Drosophila melanogaster

67 known processes

Top1 (Dmel_CG6146)

Topoisomerase 1

(Aliases: CG6146,topo I,Dmel\CG6146,l(1)G0229,TOP1,dTopoI,TopoI,top1,TopI,topoI,l(1)G0134,Topo I,l(1)top1,l(1)G0201,l(1)G0278)

Top1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
growth GO:0040007 359 0.945
cellular protein modification process GO:0006464 438 0.852
developmental growth GO:0048589 280 0.760
multicellular organismal aging GO:0010259 140 0.737
Worm
cellular catabolic process GO:0044248 372 0.667
cell cycle phase transition GO:0044770 140 0.648
chromosome organization GO:0051276 360 0.641
oocyte microtubule cytoskeleton organization GO:0016325 35 0.624
regulation of cell cycle phase transition GO:1901987 130 0.583
protein modification process GO:0036211 438 0.578
regulation of mitotic cell cycle GO:0007346 190 0.551
mitotic spindle organization GO:0007052 220 0.532
cytoplasmic transport GO:0016482 130 0.518
dna packaging GO:0006323 91 0.508
death GO:0016265 284 0.503
organic substance catabolic process GO:1901575 308 0.502
lateral inhibition GO:0046331 206 0.501
regulation of mitotic cell cycle phase transition GO:1901990 130 0.478
protein modification by small protein conjugation or removal GO:0070647 106 0.465
programmed cell death GO:0012501 257 0.454
catabolic process GO:0009056 409 0.453
cell proliferation GO:0008283 299 0.448
epithelial cell differentiation GO:0030855 322 0.437
nucleobase containing compound catabolic process GO:0034655 165 0.436
histone modification GO:0016570 106 0.405
cellular macromolecule catabolic process GO:0044265 136 0.392
regulation of vesicle mediated transport GO:0060627 59 0.392
positive regulation of developmental process GO:0051094 143 0.381
single organism biosynthetic process GO:0044711 206 0.373
regulation of chromosome organization GO:0033044 64 0.373
protein ubiquitination GO:0016567 70 0.363
macromolecule catabolic process GO:0009057 161 0.361
morphogenesis of follicular epithelium GO:0016333 36 0.358
dna metabolic process GO:0006259 227 0.356
regulation of cell cycle GO:0051726 291 0.355
aging GO:0007568 143 0.350
Worm
blastoderm segmentation GO:0007350 159 0.347
negative regulation of mitotic cell cycle GO:0045930 109 0.344
regulation of multicellular organismal development GO:2000026 414 0.344
dna integrity checkpoint GO:0031570 81 0.329
aromatic compound catabolic process GO:0019439 166 0.326
establishment of localization in cell GO:0051649 402 0.311
regulation of growth GO:0040008 233 0.307
regulation of cellular protein metabolic process GO:0032268 243 0.288
modification dependent macromolecule catabolic process GO:0043632 79 0.287
chromatin modification GO:0016568 147 0.287
Human
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.282
regulation of protein metabolic process GO:0051246 256 0.281
heterocycle catabolic process GO:0046700 166 0.275
germarium derived egg chamber formation GO:0007293 101 0.275
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.265
covalent chromatin modification GO:0016569 106 0.263
intracellular transport GO:0046907 228 0.263
positive regulation of biosynthetic process GO:0009891 316 0.260
response to abiotic stimulus GO:0009628 341 0.251
oocyte construction GO:0007308 112 0.249
positive regulation of gene expression GO:0010628 290 0.247
ubiquitin dependent protein catabolic process GO:0006511 78 0.246
spindle organization GO:0007051 253 0.244
negative regulation of cell communication GO:0010648 223 0.234
regulation of catabolic process GO:0009894 170 0.230
protein targeting GO:0006605 64 0.229
embryonic pattern specification GO:0009880 174 0.225
positive regulation of catabolic process GO:0009896 105 0.213
regulation of proteasomal protein catabolic process GO:0061136 39 0.212
protein transport GO:0015031 155 0.210
positive regulation of cellular catabolic process GO:0031331 95 0.200
positive regulation of multicellular organismal process GO:0051240 143 0.198
positive regulation of rna biosynthetic process GO:1902680 266 0.197
body morphogenesis GO:0010171 2 0.197
Worm
chromosome condensation GO:0030261 41 0.193
proteasomal protein catabolic process GO:0010498 59 0.192
positive regulation of rna metabolic process GO:0051254 271 0.188
organic cyclic compound catabolic process GO:1901361 168 0.188
single organism cellular localization GO:1902580 180 0.187
cell death GO:0008219 279 0.182
negative regulation of developmental process GO:0051093 201 0.177
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.177
regulation of cell proliferation GO:0042127 163 0.172
protein modification by small protein conjugation GO:0032446 79 0.170
regulation of cellular component biogenesis GO:0044087 201 0.166
modification dependent protein catabolic process GO:0019941 78 0.165
negative regulation of cellular metabolic process GO:0031324 382 0.165
mitotic cell cycle checkpoint GO:0007093 88 0.161
tube development GO:0035295 244 0.160
proteolysis GO:0006508 192 0.158
vesicle mediated transport GO:0016192 381 0.155
Worm
organelle fission GO:0048285 340 0.153
Worm
single organism behavior GO:0044708 391 0.153
nucleobase containing small molecule metabolic process GO:0055086 174 0.147
cellular response to chemical stimulus GO:0070887 199 0.146
positive regulation of growth GO:0045927 75 0.146
regulation of localization GO:0032879 275 0.146
cellular nitrogen compound catabolic process GO:0044270 165 0.145
determination of adult lifespan GO:0008340 137 0.143
Worm
organic substance transport GO:0071702 257 0.141
organonitrogen compound metabolic process GO:1901564 318 0.141
translation GO:0006412 69 0.139
positive regulation of response to stimulus GO:0048584 323 0.137
gonad development GO:0008406 50 0.136
Worm
germ line stem cell division GO:0042078 25 0.133
cellular macromolecular complex assembly GO:0034622 153 0.129
nucleocytoplasmic transport GO:0006913 72 0.129
positive regulation of protein metabolic process GO:0051247 128 0.126
dna damage checkpoint GO:0000077 78 0.125
purine nucleoside triphosphate catabolic process GO:0009146 108 0.124
regulation of cellular catabolic process GO:0031329 157 0.123
positive regulation of cellular protein metabolic process GO:0032270 118 0.122
regulation of intracellular protein transport GO:0033157 46 0.120
positive regulation of protein catabolic process GO:0045732 34 0.120
positive regulation of cell proliferation GO:0008284 47 0.120
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.119
ribose phosphate metabolic process GO:0019693 145 0.118
cell cell signaling involved in cell fate commitment GO:0045168 210 0.117
negative regulation of signal transduction GO:0009968 206 0.115
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.115
purine nucleoside metabolic process GO:0042278 127 0.114
digestive tract development GO:0048565 149 0.114
wing disc morphogenesis GO:0007472 344 0.113
chemical homeostasis GO:0048878 92 0.112
positive regulation of signal transduction GO:0009967 223 0.112
developmental programmed cell death GO:0010623 138 0.112
multicellular organism growth GO:0035264 46 0.111
negative regulation of cellular protein metabolic process GO:0032269 85 0.111
response to sterol GO:0036314 34 0.110
regulation of molecular function GO:0065009 217 0.109
single organism intracellular transport GO:1902582 207 0.108
regulation of developmental growth GO:0048638 174 0.106
gland morphogenesis GO:0022612 145 0.105
regulation of phosphorus metabolic process GO:0051174 210 0.104
appendage morphogenesis GO:0035107 397 0.103
hemocyte differentiation GO:0042386 38 0.103
response to oxygen containing compound GO:1901700 200 0.102
germarium derived oocyte fate determination GO:0007294 26 0.102
positive regulation of macromolecule metabolic process GO:0010604 405 0.102
nucleoside phosphate metabolic process GO:0006753 162 0.102
cellular macromolecule localization GO:0070727 220 0.102
actin filament based process GO:0030029 220 0.101
dorsal ventral pattern formation GO:0009953 133 0.099
sex differentiation GO:0007548 81 0.095
Worm
negative regulation of multicellular organismal process GO:0051241 142 0.094
cellular response to dna damage stimulus GO:0006974 223 0.093
molting cycle chitin based cuticle GO:0007591 56 0.092
epidermal cell differentiation GO:0009913 51 0.090
endocytosis GO:0006897 310 0.089
Worm
carbohydrate derivative catabolic process GO:1901136 118 0.089
actin cytoskeleton organization GO:0030036 206 0.088
intracellular protein transport GO:0006886 104 0.088
phosphorylation GO:0016310 294 0.088
dorsal ventral axis specification GO:0009950 66 0.087
rhythmic process GO:0048511 106 0.085
Human
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.085
response to radiation GO:0009314 155 0.085
spermatid differentiation GO:0048515 114 0.084
nucleotide metabolic process GO:0009117 161 0.083
regulation of cellular protein catabolic process GO:1903362 44 0.083
immune system process GO:0002376 347 0.083
salivary gland development GO:0007431 162 0.081
cellularization GO:0007349 90 0.081
regulation of phosphorylation GO:0042325 147 0.081
digestive tract morphogenesis GO:0048546 127 0.081
axis specification GO:0009798 167 0.080
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.080
cell cycle checkpoint GO:0000075 95 0.079
compound eye development GO:0048749 307 0.079
establishment of mitochondrion localization GO:0051654 7 0.078
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.078
reproductive structure development GO:0048608 74 0.078
Worm
regulation of cell differentiation GO:0045595 302 0.078
photoreceptor cell differentiation GO:0046530 170 0.077
cellular protein catabolic process GO:0044257 83 0.077
cell cycle dna replication GO:0044786 23 0.077
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.077
mitotic cell cycle phase transition GO:0044772 138 0.076
cellular lipid metabolic process GO:0044255 83 0.076
negative regulation of cell cycle phase transition GO:1901988 103 0.076
response to oxygen levels GO:0070482 59 0.075
ovarian follicle cell development GO:0030707 248 0.075
regulation of immune response GO:0050776 118 0.075
appendage development GO:0048736 401 0.074
morphogenesis of an epithelium GO:0002009 276 0.072
cytoskeleton dependent intracellular transport GO:0030705 44 0.072
organ growth GO:0035265 56 0.071
dorsal appendage formation GO:0046843 47 0.071
regulation of hydrolase activity GO:0051336 97 0.071
protein localization to organelle GO:0033365 82 0.071
cell fate determination GO:0001709 91 0.070
positive regulation of mitotic cell cycle GO:0045931 34 0.070
negative regulation of protein metabolic process GO:0051248 85 0.070
organophosphate metabolic process GO:0019637 195 0.070
compound eye morphogenesis GO:0001745 249 0.070
chromatin organization GO:0006325 207 0.069
Human
spermatogenesis GO:0007283 200 0.068
negative regulation of cell differentiation GO:0045596 143 0.068
nucleoside metabolic process GO:0009116 127 0.067
sister chromatid segregation GO:0000819 92 0.067
negative regulation of organelle organization GO:0010639 56 0.067
regulation of neuron differentiation GO:0045664 103 0.065
oocyte differentiation GO:0009994 145 0.061
regulation of organelle organization GO:0033043 196 0.061
purine nucleotide catabolic process GO:0006195 109 0.060
centrosome cycle GO:0007098 137 0.060
regulation of organ growth GO:0046620 42 0.060
nucleoside triphosphate metabolic process GO:0009141 120 0.059
meiotic cell cycle process GO:1903046 132 0.059
Worm
positive regulation of cellular biosynthetic process GO:0031328 316 0.059
glycosyl compound catabolic process GO:1901658 112 0.059
cell division GO:0051301 248 0.058
Mouse
negative regulation of phosphate metabolic process GO:0045936 45 0.057
negative regulation of molecular function GO:0044092 51 0.056
regulation of intracellular signal transduction GO:1902531 236 0.056
embryonic organ development GO:0048568 50 0.055
nitrogen compound transport GO:0071705 85 0.055
nuclear transport GO:0051169 72 0.054
embryonic development via the syncytial blastoderm GO:0001700 148 0.054
female germ line cyst formation GO:0048135 42 0.053
tissue death GO:0016271 102 0.052
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.052
regulation of multicellular organism growth GO:0040014 40 0.052
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.052
response to nutrient levels GO:0031667 114 0.052
purine nucleoside catabolic process GO:0006152 112 0.051
positive regulation of cell development GO:0010720 61 0.051
chromosome segregation GO:0007059 157 0.051
small molecule metabolic process GO:0044281 305 0.050
imaginal disc derived wing morphogenesis GO:0007476 337 0.050
germarium derived female germ line cyst formation GO:0030727 42 0.050
regulation of chromatin organization GO:1902275 32 0.050
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.050
positive regulation of nucleic acid templated transcription GO:1903508 266 0.049
positive regulation of intracellular signal transduction GO:1902533 116 0.048
membrane organization GO:0061024 112 0.048
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.048
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.048
regulation of translation GO:0006417 56 0.047
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.046
respiratory system development GO:0060541 213 0.046
oocyte axis specification GO:0007309 108 0.046
regulation of cellular localization GO:0060341 136 0.045
developmental maturation GO:0021700 172 0.045
regulation of transport GO:0051049 181 0.045
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.044
regulation of cell division GO:0051302 72 0.044
positive regulation of signaling GO:0023056 243 0.043
protein catabolic process GO:0030163 101 0.043
post embryonic appendage morphogenesis GO:0035120 385 0.042
negative regulation of growth GO:0045926 84 0.042
response to organic substance GO:0010033 284 0.042
organophosphate catabolic process GO:0046434 112 0.042
purine containing compound catabolic process GO:0072523 112 0.041
positive regulation of molecular function GO:0044093 136 0.041
regulation of jnk cascade GO:0046328 40 0.041
response to hypoxia GO:0001666 53 0.041
instar larval development GO:0002168 55 0.040
intracellular signal transduction GO:0035556 300 0.040
salivary gland cell autophagic cell death GO:0035071 83 0.040
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.040
regulation of intracellular transport GO:0032386 64 0.040
negative regulation of cell cycle GO:0045786 116 0.040
single organism membrane organization GO:0044802 93 0.040
cell growth GO:0016049 108 0.040
positive regulation of nervous system development GO:0051962 69 0.040
developmental cell growth GO:0048588 52 0.039
protein maturation GO:0051604 71 0.039
germline stem cell asymmetric division GO:0098728 15 0.038
connective tissue development GO:0061448 3 0.038
embryo development ending in birth or egg hatching GO:0009792 152 0.038
Worm
phagocytosis GO:0006909 215 0.038
positive regulation of cell communication GO:0010647 250 0.038
stem cell proliferation GO:0072089 88 0.038
imaginal disc derived appendage development GO:0048737 399 0.037
epithelial cell development GO:0002064 274 0.037
cellular response to abiotic stimulus GO:0071214 58 0.037
oocyte dorsal ventral axis specification GO:0007310 34 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.036
stem cell division GO:0017145 69 0.036
positive regulation of hydrolase activity GO:0051345 78 0.036
eye development GO:0001654 323 0.036
negative regulation of biosynthetic process GO:0009890 277 0.036
male gamete generation GO:0048232 201 0.035
regulation of purine nucleotide metabolic process GO:1900542 62 0.035
regulation of cellular ketone metabolic process GO:0010565 3 0.035
purine containing compound metabolic process GO:0072521 155 0.035
regulation of protein transport GO:0051223 57 0.034
negative regulation of cell death GO:0060548 81 0.034
organonitrogen compound catabolic process GO:1901565 128 0.034
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.034
larval development GO:0002164 104 0.034
negative regulation of response to stimulus GO:0048585 258 0.034
germarium derived female germ line cyst encapsulation GO:0030708 8 0.034
protein complex assembly GO:0006461 200 0.033
mapk cascade GO:0000165 107 0.033
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.033
purine ribonucleotide metabolic process GO:0009150 145 0.033
dna endoreduplication GO:0042023 22 0.032
muscle cell differentiation GO:0042692 103 0.032
methylation GO:0032259 47 0.032
germarium derived oocyte differentiation GO:0030706 29 0.032
ribonucleoprotein complex biogenesis GO:0022613 31 0.032
response to uv GO:0009411 24 0.032
regulation of chromosome segregation GO:0051983 32 0.032
positive regulation of multicellular organism growth GO:0040018 21 0.032
carbohydrate derivative metabolic process GO:1901135 217 0.032
nuclear export GO:0051168 24 0.031
ion transport GO:0006811 145 0.031
oocyte anterior posterior axis specification GO:0007314 72 0.031
nucleus organization GO:0006997 45 0.031
regulation of nucleocytoplasmic transport GO:0046822 35 0.031
oocyte development GO:0048599 124 0.030
reproductive system development GO:0061458 74 0.030
Worm
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.030
salivary gland morphogenesis GO:0007435 145 0.030
cellular protein localization GO:0034613 160 0.030
negative regulation of catabolic process GO:0009895 36 0.030
ovarian follicle cell stalk formation GO:0030713 17 0.030
autophagic cell death GO:0048102 83 0.030
maintenance of location GO:0051235 73 0.030
stress activated mapk cascade GO:0051403 52 0.029
regulation of proteolysis GO:0030162 87 0.029
small gtpase mediated signal transduction GO:0007264 88 0.029
production of small rna involved in gene silencing by rna GO:0070918 15 0.029
lipid storage GO:0019915 38 0.029
muscle structure development GO:0061061 224 0.029
response to wounding GO:0009611 94 0.028
histolysis GO:0007559 102 0.028
maternal determination of anterior posterior axis embryo GO:0008358 74 0.028
nucleoside catabolic process GO:0009164 112 0.028
gene silencing GO:0016458 138 0.028
regulation of establishment of protein localization GO:0070201 61 0.028
positive regulation of cell cycle process GO:0090068 28 0.027
negative regulation of stress activated mapk cascade GO:0032873 19 0.027
spermatid development GO:0007286 98 0.026
nucleoside triphosphate catabolic process GO:0009143 108 0.026
nucleoside phosphate catabolic process GO:1901292 110 0.026
striated muscle cell differentiation GO:0051146 90 0.026
imaginal disc derived appendage morphogenesis GO:0035114 395 0.025
regulation of protein localization GO:0032880 76 0.025
positive regulation of cell differentiation GO:0045597 64 0.025
transcription from rna polymerase ii promoter GO:0006366 368 0.025
cell motility GO:0048870 251 0.025
eye morphogenesis GO:0048592 260 0.025
single organism catabolic process GO:0044712 228 0.025
actin filament organization GO:0007015 126 0.025
regulation of nucleotide metabolic process GO:0006140 62 0.025
nucleotide catabolic process GO:0009166 109 0.024
development of primary sexual characteristics GO:0045137 50 0.024
Worm
skin development GO:0043588 65 0.024
response to ketone GO:1901654 34 0.024
ribonucleoside catabolic process GO:0042454 112 0.024
regulation of cell death GO:0010941 173 0.024
maintenance of protein location GO:0045185 28 0.024
rna interference GO:0016246 27 0.024
posttranscriptional regulation of gene expression GO:0010608 145 0.024
cellular protein complex disassembly GO:0043624 35 0.024
negative regulation of gene expression epigenetic GO:0045814 77 0.024
response to light stimulus GO:0009416 124 0.024
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.023
cuticle development GO:0042335 86 0.023
salivary gland histolysis GO:0035070 88 0.023
regulation of exit from mitosis GO:0007096 7 0.023
regulation of notch signaling pathway GO:0008593 100 0.023
negative regulation of signaling GO:0023057 219 0.023
protein localization GO:0008104 284 0.023
gland development GO:0048732 191 0.023
anterior posterior axis specification GO:0009948 109 0.023
positive regulation of developmental growth GO:0048639 62 0.023
locomotory behavior GO:0007626 176 0.023
innate immune response GO:0045087 144 0.022
gtp metabolic process GO:0046039 72 0.022
purine ribonucleotide catabolic process GO:0009154 109 0.022
digestive system development GO:0055123 149 0.021
microtubule based movement GO:0007018 51 0.021
cellular response to sterol depletion GO:0071501 3 0.021
eggshell chorion assembly GO:0007306 66 0.021
organic acid metabolic process GO:0006082 103 0.021
pole plasm assembly GO:0007315 61 0.021
response to ecdysone GO:0035075 34 0.021
endomembrane system organization GO:0010256 119 0.021
head development GO:0060322 135 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.021
tube morphogenesis GO:0035239 191 0.021
open tracheal system development GO:0007424 204 0.021
genitalia development GO:0048806 26 0.021
regionalization GO:0003002 416 0.021
regulation of organ morphogenesis GO:2000027 78 0.020
protein complex biogenesis GO:0070271 201 0.020
negative regulation of nervous system development GO:0051961 92 0.020
establishment of protein localization GO:0045184 163 0.020
compound eye photoreceptor cell differentiation GO:0001751 140 0.020
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.020
purine nucleotide metabolic process GO:0006163 146 0.020
response to decreased oxygen levels GO:0036293 58 0.020
macromolecular complex disassembly GO:0032984 37 0.020
forebrain development GO:0030900 2 0.020
positive regulation of cellular protein catabolic process GO:1903364 24 0.020
gene silencing by rna GO:0031047 57 0.020
eggshell formation GO:0030703 105 0.020
negative regulation of cell cycle process GO:0010948 109 0.020
regulation of protein import into nucleus GO:0042306 28 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.019
negative regulation of phosphorylation GO:0042326 35 0.019
segmentation GO:0035282 207 0.019
atp metabolic process GO:0046034 49 0.019
fusome organization GO:0045478 13 0.019
regulation of dna metabolic process GO:0051052 34 0.019
regulation of epithelial cell differentiation GO:0030856 4 0.019
regulation of catalytic activity GO:0050790 185 0.019
maintenance of protein location in cell GO:0032507 26 0.019
regulation of mitotic spindle organization GO:0060236 9 0.019
protein localization to nucleus GO:0034504 55 0.018
posttranscriptional gene silencing GO:0016441 46 0.018
positive regulation of proteolysis GO:0045862 52 0.018
regulation of chromatin binding GO:0035561 3 0.018
golgi vesicle transport GO:0048193 27 0.018
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 10 0.018
nucleoside monophosphate catabolic process GO:0009125 39 0.018
negative regulation of cellular catabolic process GO:0031330 34 0.018
regulation of chromatin modification GO:1903308 28 0.017
regulation of anatomical structure size GO:0090066 163 0.017
localization of cell GO:0051674 257 0.017
regulation of cell cycle g1 s phase transition GO:1902806 23 0.017
ribonucleotide catabolic process GO:0009261 109 0.017
cell cycle arrest GO:0007050 4 0.017
mitochondrion localization GO:0051646 17 0.017
establishment of planar polarity GO:0001736 87 0.017
fertilization GO:0009566 26 0.017
negative regulation of intracellular signal transduction GO:1902532 57 0.017
mitotic g2 m transition checkpoint GO:0044818 70 0.017
neuroblast proliferation GO:0007405 74 0.017
ribonucleoside metabolic process GO:0009119 127 0.017
dna conformation change GO:0071103 105 0.017
mitotic sister chromatid segregation GO:0000070 87 0.017
negative regulation of protein processing GO:0010955 31 0.016
golgi organization GO:0007030 66 0.016
protein processing GO:0016485 68 0.016
regulation of mapk cascade GO:0043408 92 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
negative regulation of rna biosynthetic process GO:1902679 240 0.016
regulation of cellular response to stress GO:0080135 89 0.016
positive regulation of neuron differentiation GO:0045666 26 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
mitotic dna damage checkpoint GO:0044773 74 0.015
regulation of programmed cell death GO:0043067 152 0.015
positive regulation of transcription dna templated GO:0045893 266 0.015
positive regulation of neurogenesis GO:0050769 41 0.015
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.015
cellular protein complex assembly GO:0043623 71 0.015
regulation of immune effector process GO:0002697 52 0.015
positive regulation of cellular component organization GO:0051130 156 0.015
rna localization GO:0006403 115 0.015
cellular amine metabolic process GO:0044106 12 0.015
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.015
mrna metabolic process GO:0016071 124 0.015
regulation of cytoplasmic transport GO:1903649 47 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.014
regulation of mitotic sister chromatid segregation GO:0033047 28 0.014
negative regulation of translation GO:0017148 28 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
protein k48 linked ubiquitination GO:0070936 3 0.014
phenol containing compound metabolic process GO:0018958 57 0.014
stress activated protein kinase signaling cascade GO:0031098 55 0.014
long term memory GO:0007616 62 0.014
larval lymph gland hemopoiesis GO:0035167 17 0.014
microtubule organizing center organization GO:0031023 168 0.014
positive regulation of phosphorus metabolic process GO:0010562 139 0.014
establishment of meiotic spindle orientation GO:0051296 2 0.014
chromatin assembly or disassembly GO:0006333 52 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
response to biotic stimulus GO:0009607 294 0.014
oxoacid metabolic process GO:0043436 103 0.014
heart field specification GO:0003128 0 0.014
anterior posterior pattern specification GO:0009952 136 0.014
imaginal disc growth GO:0007446 37 0.014
negative regulation of cellular component organization GO:0051129 108 0.013
purine ribonucleoside metabolic process GO:0046128 127 0.013
spindle stabilization GO:0043146 14 0.013
taxis GO:0042330 304 0.013
protein polyubiquitination GO:0000209 11 0.013
regulation of cell development GO:0060284 215 0.013
regulation of lipid metabolic process GO:0019216 15 0.013
germ line cyst formation GO:0048134 44 0.013
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.013
cell fate specification GO:0001708 71 0.013
nuclear envelope organization GO:0006998 7 0.013
ras protein signal transduction GO:0007265 88 0.013
protein import GO:0017038 55 0.013
regulation of nervous system development GO:0051960 248 0.013
regulation of neuron projection development GO:0010975 69 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.013
regulation of cytoskeleton organization GO:0051493 89 0.012
sensory organ morphogenesis GO:0090596 260 0.012
negative regulation of phosphorus metabolic process GO:0010563 45 0.012
hindgut development GO:0061525 58 0.012

Top1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.115
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024
central nervous system disease DOID:331 0 0.013
neurodegenerative disease DOID:1289 0 0.013
nervous system disease DOID:863 0 0.013