Drosophila melanogaster

76 known processes

E(Pc) (Dmel_CG7776)

Enhancer of Polycomb

(Aliases: Dmel\CG7776,E(PC),GH05739,l(2)28-28-12,anon-48Ac,e(Pc),GH14582,CG7776,III)

E(Pc) biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron projection guidance GO:0097485 241 0.287
taxis GO:0042330 304 0.249
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.237
negative regulation of gene expression GO:0010629 387 0.227
negative regulation of cellular biosynthetic process GO:0031327 277 0.206
negative regulation of rna biosynthetic process GO:1902679 240 0.200
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.198
axon development GO:0061564 297 0.160
axonogenesis GO:0007409 290 0.149
central nervous system development GO:0007417 201 0.146
negative regulation of biosynthetic process GO:0009890 277 0.139
negative regulation of rna metabolic process GO:0051253 251 0.136
transcription from rna polymerase ii promoter GO:0006366 368 0.129
response to organic substance GO:0010033 284 0.122
negative regulation of cellular metabolic process GO:0031324 382 0.122
regulation of cell differentiation GO:0045595 302 0.118
chromatin silencing GO:0006342 76 0.114
immune system process GO:0002376 347 0.113
brain development GO:0007420 120 0.110
regulation of gene expression epigenetic GO:0040029 128 0.109
chemotaxis GO:0006935 249 0.105
single organism behavior GO:0044708 391 0.102
dendrite development GO:0016358 204 0.099
response to abiotic stimulus GO:0009628 341 0.094
negative regulation of transcription dna templated GO:0045892 237 0.094
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.092
positive regulation of response to stimulus GO:0048584 323 0.089
positive regulation of gene expression GO:0010628 290 0.088
response to external biotic stimulus GO:0043207 293 0.087
camera type eye development GO:0043010 4 0.083
neuromuscular junction development GO:0007528 149 0.082
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.080
dendrite morphogenesis GO:0048813 199 0.080
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.078
positive regulation of cellular biosynthetic process GO:0031328 316 0.075
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.075
axon guidance GO:0007411 233 0.069
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 17 0.069
imaginal disc derived wing morphogenesis GO:0007476 337 0.068
negative regulation of gene expression epigenetic GO:0045814 77 0.068
positive regulation of nervous system development GO:0051962 69 0.067
dendrite guidance GO:0070983 21 0.064
positive regulation of rna biosynthetic process GO:1902680 266 0.064
gene silencing GO:0016458 138 0.063
positive regulation of signal transduction GO:0009967 223 0.059
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.058
positive regulation of rna metabolic process GO:0051254 271 0.058
organonitrogen compound metabolic process GO:1901564 318 0.058
positive regulation of nucleic acid templated transcription GO:1903508 266 0.058
regulation of nervous system development GO:0051960 248 0.058
developmental programmed cell death GO:0010623 138 0.057
retina development in camera type eye GO:0060041 4 0.057
regulation of anatomical structure size GO:0090066 163 0.056
hindbrain development GO:0030902 2 0.056
negative regulation of signal transduction GO:0009968 206 0.055
detection of stimulus GO:0051606 156 0.055
positive regulation of cell communication GO:0010647 250 0.055
chromatin remodeling GO:0006338 72 0.055
chromosome organization GO:0051276 360 0.053
epithelial cell differentiation GO:0030855 322 0.053
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.051
negative regulation of response to stimulus GO:0048585 258 0.051
tissue morphogenesis GO:0048729 297 0.051
positive regulation of biosynthetic process GO:0009891 316 0.050
negative regulation of nucleic acid templated transcription GO:1903507 240 0.050
cell death GO:0008219 279 0.050
cellular protein modification process GO:0006464 438 0.050
forebrain development GO:0030900 2 0.047
appendage morphogenesis GO:0035107 397 0.044
regulation of response to stress GO:0080134 200 0.044
programmed cell death GO:0012501 257 0.043
negative regulation of cell communication GO:0010648 223 0.043
establishment of localization in cell GO:0051649 402 0.043
immune response GO:0006955 246 0.043
developmental growth GO:0048589 280 0.043
death GO:0016265 284 0.040
response to oxygen containing compound GO:1901700 200 0.039
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.039
positive regulation of signaling GO:0023056 243 0.039
intracellular signal transduction GO:0035556 300 0.038
tissue death GO:0016271 102 0.038
muscle structure development GO:0061061 224 0.037
regulation of multi organism process GO:0043900 131 0.037
vesicle mediated transport GO:0016192 381 0.037
cellular response to dna damage stimulus GO:0006974 223 0.037
regulation of multicellular organismal development GO:2000026 414 0.037
positive regulation of macromolecule metabolic process GO:0010604 405 0.037
apoptotic process GO:0006915 159 0.037
post embryonic appendage morphogenesis GO:0035120 385 0.036
synaptic growth at neuromuscular junction GO:0051124 119 0.036
response to other organism GO:0051707 293 0.036
determination of adult lifespan GO:0008340 137 0.035
intracellular transport GO:0046907 228 0.035
endocytosis GO:0006897 310 0.035
motor neuron axon guidance GO:0008045 58 0.034
enzyme linked receptor protein signaling pathway GO:0007167 179 0.034
developmental cell growth GO:0048588 52 0.034
response to oxidative stress GO:0006979 86 0.034
dna metabolic process GO:0006259 227 0.034
response to organic cyclic compound GO:0014070 89 0.034
negative regulation of signaling GO:0023057 219 0.034
gland morphogenesis GO:0022612 145 0.032
regulation of anatomical structure morphogenesis GO:0022603 242 0.032
regulation of cell death GO:0010941 173 0.031
regulation of programmed cell death GO:0043067 152 0.031
muscle organ development GO:0007517 127 0.031
neurological system process GO:0050877 358 0.030
locomotory behavior GO:0007626 176 0.030
positive regulation of developmental process GO:0051094 143 0.030
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.029
salivary gland histolysis GO:0035070 88 0.029
regulation of cellular component biogenesis GO:0044087 201 0.029
positive regulation of cellular component organization GO:0051130 156 0.029
positive regulation of transcription dna templated GO:0045893 266 0.028
humoral immune response GO:0006959 117 0.028
appendage development GO:0048736 401 0.028
regulation of apoptotic process GO:0042981 130 0.028
signal transduction by phosphorylation GO:0023014 107 0.028
growth GO:0040007 359 0.028
chromatin assembly or disassembly GO:0006333 52 0.028
positive regulation of cell differentiation GO:0045597 64 0.028
chromatin organization GO:0006325 207 0.027
histolysis GO:0007559 102 0.027
multicellular organismal reproductive behavior GO:0033057 110 0.027
sensory perception of chemical stimulus GO:0007606 116 0.027
wnt signaling pathway GO:0016055 98 0.027
cell cell signaling involved in cell fate commitment GO:0045168 210 0.027
cellular response to external stimulus GO:0071496 66 0.027
response to alkaloid GO:0043279 26 0.027
carbohydrate derivative biosynthetic process GO:1901137 85 0.026
phosphorylation GO:0016310 294 0.026
exocrine system development GO:0035272 162 0.026
regulation of localization GO:0032879 275 0.025
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 17 0.025
regulation of cell proliferation GO:0042127 163 0.025
mapk cascade GO:0000165 107 0.025
g protein coupled receptor signaling pathway GO:0007186 136 0.025
organonitrogen compound biosynthetic process GO:1901566 117 0.024
telencephalon development GO:0021537 2 0.024
courtship behavior GO:0007619 68 0.024
eye development GO:0001654 323 0.024
regulation of cell shape GO:0008360 113 0.024
regulation of tube size GO:0035150 46 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.023
multi multicellular organism process GO:0044706 123 0.023
cell motility GO:0048870 251 0.023
response to wounding GO:0009611 94 0.023
neural retina development GO:0003407 4 0.023
regulation of lipid storage GO:0010883 22 0.023
positive regulation of phosphorus metabolic process GO:0010562 139 0.023
regulation of immune system process GO:0002682 176 0.022
single organism intracellular transport GO:1902582 207 0.022
adult locomotory behavior GO:0008344 76 0.022
carbohydrate derivative metabolic process GO:1901135 217 0.022
response to biotic stimulus GO:0009607 294 0.022
phagocytosis GO:0006909 215 0.022
gland development GO:0048732 191 0.021
salivary gland morphogenesis GO:0007435 145 0.021
organic substance transport GO:0071702 257 0.021
atp dependent chromatin remodeling GO:0043044 22 0.021
male mating behavior GO:0060179 70 0.021
maintenance of location GO:0051235 73 0.021
peptidyl lysine acetylation GO:0018394 39 0.021
imaginal disc derived appendage morphogenesis GO:0035114 395 0.021
antimicrobial humoral response GO:0019730 99 0.021
nucleobase containing small molecule metabolic process GO:0055086 174 0.020
glycoprotein metabolic process GO:0009100 41 0.020
positive regulation of nucleotide metabolic process GO:0045981 55 0.020
protein modification process GO:0036211 438 0.020
detection of abiotic stimulus GO:0009582 66 0.020
regulation of cellular response to stress GO:0080135 89 0.020
response to temperature stimulus GO:0009266 106 0.020
regulation of immune response GO:0050776 118 0.020
salivary gland cell autophagic cell death GO:0035071 83 0.020
positive regulation of immune system process GO:0002684 68 0.020
defense response GO:0006952 300 0.020
negative regulation of apoptotic process GO:0043066 63 0.020
cellular response to chemical stimulus GO:0070887 199 0.019
regulation of defense response GO:0031347 102 0.019
protein complex disassembly GO:0043241 36 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.019
single organism biosynthetic process GO:0044711 206 0.019
embryo development ending in birth or egg hatching GO:0009792 152 0.019
synaptic transmission GO:0007268 288 0.019
cytoplasmic transport GO:0016482 130 0.019
intracellular protein transport GO:0006886 104 0.019
imaginal disc derived appendage development GO:0048737 399 0.018
cell migration GO:0016477 238 0.018
cell recognition GO:0008037 102 0.018
open tracheal system development GO:0007424 204 0.018
organic acid metabolic process GO:0006082 103 0.018
body morphogenesis GO:0010171 2 0.018
cellular macromolecule localization GO:0070727 220 0.018
negative regulation of nervous system development GO:0051961 92 0.018
regulation of molecular function GO:0065009 217 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
gene silencing by rna GO:0031047 57 0.018
sensory perception of smell GO:0007608 80 0.018
carboxylic acid metabolic process GO:0019752 92 0.018
response to reactive oxygen species GO:0000302 24 0.018
cellular protein localization GO:0034613 160 0.018
positive regulation of phosphate metabolic process GO:0045937 139 0.018
regulation of cellular amine metabolic process GO:0033238 3 0.018
regulation of cell projection organization GO:0031344 92 0.018
rna processing GO:0006396 147 0.018
mitotic cell cycle embryonic GO:0045448 38 0.018
response to extracellular stimulus GO:0009991 116 0.017
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.017
regulation of synapse structure and activity GO:0050803 128 0.017
detection of external stimulus GO:0009581 66 0.017
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.017
defense response to bacterium GO:0042742 178 0.017
chromatin modification GO:0016568 147 0.017
wound healing GO:0042060 75 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
macromolecular complex assembly GO:0065003 256 0.017
regulation of cyclic nucleotide biosynthetic process GO:0030802 13 0.017
regulation of neurogenesis GO:0050767 158 0.017
negative regulation of cell differentiation GO:0045596 143 0.017
protein transport GO:0015031 155 0.017
sleep GO:0030431 49 0.017
hematopoietic or lymphoid organ development GO:0048534 57 0.017
cellular catabolic process GO:0044248 372 0.017
positive regulation of response to biotic stimulus GO:0002833 31 0.016
positive regulation of lipid storage GO:0010884 4 0.016
response to radiation GO:0009314 155 0.016
spinal cord development GO:0021510 1 0.016
peptidyl amino acid modification GO:0018193 105 0.016
regulation of cell development GO:0060284 215 0.016
amine metabolic process GO:0009308 12 0.016
regulation of neurotransmitter levels GO:0001505 38 0.016
connective tissue development GO:0061448 3 0.016
regulation of dendrite morphogenesis GO:0048814 28 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
cellular amide metabolic process GO:0043603 80 0.016
lymph gland development GO:0048542 28 0.016
response to endogenous stimulus GO:0009719 119 0.016
neuron recognition GO:0008038 101 0.016
embryonic morphogenesis GO:0048598 206 0.016
cellular component assembly involved in morphogenesis GO:0010927 151 0.016
chemosensory behavior GO:0007635 106 0.016
wing disc morphogenesis GO:0007472 344 0.016
regulation of antimicrobial peptide production GO:0002784 44 0.015
positive regulation of cell migration GO:0030335 2 0.015
head development GO:0060322 135 0.015
regulation of response to external stimulus GO:0032101 115 0.015
carbohydrate metabolic process GO:0005975 82 0.015
regulation of cell cycle GO:0051726 291 0.015
negative regulation of developmental process GO:0051093 201 0.015
regulation of response to biotic stimulus GO:0002831 63 0.015
negative regulation of neurogenesis GO:0050768 53 0.015
regulation of neuron differentiation GO:0045664 103 0.015
organic substance catabolic process GO:1901575 308 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.015
camera type eye morphogenesis GO:0048593 2 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.015
developmental growth involved in morphogenesis GO:0060560 65 0.015
immune effector process GO:0002252 98 0.015
cellular macromolecule catabolic process GO:0044265 136 0.015
homeostatic process GO:0042592 199 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
macromolecule catabolic process GO:0009057 161 0.014
regulation of wnt signaling pathway GO:0030111 68 0.014
mrna processing GO:0006397 104 0.014
leg disc morphogenesis GO:0007478 80 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
positive regulation of molecular function GO:0044093 136 0.014
catabolic process GO:0009056 409 0.014
negative regulation of cellular component organization GO:0051129 108 0.014
negative regulation of cell development GO:0010721 62 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
covalent chromatin modification GO:0016569 106 0.014
localization of cell GO:0051674 257 0.014
regionalization GO:0003002 416 0.014
olfactory behavior GO:0042048 97 0.014
cell proliferation GO:0008283 299 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.014
positive regulation of immune response GO:0050778 63 0.014
protein complex biogenesis GO:0070271 201 0.014
circadian behavior GO:0048512 76 0.014
protein localization GO:0008104 284 0.013
synapse organization GO:0050808 196 0.013
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.013
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 18 0.013
gene silencing by mirna GO:0035195 22 0.013
segmentation GO:0035282 207 0.013
response to starvation GO:0042594 97 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
cellular amine metabolic process GO:0044106 12 0.013
regulation of growth GO:0040008 233 0.013
negative regulation of cell death GO:0060548 81 0.013
respiratory system development GO:0060541 213 0.013
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.013
positive regulation of cell motility GO:2000147 3 0.013
sex differentiation GO:0007548 81 0.013
reproductive behavior GO:0019098 122 0.013
response to sterol GO:0036314 34 0.013
erbb signaling pathway GO:0038127 58 0.013
cellular response to starvation GO:0009267 61 0.013
mitotic g2 m transition checkpoint GO:0044818 70 0.013
response to alcohol GO:0097305 95 0.013
anatomical structure homeostasis GO:0060249 97 0.013
stem cell development GO:0048864 79 0.013
ribonucleoprotein complex biogenesis GO:0022613 31 0.013
protein n linked glycosylation GO:0006487 9 0.013
establishment of protein localization GO:0045184 163 0.013
oxoacid metabolic process GO:0043436 103 0.013
salivary gland development GO:0007431 162 0.013
protein phosphorylation GO:0006468 169 0.013
epithelial cell development GO:0002064 274 0.012
cellular response to biotic stimulus GO:0071216 4 0.012
regulation of mrna processing GO:0050684 71 0.012
regulation of behavior GO:0050795 75 0.012
regulation of circadian sleep wake cycle sleep GO:0045187 21 0.012
chromatin assembly GO:0031497 48 0.012
regulation of blood circulation GO:1903522 21 0.012
cellular ketone metabolic process GO:0042180 24 0.012
nucleotide metabolic process GO:0009117 161 0.012
small molecule metabolic process GO:0044281 305 0.012
stem cell maintenance GO:0019827 67 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
response to ecdysone GO:0035075 34 0.012
morphogenesis of embryonic epithelium GO:0016331 94 0.012
rhythmic behavior GO:0007622 76 0.012
positive regulation of phosphorylation GO:0042327 87 0.012
mrna metabolic process GO:0016071 124 0.012
eye antennal disc development GO:0035214 60 0.012
purine nucleotide metabolic process GO:0006163 146 0.012
ras protein signal transduction GO:0007265 88 0.012
nucleoside catabolic process GO:0009164 112 0.011
cell division GO:0051301 248 0.011
ribonucleoprotein complex subunit organization GO:0071826 28 0.011
regulation of chromatin silencing GO:0031935 36 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
purine containing compound metabolic process GO:0072521 155 0.011
regulation of organelle organization GO:0033043 196 0.011
larval development GO:0002164 104 0.011
regulation of mrna metabolic process GO:1903311 72 0.011
histone modification GO:0016570 106 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.011
male gamete generation GO:0048232 201 0.011
protein targeting GO:0006605 64 0.011
multicellular organismal aging GO:0010259 140 0.011
cell growth GO:0016049 108 0.011
interspecies interaction between organisms GO:0044419 16 0.011
digestive system development GO:0055123 149 0.011
embryonic development via the syncytial blastoderm GO:0001700 148 0.011
intracellular receptor signaling pathway GO:0030522 19 0.011
ribonucleoprotein complex assembly GO:0022618 23 0.011
positive regulation of multicellular organismal process GO:0051240 143 0.011
synaptic target recognition GO:0008039 45 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.011
stem cell differentiation GO:0048863 117 0.011
biological adhesion GO:0022610 138 0.011
multi organism reproductive behavior GO:0044705 121 0.011
cellular response to endogenous stimulus GO:0071495 80 0.011
circadian sleep wake cycle GO:0042745 28 0.011
negative chemotaxis GO:0050919 15 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
cellular response to abiotic stimulus GO:0071214 58 0.011
regulation of developmental growth GO:0048638 174 0.011
regulation of gene silencing GO:0060968 63 0.011
response to decreased oxygen levels GO:0036293 58 0.011
positive regulation of cell development GO:0010720 61 0.010
response to lipopolysaccharide GO:0032496 4 0.010
nucleobase containing compound catabolic process GO:0034655 165 0.010
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.010
defense response to other organism GO:0098542 225 0.010
cellular component disassembly GO:0022411 46 0.010
positive regulation of neurogenesis GO:0050769 41 0.010
response to bacterium GO:0009617 198 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
retina morphogenesis in camera type eye GO:0060042 2 0.010
phenol containing compound metabolic process GO:0018958 57 0.010
cellular response to nutrient levels GO:0031669 62 0.010
notch signaling pathway GO:0007219 120 0.010
tube development GO:0035295 244 0.010
neurotransmitter secretion GO:0007269 35 0.010
negative regulation of neuron death GO:1901215 18 0.010
peptidyl lysine modification GO:0018205 57 0.010
positive regulation of response to external stimulus GO:0032103 44 0.010
glycoprotein biosynthetic process GO:0009101 41 0.010
histone acetylation GO:0016573 38 0.010
positive regulation of cellular protein metabolic process GO:0032270 118 0.010
morphogenesis of an epithelium GO:0002009 276 0.010
production of molecular mediator of immune response GO:0002440 46 0.010
ribonucleoside metabolic process GO:0009119 127 0.010
mrna splicing via spliceosome GO:0000398 73 0.010

E(Pc) disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.065
vascular disease DOID:178 0 0.036
cardiovascular system disease DOID:1287 0 0.036
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
nervous system disease DOID:863 0 0.014
artery disease DOID:0050828 0 0.012