Drosophila melanogaster

67 known processes

MED16 (Dmel_CG5465)

Mediator complex subunit 16

(Aliases: med16,Trap95,Dmel\CG5465,CG5465,Med16,dTRAP95,Sin4/TRAP95)

MED16 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone acetylation GO:0016573 38 0.233
transcription from rna polymerase ii promoter GO:0006366 368 0.230
snrna 3 end processing GO:0034472 14 0.165
cellular protein modification process GO:0006464 438 0.143
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.138
peptidyl lysine modification GO:0018205 57 0.132
negative regulation of rna biosynthetic process GO:1902679 240 0.122
peptidyl lysine acetylation GO:0018394 39 0.117
internal protein amino acid acetylation GO:0006475 38 0.117
covalent chromatin modification GO:0016569 106 0.117
positive regulation of rna biosynthetic process GO:1902680 266 0.115
protein acylation GO:0043543 42 0.102
positive regulation of transcription dna templated GO:0045893 266 0.101
positive regulation of nucleic acid templated transcription GO:1903508 266 0.098
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.093
positive regulation of cellular biosynthetic process GO:0031328 316 0.091
chromatin organization GO:0006325 207 0.086
chromatin modification GO:0016568 147 0.086
growth GO:0040007 359 0.078
response to biotic stimulus GO:0009607 294 0.078
protein modification process GO:0036211 438 0.078
g2 dna damage checkpoint GO:0031572 69 0.073
negative regulation of transcription dna templated GO:0045892 237 0.072
mitotic g2 m transition checkpoint GO:0044818 70 0.070
internal peptidyl lysine acetylation GO:0018393 38 0.069
response to external biotic stimulus GO:0043207 293 0.066
embryo development ending in birth or egg hatching GO:0009792 152 0.065
positive regulation of macromolecule metabolic process GO:0010604 405 0.065
imaginal disc derived appendage development GO:0048737 399 0.064
negative regulation of mitotic cell cycle GO:0045930 109 0.063
negative regulation of cell cycle GO:0045786 116 0.060
positive regulation of biosynthetic process GO:0009891 316 0.060
histone modification GO:0016570 106 0.056
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.055
regulation of cell cycle GO:0051726 291 0.054
body morphogenesis GO:0010171 2 0.054
protein acetylation GO:0006473 39 0.052
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.052
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.051
negative regulation of cellular metabolic process GO:0031324 382 0.050
cell cycle phase transition GO:0044770 140 0.050
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.050
peptidyl amino acid modification GO:0018193 105 0.048
imaginal disc derived appendage morphogenesis GO:0035114 395 0.047
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.045
chromosome organization GO:0051276 360 0.044
mitotic dna damage checkpoint GO:0044773 74 0.044
mitotic cell cycle checkpoint GO:0007093 88 0.044
negative regulation of biosynthetic process GO:0009890 277 0.044
negative regulation of cellular biosynthetic process GO:0031327 277 0.043
regionalization GO:0003002 416 0.043
negative regulation of nucleic acid templated transcription GO:1903507 240 0.043
camera type eye development GO:0043010 4 0.043
immune response GO:0006955 246 0.042
negative regulation of rna metabolic process GO:0051253 251 0.042
mitotic g2 dna damage checkpoint GO:0007095 69 0.042
appendage morphogenesis GO:0035107 397 0.040
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.040
regulation of immune system process GO:0002682 176 0.040
appendage development GO:0048736 401 0.039
cell proliferation GO:0008283 299 0.038
leg disc morphogenesis GO:0007478 80 0.038
regulation of cellular amino acid metabolic process GO:0006521 0 0.038
regulation of cell proliferation GO:0042127 163 0.037
mitotic cell cycle phase transition GO:0044772 138 0.037
mitotic dna integrity checkpoint GO:0044774 75 0.037
post embryonic appendage morphogenesis GO:0035120 385 0.037
positive regulation of gene expression GO:0010628 290 0.035
cellular protein localization GO:0034613 160 0.035
leg disc development GO:0035218 92 0.035
response to other organism GO:0051707 293 0.034
regulation of notch signaling pathway GO:0008593 100 0.033
positive regulation of rna metabolic process GO:0051254 271 0.032
ncrna metabolic process GO:0034660 43 0.032
regulation of cell differentiation GO:0045595 302 0.032
chemotaxis GO:0006935 249 0.032
organelle fission GO:0048285 340 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.031
regulation of mitotic cell cycle GO:0007346 190 0.030
immune system process GO:0002376 347 0.030
regulation of immune response GO:0050776 118 0.030
negative regulation of cell cycle phase transition GO:1901988 103 0.030
eye development GO:0001654 323 0.029
single organism carbohydrate metabolic process GO:0044723 72 0.029
meiotic nuclear division GO:0007126 151 0.029
regulation of response to stress GO:0080134 200 0.029
establishment or maintenance of cell polarity GO:0007163 167 0.029
retina development in camera type eye GO:0060041 4 0.029
endodermal cell differentiation GO:0035987 3 0.029
phosphorylation GO:0016310 294 0.028
regulation of cell cycle phase transition GO:1901987 130 0.028
chromatin assembly or disassembly GO:0006333 52 0.027
positive regulation of cell communication GO:0010647 250 0.027
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.027
axon guidance GO:0007411 233 0.026
meiotic cell cycle GO:0051321 171 0.026
regulation of cellular amine metabolic process GO:0033238 3 0.026
dna integrity checkpoint GO:0031570 81 0.026
imaginal disc derived leg morphogenesis GO:0007480 80 0.025
regulation of meiosis GO:0040020 3 0.025
imaginal disc derived wing morphogenesis GO:0007476 337 0.025
anterior posterior pattern specification GO:0009952 136 0.025
negative regulation of gene expression GO:0010629 387 0.025
regulation of mitotic cell cycle phase transition GO:1901990 130 0.025
photoreceptor cell differentiation GO:0046530 170 0.024
notch signaling pathway GO:0007219 120 0.024
regulation of neurogenesis GO:0050767 158 0.024
organic substance catabolic process GO:1901575 308 0.024
catabolic process GO:0009056 409 0.024
immune effector process GO:0002252 98 0.024
regulation of synapse organization GO:0050807 110 0.023
snrna metabolic process GO:0016073 14 0.023
regulation of molecular function GO:0065009 217 0.023
response to bacterium GO:0009617 198 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.023
eye photoreceptor cell development GO:0042462 81 0.023
antimicrobial peptide production GO:0002775 46 0.023
response to organic substance GO:0010033 284 0.023
gastrulation GO:0007369 70 0.023
tissue morphogenesis GO:0048729 297 0.023
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
response to abiotic stimulus GO:0009628 341 0.022
cellular catabolic process GO:0044248 372 0.021
wnt signaling pathway GO:0016055 98 0.021
snrna processing GO:0016180 14 0.021
negative regulation of developmental process GO:0051093 201 0.021
vesicle mediated transport GO:0016192 381 0.021
regulation of multi organism process GO:0043900 131 0.021
cellular amine metabolic process GO:0044106 12 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.021
regulation of cell cycle process GO:0010564 181 0.021
protein localization GO:0008104 284 0.020
cellular ketone metabolic process GO:0042180 24 0.020
nuclear division GO:0000280 332 0.020
cell death GO:0008219 279 0.020
rna processing GO:0006396 147 0.020
neuroblast proliferation GO:0007405 74 0.019
regulation of nervous system development GO:0051960 248 0.019
cell cycle arrest GO:0007050 4 0.019
taxis GO:0042330 304 0.019
amine metabolic process GO:0009308 12 0.019
sensory organ morphogenesis GO:0090596 260 0.019
regulation of intracellular signal transduction GO:1902531 236 0.019
regulation of cellular response to stress GO:0080135 89 0.019
g1 s transition of mitotic cell cycle GO:0000082 31 0.019
regulation of gene silencing GO:0060968 63 0.019
carbohydrate metabolic process GO:0005975 82 0.019
cell adhesion GO:0007155 136 0.018
lateral inhibition GO:0046331 206 0.018
antimicrobial humoral response GO:0019730 99 0.018
muscle organ development GO:0007517 127 0.018
axonogenesis GO:0007409 290 0.018
intracellular signal transduction GO:0035556 300 0.018
chromatin remodeling GO:0006338 72 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
negative regulation of response to stimulus GO:0048585 258 0.018
regulation of response to biotic stimulus GO:0002831 63 0.018
protein phosphorylation GO:0006468 169 0.018
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.017
protein modification by small protein conjugation or removal GO:0070647 106 0.017
positive regulation of signaling GO:0023056 243 0.017
regulation of apoptotic process GO:0042981 130 0.017
multi organism behavior GO:0051705 175 0.017
cell migration GO:0016477 238 0.017
peptide metabolic process GO:0006518 80 0.017
biological adhesion GO:0022610 138 0.017
regulation of humoral immune response GO:0002920 51 0.017
positive regulation of response to stimulus GO:0048584 323 0.016
negative regulation of cell proliferation GO:0008285 69 0.016
response to ionizing radiation GO:0010212 32 0.016
photoreceptor cell development GO:0042461 96 0.016
defense response GO:0006952 300 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.016
small molecule metabolic process GO:0044281 305 0.016
cellular response to dna damage stimulus GO:0006974 223 0.016
negative regulation of cell differentiation GO:0045596 143 0.016
regulation of response to external stimulus GO:0032101 115 0.016
neuron projection guidance GO:0097485 241 0.016
negative regulation of cell cycle process GO:0010948 109 0.016
establishment of protein localization GO:0045184 163 0.015
regulation of immune effector process GO:0002697 52 0.015
wing disc morphogenesis GO:0007472 344 0.015
embryonic morphogenesis GO:0048598 206 0.015
proteolysis GO:0006508 192 0.015
methylation GO:0032259 47 0.015
cell cycle g1 s phase transition GO:0044843 31 0.015
imaginal disc pattern formation GO:0007447 91 0.015
positive regulation of molecular function GO:0044093 136 0.015
tube development GO:0035295 244 0.014
response to extracellular stimulus GO:0009991 116 0.014
cell cell signaling involved in cell fate commitment GO:0045168 210 0.014
g protein coupled receptor signaling pathway GO:0007186 136 0.014
dorsal ventral axis specification GO:0009950 66 0.014
response to lipopolysaccharide GO:0032496 4 0.014
signal transduction in response to dna damage GO:0042770 3 0.014
regulation of cell death GO:0010941 173 0.014
regulation of catalytic activity GO:0050790 185 0.014
mrna splicing via spliceosome GO:0000398 73 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
oocyte dorsal ventral axis specification GO:0007310 34 0.013
mrna metabolic process GO:0016071 124 0.013
neural precursor cell proliferation GO:0061351 75 0.013
humoral immune response GO:0006959 117 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
defense response to other organism GO:0098542 225 0.013
negative regulation of signal transduction GO:0009968 206 0.013
compound eye morphogenesis GO:0001745 249 0.013
organonitrogen compound metabolic process GO:1901564 318 0.013
muscle structure development GO:0061061 224 0.013
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.013
mapk cascade GO:0000165 107 0.013
ubiquitin dependent protein catabolic process GO:0006511 78 0.013
regulation of multicellular organismal development GO:2000026 414 0.013
ameboidal type cell migration GO:0001667 151 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.013
regulation of production of molecular mediator of immune response GO:0002700 44 0.013
regulation of chromatin silencing GO:0031935 36 0.013
response to oxygen containing compound GO:1901700 200 0.012
death GO:0016265 284 0.012
stem cell differentiation GO:0048863 117 0.012
regulation of cell development GO:0060284 215 0.012
positive regulation of signal transduction GO:0009967 223 0.012
single organism intracellular transport GO:1902582 207 0.012
sex comb development GO:0045498 8 0.012
rna methylation GO:0001510 2 0.012
eye photoreceptor cell differentiation GO:0001754 145 0.012
defense response to bacterium GO:0042742 178 0.012
digestive tract morphogenesis GO:0048546 127 0.012
connective tissue development GO:0061448 3 0.012
regulation of chromatin organization GO:1902275 32 0.012
regulation of defense response GO:0031347 102 0.012
modification dependent protein catabolic process GO:0019941 78 0.012
cellular amide metabolic process GO:0043603 80 0.012
camera type eye morphogenesis GO:0048593 2 0.012
eye morphogenesis GO:0048592 260 0.012
regulation of mapk cascade GO:0043408 92 0.011
regulation of autophagy GO:0010506 62 0.011
axon development GO:0061564 297 0.011
histone h3 acetylation GO:0043966 11 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
chaeta development GO:0022416 97 0.011
homeostatic process GO:0042592 199 0.011
negative regulation of nervous system development GO:0051961 92 0.011
kidney development GO:0001822 3 0.011
single organism biosynthetic process GO:0044711 206 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
organic substance transport GO:0071702 257 0.011
macromolecular complex assembly GO:0065003 256 0.011
endocytosis GO:0006897 310 0.011
dna methylation or demethylation GO:0044728 4 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
innate immune response GO:0045087 144 0.011
positive regulation of heterochromatin assembly GO:0031453 5 0.011
cellularization GO:0007349 90 0.011
embryonic development via the syncytial blastoderm GO:0001700 148 0.010
regulation of mrna splicing via spliceosome GO:0048024 64 0.010
digestive system development GO:0055123 149 0.010
ras protein signal transduction GO:0007265 88 0.010
protein ubiquitination GO:0016567 70 0.010
negative regulation of growth GO:0045926 84 0.010
endoderm formation GO:0001706 3 0.010
rna 3 end processing GO:0031123 45 0.010
regulation of phosphate metabolic process GO:0019220 210 0.010
negative regulation of apoptotic process GO:0043066 63 0.010
protein transport GO:0015031 155 0.010
wing disc pattern formation GO:0035222 66 0.010

MED16 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.087
nervous system disease DOID:863 0 0.031
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
musculoskeletal system disease DOID:17 0 0.013