Drosophila melanogaster

52 known processes

PEK (Dmel_CG2087)

pancreatic eIF-2alpha kinase

(Aliases: CG2087,PERK,EIF2-like,DPERK,DpERK,Perk,DmPEK,Dmel\CG2087)

PEK biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
developmental programmed cell death GO:0010623 138 0.303
single organism catabolic process GO:0044712 228 0.293
regulation of cellular catabolic process GO:0031329 157 0.291
heterocycle catabolic process GO:0046700 166 0.239
regulation of mitotic cell cycle GO:0007346 190 0.230
nucleotide metabolic process GO:0009117 161 0.223
compound eye development GO:0048749 307 0.212
positive regulation of cell communication GO:0010647 250 0.193
Mouse
neurological system process GO:0050877 358 0.181
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.169
Mouse
death GO:0016265 284 0.168
Mouse Worm
intracellular signal transduction GO:0035556 300 0.165
Mouse
response to biotic stimulus GO:0009607 294 0.137
Human
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.126
Mouse
purine containing compound metabolic process GO:0072521 155 0.121
organophosphate metabolic process GO:0019637 195 0.110
negative regulation of cellular metabolic process GO:0031324 382 0.107
Mouse Rat
purine ribonucleotide metabolic process GO:0009150 145 0.106
nucleobase containing compound catabolic process GO:0034655 165 0.105
negative regulation of multicellular organismal process GO:0051241 142 0.104
Mouse
compound eye morphogenesis GO:0001745 249 0.097
regulation of cell cycle GO:0051726 291 0.088
regulation of response to stress GO:0080134 200 0.086
Mouse
organonitrogen compound metabolic process GO:1901564 318 0.081
positive regulation of signaling GO:0023056 243 0.081
Mouse
positive regulation of rna metabolic process GO:0051254 271 0.076
Mouse
chromosome organization GO:0051276 360 0.076
organic substance catabolic process GO:1901575 308 0.075
purine ribonucleoside metabolic process GO:0046128 127 0.075
regulation of catabolic process GO:0009894 170 0.072
programmed cell death GO:0012501 257 0.072
Mouse
positive regulation of nervous system development GO:0051962 69 0.072
response to other organism GO:0051707 293 0.072
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.071
positive regulation of response to stimulus GO:0048584 323 0.071
Mouse
positive regulation of biosynthetic process GO:0009891 316 0.071
Mouse
phagocytosis GO:0006909 215 0.070
sensory organ morphogenesis GO:0090596 260 0.070
defense response to other organism GO:0098542 225 0.070
response to oxygen containing compound GO:1901700 200 0.068
immune system process GO:0002376 347 0.068
regulation of protein metabolic process GO:0051246 256 0.067
Mouse Rat
nucleobase containing small molecule metabolic process GO:0055086 174 0.065
establishment of localization in cell GO:0051649 402 0.065
response to temperature stimulus GO:0009266 106 0.065
purine nucleoside triphosphate metabolic process GO:0009144 119 0.064
defense response GO:0006952 300 0.063
regulation of erbb signaling pathway GO:1901184 42 0.062
regulation of phosphorus metabolic process GO:0051174 210 0.060
glycosyl compound metabolic process GO:1901657 127 0.060
response to external biotic stimulus GO:0043207 293 0.060
cell death GO:0008219 279 0.059
Mouse Worm
eye development GO:0001654 323 0.059
ribonucleoside triphosphate catabolic process GO:0009203 108 0.059
positive regulation of programmed cell death GO:0043068 62 0.058
Mouse
regulation of immune response GO:0050776 118 0.057
purine ribonucleoside catabolic process GO:0046130 112 0.055
regulation of cell differentiation GO:0045595 302 0.054
post embryonic appendage morphogenesis GO:0035120 385 0.053
head development GO:0060322 135 0.053
chromatin modification GO:0016568 147 0.052
nucleoside catabolic process GO:0009164 112 0.052
ribonucleotide metabolic process GO:0009259 145 0.052
protein modification process GO:0036211 438 0.051
vesicle mediated transport GO:0016192 381 0.050
cellular catabolic process GO:0044248 372 0.050
regulation of catalytic activity GO:0050790 185 0.050
Mouse
brain development GO:0007420 120 0.050
regulation of r7 cell differentiation GO:0045676 15 0.049
purine nucleotide metabolic process GO:0006163 146 0.049
nucleoside metabolic process GO:0009116 127 0.048
phosphorylation GO:0016310 294 0.047
atp metabolic process GO:0046034 49 0.047
immune response GO:0006955 246 0.047
ribonucleoside catabolic process GO:0042454 112 0.047
ommatidial rotation GO:0016318 20 0.046
organic substance transport GO:0071702 257 0.046
forebrain development GO:0030900 2 0.046
nucleoside phosphate metabolic process GO:0006753 162 0.045
purine nucleoside catabolic process GO:0006152 112 0.045
camera type eye development GO:0043010 4 0.045
regulation of nucleotide metabolic process GO:0006140 62 0.045
regulation of programmed cell death GO:0043067 152 0.044
Mouse
endocytosis GO:0006897 310 0.044
organic cyclic compound catabolic process GO:1901361 168 0.041
regulation of phosphate metabolic process GO:0019220 210 0.041
body morphogenesis GO:0010171 2 0.041
catabolic process GO:0009056 409 0.041
developmental growth GO:0048589 280 0.041
taxis GO:0042330 304 0.040
eye photoreceptor cell differentiation GO:0001754 145 0.040
regulation of ras protein signal transduction GO:0046578 93 0.040
defense response to bacterium GO:0042742 178 0.039
cellular nitrogen compound catabolic process GO:0044270 165 0.039
carbohydrate derivative catabolic process GO:1901136 118 0.039
nucleoside triphosphate metabolic process GO:0009141 120 0.039
positive regulation of signal transduction GO:0009967 223 0.039
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.038
regulation of cell cycle g1 s phase transition GO:1902806 23 0.038
aromatic compound catabolic process GO:0019439 166 0.038
regulation of cell cycle process GO:0010564 181 0.038
branched chain amino acid transport GO:0015803 3 0.038
ribonucleotide catabolic process GO:0009261 109 0.038
ribonucleoside triphosphate metabolic process GO:0009199 119 0.037
regulation of apoptotic process GO:0042981 130 0.037
Mouse
synaptic transmission GO:0007268 288 0.036
response to abiotic stimulus GO:0009628 341 0.036
morphogenesis of a branching epithelium GO:0061138 45 0.036
regulation of developmental growth GO:0048638 174 0.036
ribose phosphate metabolic process GO:0019693 145 0.035
regulation of molecular function GO:0065009 217 0.035
Mouse
telencephalon development GO:0021537 2 0.035
tissue morphogenesis GO:0048729 297 0.035
photoreceptor cell differentiation GO:0046530 170 0.034
transcription from rna polymerase ii promoter GO:0006366 368 0.033
Mouse
purine nucleoside metabolic process GO:0042278 127 0.033
regulation of intracellular signal transduction GO:1902531 236 0.033
Mouse
single organism biosynthetic process GO:0044711 206 0.033
positive regulation of macromolecule metabolic process GO:0010604 405 0.032
Mouse
nucleoside triphosphate catabolic process GO:0009143 108 0.032
response to lipopolysaccharide GO:0032496 4 0.032
carbohydrate derivative metabolic process GO:1901135 217 0.032
acid secretion GO:0046717 1 0.032
cell proliferation GO:0008283 299 0.031
establishment of organelle localization GO:0051656 122 0.031
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.031
Mouse Rat
establishment of tissue polarity GO:0007164 87 0.031
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.030
Mouse
cellular macromolecule catabolic process GO:0044265 136 0.030
modification dependent protein catabolic process GO:0019941 78 0.030
establishment of planar polarity GO:0001736 87 0.029
embryonic organ development GO:0048568 50 0.029
defense response to gram negative bacterium GO:0050829 94 0.029
regulation of nucleoside metabolic process GO:0009118 50 0.029
regulation of hydrolase activity GO:0051336 97 0.029
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 266 0.029
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 108 0.029
secretion GO:0046903 109 0.029
Mouse
regulation of immune system process GO:0002682 176 0.028
protein transport GO:0015031 155 0.028
regulation of small gtpase mediated signal transduction GO:0051056 93 0.028
purine nucleotide catabolic process GO:0006195 109 0.028
wing disc morphogenesis GO:0007472 344 0.028
posttranscriptional regulation of gene expression GO:0010608 145 0.028
Mouse Rat
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.027
regulation of anatomical structure size GO:0090066 163 0.027
intracellular transport GO:0046907 228 0.027
positive regulation of catabolic process GO:0009896 105 0.027
purine nucleoside monophosphate metabolic process GO:0009126 50 0.027
homeostatic process GO:0042592 199 0.026
regulation of nervous system development GO:0051960 248 0.026
Mouse
salivary gland development GO:0007431 162 0.025
extrinsic apoptotic signaling pathway GO:0097191 1 0.025
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.025
Mouse
purine containing compound catabolic process GO:0072523 112 0.025
morphogenesis of a polarized epithelium GO:0001738 93 0.025
regionalization GO:0003002 416 0.025
oxoacid metabolic process GO:0043436 103 0.024
Mouse
response to extracellular stimulus GO:0009991 116 0.024
regulation of cellular amine metabolic process GO:0033238 3 0.023
regulation of neurogenesis GO:0050767 158 0.023
pigment metabolic process GO:0042440 84 0.023
positive regulation of cell differentiation GO:0045597 64 0.023
positive regulation of cellular catabolic process GO:0031331 95 0.022
dna metabolic process GO:0006259 227 0.022
cellular macromolecule localization GO:0070727 220 0.022
negative regulation of developmental growth GO:0048640 64 0.022
regulation of mitotic sister chromatid separation GO:0010965 28 0.022
regulation of growth GO:0040008 233 0.022
Worm
small gtpase mediated signal transduction GO:0007264 88 0.022
eye morphogenesis GO:0048592 260 0.021
stem cell differentiation GO:0048863 117 0.021
endomembrane system organization GO:0010256 119 0.021
Mouse
memory GO:0007613 94 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.021
Mouse
innate immune response GO:0045087 144 0.021
apoptotic process GO:0006915 159 0.021
Mouse
establishment or maintenance of cell polarity GO:0007163 167 0.021
nucleotide catabolic process GO:0009166 109 0.021
regulation of cell death GO:0010941 173 0.021
Mouse Worm
regulation of purine nucleotide metabolic process GO:1900542 62 0.021
nucleoside monophosphate metabolic process GO:0009123 52 0.020
aging GO:0007568 143 0.020
Worm
ribonucleoside metabolic process GO:0009119 127 0.020
response to heat GO:0009408 63 0.020
cell cycle checkpoint GO:0000075 95 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
Mouse
epithelial cell development GO:0002064 274 0.019
organonitrogen compound biosynthetic process GO:1901566 117 0.019
purine ribonucleotide catabolic process GO:0009154 109 0.019
macromolecule catabolic process GO:0009057 161 0.019
negative regulation of cell proliferation GO:0008285 69 0.019
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
regulation of organ morphogenesis GO:2000027 78 0.019
nitrogen compound transport GO:0071705 85 0.019
growth GO:0040007 359 0.019
Worm
single organism intracellular transport GO:1902582 207 0.018
gtp catabolic process GO:0006184 72 0.018
mitotic cell cycle phase transition GO:0044772 138 0.018
negative regulation of cell development GO:0010721 62 0.018
regulation of innate immune response GO:0045088 71 0.018
ribonucleoside monophosphate metabolic process GO:0009161 51 0.018
proteasomal protein catabolic process GO:0010498 59 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.018
regulation of cell development GO:0060284 215 0.018
positive regulation of rna biosynthetic process GO:1902680 266 0.018
Mouse
regulation of organelle organization GO:0033043 196 0.018
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
Mouse
negative regulation of cell differentiation GO:0045596 143 0.017
organonitrogen compound catabolic process GO:1901565 128 0.017
positive regulation of cell death GO:0010942 69 0.017
Mouse
negative regulation of apoptotic process GO:0043066 63 0.017
Mouse
regulation of immune effector process GO:0002697 52 0.017
imaginal disc pattern formation GO:0007447 91 0.017
guanosine containing compound catabolic process GO:1901069 74 0.017
mitotic nuclear division GO:0007067 213 0.017
lipid localization GO:0010876 54 0.017
skin development GO:0043588 65 0.017
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.016
chemosensory behavior GO:0007635 106 0.016
tube morphogenesis GO:0035239 191 0.016
secretion by cell GO:0032940 101 0.016
small molecule metabolic process GO:0044281 305 0.016
Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.016
r3 r4 cell differentiation GO:0048056 12 0.016
regulation of intracellular transport GO:0032386 64 0.016
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.016
organophosphate catabolic process GO:0046434 112 0.016
vesicle organization GO:0016050 44 0.016
notch signaling pathway GO:0007219 120 0.016
positive regulation of multicellular organismal process GO:0051240 143 0.016
regulation of cellular localization GO:0060341 136 0.016
regulation of organ growth GO:0046620 42 0.016
actin filament organization GO:0007015 126 0.015
proteolysis GO:0006508 192 0.015
Mouse
gland development GO:0048732 191 0.015
Mouse
positive regulation of developmental process GO:0051094 143 0.015
spindle organization GO:0007051 253 0.015
response to nutrient levels GO:0031667 114 0.015
salivary gland morphogenesis GO:0007435 145 0.015
negative regulation of programmed cell death GO:0043069 72 0.015
Mouse
appendage morphogenesis GO:0035107 397 0.015
positive regulation of transcription dna templated GO:0045893 266 0.015
Mouse
regulation of gene expression epigenetic GO:0040029 128 0.014
branching morphogenesis of an epithelial tube GO:0048754 45 0.014
autophagic cell death GO:0048102 83 0.014
regulation of gtp catabolic process GO:0033124 44 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
Mouse
response to bacterium GO:0009617 198 0.014
positive regulation of phosphate metabolic process GO:0045937 139 0.014
regulation of phosphorylation GO:0042325 147 0.014
dna integrity checkpoint GO:0031570 81 0.014
negative regulation of developmental process GO:0051093 201 0.014
Mouse
respiratory system development GO:0060541 213 0.014
gland morphogenesis GO:0022612 145 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.014
positive regulation of gene expression GO:0010628 290 0.014
Mouse
regulation of notch signaling pathway GO:0008593 100 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
Mouse
negative regulation of response to stimulus GO:0048585 258 0.014
modification dependent macromolecule catabolic process GO:0043632 79 0.014
epithelial cell differentiation GO:0030855 322 0.014
ras protein signal transduction GO:0007265 88 0.014
eggshell formation GO:0030703 105 0.013
mitotic dna damage checkpoint GO:0044773 74 0.013
male gamete generation GO:0048232 201 0.013
negative regulation of phosphate metabolic process GO:0045936 45 0.013
cell cycle g1 s phase transition GO:0044843 31 0.013
atp catabolic process GO:0006200 38 0.013
negative regulation of transcription dna templated GO:0045892 237 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
positive regulation of apoptotic process GO:0043065 47 0.013
Mouse
connective tissue development GO:0061448 3 0.013
Mouse
negative regulation of signal transduction GO:0009968 206 0.013
lateral inhibition GO:0046331 206 0.013
mesenchymal cell development GO:0014031 1 0.013
establishment of protein localization GO:0045184 163 0.013
positive regulation of nucleotide catabolic process GO:0030813 46 0.013
cellular protein modification process GO:0006464 438 0.013
positive regulation of organelle organization GO:0010638 65 0.013
cell type specific apoptotic process GO:0097285 38 0.013
positive regulation of molecular function GO:0044093 136 0.013
Mouse
protein phosphorylation GO:0006468 169 0.012
nucleoside phosphate catabolic process GO:1901292 110 0.012
positive regulation of protein metabolic process GO:0051247 128 0.012
Mouse
regulation of proteolysis GO:0030162 87 0.012
Mouse
negative regulation of immune system process GO:0002683 50 0.012
epidermal growth factor receptor signaling pathway GO:0007173 58 0.012
negative regulation of cell cycle phase transition GO:1901988 103 0.012
dorsal ventral axis specification GO:0009950 66 0.012
regulation of secretion GO:0051046 44 0.012
erbb signaling pathway GO:0038127 58 0.012
developmental pigmentation GO:0048066 68 0.012
organelle localization GO:0051640 148 0.012
imaginal disc derived appendage development GO:0048737 399 0.012
positive regulation of exocytosis GO:0045921 4 0.012
regulation of photoreceptor cell differentiation GO:0046532 34 0.012
regulation of cellular component size GO:0032535 98 0.012
carbohydrate derivative biosynthetic process GO:1901137 85 0.012
signal transduction by phosphorylation GO:0023014 107 0.011
imaginal disc growth GO:0007446 37 0.011
regulation of purine nucleotide catabolic process GO:0033121 48 0.011
negative regulation of nervous system development GO:0051961 92 0.011
Mouse
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.011
nuclear division GO:0000280 332 0.011
exocytosis GO:0006887 28 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.011
imaginal disc derived appendage morphogenesis GO:0035114 395 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
Mouse Rat
cell cycle phase transition GO:0044770 140 0.011
intracellular protein transport GO:0006886 104 0.011
response to metal ion GO:0010038 23 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
salivary gland cell autophagic cell death GO:0035071 83 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
establishment of protein localization to organelle GO:0072594 62 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
anion transport GO:0006820 41 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
Human
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.011
negative regulation of nucleic acid templated transcription GO:1903507 240 0.011
regulation of hippo signaling GO:0035330 14 0.010
cell cell signaling involved in cell fate commitment GO:0045168 210 0.010
protein localization GO:0008104 284 0.010
tissue death GO:0016271 102 0.010
positive regulation of cellular protein metabolic process GO:0032270 118 0.010
Mouse
embryonic morphogenesis GO:0048598 206 0.010

PEK disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.047
disease of anatomical entity DOID:7 0 0.041
cancer DOID:162 0 0.035
organ system cancer DOID:0050686 0 0.035