Drosophila melanogaster

74 known processes

tna (Dmel_CG7958)

tonalli

(Aliases: l(3)S058302,l(3)rI075,CG7958,Dmel\CG7958,anon-WO0118547.590,0583/02,l(3)L6731)

tna biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin mediated maintenance of transcription GO:0048096 7 0.652
regulation of gene expression epigenetic GO:0040029 128 0.356
male courtship behavior veined wing vibration GO:0016545 21 0.322
male courtship behavior veined wing generated song production GO:0045433 20 0.230
autophagy GO:0006914 108 0.218
cell cell signaling involved in cell fate commitment GO:0045168 210 0.213
positive regulation of gene expression GO:0010628 290 0.205
chromatin remodeling GO:0006338 72 0.165
appendage development GO:0048736 401 0.154
lateral inhibition GO:0046331 206 0.143
single organism behavior GO:0044708 391 0.138
positive regulation of macromolecule metabolic process GO:0010604 405 0.136
single organism cellular localization GO:1902580 180 0.125
negative regulation of gene expression GO:0010629 387 0.118
imaginal disc derived appendage development GO:0048737 399 0.115
antimicrobial humoral response GO:0019730 99 0.112
regionalization GO:0003002 416 0.106
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.103
cell proliferation GO:0008283 299 0.100
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.100
positive regulation of biosynthetic process GO:0009891 316 0.099
imaginal disc derived appendage morphogenesis GO:0035114 395 0.096
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.094
establishment of localization in cell GO:0051649 402 0.093
regulation of response to stress GO:0080134 200 0.092
muscle structure development GO:0061061 224 0.092
negative regulation of transcription dna templated GO:0045892 237 0.091
regulation of multi organism process GO:0043900 131 0.090
positive regulation of transcription dna templated GO:0045893 266 0.090
sensory organ morphogenesis GO:0090596 260 0.089
response to organic substance GO:0010033 284 0.088
skeletal muscle adaptation GO:0043501 1 0.085
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.083
compound eye morphogenesis GO:0001745 249 0.082
chromatin silencing GO:0006342 76 0.081
wing disc morphogenesis GO:0007472 344 0.081
protein modification by small protein conjugation or removal GO:0070647 106 0.081
post embryonic appendage morphogenesis GO:0035120 385 0.079
vesicle mediated transport GO:0016192 381 0.079
compound eye development GO:0048749 307 0.079
regulation of cellular component biogenesis GO:0044087 201 0.077
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.077
chemotaxis GO:0006935 249 0.076
protein modification by small protein removal GO:0070646 28 0.075
appendage morphogenesis GO:0035107 397 0.071
positive regulation of gene expression epigenetic GO:0045815 16 0.070
positive regulation of defense response to bacterium GO:1900426 23 0.070
muscle tissue development GO:0060537 30 0.066
cytoskeleton dependent cytokinesis GO:0061640 81 0.065
male courtship behavior veined wing extension GO:0048065 22 0.064
response to other organism GO:0051707 293 0.064
regulation of rna splicing GO:0043484 69 0.063
negative regulation of rna biosynthetic process GO:1902679 240 0.063
response to external biotic stimulus GO:0043207 293 0.061
intracellular signal transduction GO:0035556 300 0.060
positive regulation of response to external stimulus GO:0032103 44 0.059
myotube differentiation GO:0014902 46 0.058
regulation of cell cycle phase transition GO:1901987 130 0.058
regulation of defense response GO:0031347 102 0.058
locomotory behavior GO:0007626 176 0.057
neurological system process GO:0050877 358 0.056
negative regulation of rna metabolic process GO:0051253 251 0.056
regulation of production of molecular mediator of immune response GO:0002700 44 0.056
eye morphogenesis GO:0048592 260 0.054
positive regulation of rna metabolic process GO:0051254 271 0.054
response to bacterium GO:0009617 198 0.053
regulation of antimicrobial humoral response GO:0002759 50 0.052
programmed cell death GO:0012501 257 0.051
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.051
gene silencing by rna GO:0031047 57 0.050
stem cell differentiation GO:0048863 117 0.050
regulation of molecular function GO:0065009 217 0.050
developmental programmed cell death GO:0010623 138 0.049
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.048
transcription from rna polymerase ii promoter GO:0006366 368 0.047
Human Mouse
cell death GO:0008219 279 0.047
response to nutrient levels GO:0031667 114 0.047
organonitrogen compound biosynthetic process GO:1901566 117 0.046
response to biotic stimulus GO:0009607 294 0.046
negative regulation of cell proliferation GO:0008285 69 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.045
establishment or maintenance of cell polarity GO:0007163 167 0.045
taxis GO:0042330 304 0.044
response to alcohol GO:0097305 95 0.044
regulation of immune effector process GO:0002697 52 0.043
negative regulation of response to stimulus GO:0048585 258 0.043
negative regulation of cell communication GO:0010648 223 0.043
striated muscle adaptation GO:0014888 1 0.042
posttranscriptional regulation of gene expression GO:0010608 145 0.042
gene silencing GO:0016458 138 0.041
sensory perception of mechanical stimulus GO:0050954 72 0.041
adult behavior GO:0030534 137 0.041
cellular catabolic process GO:0044248 372 0.041
regulation of immune system process GO:0002682 176 0.040
myotube cell development GO:0014904 3 0.040
embryonic axis specification GO:0000578 107 0.039
eye photoreceptor cell differentiation GO:0001754 145 0.038
positive regulation of endopeptidase activity GO:0010950 26 0.037
negative regulation of cell cycle process GO:0010948 109 0.037
regulation of nf kappab import into nucleus GO:0042345 1 0.037
death GO:0016265 284 0.037
negative regulation of developmental process GO:0051093 201 0.037
dendrite development GO:0016358 204 0.037
negative regulation of cellular biosynthetic process GO:0031327 277 0.037
retina development in camera type eye GO:0060041 4 0.036
negative regulation of stem cell proliferation GO:2000647 30 0.036
regulation of multicellular organismal development GO:2000026 414 0.035
positive regulation of immune effector process GO:0002699 28 0.035
cellular response to chemical stimulus GO:0070887 199 0.035
skeletal muscle fiber development GO:0048741 3 0.035
response to mechanical stimulus GO:0009612 28 0.034
protein dna complex assembly GO:0065004 63 0.034
negative regulation of nucleic acid templated transcription GO:1903507 240 0.034
response to ketone GO:1901654 34 0.034
regulation of synapse assembly GO:0051963 94 0.033
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.033
positive regulation of nf kappab import into nucleus GO:0042346 1 0.033
regulation of humoral immune response GO:0002920 51 0.033
regulation of cell proliferation GO:0042127 163 0.032
Mouse
protein modification process GO:0036211 438 0.032
regulation of erbb signaling pathway GO:1901184 42 0.032
regulation of immune response GO:0050776 118 0.032
histolysis GO:0007559 102 0.032
protein localization GO:0008104 284 0.031
nf kappab import into nucleus GO:0042348 1 0.031
autophagic cell death GO:0048102 83 0.031
immune response GO:0006955 246 0.031
endocytosis GO:0006897 310 0.030
antimicrobial peptide production GO:0002775 46 0.030
cytokinesis GO:0000910 90 0.030
cellular response to dna damage stimulus GO:0006974 223 0.030
sex differentiation GO:0007548 81 0.030
mitotic cytokinesis GO:0000281 50 0.029
necrotic cell death GO:0070265 1 0.029
innate immune response GO:0045087 144 0.029
tripartite regional subdivision GO:0007351 103 0.029
positive regulation of cellular biosynthetic process GO:0031328 316 0.029
establishment of protein localization GO:0045184 163 0.029
regulation of gene silencing GO:0060968 63 0.029
compound eye cone cell differentiation GO:0042675 13 0.028
regulation of chromatin silencing GO:0031935 36 0.028
eye development GO:0001654 323 0.028
cell cycle phase transition GO:0044770 140 0.028
muscle organ development GO:0007517 127 0.028
axon development GO:0061564 297 0.028
positive regulation of immune response GO:0050778 63 0.028
skeletal muscle organ development GO:0060538 48 0.027
cellular protein modification process GO:0006464 438 0.027
male gamete generation GO:0048232 201 0.027
mesenchymal cell development GO:0014031 1 0.027
negative regulation of chromatin silencing GO:0031936 9 0.027
regulation of defense response to bacterium GO:1900424 30 0.027
induction of programmed cell death by hormones GO:0035081 12 0.027
protein deubiquitination GO:0016579 17 0.026
negative regulation of biosynthetic process GO:0009890 277 0.026
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.026
positive regulation of nucleic acid templated transcription GO:1903508 266 0.026
synapse assembly GO:0007416 143 0.026
alternative mrna splicing via spliceosome GO:0000380 60 0.025
cell division GO:0051301 248 0.025
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.025
regulation of programmed cell death GO:0043067 152 0.025
regulation of cellular localization GO:0060341 136 0.025
positive regulation of cellular component organization GO:0051130 156 0.025
induction of programmed cell death by ecdysone GO:0035078 12 0.025
salivary gland cell autophagic cell death GO:0035071 83 0.025
regulation of mrna metabolic process GO:1903311 72 0.024
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.024
response to ecdysone GO:0035075 34 0.024
positive regulation of multicellular organismal process GO:0051240 143 0.024
localization of cell GO:0051674 257 0.024
positive regulation of multi organism process GO:0043902 40 0.024
mesenchymal cell differentiation GO:0048762 1 0.024
axonogenesis GO:0007409 290 0.024
wnt signaling pathway GO:0016055 98 0.024
photoreceptor cell differentiation GO:0046530 170 0.024
striated muscle cell differentiation GO:0051146 90 0.024
regulation of intracellular transport GO:0032386 64 0.024
cellular response to ketone GO:1901655 17 0.023
negative regulation of signaling GO:0023057 219 0.023
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.023
production of molecular mediator of immune response GO:0002440 46 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
cellular response to organic substance GO:0071310 132 0.023
positive regulation of response to biotic stimulus GO:0002833 31 0.023
chromosome organization GO:0051276 360 0.023
imaginal disc derived wing morphogenesis GO:0007476 337 0.022
response to radiation GO:0009314 155 0.022
skeletal muscle tissue development GO:0007519 13 0.022
stem cell development GO:0048864 79 0.022
positive regulation of antimicrobial peptide production GO:0002225 28 0.022
antimicrobial peptide biosynthetic process GO:0002777 38 0.022
gonad development GO:0008406 50 0.022
defense response to other organism GO:0098542 225 0.022
negative regulation of epithelial cell proliferation GO:0050680 4 0.022
sensory perception GO:0007600 196 0.022
regulation of phosphorus metabolic process GO:0051174 210 0.022
tissue death GO:0016271 102 0.022
regulation of cellular protein metabolic process GO:0032268 243 0.021
regulation of localization GO:0032879 275 0.021
salivary gland histolysis GO:0035070 88 0.021
mating GO:0007618 120 0.021
negative regulation of signal transduction GO:0009968 206 0.021
posttranscriptional gene silencing by rna GO:0035194 45 0.021
cellular response to radiation GO:0071478 52 0.021
macromolecular complex assembly GO:0065003 256 0.021
compound eye photoreceptor cell differentiation GO:0001751 140 0.021
neuroblast differentiation GO:0014016 29 0.021
phagocytosis GO:0006909 215 0.021
hindbrain development GO:0030902 2 0.021
larval development GO:0002164 104 0.021
positive regulation of humoral immune response GO:0002922 28 0.021
negative regulation of nervous system development GO:0051961 92 0.021
syncytium formation GO:0006949 43 0.020
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.020
development of primary sexual characteristics GO:0045137 50 0.020
regulation of r7 cell differentiation GO:0045676 15 0.020
cellular response to oxygen containing compound GO:1901701 79 0.020
response to gravity GO:0009629 26 0.019
chemosensory behavior GO:0007635 106 0.019
reproductive structure development GO:0048608 74 0.019
cognition GO:0050890 141 0.019
defense response to bacterium GO:0042742 178 0.019
protein complex localization GO:0031503 4 0.019
open tracheal system development GO:0007424 204 0.019
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.019
regulation of nervous system development GO:0051960 248 0.019
regulation of transport GO:0051049 181 0.019
cellular macromolecular complex assembly GO:0034622 153 0.019
protein modification by small protein conjugation GO:0032446 79 0.019
epithelial cell development GO:0002064 274 0.018
translation GO:0006412 69 0.018
apoptotic process GO:0006915 159 0.018
protein complex biogenesis GO:0070271 201 0.018
humoral immune response GO:0006959 117 0.018
cation transmembrane transport GO:0098655 88 0.018
camera type eye development GO:0043010 4 0.018
regulation of phosphorylation GO:0042325 147 0.018
cell migration GO:0016477 238 0.018
dendrite morphogenesis GO:0048813 199 0.018
detection of external stimulus GO:0009581 66 0.018
immune system process GO:0002376 347 0.018
imaginal disc growth GO:0007446 37 0.018
gene silencing by mirna GO:0035195 22 0.018
circulatory system development GO:0072359 82 0.017
Mouse
response to organic cyclic compound GO:0014070 89 0.017
protein import GO:0017038 55 0.017
positive regulation of developmental process GO:0051094 143 0.017
regulation of cell fate commitment GO:0010453 29 0.017
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.017
dna methylation GO:0006306 4 0.016
sensory perception of sound GO:0007605 56 0.016
amide biosynthetic process GO:0043604 42 0.016
catabolic process GO:0009056 409 0.016
positive regulation of protein import into nucleus GO:0042307 21 0.016
regulation of protein localization to nucleus GO:1900180 29 0.016
positive regulation of immune system process GO:0002684 68 0.016
neuroblast fate commitment GO:0014017 19 0.016
gravitaxis GO:0042332 26 0.016
cellular amide metabolic process GO:0043603 80 0.016
cellular response to ethanol GO:0071361 4 0.016
axon guidance GO:0007411 233 0.016
posttranscriptional gene silencing GO:0016441 46 0.016
protein localization to nucleus GO:0034504 55 0.016
mrna processing GO:0006397 104 0.016
rna splicing GO:0008380 83 0.016
muscle fiber development GO:0048747 12 0.016
eye photoreceptor cell development GO:0042462 81 0.016
organic substance transport GO:0071702 257 0.016
regulation of protein localization GO:0032880 76 0.015
protein complex assembly GO:0006461 200 0.015
positive regulation of protein localization to nucleus GO:1900182 21 0.015
activation of cysteine type endopeptidase activity GO:0097202 17 0.015
synaptic growth at neuromuscular junction GO:0051124 119 0.015
negative regulation of multicellular organismal process GO:0051241 142 0.015
response to sterol GO:0036314 34 0.015
positive regulation of cell death GO:0010942 69 0.015
negative regulation of cellular protein metabolic process GO:0032269 85 0.015
neuron remodeling GO:0016322 29 0.015
response to oxygen containing compound GO:1901700 200 0.015
oocyte dorsal ventral axis specification GO:0007310 34 0.015
cellular response to abiotic stimulus GO:0071214 58 0.015
positive regulation of molecular function GO:0044093 136 0.015
regulation of cell death GO:0010941 173 0.015
nuclear import GO:0051170 51 0.015
mrna metabolic process GO:0016071 124 0.014
protein import into nucleus GO:0006606 51 0.014
establishment of ommatidial planar polarity GO:0042067 49 0.014
neuron fate commitment GO:0048663 50 0.014
oocyte construction GO:0007308 112 0.014
negative regulation of cell differentiation GO:0045596 143 0.014
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.014
ecdysone mediated induction of salivary gland cell autophagic cell death GO:0035072 12 0.014
phosphorylation GO:0016310 294 0.014
regulation of epithelial cell proliferation GO:0050678 4 0.014
immune effector process GO:0002252 98 0.014
regulation of photoreceptor cell differentiation GO:0046532 34 0.014
cellular response to endogenous stimulus GO:0071495 80 0.014
negative regulation of wnt signaling pathway GO:0030178 28 0.014
cell junction assembly GO:0034329 42 0.014
axis specification GO:0009798 167 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.014
embryonic pattern specification GO:0009880 174 0.014
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.014
regulation of protein import into nucleus GO:0042306 28 0.014
detection of stimulus involved in sensory perception GO:0050906 92 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.014
response to endogenous stimulus GO:0009719 119 0.014
negative regulation of cell development GO:0010721 62 0.014
rrna processing GO:0006364 3 0.014
dna alkylation GO:0006305 4 0.014
positive regulation of cellular amide metabolic process GO:0034250 26 0.013
connective tissue development GO:0061448 3 0.013
syncytium formation by plasma membrane fusion GO:0000768 43 0.013
cell recognition GO:0008037 102 0.013
oocyte differentiation GO:0009994 145 0.013
negative regulation of immune system process GO:0002683 50 0.013
cellular protein localization GO:0034613 160 0.013
positive regulation of calcium ion transport GO:0051928 4 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
neuroblast fate determination GO:0007400 12 0.013
negative regulation of cell cycle phase transition GO:1901988 103 0.013
response to growth factor GO:0070848 31 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.013
Human Mouse
positive regulation of rna biosynthetic process GO:1902680 266 0.013
regulation of antimicrobial peptide production GO:0002784 44 0.013
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
cytoplasmic transport GO:0016482 130 0.013
regulation of intracellular signal transduction GO:1902531 236 0.013
development of primary female sexual characteristics GO:0046545 12 0.013
regulation of anatomical structure size GO:0090066 163 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.013
synapse organization GO:0050808 196 0.012
single organism intracellular transport GO:1902582 207 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
jak stat cascade GO:0007259 49 0.012
feeding behavior GO:0007631 50 0.012
oocyte axis specification GO:0007309 108 0.012
negative regulation of cellular catabolic process GO:0031330 34 0.012
regulation of proteolysis GO:0030162 87 0.012
response to light stimulus GO:0009416 124 0.012
gland morphogenesis GO:0022612 145 0.012
intracellular protein transport GO:0006886 104 0.012
intrinsic apoptotic signaling pathway GO:0097193 16 0.012
defense response GO:0006952 300 0.012
mushroom body development GO:0016319 70 0.012
associative learning GO:0008306 65 0.012
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.012
regulation of cell shape GO:0008360 113 0.012
neuron projection guidance GO:0097485 241 0.012
induction of programmed cell death GO:0012502 12 0.012
positive regulation of peptidase activity GO:0010952 29 0.012
morphogenesis of follicular epithelium GO:0016333 36 0.012
macromolecule catabolic process GO:0009057 161 0.012
peptide biosynthetic process GO:0043043 42 0.012
mapk cascade GO:0000165 107 0.012
positive regulation of programmed cell death GO:0043068 62 0.011
negative regulation of erbb signaling pathway GO:1901185 29 0.011
negative regulation of molecular function GO:0044092 51 0.011
neural precursor cell proliferation GO:0061351 75 0.011
antibacterial humoral response GO:0019731 44 0.011
neuromuscular synaptic transmission GO:0007274 67 0.011
antibacterial peptide production GO:0002778 22 0.011
rna processing GO:0006396 147 0.011
regulation of mrna processing GO:0050684 71 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
circadian rhythm GO:0007623 105 0.011
regulation of mapk cascade GO:0043408 92 0.011
anterior head development GO:0097065 3 0.011
regulation of cell cycle process GO:0010564 181 0.011
photoreceptor cell development GO:0042461 96 0.011
proteolysis GO:0006508 192 0.011
intracellular transport GO:0046907 228 0.011
tissue migration GO:0090130 155 0.011
regulation of neurogenesis GO:0050767 158 0.011
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.011
regulation of endopeptidase activity GO:0052548 36 0.011
nuclear transport GO:0051169 72 0.011
compound eye photoreceptor development GO:0042051 78 0.011
single organism carbohydrate metabolic process GO:0044723 72 0.011
mitotic cell cycle embryonic GO:0045448 38 0.011
muscle contraction GO:0006936 13 0.011
positive regulation of apoptotic process GO:0043065 47 0.010
membrane depolarization GO:0051899 4 0.010
spermatogenesis GO:0007283 200 0.010
muscle adaptation GO:0043500 1 0.010
regulation of apoptotic process GO:0042981 130 0.010
nucleocytoplasmic transport GO:0006913 72 0.010
signal transduction in response to dna damage GO:0042770 3 0.010
cellular macromolecule localization GO:0070727 220 0.010
wing disc pattern formation GO:0035222 66 0.010
positive regulation of cell cycle g2 m phase transition GO:1902751 2 0.010
regulation of cellular amide metabolic process GO:0034248 39 0.010
cell motility GO:0048870 251 0.010
reproductive system development GO:0061458 74 0.010
chromatin modification GO:0016568 147 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
negative regulation of chromosome organization GO:2001251 19 0.010
embryonic hemopoiesis GO:0035162 26 0.010
g2 m transition of mitotic cell cycle GO:0000086 19 0.010
response to nitrogen compound GO:1901698 90 0.010

tna disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
heart conduction disease DOID:10273 0 0.151
disease of anatomical entity DOID:7 0 0.151
cardiovascular system disease DOID:1287 0 0.151
diabetes mellitus DOID:9351 0 0.020
disease of metabolism DOID:0014667 0 0.020
carbohydrate metabolism disease DOID:0050013 0 0.020
glucose metabolism disease DOID:4194 0 0.020
acquired metabolic disease DOID:0060158 0 0.020
type 2 diabetes mellitus DOID:9352 0 0.014
nervous system disease DOID:863 0 0.011