Drosophila melanogaster

66 known processes

cathD (Dmel_CG1548)

CG1548 gene product from transcript CG1548-RA

(Aliases: CT3996,CathD,CATH,T17,Dmel\CG1548,CG1548)

cathD biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
programmed cell death GO:0012501 257 0.533
cell death GO:0008219 279 0.511
tissue death GO:0016271 102 0.479
autophagy GO:0006914 108 0.376
Rat
regulation of cell death GO:0010941 173 0.337
defense response GO:0006952 300 0.321
proteolysis GO:0006508 192 0.293
Human Mouse Rat
male gamete generation GO:0048232 201 0.264
response to mechanical stimulus GO:0009612 28 0.256
cell proliferation GO:0008283 299 0.252
histolysis GO:0007559 102 0.249
exocrine system development GO:0035272 162 0.222
negative regulation of signaling GO:0023057 219 0.218
developmental programmed cell death GO:0010623 138 0.204
immune system process GO:0002376 347 0.202
organic substance transport GO:0071702 257 0.197
gland morphogenesis GO:0022612 145 0.194
regulation of endopeptidase activity GO:0052548 36 0.191
death GO:0016265 284 0.171
protein maturation GO:0051604 71 0.168
Human Mouse
negative regulation of gene expression GO:0010629 387 0.152
salivary gland histolysis GO:0035070 88 0.152
positive regulation of cell death GO:0010942 69 0.151
regulation of hydrolase activity GO:0051336 97 0.149
dorsal ventral pattern formation GO:0009953 133 0.148
cellular response to external stimulus GO:0071496 66 0.139
salivary gland development GO:0007431 162 0.137
response to abiotic stimulus GO:0009628 341 0.135
salivary gland morphogenesis GO:0007435 145 0.134
innate immune response GO:0045087 144 0.127
salivary gland cell autophagic cell death GO:0035071 83 0.127
macroautophagy GO:0016236 42 0.127
rna localization GO:0006403 115 0.126
regulation of cell cycle GO:0051726 291 0.122
catabolic process GO:0009056 409 0.120
Rat
determination of adult lifespan GO:0008340 137 0.117
cellular response to extracellular stimulus GO:0031668 64 0.117
cellular response to mechanical stimulus GO:0071260 2 0.106
cellular ketone metabolic process GO:0042180 24 0.103
protein complex biogenesis GO:0070271 201 0.103
growth GO:0040007 359 0.099
protein complex assembly GO:0006461 200 0.099
regulation of programmed cell death GO:0043067 152 0.098
positive regulation of multicellular organismal process GO:0051240 143 0.098
gland development GO:0048732 191 0.093
multicellular organismal aging GO:0010259 140 0.093
response to other organism GO:0051707 293 0.088
regulation of peptidase activity GO:0052547 39 0.086
cellular response to nutrient levels GO:0031669 62 0.085
negative regulation of cell death GO:0060548 81 0.085
regulation of apoptotic process GO:0042981 130 0.084
peptide metabolic process GO:0006518 80 0.081
Human Mouse
apoptotic process GO:0006915 159 0.081
transcription from rna polymerase ii promoter GO:0006366 368 0.080
response to organic substance GO:0010033 284 0.080
Mouse
spermatogenesis GO:0007283 200 0.079
response to organic cyclic compound GO:0014070 89 0.078
positive regulation of macromolecule metabolic process GO:0010604 405 0.077
response to glucose GO:0009749 2 0.075
regulation of protein metabolic process GO:0051246 256 0.073
Human Mouse
intracellular signal transduction GO:0035556 300 0.069
Human
larval development GO:0002164 104 0.066
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.066
response to hexose GO:0009746 3 0.065
regulation of response to nutrient levels GO:0032107 18 0.065
cellular catabolic process GO:0044248 372 0.064
Rat
response to bacterium GO:0009617 198 0.061
ectopic germ cell programmed cell death GO:0035234 8 0.060
regulation of response to stress GO:0080134 200 0.060
positive regulation of biosynthetic process GO:0009891 316 0.060
response to monosaccharide GO:0034284 4 0.057
regulation of cell proliferation GO:0042127 163 0.057
secretion by cell GO:0032940 101 0.056
establishment of localization in cell GO:0051649 402 0.056
aging GO:0007568 143 0.055
lateral inhibition GO:0046331 206 0.055
positive regulation of cellular catabolic process GO:0031331 95 0.055
regulation of response to external stimulus GO:0032101 115 0.054
zymogen activation GO:0031638 20 0.053
regulation of cysteine type endopeptidase activity GO:2000116 27 0.052
organonitrogen compound metabolic process GO:1901564 318 0.052
Human Mouse
negative regulation of cell cycle phase transition GO:1901988 103 0.051
macromolecular complex assembly GO:0065003 256 0.050
regulation of defense response GO:0031347 102 0.050
positive regulation of peptidase activity GO:0010952 29 0.049
intracellular transport GO:0046907 228 0.048
positive regulation of cellular biosynthetic process GO:0031328 316 0.047
regulation of proteolysis GO:0030162 87 0.046
regulation of immune system process GO:0002682 176 0.045
apoptotic signaling pathway GO:0097190 27 0.045
positive regulation of cell communication GO:0010647 250 0.043
activation of cysteine type endopeptidase activity GO:0097202 17 0.043
positive regulation of response to stimulus GO:0048584 323 0.043
enzyme linked receptor protein signaling pathway GO:0007167 179 0.042
columnar cuboidal epithelial cell development GO:0002066 249 0.042
Fly
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.041
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.041
positive regulation of apoptotic process GO:0043065 47 0.040
response to alcohol GO:0097305 95 0.040
macromolecule catabolic process GO:0009057 161 0.040
regulation of cellular protein metabolic process GO:0032268 243 0.039
epithelial cell differentiation GO:0030855 322 0.039
Fly
brain development GO:0007420 120 0.039
immune response GO:0006955 246 0.038
regulation of cellular catabolic process GO:0031329 157 0.037
response to oxygen containing compound GO:1901700 200 0.037
regulation of autophagy GO:0010506 62 0.037
developmental growth GO:0048589 280 0.037
protein processing GO:0016485 68 0.037
Human Mouse
protein modification process GO:0036211 438 0.036
positive regulation of protein metabolic process GO:0051247 128 0.036
regulation of molecular function GO:0065009 217 0.036
negative regulation of cell cycle GO:0045786 116 0.036
protein localization GO:0008104 284 0.036
autophagic cell death GO:0048102 83 0.035
response to nutrient levels GO:0031667 114 0.035
positive regulation of programmed cell death GO:0043068 62 0.035
lipid metabolic process GO:0006629 121 0.034
regulation of catabolic process GO:0009894 170 0.034
response to hypoxia GO:0001666 53 0.034
membrane organization GO:0061024 112 0.034
secretion GO:0046903 109 0.033
response to extracellular stimulus GO:0009991 116 0.033
positive regulation of endopeptidase activity GO:0010950 26 0.033
cellular response to starvation GO:0009267 61 0.033
protein transport GO:0015031 155 0.033
imaginal disc derived wing morphogenesis GO:0007476 337 0.032
Fly
chromosome organization GO:0051276 360 0.032
vesicle mediated transport GO:0016192 381 0.031
response to endogenous stimulus GO:0009719 119 0.031
Mouse
negative regulation of cellular metabolic process GO:0031324 382 0.031
imaginal disc derived appendage development GO:0048737 399 0.031
Fly
humoral immune response GO:0006959 117 0.030
cellular cation homeostasis GO:0030003 38 0.030
cellular transition metal ion homeostasis GO:0046916 9 0.030
negative regulation of cell proliferation GO:0008285 69 0.029
cellular amide metabolic process GO:0043603 80 0.029
Human Mouse
central nervous system development GO:0007417 201 0.029
small molecule metabolic process GO:0044281 305 0.029
nitrogen compound transport GO:0071705 85 0.029
response to metal ion GO:0010038 23 0.028
spermatid development GO:0007286 98 0.028
multicellular organismal homeostasis GO:0048871 41 0.028
Human
cellular modified amino acid metabolic process GO:0006575 45 0.028
negative regulation of cell communication GO:0010648 223 0.028
regulation of cell differentiation GO:0045595 302 0.027
positive regulation of proteolysis GO:0045862 52 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.027
anatomical structure homeostasis GO:0060249 97 0.027
Human
carbohydrate metabolic process GO:0005975 82 0.027
regulation of dna metabolic process GO:0051052 34 0.027
sperm individualization GO:0007291 48 0.027
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.026
Fly
response to starvation GO:0042594 97 0.026
homeostatic process GO:0042592 199 0.026
Human
nucleobase containing compound transport GO:0015931 56 0.026
posttranscriptional regulation of gene expression GO:0010608 145 0.025
regionalization GO:0003002 416 0.025
regulation of cellular ketone metabolic process GO:0010565 3 0.025
negative regulation of programmed cell death GO:0043069 72 0.025
regulation of transport GO:0051049 181 0.025
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.025
positive regulation of catabolic process GO:0009896 105 0.025
endomembrane system organization GO:0010256 119 0.024
execution phase of apoptosis GO:0097194 7 0.024
male sex differentiation GO:0046661 25 0.023
Mouse
regulation of catalytic activity GO:0050790 185 0.023
negative regulation of protein metabolic process GO:0051248 85 0.023
organelle membrane fusion GO:0090174 16 0.023
striated muscle tissue development GO:0014706 27 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.023
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.023
positive regulation of rna metabolic process GO:0051254 271 0.023
cellular homeostasis GO:0019725 80 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.023
Human
metal ion homeostasis GO:0055065 44 0.022
positive regulation of apoptotic signaling pathway GO:2001235 4 0.022
positive regulation of hydrolase activity GO:0051345 78 0.022
membrane fusion GO:0061025 42 0.022
digestive system development GO:0055123 149 0.022
reproductive structure development GO:0048608 74 0.022
Mouse
response to biotic stimulus GO:0009607 294 0.022
negative regulation of apoptotic process GO:0043066 63 0.021
positive regulation of autophagy GO:0010508 21 0.021
phagocytosis GO:0006909 215 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.021
negative regulation of cellular protein metabolic process GO:0032269 85 0.021
cellularization GO:0007349 90 0.021
positive regulation of nucleic acid templated transcription GO:1903508 266 0.021
defense response to other organism GO:0098542 225 0.021
immune response regulating signaling pathway GO:0002764 2 0.021
circulatory system development GO:0072359 82 0.020
positive regulation of rna biosynthetic process GO:1902680 266 0.020
positive regulation of signal transduction GO:0009967 223 0.020
locomotory behavior GO:0007626 176 0.020
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.020
negative regulation of cell cycle process GO:0010948 109 0.020
organelle assembly GO:0070925 198 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.020
post embryonic appendage morphogenesis GO:0035120 385 0.020
Fly
regulation of mitotic cell cycle phase transition GO:1901990 130 0.019
immune response activating signal transduction GO:0002757 2 0.019
negative regulation of signal transduction GO:0009968 206 0.019
endocytosis GO:0006897 310 0.019
cell cell signaling involved in cell fate commitment GO:0045168 210 0.019
protein secretion GO:0009306 45 0.019
positive regulation of signaling GO:0023056 243 0.019
regulation of innate immune response GO:0045088 71 0.019
positive regulation of transport GO:0051050 92 0.018
response to temperature stimulus GO:0009266 106 0.018
positive regulation of defense response GO:0031349 59 0.018
response to ionizing radiation GO:0010212 32 0.018
regulation of gene expression epigenetic GO:0040029 128 0.018
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.018
mitotic cell cycle phase transition GO:0044772 138 0.018
cellular response to abiotic stimulus GO:0071214 58 0.018
spermatid differentiation GO:0048515 114 0.018
response to radiation GO:0009314 155 0.018
cellular amino acid metabolic process GO:0006520 61 0.017
establishment of protein localization GO:0045184 163 0.017
regulation of cellular response to stress GO:0080135 89 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.017
development of primary male sexual characteristics GO:0046546 9 0.017
Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.017
positive regulation of transcription dna templated GO:0045893 266 0.017
regulation of multi organism process GO:0043900 131 0.017
regulation of cellular localization GO:0060341 136 0.017
positive regulation of molecular function GO:0044093 136 0.017
response to nitrogen compound GO:1901698 90 0.017
cellular response to dna damage stimulus GO:0006974 223 0.017
cellular protein catabolic process GO:0044257 83 0.016
mitochondrion organization GO:0007005 65 0.016
mitotic dna damage checkpoint GO:0044773 74 0.016
gliogenesis GO:0042063 80 0.016
dna metabolic process GO:0006259 227 0.016
single organism intracellular transport GO:1902582 207 0.016
rna transport GO:0050658 46 0.016
cellular macromolecular complex assembly GO:0034622 153 0.016
negative regulation of response to stimulus GO:0048585 258 0.016
mitotic spindle organization GO:0007052 220 0.016
forebrain development GO:0030900 2 0.016
organic substance catabolic process GO:1901575 308 0.015
muscle structure development GO:0061061 224 0.015
Zebrafish
chromatin modification GO:0016568 147 0.015
muscle tissue development GO:0060537 30 0.015
tissue homeostasis GO:0001894 36 0.015
Human
regulation of protein transport GO:0051223 57 0.015
intrinsic apoptotic signaling pathway GO:0097193 16 0.015
response to external biotic stimulus GO:0043207 293 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
chemical homeostasis GO:0048878 92 0.014
Human
regulation of protein localization GO:0032880 76 0.014
single organism membrane organization GO:0044802 93 0.014
negative regulation of biosynthetic process GO:0009890 277 0.014
cellular macromolecule catabolic process GO:0044265 136 0.014
negative regulation of nucleic acid templated transcription GO:1903507 240 0.014
regulation of cell cycle phase transition GO:1901987 130 0.014
wound healing GO:0042060 75 0.014
positive regulation of macroautophagy GO:0016239 8 0.014
chromatin organization GO:0006325 207 0.014
appendage development GO:0048736 401 0.013
Fly
positive regulation of canonical wnt signaling pathway GO:0090263 7 0.013
mesenchymal cell development GO:0014031 1 0.013
organonitrogen compound biosynthetic process GO:1901566 117 0.013
regulation of establishment of protein localization GO:0070201 61 0.013
positive regulation of gene expression GO:0010628 290 0.013
iron ion homeostasis GO:0055072 5 0.013
muscle organ development GO:0007517 127 0.013
negative regulation of mitotic cell cycle GO:0045930 109 0.013
oxoacid metabolic process GO:0043436 103 0.013
single organism catabolic process GO:0044712 228 0.013
regulation of phosphorylation GO:0042325 147 0.013
Human
negative regulation of developmental process GO:0051093 201 0.013
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.013
aromatic compound catabolic process GO:0019439 166 0.012
centrosome cycle GO:0007098 137 0.012
neuron death GO:0070997 27 0.012
energy derivation by oxidation of organic compounds GO:0015980 32 0.012
single organism cell adhesion GO:0098602 47 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.012
response to copper ion GO:0046688 4 0.012
instar larval development GO:0002168 55 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
carboxylic acid metabolic process GO:0019752 92 0.012
response to virus GO:0009615 28 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
regulation of cell cycle process GO:0010564 181 0.011
translation GO:0006412 69 0.011
response to ethanol GO:0045471 59 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.011
negative regulation of protein processing GO:0010955 31 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.011
sensory organ morphogenesis GO:0090596 260 0.011
regulation of intracellular transport GO:0032386 64 0.011
ameboidal type cell migration GO:0001667 151 0.011
cellular response to organic substance GO:0071310 132 0.011
Mouse
positive regulation of catalytic activity GO:0043085 118 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
establishment of rna localization GO:0051236 47 0.011
cation transport GO:0006812 110 0.011
response to wounding GO:0009611 94 0.011
immune effector process GO:0002252 98 0.011
regulation of developmental growth GO:0048638 174 0.010
respiratory system development GO:0060541 213 0.010
stem cell proliferation GO:0072089 88 0.010
regulation of gtpase activity GO:0043087 44 0.010
positive regulation of cell cycle GO:0045787 43 0.010
body morphogenesis GO:0010171 2 0.010
biological adhesion GO:0022610 138 0.010
regulation of retinal cell programmed cell death GO:0046668 18 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
negative regulation of rna metabolic process GO:0051253 251 0.010

cathD disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.062
Human
nervous system disease DOID:863 0 0.020
central nervous system disease DOID:331 0 0.011
neurodegenerative disease DOID:1289 0 0.010