Drosophila melanogaster

72 known processes

Sam-S (Dmel_CG2674)

S-adenosylmethionine Synthetase

(Aliases: Su(z)5,CG2674,Dmel\CG2674,SamS,METK,M(2)21AB,M(2)21A-B,m(2)21ab)

Sam-S biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin organization GO:0006325 207 0.840
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.829
negative regulation of cellular biosynthetic process GO:0031327 277 0.623
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.557
chromosome organization GO:0051276 360 0.549
organonitrogen compound metabolic process GO:1901564 318 0.392
purine containing compound metabolic process GO:0072521 155 0.389
gene silencing GO:0016458 138 0.345
organophosphate metabolic process GO:0019637 195 0.311
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.309
establishment of localization in cell GO:0051649 402 0.267
peptidyl lysine modification GO:0018205 57 0.264
nucleoside metabolic process GO:0009116 127 0.264
endocytosis GO:0006897 310 0.233
heterocycle catabolic process GO:0046700 166 0.212
small molecule metabolic process GO:0044281 305 0.181
purine ribonucleotide metabolic process GO:0009150 145 0.176
negative regulation of biosynthetic process GO:0009890 277 0.167
immune system development GO:0002520 57 0.161
cellular catabolic process GO:0044248 372 0.158
histone modification GO:0016570 106 0.150
response to biotic stimulus GO:0009607 294 0.147
purine nucleotide metabolic process GO:0006163 146 0.145
covalent chromatin modification GO:0016569 106 0.143
negative regulation of cellular metabolic process GO:0031324 382 0.134
purine ribonucleoside metabolic process GO:0046128 127 0.134
posttranscriptional regulation of gene expression GO:0010608 145 0.133
nucleotide metabolic process GO:0009117 161 0.132
regulation of cell cycle GO:0051726 291 0.131
death GO:0016265 284 0.127
nucleobase containing compound catabolic process GO:0034655 165 0.125
purine nucleoside metabolic process GO:0042278 127 0.122
nucleoside phosphate metabolic process GO:0006753 162 0.121
catabolic process GO:0009056 409 0.109
posttranscriptional gene silencing GO:0016441 46 0.104
response to oxidative stress GO:0006979 86 0.101
aromatic compound catabolic process GO:0019439 166 0.101
organic acid metabolic process GO:0006082 103 0.100
cellular protein modification process GO:0006464 438 0.099
ribonucleoside metabolic process GO:0009119 127 0.097
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.095
cell death GO:0008219 279 0.093
negative regulation of nucleic acid templated transcription GO:1903507 240 0.092
organonitrogen compound catabolic process GO:1901565 128 0.090
ribonucleoside triphosphate catabolic process GO:0009203 108 0.087
negative regulation of rna biosynthetic process GO:1902679 240 0.087
single organism membrane fusion GO:0044801 42 0.085
cellular nitrogen compound catabolic process GO:0044270 165 0.085
programmed cell death GO:0012501 257 0.085
regulation of translation GO:0006417 56 0.085
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.084
ribonucleotide metabolic process GO:0009259 145 0.084
chromatin modification GO:0016568 147 0.084
regulation of multicellular organism growth GO:0040014 40 0.081
translation GO:0006412 69 0.080
carbohydrate derivative metabolic process GO:1901135 217 0.080
nucleoside triphosphate metabolic process GO:0009141 120 0.079
axonogenesis GO:0007409 290 0.075
ribose phosphate metabolic process GO:0019693 145 0.075
neuron projection guidance GO:0097485 241 0.074
oxoacid metabolic process GO:0043436 103 0.073
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.073
response to external biotic stimulus GO:0043207 293 0.073
chromatin assembly GO:0031497 48 0.072
cellular response to dna damage stimulus GO:0006974 223 0.070
multicellular organism growth GO:0035264 46 0.068
organic substance catabolic process GO:1901575 308 0.067
purine ribonucleotide catabolic process GO:0009154 109 0.066
learning GO:0007612 75 0.066
gene silencing by rna GO:0031047 57 0.064
positive regulation of growth GO:0045927 75 0.063
purine nucleoside catabolic process GO:0006152 112 0.062
organonitrogen compound biosynthetic process GO:1901566 117 0.062
cellular protein localization GO:0034613 160 0.061
regulation of gene expression epigenetic GO:0040029 128 0.060
cellular macromolecule catabolic process GO:0044265 136 0.058
growth GO:0040007 359 0.058
regulation of immune system process GO:0002682 176 0.057
response to other organism GO:0051707 293 0.057
regulation of molecular function GO:0065009 217 0.055
protein complex biogenesis GO:0070271 201 0.055
nucleobase containing small molecule metabolic process GO:0055086 174 0.055
purine nucleoside monophosphate metabolic process GO:0009126 50 0.055
negative regulation of rna metabolic process GO:0051253 251 0.054
carbohydrate derivative catabolic process GO:1901136 118 0.054
amine metabolic process GO:0009308 12 0.054
intracellular transport GO:0046907 228 0.052
ribonucleoside triphosphate metabolic process GO:0009199 119 0.052
chromatin silencing GO:0006342 76 0.052
morphogenesis of an epithelium GO:0002009 276 0.051
purine containing compound catabolic process GO:0072523 112 0.051
nuclear division GO:0000280 332 0.051
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.051
epithelial cell differentiation GO:0030855 322 0.051
embryo development ending in birth or egg hatching GO:0009792 152 0.050
reproductive structure development GO:0048608 74 0.050
ribonucleoside monophosphate metabolic process GO:0009161 51 0.050
positive regulation of biosynthetic process GO:0009891 316 0.049
regulation of programmed cell death GO:0043067 152 0.048
protein complex disassembly GO:0043241 36 0.048
organic cyclic compound catabolic process GO:1901361 168 0.048
negative regulation of gene expression GO:0010629 387 0.047
atp metabolic process GO:0046034 49 0.047
negative regulation of apoptotic process GO:0043066 63 0.047
immune system process GO:0002376 347 0.046
mitotic sister chromatid segregation GO:0000070 87 0.046
mating GO:0007618 120 0.046
dna damage checkpoint GO:0000077 78 0.046
purine nucleoside triphosphate catabolic process GO:0009146 108 0.045
apoptotic process GO:0006915 159 0.045
nucleoside catabolic process GO:0009164 112 0.045
negative regulation of developmental process GO:0051093 201 0.044
nucleoside triphosphate catabolic process GO:0009143 108 0.043
protein acetylation GO:0006473 39 0.042
regulation of growth GO:0040008 233 0.042
neurological system process GO:0050877 358 0.042
regulation of protein metabolic process GO:0051246 256 0.042
single organism behavior GO:0044708 391 0.042
mitotic dna damage checkpoint GO:0044773 74 0.041
determination of adult lifespan GO:0008340 137 0.041
response to oxygen containing compound GO:1901700 200 0.041
stem cell maintenance GO:0019827 67 0.039
positive regulation of developmental growth GO:0048639 62 0.039
sister chromatid segregation GO:0000819 92 0.039
protein modification process GO:0036211 438 0.039
purine nucleotide catabolic process GO:0006195 109 0.039
nucleotide catabolic process GO:0009166 109 0.039
ribonucleoside monophosphate catabolic process GO:0009158 39 0.038
regulation of cell cycle process GO:0010564 181 0.037
positive regulation of multicellular organism growth GO:0040018 21 0.036
regulation of catalytic activity GO:0050790 185 0.036
maintenance of location GO:0051235 73 0.035
cell cell signaling involved in cell fate commitment GO:0045168 210 0.035
intracellular signal transduction GO:0035556 300 0.035
localization of cell GO:0051674 257 0.035
eye photoreceptor cell differentiation GO:0001754 145 0.034
regulation of gene silencing GO:0060968 63 0.034
organelle fission GO:0048285 340 0.034
transcription from rna polymerase ii promoter GO:0006366 368 0.033
regulation of cell death GO:0010941 173 0.033
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.033
glycosyl compound catabolic process GO:1901658 112 0.033
protein acylation GO:0043543 42 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.032
mitotic nuclear division GO:0007067 213 0.032
ribonucleoside catabolic process GO:0042454 112 0.031
nucleoside phosphate catabolic process GO:1901292 110 0.031
posttranscriptional gene silencing by rna GO:0035194 45 0.031
defense response GO:0006952 300 0.031
positive regulation of gene expression GO:0010628 290 0.031
dna integrity checkpoint GO:0031570 81 0.031
rna localization GO:0006403 115 0.030
organic substance transport GO:0071702 257 0.030
organophosphate biosynthetic process GO:0090407 46 0.030
sensory perception of sound GO:0007605 56 0.029
purine nucleoside triphosphate metabolic process GO:0009144 119 0.029
associative learning GO:0008306 65 0.029
negative regulation of response to stimulus GO:0048585 258 0.029
axon guidance GO:0007411 233 0.029
homeostatic process GO:0042592 199 0.029
macromolecule catabolic process GO:0009057 161 0.029
regulation of nervous system development GO:0051960 248 0.029
positive regulation of nucleic acid templated transcription GO:1903508 266 0.028
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.028
cellular homeostasis GO:0019725 80 0.028
negative regulation of cell cycle process GO:0010948 109 0.028
hemopoiesis GO:0030097 46 0.028
body morphogenesis GO:0010171 2 0.027
purine ribonucleoside catabolic process GO:0046130 112 0.027
meiotic nuclear division GO:0007126 151 0.027
enteroendocrine cell differentiation GO:0035883 1 0.027
positive regulation of cell death GO:0010942 69 0.026
macromolecular complex assembly GO:0065003 256 0.026
regulation of developmental growth GO:0048638 174 0.026
cytoplasmic transport GO:0016482 130 0.026
sex differentiation GO:0007548 81 0.026
protein localization to organelle GO:0033365 82 0.026
single organism biosynthetic process GO:0044711 206 0.026
positive regulation of immune system process GO:0002684 68 0.026
internal protein amino acid acetylation GO:0006475 38 0.026
positive regulation of cell migration GO:0030335 2 0.026
chemotaxis GO:0006935 249 0.025
cellular amino acid metabolic process GO:0006520 61 0.025
regulation of cellular protein metabolic process GO:0032268 243 0.025
organelle localization GO:0051640 148 0.025
positive regulation of rna biosynthetic process GO:1902680 266 0.025
reproductive system development GO:0061458 74 0.025
lipid localization GO:0010876 54 0.025
negative regulation of cellular component organization GO:0051129 108 0.024
regulation of anatomical structure morphogenesis GO:0022603 242 0.024
positive regulation of catalytic activity GO:0043085 118 0.024
ovarian follicle cell development GO:0030707 248 0.024
mesenchymal cell differentiation GO:0048762 1 0.023
genitalia development GO:0048806 26 0.023
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.023
appendage development GO:0048736 401 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.023
cell migration GO:0016477 238 0.022
response to bacterium GO:0009617 198 0.022
regulation of mitotic cell cycle GO:0007346 190 0.022
negative regulation of cell death GO:0060548 81 0.022
dorsal ventral pattern formation GO:0009953 133 0.022
imaginal disc derived wing morphogenesis GO:0007476 337 0.022
cellular response to chemical stimulus GO:0070887 199 0.022
positive regulation of translation GO:0045727 12 0.022
regulation of proteolysis GO:0030162 87 0.022
dna metabolic process GO:0006259 227 0.022
atp catabolic process GO:0006200 38 0.021
protein modification by small protein conjugation or removal GO:0070647 106 0.021
organophosphate catabolic process GO:0046434 112 0.021
phagocytosis GO:0006909 215 0.021
response to alcohol GO:0097305 95 0.021
ribonucleotide catabolic process GO:0009261 109 0.021
stem cell development GO:0048864 79 0.021
carbohydrate metabolic process GO:0005975 82 0.020
cell cycle phase transition GO:0044770 140 0.020
cation homeostasis GO:0055080 51 0.020
rna interference GO:0016246 27 0.020
glycosyl compound metabolic process GO:1901657 127 0.020
developmental growth GO:0048589 280 0.020
dna replication GO:0006260 48 0.019
positive regulation of protein metabolic process GO:0051247 128 0.019
eye development GO:0001654 323 0.019
regulation of cell differentiation GO:0045595 302 0.019
nucleoside monophosphate metabolic process GO:0009123 52 0.019
cellular amine metabolic process GO:0044106 12 0.019
positive regulation of cellular protein metabolic process GO:0032270 118 0.019
regulation of notch signaling pathway GO:0008593 100 0.019
nucleocytoplasmic transport GO:0006913 72 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
vesicle mediated transport GO:0016192 381 0.019
response to radiation GO:0009314 155 0.019
negative regulation of cell differentiation GO:0045596 143 0.018
cellular response to dsrna GO:0071359 15 0.018
negative regulation of transcription dna templated GO:0045892 237 0.017
nuclear transport GO:0051169 72 0.017
cellular macromolecular complex assembly GO:0034622 153 0.017
compound eye photoreceptor cell differentiation GO:0001751 140 0.017
cellular response to organic cyclic compound GO:0071407 32 0.017
regulation of organelle organization GO:0033043 196 0.017
ncrna metabolic process GO:0034660 43 0.017
learning or memory GO:0007611 141 0.017
tissue death GO:0016271 102 0.017
regulation of apoptotic process GO:0042981 130 0.017
hematopoietic or lymphoid organ development GO:0048534 57 0.017
adult behavior GO:0030534 137 0.017
cellular response to decreased oxygen levels GO:0036294 30 0.016
mitotic dna integrity checkpoint GO:0044774 75 0.016
alcohol metabolic process GO:0006066 25 0.016
appendage morphogenesis GO:0035107 397 0.016
protein transmembrane transport GO:0071806 4 0.016
negative regulation of cellular protein metabolic process GO:0032269 85 0.016
developmental maturation GO:0021700 172 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
protein localization GO:0008104 284 0.016
regulation of cellular localization GO:0060341 136 0.016
response to glucose GO:0009749 2 0.016
peptidyl amino acid modification GO:0018193 105 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
nitrogen compound transport GO:0071705 85 0.015
cell cycle checkpoint GO:0000075 95 0.015
organic hydroxy compound biosynthetic process GO:1901617 21 0.015
regulation of chromatin silencing GO:0031935 36 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
g2 dna damage checkpoint GO:0031572 69 0.015
protein dna complex subunit organization GO:0071824 86 0.015
regulation of localization GO:0032879 275 0.015
cellular component disassembly GO:0022411 46 0.015
meiotic cell cycle GO:0051321 171 0.014
stem cell differentiation GO:0048863 117 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.014
mitotic g2 m transition checkpoint GO:0044818 70 0.014
cognition GO:0050890 141 0.014
positive regulation of response to stimulus GO:0048584 323 0.014
cell maturation GO:0048469 144 0.014
proteolysis GO:0006508 192 0.014
purine nucleoside monophosphate catabolic process GO:0009128 38 0.014
regionalization GO:0003002 416 0.014
positive regulation of programmed cell death GO:0043068 62 0.014
hematopoietic progenitor cell differentiation GO:0002244 1 0.014
nucleoside monophosphate catabolic process GO:0009125 39 0.014
dna packaging GO:0006323 91 0.014
positive regulation of molecular function GO:0044093 136 0.014
cell type specific apoptotic process GO:0097285 38 0.013
negative regulation of programmed cell death GO:0043069 72 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.013
protein transport GO:0015031 155 0.013
spindle assembly involved in mitosis GO:0090307 50 0.013
taxis GO:0042330 304 0.013
positive regulation of hydrolase activity GO:0051345 78 0.013
regulation of cell cycle phase transition GO:1901987 130 0.013
positive regulation of apoptotic process GO:0043065 47 0.013
histone deubiquitination GO:0016578 8 0.013
positive regulation of proteolysis GO:0045862 52 0.013
cellular macromolecule localization GO:0070727 220 0.013
spindle organization GO:0007051 253 0.013
histolysis GO:0007559 102 0.013
mitotic g2 dna damage checkpoint GO:0007095 69 0.013
secretion by cell GO:0032940 101 0.013
peptidyl lysine acetylation GO:0018394 39 0.013
hindbrain development GO:0030902 2 0.013
olfactory learning GO:0008355 56 0.013
production of sirna involved in rna interference GO:0030422 11 0.012
epithelial cell development GO:0002064 274 0.012
male mating behavior GO:0060179 70 0.012
organelle fusion GO:0048284 46 0.012
sensory organ morphogenesis GO:0090596 260 0.012
organic hydroxy compound metabolic process GO:1901615 83 0.012
purine containing compound biosynthetic process GO:0072522 30 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
response to temperature stimulus GO:0009266 106 0.012
regulation of neurogenesis GO:0050767 158 0.012
chromatin assembly or disassembly GO:0006333 52 0.012
cellular protein complex disassembly GO:0043624 35 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.012
exocrine system development GO:0035272 162 0.011
salivary gland cell autophagic cell death GO:0035071 83 0.011
spindle assembly GO:0051225 80 0.011
single organism cellular localization GO:1902580 180 0.011
salivary gland histolysis GO:0035070 88 0.011
positive regulation of cell motility GO:2000147 3 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
sensory perception of mechanical stimulus GO:0050954 72 0.011
protein catabolic process GO:0030163 101 0.011
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
locomotory behavior GO:0007626 176 0.011
spermatogenesis GO:0007283 200 0.011
positive regulation of transcription dna templated GO:0045893 266 0.010
positive regulation of rna metabolic process GO:0051254 271 0.010
nuclear export GO:0051168 24 0.010
response to monosaccharide GO:0034284 4 0.010
lipid storage GO:0019915 38 0.010
macromolecular complex disassembly GO:0032984 37 0.010
anterior posterior pattern specification GO:0009952 136 0.010
regulation of dna templated transcription in response to stress GO:0043620 4 0.010
embryonic organ development GO:0048568 50 0.010

Sam-S disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
nervous system disease DOID:863 0 0.026