Drosophila melanogaster

0 known processes

Hsc70-2 (Dmel_CG7756)

Heat shock protein cognate 2

(Aliases: Hsc70.2,Hsc2,hsc70,Hsc70,HSC70,hsc2,CG7756,HSC2,dhsc70,HSC-70,Hsc-2,Dmel\CG7756)

Hsc70-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spermatogenesis GO:0007283 200 0.080
negative regulation of cell communication GO:0010648 223 0.073
male gamete generation GO:0048232 201 0.068
spermatid differentiation GO:0048515 114 0.065
cellular protein modification process GO:0006464 438 0.059
vesicle mediated transport GO:0016192 381 0.059
protein modification process GO:0036211 438 0.057
organelle fission GO:0048285 340 0.057
cellular response to heat GO:0034605 24 0.057
Fly
response to abiotic stimulus GO:0009628 341 0.055
Fly
homeostatic process GO:0042592 199 0.054
establishment of localization in cell GO:0051649 402 0.053
response to organic substance GO:0010033 284 0.051
Fly
cellular response to chemical stimulus GO:0070887 199 0.050
positive regulation of cellular protein metabolic process GO:0032270 118 0.048
chromosome organization GO:0051276 360 0.047
Fly
small molecule metabolic process GO:0044281 305 0.047
growth GO:0040007 359 0.046
phosphorylation GO:0016310 294 0.045
regulation of multicellular organismal development GO:2000026 414 0.045
taxis GO:0042330 304 0.044
regulation of phosphorus metabolic process GO:0051174 210 0.044
organophosphate metabolic process GO:0019637 195 0.043
negative regulation of signal transduction GO:0009968 206 0.043
defense response GO:0006952 300 0.043
positive regulation of macromolecule metabolic process GO:0010604 405 0.042
organic substance transport GO:0071702 257 0.042
organonitrogen compound metabolic process GO:1901564 318 0.042
positive regulation of rna metabolic process GO:0051254 271 0.041
nucleoside phosphate metabolic process GO:0006753 162 0.041
negative regulation of response to stimulus GO:0048585 258 0.040
negative regulation of biosynthetic process GO:0009890 277 0.040
single organism cellular localization GO:1902580 180 0.040
intracellular transport GO:0046907 228 0.039
proteolysis GO:0006508 192 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.038
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.038
nucleotide metabolic process GO:0009117 161 0.038
rna processing GO:0006396 147 0.038
mitotic cell cycle phase transition GO:0044772 138 0.038
positive regulation of protein metabolic process GO:0051247 128 0.037
gene silencing GO:0016458 138 0.037
cell cell signaling involved in cell fate commitment GO:0045168 210 0.037
death GO:0016265 284 0.037
regulation of anatomical structure size GO:0090066 163 0.036
positive regulation of gene expression GO:0010628 290 0.036
oxoacid metabolic process GO:0043436 103 0.035
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.035
positive regulation of phosphorus metabolic process GO:0010562 139 0.035
regulation of rna splicing GO:0043484 69 0.035
organic acid metabolic process GO:0006082 103 0.034
regulation of protein metabolic process GO:0051246 256 0.034
ribonucleoside triphosphate metabolic process GO:0009199 119 0.034
carbohydrate derivative metabolic process GO:1901135 217 0.034
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.034
regulation of phosphate metabolic process GO:0019220 210 0.033
positive regulation of phosphate metabolic process GO:0045937 139 0.033
protein localization GO:0008104 284 0.033
posttranscriptional regulation of gene expression GO:0010608 145 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.032
chemotaxis GO:0006935 249 0.032
single organism intracellular transport GO:1902582 207 0.032
response to heat GO:0009408 63 0.032
Fly
endocytosis GO:0006897 310 0.031
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.031
intracellular signal transduction GO:0035556 300 0.031
regulation of cellular protein metabolic process GO:0032268 243 0.031
purine ribonucleotide catabolic process GO:0009154 109 0.031
regulation of cellular ketone metabolic process GO:0010565 3 0.031
cell death GO:0008219 279 0.031
forebrain development GO:0030900 2 0.031
organic substance catabolic process GO:1901575 308 0.030
catabolic process GO:0009056 409 0.030
axonogenesis GO:0007409 290 0.030
positive regulation of signaling GO:0023056 243 0.030
phagocytosis GO:0006909 215 0.030
purine nucleoside catabolic process GO:0006152 112 0.030
cell cycle phase transition GO:0044770 140 0.030
protein modification by small protein conjugation or removal GO:0070647 106 0.030
lateral inhibition GO:0046331 206 0.030
single organism catabolic process GO:0044712 228 0.030
purine ribonucleotide metabolic process GO:0009150 145 0.029
regulation of molecular function GO:0065009 217 0.029
negative regulation of cellular biosynthetic process GO:0031327 277 0.029
glycosyl compound metabolic process GO:1901657 127 0.029
programmed cell death GO:0012501 257 0.029
single organism behavior GO:0044708 391 0.029
microtubule organizing center organization GO:0031023 168 0.029
apoptotic process GO:0006915 159 0.029
positive regulation of cellular biosynthetic process GO:0031328 316 0.029
regulation of growth GO:0040008 233 0.028
nucleoside triphosphate catabolic process GO:0009143 108 0.028
neuron recognition GO:0008038 101 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.027
carboxylic acid metabolic process GO:0019752 92 0.027
axon development GO:0061564 297 0.027
transmembrane transport GO:0055085 139 0.027
positive regulation of cell communication GO:0010647 250 0.027
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.027
negative regulation of signaling GO:0023057 219 0.027
neuron projection guidance GO:0097485 241 0.027
spindle organization GO:0007051 253 0.027
negative regulation of rna biosynthetic process GO:1902679 240 0.026
regulation of nervous system development GO:0051960 248 0.026
embryonic development via the syncytial blastoderm GO:0001700 148 0.026
negative regulation of transcription dna templated GO:0045892 237 0.026
negative regulation of rna metabolic process GO:0051253 251 0.026
axon guidance GO:0007411 233 0.026
cell recognition GO:0008037 102 0.026
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.026
cellular macromolecule localization GO:0070727 220 0.026
cellular protein localization GO:0034613 160 0.026
regulation of cell death GO:0010941 173 0.025
oxidation reduction process GO:0055114 123 0.025
regulation of gene expression epigenetic GO:0040029 128 0.025
ribonucleoside metabolic process GO:0009119 127 0.025
pyridine containing compound metabolic process GO:0072524 3 0.025
aromatic compound catabolic process GO:0019439 166 0.025
regulation of phosphorylation GO:0042325 147 0.025
ribose phosphate metabolic process GO:0019693 145 0.025
purine nucleoside monophosphate metabolic process GO:0009126 50 0.025
nucleoside triphosphate metabolic process GO:0009141 120 0.025
cytoplasmic transport GO:0016482 130 0.025
purine nucleotide catabolic process GO:0006195 109 0.025
regulation of mrna splicing via spliceosome GO:0048024 64 0.025
cellular protein complex disassembly GO:0043624 35 0.025
macromolecular complex disassembly GO:0032984 37 0.025
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.024
response to other organism GO:0051707 293 0.024
nuclear division GO:0000280 332 0.024
regulation of cell differentiation GO:0045595 302 0.024
nucleoside phosphate catabolic process GO:1901292 110 0.024
positive regulation of phosphorylation GO:0042327 87 0.024
regulation of cellular component biogenesis GO:0044087 201 0.024
negative regulation of cellular metabolic process GO:0031324 382 0.024
nucleobase containing small molecule metabolic process GO:0055086 174 0.024
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.024
purine nucleotide metabolic process GO:0006163 146 0.023
positive regulation of biosynthetic process GO:0009891 316 0.023
ribonucleotide metabolic process GO:0009259 145 0.023
positive regulation of transcription dna templated GO:0045893 266 0.023
regulation of cell cycle GO:0051726 291 0.023
organelle assembly GO:0070925 198 0.023
purine containing compound metabolic process GO:0072521 155 0.023
regulation of catalytic activity GO:0050790 185 0.023
nucleoside catabolic process GO:0009164 112 0.023
negative regulation of growth GO:0045926 84 0.023
epithelial cell differentiation GO:0030855 322 0.023
regulation of localization GO:0032879 275 0.023
negative regulation of multicellular organismal process GO:0051241 142 0.023
macromolecule catabolic process GO:0009057 161 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.023
purine ribonucleoside metabolic process GO:0046128 127 0.022
protein phosphorylation GO:0006468 169 0.022
signal release GO:0023061 49 0.022
purine nucleoside triphosphate catabolic process GO:0009146 108 0.022
sperm individualization GO:0007291 48 0.022
secretion by cell GO:0032940 101 0.022
positive regulation of molecular function GO:0044093 136 0.022
positive regulation of response to stimulus GO:0048584 323 0.022
l amino acid import GO:0043092 2 0.022
ribonucleotide catabolic process GO:0009261 109 0.022
regulation of proteolysis GO:0030162 87 0.022
positive regulation of nucleic acid templated transcription GO:1903508 266 0.021
mrna metabolic process GO:0016071 124 0.021
positive regulation of signal transduction GO:0009967 223 0.021
ribonucleoside triphosphate catabolic process GO:0009203 108 0.021
central nervous system development GO:0007417 201 0.021
positive regulation of catalytic activity GO:0043085 118 0.021
response to biotic stimulus GO:0009607 294 0.021
glycosyl compound catabolic process GO:1901658 112 0.021
regulation of apoptotic process GO:0042981 130 0.021
regionalization GO:0003002 416 0.021
ribonucleoside catabolic process GO:0042454 112 0.020
negative regulation of cellular component organization GO:0051129 108 0.020
response to lipopolysaccharide GO:0032496 4 0.020
mrna processing GO:0006397 104 0.020
purine ribonucleoside catabolic process GO:0046130 112 0.020
cellular macromolecule catabolic process GO:0044265 136 0.020
response to external biotic stimulus GO:0043207 293 0.020
regulation of immune system process GO:0002682 176 0.020
mitotic spindle organization GO:0007052 220 0.020
secretion GO:0046903 109 0.020
transcription from rna polymerase ii promoter GO:0006366 368 0.020
nicotinamide nucleotide metabolic process GO:0046496 2 0.020
translation GO:0006412 69 0.020
eye development GO:0001654 323 0.020
response to radiation GO:0009314 155 0.020
response to glucose GO:0009749 2 0.019
kidney development GO:0001822 3 0.019
cellular protein catabolic process GO:0044257 83 0.019
response to ethanol GO:0045471 59 0.019
regulation of endopeptidase activity GO:0052548 36 0.019
cell proliferation GO:0008283 299 0.019
cell growth GO:0016049 108 0.019
protein localization to organelle GO:0033365 82 0.019
epithelial cell development GO:0002064 274 0.019
cellular nitrogen compound catabolic process GO:0044270 165 0.019
single organism membrane organization GO:0044802 93 0.019
nucleobase containing compound catabolic process GO:0034655 165 0.019
atp metabolic process GO:0046034 49 0.019
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.019
centrosome organization GO:0051297 163 0.018
cellular response to organic substance GO:0071310 132 0.018
sensory perception of salty taste GO:0050914 3 0.018
negative regulation of programmed cell death GO:0043069 72 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
cellular ketone metabolic process GO:0042180 24 0.018
mitochondrion organization GO:0007005 65 0.018
heterocycle catabolic process GO:0046700 166 0.018
organophosphate catabolic process GO:0046434 112 0.018
ribonucleoside monophosphate catabolic process GO:0009158 39 0.018
telencephalon development GO:0021537 2 0.018
protein import GO:0017038 55 0.018
body morphogenesis GO:0010171 2 0.018
exocrine system development GO:0035272 162 0.018
rna splicing GO:0008380 83 0.017
regulation of neurogenesis GO:0050767 158 0.017
macromolecular complex assembly GO:0065003 256 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.017
open tracheal system development GO:0007424 204 0.017
positive regulation of developmental process GO:0051094 143 0.017
oxidoreduction coenzyme metabolic process GO:0006733 2 0.017
cellular component disassembly GO:0022411 46 0.017
intracellular protein transmembrane transport GO:0065002 4 0.017
developmental growth GO:0048589 280 0.017
cellular catabolic process GO:0044248 372 0.017
rna catabolic process GO:0006401 37 0.017
protein maturation GO:0051604 71 0.017
response to hexose GO:0009746 3 0.017
negative regulation of gene expression GO:0010629 387 0.017
compound eye morphogenesis GO:0001745 249 0.017
appendage development GO:0048736 401 0.017
response to bacterium GO:0009617 198 0.017
regulation of hydrolase activity GO:0051336 97 0.017
centrosome cycle GO:0007098 137 0.017
immune system process GO:0002376 347 0.017
ion transport GO:0006811 145 0.017
endomembrane system organization GO:0010256 119 0.017
response to monosaccharide GO:0034284 4 0.016
negative regulation of cellular protein metabolic process GO:0032269 85 0.016
compound eye development GO:0048749 307 0.016
localization of cell GO:0051674 257 0.016
protein transport GO:0015031 155 0.016
eye morphogenesis GO:0048592 260 0.016
rna splicing via transesterification reactions GO:0000375 73 0.016
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.016
nucleoside monophosphate metabolic process GO:0009123 52 0.016
sensory perception GO:0007600 196 0.016
immune response GO:0006955 246 0.016
mrna splicing via spliceosome GO:0000398 73 0.016
pyridine nucleotide metabolic process GO:0019362 2 0.016
regulation of mrna metabolic process GO:1903311 72 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
regulation of cellular catabolic process GO:0031329 157 0.016
regulation of protein phosphorylation GO:0001932 64 0.016
protein modification by small protein conjugation GO:0032446 79 0.016
meiosis i GO:0007127 59 0.016
carbohydrate derivative catabolic process GO:1901136 118 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
defense response to bacterium GO:0042742 178 0.015
protein transmembrane transport GO:0071806 4 0.015
actin filament based process GO:0030029 220 0.015
extrinsic apoptotic signaling pathway GO:0097191 1 0.015
positive regulation of multicellular organismal process GO:0051240 143 0.015
response to alcohol GO:0097305 95 0.015
defense response to other organism GO:0098542 225 0.015
regulation of protein modification process GO:0031399 112 0.015
amine metabolic process GO:0009308 12 0.015
single organism carbohydrate metabolic process GO:0044723 72 0.015
carbohydrate metabolic process GO:0005975 82 0.015
purine containing compound catabolic process GO:0072523 112 0.015
wing disc morphogenesis GO:0007472 344 0.015
positive regulation of protein phosphorylation GO:0001934 34 0.015
mrna catabolic process GO:0006402 33 0.015
salt aversion GO:0035199 3 0.015
ovarian follicle cell development GO:0030707 248 0.014
appendage morphogenesis GO:0035107 397 0.014
regulation of programmed cell death GO:0043067 152 0.014
regulation of synapse structure and activity GO:0050803 128 0.014
regulation of intracellular signal transduction GO:1902531 236 0.014
regulation of transport GO:0051049 181 0.014
positive regulation of cell development GO:0010720 61 0.014
protein catabolic process GO:0030163 101 0.014
protein complex biogenesis GO:0070271 201 0.014
imaginal disc derived wing morphogenesis GO:0007476 337 0.014
intracellular protein transport GO:0006886 104 0.014
nadh metabolic process GO:0006734 1 0.014
protein import into nucleus GO:0006606 51 0.014
regulation of neuron differentiation GO:0045664 103 0.014
camera type eye development GO:0043010 4 0.014
regulation of mitotic cell cycle phase transition GO:1901990 130 0.014
cellular amine metabolic process GO:0044106 12 0.014
hindbrain development GO:0030902 2 0.014
protein ubiquitination GO:0016567 70 0.014
meiotic cell cycle process GO:1903046 132 0.014
single organism nuclear import GO:1902593 51 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
salivary gland morphogenesis GO:0007435 145 0.014
columnar cuboidal epithelial cell development GO:0002066 249 0.014
chromatin remodeling GO:0006338 72 0.014
positive regulation of protein modification process GO:0031401 58 0.014
regulation of response to stress GO:0080134 200 0.014
gene silencing by rna GO:0031047 57 0.013
imaginal disc derived appendage morphogenesis GO:0035114 395 0.013
single organism biosynthetic process GO:0044711 206 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
sterol homeostasis GO:0055092 4 0.013
positive regulation of rna biosynthetic process GO:1902680 266 0.013
cell motility GO:0048870 251 0.013
actin cytoskeleton organization GO:0030036 206 0.013
regulation of catabolic process GO:0009894 170 0.013
establishment or maintenance of cell polarity GO:0007163 167 0.013
cellular homeostasis GO:0019725 80 0.013
imaginal disc derived appendage development GO:0048737 399 0.013
purine nucleoside monophosphate catabolic process GO:0009128 38 0.013
negative regulation of nucleic acid templated transcription GO:1903507 240 0.013
cation transport GO:0006812 110 0.013
nad metabolic process GO:0019674 1 0.013
tricarboxylic acid metabolic process GO:0072350 1 0.013
negative regulation of developmental process GO:0051093 201 0.013
segmentation GO:0035282 207 0.013
adult behavior GO:0030534 137 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.013
cholesterol homeostasis GO:0042632 3 0.013
protein targeting to nucleus GO:0044744 51 0.013
ribonucleoside monophosphate metabolic process GO:0009161 51 0.013
apoptotic signaling pathway GO:0097190 27 0.013
blastoderm segmentation GO:0007350 159 0.013
axis specification GO:0009798 167 0.013
chromatin organization GO:0006325 207 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
cell migration GO:0016477 238 0.013
positive regulation of catabolic process GO:0009896 105 0.013
kidney epithelium development GO:0072073 3 0.013
limb morphogenesis GO:0035108 1 0.012
regulation of cellular localization GO:0060341 136 0.012
positive regulation of cell motility GO:2000147 3 0.012
notch signaling pathway GO:0007219 120 0.012
mitotic nuclear division GO:0007067 213 0.012
limb development GO:0060173 1 0.012
positive regulation of cell cycle GO:0045787 43 0.012
nuclear transport GO:0051169 72 0.012
dna metabolic process GO:0006259 227 0.012
neurological system process GO:0050877 358 0.012
chemical homeostasis GO:0048878 92 0.012
regulation of protein serine threonine kinase activity GO:0071900 25 0.012
regulation of gene silencing GO:0060968 63 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
regulation of cysteine type endopeptidase activity GO:2000116 27 0.012
cell maturation GO:0048469 144 0.012
cellular component assembly involved in morphogenesis GO:0010927 151 0.012
embryo development ending in birth or egg hatching GO:0009792 152 0.012
regulation of cell cycle process GO:0010564 181 0.012
germarium derived egg chamber formation GO:0007293 101 0.012
sensory organ morphogenesis GO:0090596 260 0.012
salivary gland development GO:0007431 162 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
ras protein signal transduction GO:0007265 88 0.012
generation of precursor metabolites and energy GO:0006091 42 0.012
fertilization GO:0009566 26 0.012
response to light stimulus GO:0009416 124 0.011
positive regulation of cellular catabolic process GO:0031331 95 0.011
regulation of cell size GO:0008361 63 0.011
cell division GO:0051301 248 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
cell aging GO:0007569 2 0.011
cellular response to dna damage stimulus GO:0006974 223 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.011
regulation of cell development GO:0060284 215 0.011
nucleotide catabolic process GO:0009166 109 0.011
chromatin modification GO:0016568 147 0.011
store operated calcium entry GO:0002115 3 0.011
energy derivation by oxidation of organic compounds GO:0015980 32 0.011
nucleoside monophosphate catabolic process GO:0009125 39 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
chromosome segregation GO:0007059 157 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.011
embryonic pattern specification GO:0009880 174 0.011
nuclear import GO:0051170 51 0.011
spindle assembly GO:0051225 80 0.011
protein localization to nucleus GO:0034504 55 0.011
regulation of multi organism process GO:0043900 131 0.011
membrane organization GO:0061024 112 0.011
ribonucleoprotein complex subunit organization GO:0071826 28 0.011
atp catabolic process GO:0006200 38 0.011
immune response activating signal transduction GO:0002757 2 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.011
response to endogenous stimulus GO:0009719 119 0.011
Fly
respiratory system development GO:0060541 213 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
regulation of cellular component size GO:0032535 98 0.011
gland development GO:0048732 191 0.011
gland morphogenesis GO:0022612 145 0.011
detection of chemical stimulus GO:0009593 93 0.011
mitotic cell cycle checkpoint GO:0007093 88 0.011
epidermal growth factor receptor signaling pathway GO:0007173 58 0.011
regulation of developmental growth GO:0048638 174 0.011
wound healing GO:0042060 75 0.011
oocyte axis specification GO:0007309 108 0.011
connective tissue development GO:0061448 3 0.011
neurotransmitter secretion GO:0007269 35 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.010
cation transmembrane transport GO:0098655 88 0.010
dna packaging GO:0006323 91 0.010
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.010
antimicrobial humoral response GO:0019730 99 0.010
synaptic transmission GO:0007268 288 0.010
centrosome duplication GO:0051298 121 0.010
mitotic sister chromatid segregation GO:0000070 87 0.010
mesenchymal cell development GO:0014031 1 0.010
negative regulation of cell death GO:0060548 81 0.010
tripartite regional subdivision GO:0007351 103 0.010
meiotic cell cycle GO:0051321 171 0.010
cytoplasm organization GO:0007028 64 0.010
purine nucleoside metabolic process GO:0042278 127 0.010
melanization defense response GO:0035006 45 0.010
actin filament organization GO:0007015 126 0.010
embryonic axis specification GO:0000578 107 0.010

Hsc70-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
disease of metabolism DOID:0014667 0 0.019
nervous system disease DOID:863 0 0.016
acquired metabolic disease DOID:0060158 0 0.016
glucose metabolism disease DOID:4194 0 0.016
carbohydrate metabolism disease DOID:0050013 0 0.016
type 2 diabetes mellitus DOID:9352 0 0.015
diabetes mellitus DOID:9351 0 0.015
cardiovascular system disease DOID:1287 0 0.013
disease of cellular proliferation DOID:14566 0 0.011
cancer DOID:162 0 0.011
musculoskeletal system disease DOID:17 0 0.011