Drosophila melanogaster

29 known processes

ref(2)P (Dmel_CG10360)

refractory to sigma P

(Aliases: Dmel\CG10360,ref(2)p,CG10360,ref(2)Pn,Ref(2)P,ref2p,ref(2)Po2,Ref2P,ref,Ref(2)p)

ref(2)P biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrion morphogenesis GO:0070584 8 0.935
mitochondrion organization GO:0007005 65 0.783
spermatid development GO:0007286 98 0.384
acylglycerol biosynthetic process GO:0046463 2 0.369
response to starvation GO:0042594 97 0.350
intracellular signal transduction GO:0035556 300 0.312
cellular protein modification process GO:0006464 438 0.312
positive regulation of mitochondrion organization GO:0010822 8 0.263
mitochondrial fission GO:0000266 8 0.259
regulation of organelle organization GO:0033043 196 0.258
synaptic transmission GO:0007268 288 0.215
localization of cell GO:0051674 257 0.209
regulation of catabolic process GO:0009894 170 0.208
post embryonic appendage morphogenesis GO:0035120 385 0.193
regulation of mitochondrial fission GO:0090140 7 0.175
negative regulation of response to stimulus GO:0048585 258 0.169
negative regulation of programmed cell death GO:0043069 72 0.166
apoptotic process GO:0006915 159 0.166
imaginal disc derived appendage morphogenesis GO:0035114 395 0.161
appendage development GO:0048736 401 0.154
positive regulation of lipid metabolic process GO:0045834 4 0.154
protein modification process GO:0036211 438 0.149
cell death GO:0008219 279 0.148
regulation of cell death GO:0010941 173 0.147
phosphorylation GO:0016310 294 0.132
regulation of apoptotic process GO:0042981 130 0.123
death GO:0016265 284 0.120
regulation of multicellular organismal development GO:2000026 414 0.108
regulation of programmed cell death GO:0043067 152 0.107
imaginal disc derived appendage development GO:0048737 399 0.106
negative regulation of cell death GO:0060548 81 0.103
response to nutrient levels GO:0031667 114 0.098
regulation of nervous system development GO:0051960 248 0.095
small molecule metabolic process GO:0044281 305 0.094
autophagy GO:0006914 108 0.093
aging GO:0007568 143 0.092
positive regulation of gene expression GO:0010628 290 0.091
intracellular transport GO:0046907 228 0.091
nuclear division GO:0000280 332 0.090
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.089
programmed cell death GO:0012501 257 0.088
negative regulation of apoptotic process GO:0043066 63 0.086
organelle fission GO:0048285 340 0.085
spermatogenesis GO:0007283 200 0.084
single organism membrane fusion GO:0044801 42 0.079
neurological system process GO:0050877 358 0.079
organelle fusion GO:0048284 46 0.078
ubiquitin dependent protein catabolic process GO:0006511 78 0.075
single organism biosynthetic process GO:0044711 206 0.072
microtubule polymerization or depolymerization GO:0031109 39 0.071
developmental maturation GO:0021700 172 0.071
cellular response to chemical stimulus GO:0070887 199 0.067
oxoacid metabolic process GO:0043436 103 0.067
cellular response to oxidative stress GO:0034599 28 0.063
cytokinesis GO:0000910 90 0.063
tissue migration GO:0090130 155 0.062
regulation of protein phosphorylation GO:0001932 64 0.062
regulation of protein complex disassembly GO:0043244 29 0.061
negative regulation of cellular metabolic process GO:0031324 382 0.061
organic substance transport GO:0071702 257 0.059
positive regulation of organelle organization GO:0010638 65 0.059
negative regulation of growth GO:0045926 84 0.059
negative regulation of cellular component organization GO:0051129 108 0.059
regulation of cellular amine metabolic process GO:0033238 3 0.057
regulation of mitochondrion organization GO:0010821 12 0.056
ribonucleoside monophosphate catabolic process GO:0009158 39 0.055
protein transport GO:0015031 155 0.054
lipid homeostasis GO:0055088 33 0.054
regulation of cellular component biogenesis GO:0044087 201 0.053
cell motility GO:0048870 251 0.051
single organism behavior GO:0044708 391 0.050
spermatid differentiation GO:0048515 114 0.050
positive regulation of developmental process GO:0051094 143 0.050
response to oxidative stress GO:0006979 86 0.050
regulation of mitochondrial fusion GO:0010635 5 0.049
triglyceride biosynthetic process GO:0019432 2 0.049
actin filament organization GO:0007015 126 0.048
metal ion transport GO:0030001 74 0.047
positive regulation of signaling GO:0023056 243 0.046
nucleotide metabolic process GO:0009117 161 0.046
negative regulation of signal transduction GO:0009968 206 0.045
cytoskeleton dependent cytokinesis GO:0061640 81 0.045
regulation of cellular ketone metabolic process GO:0010565 3 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.044
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.044
developmental growth GO:0048589 280 0.044
organonitrogen compound metabolic process GO:1901564 318 0.044
purine nucleoside monophosphate metabolic process GO:0009126 50 0.044
actin filament based process GO:0030029 220 0.043
single organism cellular localization GO:1902580 180 0.043
multicellular organismal aging GO:0010259 140 0.042
establishment of localization in cell GO:0051649 402 0.042
metal ion homeostasis GO:0055065 44 0.042
positive regulation of rna biosynthetic process GO:1902680 266 0.042
regulation of transport GO:0051049 181 0.042
purine nucleotide catabolic process GO:0006195 109 0.042
ion transmembrane transport GO:0034220 122 0.042
negative regulation of signaling GO:0023057 219 0.041
cell migration GO:0016477 238 0.041
regulation of intracellular signal transduction GO:1902531 236 0.041
forebrain development GO:0030900 2 0.039
regulation of molecular function GO:0065009 217 0.039
negative regulation of cytoskeleton organization GO:0051494 30 0.039
positive regulation of macromolecule metabolic process GO:0010604 405 0.039
regulation of protein metabolic process GO:0051246 256 0.038
cellular catabolic process GO:0044248 372 0.038
nucleoside monophosphate metabolic process GO:0009123 52 0.038
mitochondrion distribution GO:0048311 10 0.037
homeostatic process GO:0042592 199 0.037
cytoplasmic transport GO:0016482 130 0.037
response to inorganic substance GO:0010035 44 0.037
cellular ketone metabolic process GO:0042180 24 0.036
membrane organization GO:0061024 112 0.036
regulation of cellular localization GO:0060341 136 0.035
larval development GO:0002164 104 0.035
telencephalon development GO:0021537 2 0.035
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.035
protein complex assembly GO:0006461 200 0.034
tissue morphogenesis GO:0048729 297 0.034
morphogenesis of an epithelium GO:0002009 276 0.034
positive regulation of cellular biosynthetic process GO:0031328 316 0.034
response to extracellular stimulus GO:0009991 116 0.034
growth GO:0040007 359 0.034
regulation of phosphorylation GO:0042325 147 0.033
ion homeostasis GO:0050801 55 0.033
regulation of mitotic cell cycle GO:0007346 190 0.032
proteolysis GO:0006508 192 0.032
imaginal disc derived wing morphogenesis GO:0007476 337 0.032
muscle structure development GO:0061061 224 0.032
chemical homeostasis GO:0048878 92 0.032
protein complex disassembly GO:0043241 36 0.031
positive regulation of cellular component organization GO:0051130 156 0.031
regulation of cellular amino acid metabolic process GO:0006521 0 0.031
regulation of protein modification process GO:0031399 112 0.030
endoplasmic reticulum organization GO:0007029 13 0.030
stress activated protein kinase signaling cascade GO:0031098 55 0.030
catabolic process GO:0009056 409 0.030
regulation of response to oxidative stress GO:1902882 4 0.030
protein localization GO:0008104 284 0.029
positive regulation of signal transduction GO:0009967 223 0.028
response to alcohol GO:0097305 95 0.028
single organism intracellular transport GO:1902582 207 0.028
regulation of protein depolymerization GO:1901879 27 0.028
regulation of localization GO:0032879 275 0.028
non sensory hair organization GO:0035316 47 0.027
negative regulation of intracellular signal transduction GO:1902532 57 0.027
regulation of intracellular transport GO:0032386 64 0.027
positive regulation of response to stimulus GO:0048584 323 0.027
male gamete generation GO:0048232 201 0.026
response to metal ion GO:0010038 23 0.026
cell division GO:0051301 248 0.026
cell proliferation GO:0008283 299 0.026
nucleobase containing small molecule metabolic process GO:0055086 174 0.026
organelle assembly GO:0070925 198 0.026
macromolecular complex assembly GO:0065003 256 0.026
epithelial cell migration GO:0010631 148 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.025
mitochondrial fusion GO:0008053 7 0.025
positive regulation of cellular catabolic process GO:0031331 95 0.025
neutral lipid biosynthetic process GO:0046460 2 0.025
protein modification by small protein conjugation or removal GO:0070647 106 0.024
ribonucleoside monophosphate metabolic process GO:0009161 51 0.024
meiotic cell cycle GO:0051321 171 0.024
organelle localization GO:0051640 148 0.024
atp metabolic process GO:0046034 49 0.024
response to oxygen containing compound GO:1901700 200 0.024
neuron projection guidance GO:0097485 241 0.024
positive regulation of cellular component biogenesis GO:0044089 80 0.023
regulation of proteolysis GO:0030162 87 0.023
ribose phosphate metabolic process GO:0019693 145 0.023
cellular protein localization GO:0034613 160 0.023
adult locomotory behavior GO:0008344 76 0.023
regionalization GO:0003002 416 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.022
purine nucleoside metabolic process GO:0042278 127 0.022
negative regulation of organelle organization GO:0010639 56 0.022
positive regulation of nucleic acid templated transcription GO:1903508 266 0.022
actin cytoskeleton organization GO:0030036 206 0.022
regulation of cell proliferation GO:0042127 163 0.022
modification dependent macromolecule catabolic process GO:0043632 79 0.022
carboxylic acid metabolic process GO:0019752 92 0.021
nuclear transport GO:0051169 72 0.021
regulation of transferase activity GO:0051338 58 0.021
meiotic cytokinesis GO:0033206 33 0.021
sperm mitochondrion organization GO:0030382 7 0.021
response to biotic stimulus GO:0009607 294 0.021
nucleoside triphosphate catabolic process GO:0009143 108 0.021
positive regulation of transcription dna templated GO:0045893 266 0.021
response to abiotic stimulus GO:0009628 341 0.021
negative regulation of rna biosynthetic process GO:1902679 240 0.021
epithelium migration GO:0090132 148 0.020
mitochondrion degradation GO:0000422 8 0.020
ribonucleotide metabolic process GO:0009259 145 0.020
organic acid metabolic process GO:0006082 103 0.020
biological adhesion GO:0022610 138 0.020
cell growth GO:0016049 108 0.020
regulation of cellular catabolic process GO:0031329 157 0.020
maintenance of location GO:0051235 73 0.020
regulation of cell cycle GO:0051726 291 0.020
regulation of steroid metabolic process GO:0019218 2 0.020
axon guidance GO:0007411 233 0.020
cellular divalent inorganic cation homeostasis GO:0072503 23 0.020
cellular nitrogen compound catabolic process GO:0044270 165 0.019
taxis GO:0042330 304 0.019
protein catabolic process GO:0030163 101 0.019
negative regulation of phosphatase activity GO:0010923 3 0.019
positive regulation of phosphate metabolic process GO:0045937 139 0.019
cellular response to dna damage stimulus GO:0006974 223 0.019
secretion GO:0046903 109 0.019
negative regulation of mitotic cell cycle GO:0045930 109 0.019
cellular protein complex assembly GO:0043623 71 0.018
positive regulation of cell differentiation GO:0045597 64 0.018
peptidyl amino acid modification GO:0018193 105 0.018
positive regulation of growth GO:0045927 75 0.018
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.018
carbohydrate derivative metabolic process GO:1901135 217 0.018
purine ribonucleoside metabolic process GO:0046128 127 0.018
cellular amino acid metabolic process GO:0006520 61 0.018
wing disc morphogenesis GO:0007472 344 0.018
glycosyl compound catabolic process GO:1901658 112 0.017
cellular macromolecule localization GO:0070727 220 0.017
regulation of microtubule cytoskeleton organization GO:0070507 41 0.017
positive regulation of programmed cell death GO:0043068 62 0.017
protein modification by small protein removal GO:0070646 28 0.017
protein complex biogenesis GO:0070271 201 0.017
g2 dna damage checkpoint GO:0031572 69 0.017
organic substance catabolic process GO:1901575 308 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.017
tube morphogenesis GO:0035239 191 0.017
connective tissue development GO:0061448 3 0.017
lipid biosynthetic process GO:0008610 46 0.016
dna metabolic process GO:0006259 227 0.016
positive regulation of biosynthetic process GO:0009891 316 0.016
positive regulation of cellular protein metabolic process GO:0032270 118 0.016
lipid modification GO:0030258 24 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
negative regulation of protein depolymerization GO:1901880 23 0.016
ion transport GO:0006811 145 0.016
transcription from rna polymerase ii promoter GO:0006366 368 0.016
actin filament based movement GO:0030048 26 0.016
cytokinetic process GO:0032506 27 0.016
inorganic cation transmembrane transport GO:0098662 61 0.015
protein k48 linked ubiquitination GO:0070936 3 0.015
macroautophagy GO:0016236 42 0.015
regulation of cell cycle process GO:0010564 181 0.015
cellular response to oxygen levels GO:0071453 30 0.015
adult behavior GO:0030534 137 0.015
regulation of anatomical structure size GO:0090066 163 0.015
cellular amine metabolic process GO:0044106 12 0.015
positive regulation of rna metabolic process GO:0051254 271 0.015
regulation of chromosome organization GO:0033044 64 0.015
gliogenesis GO:0042063 80 0.015
response to virus GO:0009615 28 0.015
regulation of phosphorus metabolic process GO:0051174 210 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.014
glycosyl compound metabolic process GO:1901657 127 0.014
negative regulation of cell communication GO:0010648 223 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
actin mediated cell contraction GO:0070252 21 0.014
cellular homeostasis GO:0019725 80 0.014
meiotic nuclear division GO:0007126 151 0.014
mapk cascade GO:0000165 107 0.014
cellular protein catabolic process GO:0044257 83 0.014
protein localization to nucleus GO:0034504 55 0.014
regulation of microtubule based process GO:0032886 49 0.014
heterocycle catabolic process GO:0046700 166 0.014
single organism catabolic process GO:0044712 228 0.014
modification dependent protein catabolic process GO:0019941 78 0.014
inorganic ion transmembrane transport GO:0098660 73 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.014
purine ribonucleotide catabolic process GO:0009154 109 0.013
positive regulation of phosphorylation GO:0042327 87 0.013
regulation of kinase activity GO:0043549 53 0.013
learning GO:0007612 75 0.013
response to toxic substance GO:0009636 22 0.013
establishment of protein localization to organelle GO:0072594 62 0.013
appendage morphogenesis GO:0035107 397 0.013
amine metabolic process GO:0009308 12 0.013
negative regulation of cellular biosynthetic process GO:0031327 277 0.013
muscle system process GO:0003012 21 0.013
vesicle mediated transport GO:0016192 381 0.013
purine containing compound metabolic process GO:0072521 155 0.013
purine nucleotide metabolic process GO:0006163 146 0.013
actin filament polymerization GO:0030041 27 0.013
endosomal transport GO:0016197 44 0.013
epithelial cell development GO:0002064 274 0.013
posttranscriptional regulation of gene expression GO:0010608 145 0.013
ribonucleoside catabolic process GO:0042454 112 0.012
regulation of jnk cascade GO:0046328 40 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
neuromuscular synaptic transmission GO:0007274 67 0.012
positive regulation of cell communication GO:0010647 250 0.012
nucleocytoplasmic transport GO:0006913 72 0.012
protein polymerization GO:0051258 42 0.012
divalent inorganic cation homeostasis GO:0072507 29 0.012
positive regulation of protein metabolic process GO:0051247 128 0.012
nucleoside triphosphate metabolic process GO:0009141 120 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
embryo development ending in birth or egg hatching GO:0009792 152 0.011
body morphogenesis GO:0010171 2 0.011
reactive oxygen species metabolic process GO:0072593 22 0.011
organophosphate metabolic process GO:0019637 195 0.011
muscle organ development GO:0007517 127 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
stress activated mapk cascade GO:0051403 52 0.011
protein localization to organelle GO:0033365 82 0.011
cellular macromolecular complex assembly GO:0034622 153 0.011
head development GO:0060322 135 0.011
nucleoside metabolic process GO:0009116 127 0.011
positive regulation of catabolic process GO:0009896 105 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
atp catabolic process GO:0006200 38 0.011
sodium ion transport GO:0006814 22 0.010
regulation of catalytic activity GO:0050790 185 0.010
nucleoside monophosphate catabolic process GO:0009125 39 0.010
chemotaxis GO:0006935 249 0.010
kidney development GO:0001822 3 0.010
response to copper ion GO:0046688 4 0.010
response to organic substance GO:0010033 284 0.010
regulation of developmental growth GO:0048638 174 0.010
immune system process GO:0002376 347 0.010
cellular response to monosaccharide stimulus GO:0071326 2 0.010

ref(2)P disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.042
synucleinopathy DOID:0050890 0 0.020
central nervous system disease DOID:331 0 0.020
neurodegenerative disease DOID:1289 0 0.020
nervous system disease DOID:863 0 0.020