Drosophila melanogaster

333 known processes

hh (Dmel_CG4637)

hedgehog

(Aliases: bar3,bar,anon-WO0182946.19,Mrt,l(3)hh,Hh,anon-WO0134654.19,HH,l(3)neo57,CG4637,Dmel\CG4637,Mir,hg,bar-3,l(3)neo56)

hh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
genital disc anterior posterior pattern formation GO:0035224 8 1.000
labial disc development GO:0035217 4 1.000
organ induction GO:0001759 3 1.000
heart induction GO:0003129 3 0.999
nephron tubule morphogenesis GO:0072078 3 0.999
Mouse
regulation of heart morphogenesis GO:2000826 3 0.998
Zebrafish
genital disc pattern formation GO:0035221 8 0.998
kidney morphogenesis GO:0060993 3 0.998
Mouse
neuron projection guidance GO:0097485 241 0.995
Zebrafish Mouse
determination of genital disc primordium GO:0035225 10 0.994
ventral midline development GO:0007418 9 0.992
morphogenesis of an epithelial bud GO:0060572 3 0.991
Mouse
eye antennal disc development GO:0035214 60 0.991
appendage development GO:0048736 401 0.990
Zebrafish Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.989
Mouse
genital disc sexually dimorphic development GO:0035263 4 0.987
regulation of heart induction GO:0090381 3 0.986
imaginal disc derived appendage morphogenesis GO:0035114 395 0.985
apoptotic process involved in morphogenesis GO:0060561 3 0.981
glial cell migration GO:0008347 31 0.981
germ cell migration GO:0008354 43 0.981
negative regulation of cardioblast differentiation GO:0051892 7 0.980
open tracheal system development GO:0007424 204 0.979
cardioblast cell fate specification GO:0042685 9 0.978
axonogenesis GO:0007409 290 0.978
spiracle morphogenesis open tracheal system GO:0035277 22 0.974
regulation of cardioblast differentiation GO:0051890 9 0.973
determination of imaginal disc primordium GO:0007445 11 0.972
post embryonic hemopoiesis GO:0035166 17 0.971
negative regulation of heart induction by canonical wnt signaling pathway GO:0003136 3 0.969
nephron morphogenesis GO:0072028 3 0.969
Mouse
positive regulation of retinal cell programmed cell death GO:0046670 9 0.967
motor neuron axon guidance GO:0008045 58 0.966
taxis GO:0042330 304 0.965
Zebrafish Mouse
larval lymph gland hemopoiesis GO:0035167 17 0.964
heart field specification GO:0003128 0 0.963
mesodermal cell fate specification GO:0007501 2 0.963
epithelial cell development GO:0002064 274 0.958
Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.954
epidermal cell differentiation GO:0009913 51 0.952
embryonic pattern specification GO:0009880 174 0.951
imaginal disc derived appendage development GO:0048737 399 0.949
negative regulation of cardiac cell fate specification GO:2000044 7 0.948
eye antennal disc morphogenesis GO:0007455 34 0.947
positive regulation of compound eye retinal cell programmed cell death GO:0046672 9 0.945
malpighian tubule tip cell differentiation GO:0061382 9 0.944
imaginal disc derived wing vein specification GO:0007474 48 0.940
crystal cell differentiation GO:0042688 7 0.940
epithelial cell type specification open tracheal system GO:0035153 11 0.935
sensory organ morphogenesis GO:0090596 260 0.935
larval lymph gland hemocyte differentiation GO:0035168 11 0.931
axon development GO:0061564 297 0.928
appendage morphogenesis GO:0035107 397 0.928
Zebrafish Mouse
enteroendocrine cell differentiation GO:0035883 1 0.917
negative regulation of cell differentiation GO:0045596 143 0.916
Mouse
segmentation GO:0035282 207 0.911
cell fate specification involved in pattern specification GO:0060573 8 0.910
specification of organ identity GO:0010092 3 0.907
ovarian follicle cell development GO:0030707 248 0.905
respiratory system development GO:0060541 213 0.892
heart formation GO:0060914 6 0.885
formation of anatomical boundary GO:0048859 37 0.883
Mouse
negative regulation of heart induction GO:1901320 3 0.878
negative regulation of rna metabolic process GO:0051253 251 0.875
Mouse
nephron epithelium morphogenesis GO:0072088 3 0.874
Mouse
nephron development GO:0072006 3 0.869
Zebrafish Mouse
wnt signaling pathway involved in heart development GO:0003306 3 0.863
regulation of insulin like growth factor receptor signaling pathway GO:0043567 3 0.860
wing and notum subfield formation GO:0035309 13 0.858
epithelial cell proliferation GO:0050673 15 0.858
Mouse
axon guidance GO:0007411 233 0.851
Zebrafish Mouse
regulation of cardioblast cell fate specification GO:0042686 8 0.848
lymph gland development GO:0048542 28 0.845
eye photoreceptor cell differentiation GO:0001754 145 0.841
Zebrafish Mouse
spinal cord dorsal ventral patterning GO:0021513 1 0.840
Mouse
chemotaxis GO:0006935 249 0.839
Zebrafish Mouse
nephron tubule development GO:0072080 3 0.837
Mouse
epithelial tube formation GO:0072175 7 0.834
transcription from rna polymerase ii promoter GO:0006366 368 0.830
Mouse
regulation of epithelial cell proliferation GO:0050678 4 0.828
Mouse
kidney epithelium development GO:0072073 3 0.828
Mouse
epidermis development GO:0008544 65 0.827
Mouse
negative regulation of transcription dna templated GO:0045892 237 0.827
Mouse
regulation of cardiac cell fate specification GO:2000043 8 0.817
positive regulation of muscle organ development GO:0048636 6 0.812
Mouse
regionalization GO:0003002 416 0.811
cell fate specification GO:0001708 71 0.810
Zebrafish Mouse
segment polarity determination GO:0007367 25 0.803
cell surface receptor signaling pathway involved in heart development GO:0061311 3 0.802
Zebrafish
bmp signaling pathway GO:0030509 27 0.792
Zebrafish
genital disc development GO:0035215 44 0.788
epithelial cell proliferation involved in malpighian tubule morphogenesis GO:0061331 11 0.786
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.780
cardioblast differentiation GO:0010002 20 0.769
Zebrafish
nephrocyte differentiation GO:0061319 12 0.766
tube formation GO:0035148 21 0.764
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.762
stem cell maintenance GO:0019827 67 0.751
eye morphogenesis GO:0048592 260 0.748
neuron fate specification GO:0048665 12 0.747
Zebrafish
stem cell development GO:0048864 79 0.745
Mouse
hair cell differentiation GO:0035315 47 0.743
anterior posterior pattern specification imaginal disc GO:0007448 16 0.733
germ line stem cell maintenance GO:0030718 50 0.732
imaginal disc pattern formation GO:0007447 91 0.732
columnar cuboidal epithelial cell development GO:0002066 249 0.725
developmental induction GO:0031128 3 0.724
skin development GO:0043588 65 0.720
Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.713
organ formation GO:0048645 39 0.712
regulation of growth GO:0040008 233 0.709
Mouse Worm
eggshell chorion assembly GO:0007306 66 0.702
morphogenesis of an epithelial fold GO:0060571 6 0.694
Mouse
regulation of developmental growth GO:0048638 174 0.691
Worm
retinal ganglion cell axon guidance GO:0031290 12 0.690
wing disc morphogenesis GO:0007472 344 0.687
negative regulation of cell fate specification GO:0009996 15 0.684
dorsal closure GO:0007391 79 0.680
mesenchymal cell differentiation GO:0048762 1 0.662
Mouse
stem cell differentiation GO:0048863 117 0.657
Zebrafish Mouse
determination of dorsal ventral asymmetry GO:0048262 3 0.657
positive regulation of macromolecule metabolic process GO:0010604 405 0.648
Mouse
regulation of organ formation GO:0003156 3 0.646
Mouse
limb morphogenesis GO:0035108 1 0.645
Mouse
cellular component assembly involved in morphogenesis GO:0010927 151 0.642
negative regulation of gene expression GO:0010629 387 0.640
compound eye morphogenesis GO:0001745 249 0.638
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.633
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.625
Mouse
morphogenesis of embryonic epithelium GO:0016331 94 0.617
Zebrafish Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.614
embryonic heart tube development GO:0035050 22 0.612
Zebrafish Mouse
wing cell fate specification GO:0035311 3 0.602
positive regulation of multicellular organismal process GO:0051240 143 0.599
Mouse Worm
chorion containing eggshell formation GO:0007304 105 0.597
imaginal disc derived wing hair organization GO:0035317 45 0.596
dorsal ventral pattern formation GO:0009953 133 0.574
Zebrafish Mouse
cell fate commitment involved in pattern specification GO:0060581 31 0.569
dorsal appendage formation GO:0046843 47 0.568
periodic partitioning GO:0007365 29 0.561
regulation of cell cycle GO:0051726 291 0.554
notch signaling pathway GO:0007219 120 0.552
mesodermal cell differentiation GO:0048333 7 0.543
tissue morphogenesis GO:0048729 297 0.538
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.538
ovarian follicle cell stalk formation GO:0030713 17 0.535
positive regulation of epithelial cell differentiation GO:0030858 1 0.531
regulation of bmp signaling pathway GO:0030510 23 0.523
Zebrafish
cuticle pattern formation GO:0035017 27 0.518
neuron fate commitment GO:0048663 50 0.514
Zebrafish Mouse
negative regulation of rna biosynthetic process GO:1902679 240 0.509
Mouse
response to organic substance GO:0010033 284 0.508
negative regulation of wnt signaling pathway GO:0030178 28 0.503
Mouse
telencephalon development GO:0021537 2 0.498
bolwig s organ development GO:0055034 8 0.498
reproductive system development GO:0061458 74 0.493
hemocyte differentiation GO:0042386 38 0.488
synapse organization GO:0050808 196 0.481
smoothened signaling pathway GO:0007224 49 0.480
regulation of muscle organ development GO:0048634 13 0.471
Mouse
brain development GO:0007420 120 0.471
embryonic morphogenesis GO:0048598 206 0.470
Zebrafish Mouse
pericardial nephrocyte differentiation GO:0061320 9 0.468
determination of ventral identity GO:0048264 1 0.466
morphogenesis of an epithelium GO:0002009 276 0.461
eggshell formation GO:0030703 105 0.457
growth GO:0040007 359 0.456
Mouse Worm
regulation of cell fate specification GO:0042659 27 0.456
negative regulation of biosynthetic process GO:0009890 277 0.454
Mouse
negative regulation of signal transduction GO:0009968 206 0.435
Mouse
positive regulation of response to stimulus GO:0048584 323 0.435
blastoderm segmentation GO:0007350 159 0.434
mesenchyme development GO:0060485 9 0.434
negative regulation of dna endoreduplication GO:0032876 2 0.434
cell fate determination GO:0001709 91 0.433
cardiac cell fate commitment GO:0060911 17 0.432
mesoderm development GO:0007498 78 0.428
anterior posterior pattern specification GO:0009952 136 0.427
imaginal disc derived leg morphogenesis GO:0007480 80 0.418
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.415
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.412
cardioblast cell fate commitment GO:0042684 14 0.408
camera type eye development GO:0043010 4 0.407
Zebrafish Mouse
negative regulation of nucleic acid templated transcription GO:1903507 240 0.406
Mouse
multicellular organism growth GO:0035264 46 0.400
Mouse Worm
regulation of pathway restricted smad protein phosphorylation GO:0060393 1 0.394
regulation of mitotic cell cycle GO:0007346 190 0.382
second mitotic wave involved in compound eye morphogenesis GO:0016330 7 0.381
neurological system process GO:0050877 358 0.373
non sensory hair organization GO:0035316 47 0.372
renal tubule development GO:0061326 64 0.371
Mouse
imaginal disc derived leg segmentation GO:0036011 26 0.365
negative regulation of cellular biosynthetic process GO:0031327 277 0.361
Mouse
photoreceptor cell fate commitment GO:0046552 41 0.350
Mouse
positive regulation of nervous system development GO:0051962 69 0.345
Mouse
regulation of eye pigmentation GO:0048073 7 0.342
Mouse
developmental growth GO:0048589 280 0.338
Mouse Worm
negative regulation of multicellular organismal process GO:0051241 142 0.338
Mouse
cell migration involved in gastrulation GO:0042074 9 0.331
embryonic epithelial tube formation GO:0001838 6 0.330
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.325
Zebrafish Mouse
body morphogenesis GO:0010171 2 0.321
Mouse
regulation of epithelial cell migration GO:0010632 12 0.320
gliogenesis GO:0042063 80 0.319
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.318
Mouse
renal filtration cell differentiation GO:0061318 12 0.316
epithelial cell differentiation GO:0030855 322 0.311
Zebrafish Mouse
response to radiation GO:0009314 155 0.309
glandular epithelial cell differentiation GO:0002067 1 0.309
reproductive structure development GO:0048608 74 0.308
cardiac cell fate specification GO:0060912 10 0.302
positive regulation of hh target transcription factor activity GO:0007228 5 0.300
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.297
Mouse
pericardium morphogenesis GO:0003344 2 0.296
heart morphogenesis GO:0003007 32 0.288
chaeta development GO:0022416 97 0.287
pericardium development GO:0060039 2 0.281
regulation of multicellular organismal development GO:2000026 414 0.277
positive regulation of cell proliferation GO:0008284 47 0.276
Mouse
gonad development GO:0008406 50 0.270
heart development GO:0007507 82 0.269
forebrain development GO:0030900 2 0.265
regulation of stem cell differentiation GO:2000736 14 0.265
positive regulation of programmed cell death GO:0043068 62 0.264
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 1 0.263
negative regulation of dna dependent dna replication GO:2000104 2 0.260
regulation of compound eye pigmentation GO:0048076 7 0.260
regulation of retinal cell programmed cell death GO:0046668 18 0.251
germarium derived egg chamber formation GO:0007293 101 0.249
death GO:0016265 284 0.249
Mouse
regulation of cell morphogenesis GO:0022604 163 0.249
positive regulation of stem cell differentiation GO:2000738 3 0.242
organic substance transport GO:0071702 257 0.237
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.237
Mouse
neuroblast development GO:0014019 13 0.233
nephron epithelium development GO:0072009 3 0.232
Mouse
wing disc pattern formation GO:0035222 66 0.231
limb development GO:0060173 1 0.227
Mouse
regulation of embryonic development GO:0045995 68 0.227
Zebrafish Mouse
negative regulation of stem cell differentiation GO:2000737 8 0.226
nephron tubule formation GO:0072079 3 0.223
negative regulation of response to stimulus GO:0048585 258 0.222
Mouse
posttranscriptional regulation of gene expression GO:0010608 145 0.219
protein localization GO:0008104 284 0.219
positive regulation of bmp signaling pathway GO:0030513 5 0.218
central nervous system projection neuron axonogenesis GO:0021952 6 0.218
apoptotic process GO:0006915 159 0.217
Mouse
muscle cell fate specification GO:0042694 7 0.217
Zebrafish
regulation of imaginal disc derived wing size GO:0044719 20 0.215
long term memory GO:0007616 62 0.212
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.209
cell death GO:0008219 279 0.207
Mouse
central nervous system development GO:0007417 201 0.207
regulation of anatomical structure size GO:0090066 163 0.206
connective tissue development GO:0061448 3 0.199
Zebrafish Mouse
negative regulation of cell fate commitment GO:0010454 17 0.199
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.196
Zebrafish
neuroblast fate determination GO:0007400 12 0.196
neuroblast fate commitment GO:0014017 19 0.196
regulation of cell death GO:0010941 173 0.190
Mouse
hindbrain development GO:0030902 2 0.188
Zebrafish Mouse
embryonic hindgut morphogenesis GO:0048619 48 0.187
epithelial cell morphogenesis GO:0003382 25 0.185
Mouse
renal tubule morphogenesis GO:0061333 44 0.183
Mouse
retina development in camera type eye GO:0060041 4 0.181
Mouse
specification of symmetry GO:0009799 13 0.180
Zebrafish Mouse
initiation of dorsal closure GO:0007392 12 0.178
positive regulation of rna metabolic process GO:0051254 271 0.175
Mouse
compound eye development GO:0048749 307 0.175
eye pigmentation GO:0048069 43 0.173
Mouse
muscle organ morphogenesis GO:0048644 7 0.173
negative regulation of signaling GO:0023057 219 0.167
Mouse
mesoderm formation GO:0001707 21 0.165
stem cell proliferation GO:0072089 88 0.165
Mouse
regulation of cellular protein metabolic process GO:0032268 243 0.164
germ line stem cell division GO:0042078 25 0.163
negative regulation of cellular metabolic process GO:0031324 382 0.161
negative regulation of developmental process GO:0051093 201 0.161
Mouse
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.161
positive regulation of cell communication GO:0010647 250 0.160
spinal cord patterning GO:0021511 1 0.159
Mouse
programmed cell death GO:0012501 257 0.159
Mouse
organic substance catabolic process GO:1901575 308 0.159
Mouse
response to hypoxia GO:0001666 53 0.158
developmental programmed cell death GO:0010623 138 0.158
actin filament based process GO:0030029 220 0.158
canonical wnt signaling pathway GO:0060070 21 0.156
Mouse
mesenchymal cell development GO:0014031 1 0.156
Mouse
epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013 11 0.155
regulation of glial cell differentiation GO:0045685 1 0.155
Mouse
embryonic organ development GO:0048568 50 0.154
Zebrafish Mouse
malpighian tubule morphogenesis GO:0007443 44 0.152
eye photoreceptor cell fate commitment GO:0042706 37 0.151
Mouse
positive regulation of protein import into nucleus GO:0042307 21 0.150
positive regulation of cellular component organization GO:0051130 156 0.150
ommatidial rotation GO:0016318 20 0.150
regulation of anatomical structure morphogenesis GO:0022603 242 0.149
Zebrafish Mouse
negative regulation of cell cell adhesion GO:0022408 8 0.149
intracellular signal transduction GO:0035556 300 0.147
somatic muscle development GO:0007525 66 0.147
leg disc development GO:0035218 92 0.144
negative regulation of bmp signaling pathway GO:0030514 12 0.144
fusion cell fate specification GO:0035156 4 0.143
regulation of cell differentiation GO:0045595 302 0.136
Mouse
actin cytoskeleton organization GO:0030036 206 0.136
regulation of epithelial cell differentiation GO:0030856 4 0.135
positive regulation of cell death GO:0010942 69 0.134
regulation of smoothened signaling pathway GO:0008589 28 0.132
Mouse
positive regulation of protein metabolic process GO:0051247 128 0.132
positive regulation of developmental growth GO:0048639 62 0.131
Worm
compound eye retinal cell programmed cell death GO:0046667 23 0.130
organic acid metabolic process GO:0006082 103 0.130
embryonic hemopoiesis GO:0035162 26 0.129
regulation of nucleocytoplasmic transport GO:0046822 35 0.124
regulation of programmed cell death GO:0043067 152 0.124
Mouse
protein modification by small protein conjugation GO:0032446 79 0.124
sex differentiation GO:0007548 81 0.123
skeletal muscle organ development GO:0060538 48 0.123
Zebrafish Mouse
macromolecule catabolic process GO:0009057 161 0.120
Mouse
synaptic transmission GO:0007268 288 0.119
regulation of synapse assembly GO:0051963 94 0.119
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.118
gastrulation GO:0007369 70 0.117
neuroblast differentiation GO:0014016 29 0.117
axis specification GO:0009798 167 0.116
Mouse
cell cell adhesion GO:0098609 26 0.116
tube development GO:0035295 244 0.114
negative regulation of smoothened signaling pathway GO:0045879 16 0.114
eye photoreceptor cell development GO:0042462 81 0.113
Zebrafish
malpighian tubule bud morphogenesis GO:0061332 3 0.113
cell motility GO:0048870 251 0.112
renal system development GO:0072001 72 0.111
Zebrafish Mouse
single organism biosynthetic process GO:0044711 206 0.109
Mouse
establishment of planar polarity GO:0001736 87 0.108
cell fate commitment involved in formation of primary germ layer GO:0060795 10 0.108
leg disc morphogenesis GO:0007478 80 0.107
single organismal cell cell adhesion GO:0016337 45 0.107
Mouse
retinal cell programmed cell death GO:0046666 25 0.107
neuron recognition GO:0008038 101 0.106
skeletal muscle fiber development GO:0048741 3 0.105
Zebrafish
anterior posterior axis specification GO:0009948 109 0.105
Mouse
mesodermal cell fate commitment GO:0001710 7 0.102
regulation of wnt signaling pathway GO:0030111 68 0.100
Mouse
embryonic axis specification GO:0000578 107 0.100
spinal cord development GO:0021510 1 0.098
Zebrafish Mouse
stem cell fate determination GO:0048867 15 0.097
response to nutrient levels GO:0031667 114 0.097
antennal morphogenesis GO:0048800 14 0.096
larval development GO:0002164 104 0.094
positive regulation of signaling GO:0023056 243 0.094
regulation of cellular catabolic process GO:0031329 157 0.094
Mouse
negative regulation of cell death GO:0060548 81 0.093
Mouse
glial cell differentiation GO:0010001 35 0.093
Zebrafish Mouse
immune system process GO:0002376 347 0.093
Mouse
axis elongation GO:0003401 3 0.092
Mouse
malpighian tubule development GO:0072002 64 0.092
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.092
intracellular protein transport GO:0006886 104 0.091
axon extension GO:0048675 32 0.091
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.091
Zebrafish
cuticle development GO:0042335 86 0.091
Worm
negative regulation of immune system process GO:0002683 50 0.090
Mouse
regulation of protein localization GO:0032880 76 0.089
myotube cell development GO:0014904 3 0.089
Zebrafish
neuron projection extension GO:1990138 32 0.088
gland development GO:0048732 191 0.087
Zebrafish Mouse
dna metabolic process GO:0006259 227 0.087
protein localization to nucleus GO:0034504 55 0.085
central nervous system segmentation GO:0035283 5 0.084
cell maturation GO:0048469 144 0.084
Mouse
cellular protein modification process GO:0006464 438 0.080
chaeta morphogenesis GO:0008407 42 0.080
membrane organization GO:0061024 112 0.080
proximal distal pattern formation GO:0009954 15 0.080
wnt signaling pathway GO:0016055 98 0.079
Mouse
negative regulation of cell communication GO:0010648 223 0.079
Mouse
regulation of apoptotic process GO:0042981 130 0.079
Mouse
circulatory system development GO:0072359 82 0.079
single organism cell adhesion GO:0098602 47 0.078
Mouse
regulation of neuroblast proliferation GO:1902692 34 0.077
Mouse
regulation of catabolic process GO:0009894 170 0.077
Mouse
eye development GO:0001654 323 0.076
positive regulation of cell differentiation GO:0045597 64 0.076
Mouse
negative regulation of cardioblast cell fate specification GO:0009997 7 0.074
regulation of notch signaling pathway GO:0008593 100 0.074
cellular catabolic process GO:0044248 372 0.074
Mouse
development of primary female sexual characteristics GO:0046545 12 0.073
positive regulation of molecular function GO:0044093 136 0.072
unidimensional cell growth GO:0009826 15 0.072
regulation of protein transport GO:0051223 57 0.072
establishment of tissue polarity GO:0007164 87 0.071
negative regulation of epithelial cell proliferation GO:0050680 4 0.070
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.070
protein localization to organelle GO:0033365 82 0.069
cell recognition GO:0008037 102 0.069
regulation of epidermal cell differentiation GO:0045604 3 0.068
positive regulation of growth GO:0045927 75 0.067
Worm
positive regulation of nucleic acid templated transcription GO:1903508 266 0.067
Mouse
proteoglycan metabolic process GO:0006029 10 0.066
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.066
Mouse
dorsal closure elongation of leading edge cells GO:0007394 10 0.066
negative regulation of growth GO:0045926 84 0.065
hindgut development GO:0061525 58 0.065
negative regulation of neurogenesis GO:0050768 53 0.064
neuron fate determination GO:0048664 1 0.064
mesoderm morphogenesis GO:0048332 22 0.064
sensory perception of sound GO:0007605 56 0.063
regulation of cell cycle g1 s phase transition GO:1902806 23 0.063
synapse assembly GO:0007416 143 0.063
regulation of nervous system development GO:0051960 248 0.062
Mouse
regulation of phosphorus metabolic process GO:0051174 210 0.062
embryonic digestive tract development GO:0048566 5 0.062
Zebrafish Mouse
response to oxygen containing compound GO:1901700 200 0.061
ketone biosynthetic process GO:0042181 16 0.061
oocyte axis specification GO:0007309 108 0.061
regulation of synapse structure and activity GO:0050803 128 0.060
phosphorylation GO:0016310 294 0.059
protein import into nucleus GO:0006606 51 0.059
regulation of cell fate commitment GO:0010453 29 0.059
positive regulation of signal transduction GO:0009967 223 0.058
positive regulation of cell migration GO:0030335 2 0.058
asymmetric cell division GO:0008356 37 0.058
actin filament organization GO:0007015 126 0.058
cardiocyte differentiation GO:0035051 29 0.058
Zebrafish
muscle cell fate commitment GO:0042693 14 0.057
Zebrafish
camera type eye morphogenesis GO:0048593 2 0.057
Mouse
development of primary sexual characteristics GO:0045137 50 0.057
protein transport GO:0015031 155 0.056
haltere disc development GO:0035216 10 0.056
regulation of hemocyte differentiation GO:0045610 22 0.056
negative chemotaxis GO:0050919 15 0.056
negative regulation of programmed cell death GO:0043069 72 0.055
Mouse
regulation of protein import into nucleus GO:0042306 28 0.055
imaginal disc derived leg joint morphogenesis GO:0016348 15 0.055
embryonic development via the syncytial blastoderm GO:0001700 148 0.054
kidney development GO:0001822 3 0.054
Zebrafish Mouse
regulation of establishment of protein localization GO:0070201 61 0.053
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.053
morphogenesis of a branching epithelium GO:0061138 45 0.052
Mouse
mushroom body development GO:0016319 70 0.052
hematopoietic or lymphoid organ development GO:0048534 57 0.052
Mouse
developmental cell growth GO:0048588 52 0.051
regulation of molecular function GO:0065009 217 0.051
oxoacid metabolic process GO:0043436 103 0.050
positive regulation of cell development GO:0010720 61 0.050
Mouse
wing disc dorsal ventral pattern formation GO:0048190 47 0.050
protein modification by small protein conjugation or removal GO:0070647 106 0.050
pigmentation GO:0043473 75 0.050
Mouse
actin filament bundle assembly GO:0051017 26 0.050
regulation of catalytic activity GO:0050790 185 0.049
gastrulation involving germ band extension GO:0010004 36 0.049
branching morphogenesis of an epithelial tube GO:0048754 45 0.048
Mouse
positive regulation of catalytic activity GO:0043085 118 0.048
wnt signaling pathway planar cell polarity pathway GO:0060071 6 0.047
cytoplasmic transport GO:0016482 130 0.047
epithelial tube morphogenesis GO:0060562 88 0.047
Zebrafish Mouse
female sex differentiation GO:0046660 20 0.046
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 4 0.046
developmental growth involved in morphogenesis GO:0060560 65 0.046
Mouse
catabolic process GO:0009056 409 0.046
Mouse
tripartite regional subdivision GO:0007351 103 0.046
head development GO:0060322 135 0.045
establishment of protein localization GO:0045184 163 0.045
formation of organ boundary GO:0010160 30 0.045
response to organic cyclic compound GO:0014070 89 0.045
antennal development GO:0007469 25 0.044
multi organism reproductive behavior GO:0044705 121 0.044
appendage segmentation GO:0035285 26 0.044
negative regulation of apoptotic process GO:0043066 63 0.043
Mouse
visceral muscle development GO:0007522 14 0.043
stem cell fate commitment GO:0048865 25 0.042
regulation of reproductive process GO:2000241 54 0.042
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.042
regulation of intracellular protein transport GO:0033157 46 0.041
formation of primary germ layer GO:0001704 24 0.041
negative regulation of nervous system development GO:0051961 92 0.041
determination of left right symmetry GO:0007368 9 0.040
Zebrafish Mouse
salivary gland morphogenesis GO:0007435 145 0.040
Mouse
cell cell signaling involved in cell fate commitment GO:0045168 210 0.040
regulation of tube architecture open tracheal system GO:0035152 68 0.040
cilium organization GO:0044782 41 0.040
response to endogenous stimulus GO:0009719 119 0.039
regulation of response to external stimulus GO:0032101 115 0.039
regulation of cell proliferation GO:0042127 163 0.039
Zebrafish Mouse
regulation of cytoplasmic transport GO:1903649 47 0.039
synaptic growth at neuromuscular junction GO:0051124 119 0.038
amine metabolic process GO:0009308 12 0.038
establishment of protein localization to organelle GO:0072594 62 0.038

hh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.823
musculoskeletal system disease DOID:17 0 0.506
cardiovascular system disease DOID:1287 0 0.458
bone development disease DOID:0080006 0 0.421
bone disease DOID:0080001 0 0.421
connective tissue disease DOID:65 0 0.421
dysostosis DOID:1934 0 0.272
disease of cellular proliferation DOID:14566 0 0.159
nervous system disease DOID:863 0 0.064