Drosophila melanogaster

70 known processes

Sin1 (Dmel_CG10105)

SAPK-interacting protein 1

(Aliases: CG10105,dSin1,Dmel\CG10105,sin1)

Sin1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dendrite development GO:0016358 204 0.964
dendrite morphogenesis GO:0048813 199 0.947
male gamete generation GO:0048232 201 0.397
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.381
transcription from rna polymerase ii promoter GO:0006366 368 0.372
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.352
regulation of dendrite morphogenesis GO:0048814 28 0.329
response to bacterium GO:0009617 198 0.311
negative regulation of transcription dna templated GO:0045892 237 0.298
sensory organ morphogenesis GO:0090596 260 0.255
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.252
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.250
regulation of cell differentiation GO:0045595 302 0.247
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.245
positive regulation of rna biosynthetic process GO:1902680 266 0.240
stem cell differentiation GO:0048863 117 0.232
localization of cell GO:0051674 257 0.230
negative regulation of cellular biosynthetic process GO:0031327 277 0.230
negative regulation of cell differentiation GO:0045596 143 0.220
spermatogenesis GO:0007283 200 0.215
regulation of multicellular organismal development GO:2000026 414 0.212
gland development GO:0048732 191 0.208
positive regulation of transcription dna templated GO:0045893 266 0.206
cell motility GO:0048870 251 0.205
stem cell development GO:0048864 79 0.186
respiratory system development GO:0060541 213 0.185
cellular response to starvation GO:0009267 61 0.179
regulation of dendrite development GO:0050773 37 0.177
negative regulation of rna metabolic process GO:0051253 251 0.175
positive regulation of gene expression GO:0010628 290 0.164
cellular response to extracellular stimulus GO:0031668 64 0.163
enzyme linked receptor protein signaling pathway GO:0007167 179 0.160
positive regulation of macromolecule metabolic process GO:0010604 405 0.152
negative regulation of biosynthetic process GO:0009890 277 0.146
epithelial tube morphogenesis GO:0060562 88 0.145
cellular response to dna damage stimulus GO:0006974 223 0.144
protein modification process GO:0036211 438 0.140
negative regulation of nucleic acid templated transcription GO:1903507 240 0.139
tissue morphogenesis GO:0048729 297 0.135
negative regulation of gene expression GO:0010629 387 0.129
neuron recognition GO:0008038 101 0.129
morphogenesis of an epithelium GO:0002009 276 0.122
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.120
negative regulation of developmental process GO:0051093 201 0.118
tube development GO:0035295 244 0.110
morphogenesis of a polarized epithelium GO:0001738 93 0.110
hair cell differentiation GO:0035315 47 0.102
negative regulation of rna biosynthetic process GO:1902679 240 0.101
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.099
positive regulation of rna metabolic process GO:0051254 271 0.096
nuclear division GO:0000280 332 0.091
cellular catabolic process GO:0044248 372 0.090
cellular protein modification process GO:0006464 438 0.089
negative regulation of cellular metabolic process GO:0031324 382 0.089
regulation of cell development GO:0060284 215 0.089
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.089
fat soluble vitamin biosynthetic process GO:0042362 1 0.089
tube morphogenesis GO:0035239 191 0.088
epithelial cell differentiation GO:0030855 322 0.085
cell migration GO:0016477 238 0.083
negative regulation of cell communication GO:0010648 223 0.081
positive regulation of response to stimulus GO:0048584 323 0.080
establishment or maintenance of cell polarity GO:0007163 167 0.080
muscle cell differentiation GO:0042692 103 0.077
homeostatic process GO:0042592 199 0.074
lipid homeostasis GO:0055088 33 0.073
response to biotic stimulus GO:0009607 294 0.072
appendage development GO:0048736 401 0.070
spermatid development GO:0007286 98 0.070
imaginal disc derived appendage development GO:0048737 399 0.069
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.069
cellular response to nutrient levels GO:0031669 62 0.069
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.068
regulation of anatomical structure size GO:0090066 163 0.068
response to extracellular stimulus GO:0009991 116 0.067
positive regulation of nucleic acid templated transcription GO:1903508 266 0.067
cellular response to external stimulus GO:0071496 66 0.066
cell recognition GO:0008037 102 0.064
catabolic process GO:0009056 409 0.063
circulatory system process GO:0003013 37 0.063
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.062
appendage morphogenesis GO:0035107 397 0.062
regulation of cellular component size GO:0032535 98 0.062
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.062
detection of stimulus GO:0051606 156 0.060
organic substance catabolic process GO:1901575 308 0.060
positive regulation of biosynthetic process GO:0009891 316 0.060
blood circulation GO:0008015 26 0.059
response to organic substance GO:0010033 284 0.058
regulation of neurogenesis GO:0050767 158 0.058
forebrain development GO:0030900 2 0.058
regulation of neuron projection development GO:0010975 69 0.056
regionalization GO:0003002 416 0.056
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.056
ameboidal type cell migration GO:0001667 151 0.055
positive regulation of cellular biosynthetic process GO:0031328 316 0.054
negative regulation of multicellular organismal process GO:0051241 142 0.053
negative regulation of response to stimulus GO:0048585 258 0.053
imaginal disc derived appendage morphogenesis GO:0035114 395 0.052
muscle organ development GO:0007517 127 0.051
response to other organism GO:0051707 293 0.051
epithelium migration GO:0090132 148 0.050
skin development GO:0043588 65 0.048
regulation of anatomical structure morphogenesis GO:0022603 242 0.048
developmental growth GO:0048589 280 0.048
cellular ketone metabolic process GO:0042180 24 0.047
negative regulation of signal transduction GO:0009968 206 0.047
cellular macromolecular complex assembly GO:0034622 153 0.047
open tracheal system development GO:0007424 204 0.046
camera type eye development GO:0043010 4 0.045
camera type eye morphogenesis GO:0048593 2 0.044
negative regulation of signaling GO:0023057 219 0.044
regulation of nervous system development GO:0051960 248 0.043
regulation of localization GO:0032879 275 0.043
single organism catabolic process GO:0044712 228 0.042
regulation of cell size GO:0008361 63 0.042
proteolysis GO:0006508 192 0.042
regulation of cell projection organization GO:0031344 92 0.041
exocrine system development GO:0035272 162 0.041
organic acid metabolic process GO:0006082 103 0.040
maintenance of location GO:0051235 73 0.040
Worm
response to abiotic stimulus GO:0009628 341 0.039
spermatid differentiation GO:0048515 114 0.039
positive regulation of signal transduction GO:0009967 223 0.039
chromatin organization GO:0006325 207 0.038
mitotic spindle organization GO:0007052 220 0.038
chromosome organization GO:0051276 360 0.038
ion transmembrane transport GO:0034220 122 0.038
response to fungus GO:0009620 50 0.037
post embryonic appendage morphogenesis GO:0035120 385 0.037
stem cell proliferation GO:0072089 88 0.036
response to lipopolysaccharide GO:0032496 4 0.035
positive regulation of multicellular organismal process GO:0051240 143 0.034
salivary gland development GO:0007431 162 0.034
positive regulation of signaling GO:0023056 243 0.034
regulation of rac protein signal transduction GO:0035020 3 0.034
positive regulation of cell communication GO:0010647 250 0.034
intracellular signal transduction GO:0035556 300 0.034
tor signaling GO:0031929 32 0.033
organelle fission GO:0048285 340 0.033
cellular response to organic substance GO:0071310 132 0.033
regulation of wnt signaling pathway GO:0030111 68 0.032
sterol homeostasis GO:0055092 4 0.032
regulation of notch signaling pathway GO:0008593 100 0.032
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.032
positive regulation of wnt signaling pathway GO:0030177 25 0.032
cation transport GO:0006812 110 0.031
regulation of organelle organization GO:0033043 196 0.031
retina development in camera type eye GO:0060041 4 0.031
purine ribonucleotide metabolic process GO:0009150 145 0.031
small molecule metabolic process GO:0044281 305 0.031
axon development GO:0061564 297 0.031
purine ribonucleoside metabolic process GO:0046128 127 0.031
response to wounding GO:0009611 94 0.030
neuromuscular junction development GO:0007528 149 0.030
regulation of microtubule depolymerization GO:0031114 24 0.030
eye development GO:0001654 323 0.030
head development GO:0060322 135 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.030
regulation of cellular amine metabolic process GO:0033238 3 0.030
response to endogenous stimulus GO:0009719 119 0.029
macromolecular complex assembly GO:0065003 256 0.029
steroid catabolic process GO:0006706 1 0.029
regulation of cell morphogenesis GO:0022604 163 0.028
purine containing compound metabolic process GO:0072521 155 0.028
regulation of cellular ketone metabolic process GO:0010565 3 0.028
cytokinetic cell separation GO:0000920 1 0.028
ketone biosynthetic process GO:0042181 16 0.028
defense response to other organism GO:0098542 225 0.027
carbohydrate derivative metabolic process GO:1901135 217 0.027
small gtpase mediated signal transduction GO:0007264 88 0.027
central nervous system development GO:0007417 201 0.027
purine nucleoside metabolic process GO:0042278 127 0.026
regulation of catabolic process GO:0009894 170 0.026
digestive tract morphogenesis GO:0048546 127 0.026
synapse assembly GO:0007416 143 0.026
response to nutrient levels GO:0031667 114 0.026
non sensory hair organization GO:0035316 47 0.026
connective tissue development GO:0061448 3 0.026
cell division GO:0051301 248 0.026
wing disc morphogenesis GO:0007472 344 0.025
synapse organization GO:0050808 196 0.025
organonitrogen compound catabolic process GO:1901565 128 0.025
regulation of protein metabolic process GO:0051246 256 0.025
actin filament based process GO:0030029 220 0.025
lipid storage GO:0019915 38 0.025
Worm
imaginal disc derived wing morphogenesis GO:0007476 337 0.025
anion homeostasis GO:0055081 3 0.025
fat soluble vitamin metabolic process GO:0006775 1 0.025
inter male aggressive behavior GO:0002121 60 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
organonitrogen compound metabolic process GO:1901564 318 0.024
response to lipid GO:0033993 38 0.024
cell projection assembly GO:0030031 94 0.024
regulation of cellular component biogenesis GO:0044087 201 0.024
nucleotide metabolic process GO:0009117 161 0.024
kidney development GO:0001822 3 0.024
sensory perception GO:0007600 196 0.024
epidermal cell differentiation GO:0009913 51 0.023
brain development GO:0007420 120 0.023
eggshell chorion assembly GO:0007306 66 0.023
regulation of cellular catabolic process GO:0031329 157 0.023
regulation of rho protein signal transduction GO:0035023 20 0.023
axonogenesis GO:0007409 290 0.023
imaginal disc derived wing hair organization GO:0035317 45 0.023
ribose phosphate metabolic process GO:0019693 145 0.023
organonitrogen compound biosynthetic process GO:1901566 117 0.022
regulation of small gtpase mediated signal transduction GO:0051056 93 0.022
epithelial cell migration GO:0010631 148 0.022
eye morphogenesis GO:0048592 260 0.022
chemical homeostasis GO:0048878 92 0.022
regulation of ras protein signal transduction GO:0046578 93 0.022
regulation of neuron differentiation GO:0045664 103 0.022
positive regulation of cellular protein metabolic process GO:0032270 118 0.021
negative regulation of cell size GO:0045792 19 0.021
regulation of synapse structure and activity GO:0050803 128 0.021
nucleoside catabolic process GO:0009164 112 0.021
single organism biosynthetic process GO:0044711 206 0.021
segmentation GO:0035282 207 0.021
establishment of cell polarity GO:0030010 40 0.021
cuticle development GO:0042335 86 0.021
carbohydrate derivative biosynthetic process GO:1901137 85 0.020
rho protein signal transduction GO:0007266 14 0.020
ribonucleoside catabolic process GO:0042454 112 0.020
wound healing GO:0042060 75 0.020
peptidyl amino acid modification GO:0018193 105 0.020
cellular response to chemical stimulus GO:0070887 199 0.020
oocyte maturation GO:0001556 3 0.020
striated muscle cell development GO:0055002 50 0.020
epidermis development GO:0008544 65 0.019
response to organonitrogen compound GO:0010243 75 0.019
morphogenesis of a branching structure GO:0001763 45 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
purine nucleotide metabolic process GO:0006163 146 0.019
chemotaxis GO:0006935 249 0.019
aromatic compound catabolic process GO:0019439 166 0.019
nucleoside metabolic process GO:0009116 127 0.019
single organism carbohydrate metabolic process GO:0044723 72 0.019
purine nucleoside catabolic process GO:0006152 112 0.019
negative regulation of nervous system development GO:0051961 92 0.019
negative regulation of cellular component organization GO:0051129 108 0.018
taxis GO:0042330 304 0.018
cellular component assembly involved in morphogenesis GO:0010927 151 0.018
salivary gland morphogenesis GO:0007435 145 0.018
wnt signaling pathway GO:0016055 98 0.018
response to external biotic stimulus GO:0043207 293 0.018
axon guidance GO:0007411 233 0.018
single organism intracellular transport GO:1902582 207 0.018
neuroblast proliferation GO:0007405 74 0.018
defense response to gram negative bacterium GO:0050829 94 0.018
regulation of cellular protein metabolic process GO:0032268 243 0.018
regulation of intracellular signal transduction GO:1902531 236 0.017
protein ubiquitination GO:0016567 70 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
aggressive behavior GO:0002118 63 0.017
mesenchymal cell development GO:0014031 1 0.017
guanosine containing compound catabolic process GO:1901069 74 0.017
dorsal ventral pattern formation GO:0009953 133 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
regulation of autophagy GO:0010506 62 0.017
protein phosphorylation GO:0006468 169 0.017
regulation of cell proliferation GO:0042127 163 0.017
ubiquitin dependent protein catabolic process GO:0006511 78 0.017
regulation of epithelial cell proliferation GO:0050678 4 0.017
cellular response to endogenous stimulus GO:0071495 80 0.017
cellular response to oxygen containing compound GO:1901701 79 0.017
regulation of tube architecture open tracheal system GO:0035152 68 0.017
nucleoside triphosphate catabolic process GO:0009143 108 0.016
digestive system development GO:0055123 149 0.016
regulation of developmental growth GO:0048638 174 0.016
lateral inhibition GO:0046331 206 0.016
striated muscle tissue development GO:0014706 27 0.016
purine ribonucleotide catabolic process GO:0009154 109 0.016
stem cell maintenance GO:0019827 67 0.016
response to alcohol GO:0097305 95 0.016
leg disc development GO:0035218 92 0.016
carbohydrate metabolic process GO:0005975 82 0.016
regulation of tor signaling GO:0032006 21 0.016
response to starvation GO:0042594 97 0.016
tissue migration GO:0090130 155 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.015
cholesterol homeostasis GO:0042632 3 0.015
ras protein signal transduction GO:0007265 88 0.015
chaeta development GO:0022416 97 0.015
response to osmotic stress GO:0006970 14 0.015
actin polymerization or depolymerization GO:0008154 31 0.015
cellular amine metabolic process GO:0044106 12 0.015
protein localization GO:0008104 284 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.015
guanosine containing compound metabolic process GO:1901068 74 0.015
actin cytoskeleton organization GO:0030036 206 0.015
purine ribonucleoside catabolic process GO:0046130 112 0.015
columnar cuboidal epithelial cell development GO:0002066 249 0.015
neuron fate commitment GO:0048663 50 0.015
glycosyl compound metabolic process GO:1901657 127 0.015
skeletal muscle organ development GO:0060538 48 0.015
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.015
mesenchymal cell differentiation GO:0048762 1 0.014
myotube cell development GO:0014904 3 0.014
digestive tract development GO:0048565 149 0.014
regulation of cell cycle GO:0051726 291 0.014
gastrulation involving germ band extension GO:0010004 36 0.014
cellular protein complex disassembly GO:0043624 35 0.014
dna metabolic process GO:0006259 227 0.014
positive regulation of protein metabolic process GO:0051247 128 0.014
meiotic nuclear division GO:0007126 151 0.014
detection of stimulus involved in sensory perception GO:0050906 92 0.014
gland morphogenesis GO:0022612 145 0.014
cytokinetic process GO:0032506 27 0.014
axis specification GO:0009798 167 0.014
protein depolymerization GO:0051261 31 0.014
cell adhesion GO:0007155 136 0.014
purine containing compound catabolic process GO:0072523 112 0.014
positive regulation of organelle organization GO:0010638 65 0.014
regulation of actin polymerization or depolymerization GO:0008064 27 0.014
negative regulation of epithelial cell proliferation GO:0050680 4 0.014
cellular response to hormone stimulus GO:0032870 44 0.014
fertilization GO:0009566 26 0.014
nucleoside phosphate catabolic process GO:1901292 110 0.013
leg disc morphogenesis GO:0007478 80 0.013
chromatin assembly or disassembly GO:0006333 52 0.013
regulation of molecular function GO:0065009 217 0.013
heterochromatin organization GO:0070828 25 0.013
outflow tract morphogenesis GO:0003151 4 0.013
cell matrix adhesion GO:0007160 6 0.013
spinal cord development GO:0021510 1 0.013
vitamin metabolic process GO:0006766 2 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
positive regulation of neurogenesis GO:0050769 41 0.013
rac protein signal transduction GO:0016601 3 0.013
cellular protein complex assembly GO:0043623 71 0.013
germ line stem cell maintenance GO:0030718 50 0.013
regulation of rho gtpase activity GO:0032319 20 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
growth GO:0040007 359 0.013
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
branching morphogenesis of an epithelial tube GO:0048754 45 0.013
protein complex assembly GO:0006461 200 0.013
ribonucleoside metabolic process GO:0009119 127 0.013
cellular macromolecule catabolic process GO:0044265 136 0.013
sensory perception of pain GO:0019233 4 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
inorganic cation transmembrane transport GO:0098662 61 0.013
skeletal muscle fiber development GO:0048741 3 0.013
cellularization GO:0007349 90 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.012
cellular response to water stimulus GO:0071462 2 0.012
oxoacid metabolic process GO:0043436 103 0.012
positive regulation of dendrite morphogenesis GO:0050775 9 0.012
synaptic growth at neuromuscular junction GO:0051124 119 0.012
sensory organ boundary specification GO:0008052 22 0.012
cell proliferation GO:0008283 299 0.012
glycoprotein biosynthetic process GO:0009101 41 0.012
ecdysteroid biosynthetic process GO:0045456 15 0.012
compound eye development GO:0048749 307 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.012
positive regulation of canonical wnt signaling pathway GO:0090263 7 0.012
regulation of response to dna damage stimulus GO:2001020 23 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
gliogenesis GO:0042063 80 0.012
cellular protein catabolic process GO:0044257 83 0.012
muscle tissue development GO:0060537 30 0.012
macromolecular complex disassembly GO:0032984 37 0.012
regulation of synapse organization GO:0050807 110 0.012
gtp metabolic process GO:0046039 72 0.012
developmental maturation GO:0021700 172 0.012
protein catabolic process GO:0030163 101 0.012
death GO:0016265 284 0.012
positive regulation of phosphorylation GO:0042327 87 0.012
border follicle cell migration GO:0007298 113 0.012
convergent extension GO:0060026 2 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
protein complex disassembly GO:0043241 36 0.011
spinal cord patterning GO:0021511 1 0.011
regulation of protein depolymerization GO:1901879 27 0.011
notch signaling pathway GO:0007219 120 0.011
microtubule polymerization or depolymerization GO:0031109 39 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
eggshell formation GO:0030703 105 0.011
chromatin modification GO:0016568 147 0.011
macromolecule catabolic process GO:0009057 161 0.011
torso signaling pathway GO:0008293 21 0.011
formation of organ boundary GO:0010160 30 0.011
chromatin assembly GO:0031497 48 0.011
negative regulation of notch signaling pathway GO:0045746 41 0.011
amine metabolic process GO:0009308 12 0.011
developmental pigmentation GO:0048066 68 0.011
positive regulation of tor signaling GO:0032008 13 0.011
cell growth GO:0016049 108 0.011
ovarian follicle cell development GO:0030707 248 0.011
positive regulation of cellular protein catabolic process GO:1903364 24 0.011
neuron remodeling GO:0016322 29 0.011
organophosphate metabolic process GO:0019637 195 0.011
regulation of response to stress GO:0080134 200 0.011
regulation of cell cycle process GO:0010564 181 0.011
meiotic cell cycle GO:0051321 171 0.011
sensory perception of chemical stimulus GO:0007606 116 0.010
regulation of organ morphogenesis GO:2000027 78 0.010
phosphorylation GO:0016310 294 0.010
regulation of lipid metabolic process GO:0019216 15 0.010
negative regulation of cell development GO:0010721 62 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
cellular homeostasis GO:0019725 80 0.010
negative regulation of intracellular signal transduction GO:1902532 57 0.010
oocyte dorsal ventral axis specification GO:0007310 34 0.010
response to transforming growth factor beta GO:0071559 18 0.010
multi organism behavior GO:0051705 175 0.010
lauric acid metabolic process GO:0048252 1 0.010
cellular carbohydrate metabolic process GO:0044262 22 0.010
water homeostasis GO:0030104 3 0.010
regulation of proteolysis GO:0030162 87 0.010
autophagy GO:0006914 108 0.010
regulation of tube size open tracheal system GO:0035151 43 0.010
negative regulation of protein metabolic process GO:0051248 85 0.010

Sin1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.087
respiratory system disease DOID:1579 0 0.019
lower respiratory tract disease DOID:0050161 0 0.019
bronchial disease DOID:1176 0 0.019
kidney disease DOID:557 0 0.018
urinary system disease DOID:18 0 0.018
nervous system disease DOID:863 0 0.018
musculoskeletal system disease DOID:17 0 0.011