO:0048017 4 0.017
response to oxygen containing compound GO:1901700 200 0.017
positive regulation of antimicrobial peptide production GO:0002225 28 0.017
regulation of cell projection organization GO:0031344 92 0.017
biological adhesion GO:0022610 138 0.016
establishment of protein localization GO:0045184 163 0.016
organic substance catabolic process GO:1901575 308 0.016
regulation of cell shape GO:0008360 113 0.016
developmental growth involved in morphogenesis GO:0060560 65 0.016
Fly
neuroblast fate determination GO:0007400 12 0.016
olfactory bulb axon guidance GO:0071678 3 0.016
regulation of notch signaling pathway GO:0008593 100 0.016
Fly
neuron apoptotic process GO:0051402 17 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
regulation of neuronal synaptic plasticity GO:0048168 8 0.016
formation of organ boundary GO:0010160 30 0.015
regulation of response to biotic stimulus GO:0002831 63 0.015
positive regulation of protein metabolic process GO:0051247 128 0.015
appendage development GO:0048736 401 0.015
Fly
regulation of synaptic plasticity GO:0048167 14 0.015
rna localization GO:0006403 115 0.015
gliogenesis GO:0042063 80 0.015
vesicle organization GO:0016050 44 0.014
cellular protein localization GO:0034613 160 0.014
ribonucleotide catabolic process GO:0009261 109 0.014
small gtpase mediated signal transduction GO:0007264 88 0.014
single organism biosynthetic process GO:0044711 206 0.014
cardioblast cell fate commitment GO:0042684 14 0.014
glycosyl compound catabolic process GO:1901658 112 0.014
positive regulation of protein modification process GO:0031401 58 0.014
oocyte differentiation GO:0009994 145 0.014
ribonucleoside metabolic process GO:0009119 127 0.014
regulation of mitotic cell cycle GO:0007346 190 0.014
embryonic development via the syncytial blastoderm GO:0001700 148 0.014
developmental maturation GO:0021700 172 0.013
negative regulation of sequestering of calcium ion GO:0051283 2 0.013
neural precursor cell proliferation GO:0061351 75 0.013
positive regulation of programmed cell death GO:0043068 62 0.013
synaptic growth at neuromuscular junction GO:0051124 119 0.013
covalent chromatin modification GO:0016569 106 0.013
phagocytosis GO:0006909 215 0.013
neuroblast fate commitment GO:0014017 19 0.013
rho protein signal transduction GO:0007266 14 0.013
lamellipodium organization GO:0097581 21 0.013
regulation of antimicrobial humoral response GO:0002759 50 0.013
nucleoside triphosphate metabolic process GO:0009141 120 0.013
chaeta morphogenesis GO:0008407 42 0.013
positive regulation of developmental process GO:0051094 143 0.013
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.013
germ cell migration GO:0008354 43 0.013
ectodermal placode development GO:0071696 4 0.013
regulation of humoral immune response GO:0002920 51 0.013
purine nucleoside triphosphate metabolic process GO:0009144 119 0.013
central nervous system neuron development GO:0021954 8 0.013
antimicrobial peptide biosynthetic process GO:0002777 38 0.013
production of molecular mediator of immune response GO:0002440 46 0.013
heterocycle catabolic process GO:0046700 166 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
protein methylation GO:0006479 43 0.012
adult locomotory behavior GO:0008344 76 0.012
vesicle mediated transport GO:0016192 381 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.012
carbohydrate metabolic process GO:0005975 82 0.012
cell type specific apoptotic process GO:0097285 38 0.012
compound eye morphogenesis GO:0001745 249 0.012
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.012
digestive system development GO:0055123 149 0.012
oocyte development GO:0048599 124 0.012
regulation of catabolic process GO:0009894 170 0.012
epidermis development GO:0008544 65 0.011
regulation of nucleoside metabolic process GO:0009118 50 0.011
regulation of chromatin organization GO:1902275 32 0.011
regulation of phosphorus metabolic process GO:0051174 210 0.011
locomotory behavior GO:0007626 176 0.011
salivary gland cell autophagic cell death GO:0035071 83 0.011
organophosphate metabolic process GO:0019637 195 0.011
carbohydrate derivative catabolic process GO:1901136 118 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
pyridine nucleotide metabolic process GO:0019362 2 0.011
muscle cell differentiation GO:0042692 103 0.011
single organism membrane organization GO:0044802 93 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
cell cell adhesion GO:0098609 26 0.011
establishment of planar polarity GO:0001736 87 0.011
antimicrobial humoral response GO:0019730 99 0.011
developmental programmed cell death GO:0010623 138 0.011
cell projection assembly GO:0030031 94 0.011
negative regulation of programmed cell death GO:0043069 72 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
negative chemotaxis GO:0050919 15 0.011
positive regulation of organelle organization GO:0010638 65 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
chemosensory behavior GO:0007635 106 0.010
positive regulation of cell death GO:0010942 69 0.010
amine metabolic process GO:0009308 12 0.010
imaginal disc derived appendage morphogenesis GO:0035114 395 0.010
Fly
cellular homeostasis GO:0019725 80 0.010
notch signaling pathway GO:0007219 120 0.010
Fly
negative regulation of cell cycle GO:0045786 116 0.010
regulation of cell cycle process GO:0010564 181 0.010
cell cycle dna replication GO:0044786 23 0.010

HGTX disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
waardenburg s syndrome DOID:9258 0 0.116
cancer DOID:162 0 0.057
disease of cellular proliferation DOID:14566 0 0.057
organ system cancer DOID:0050686 0 0.038
disease of anatomical entity DOID:7 0 0.017