Drosophila melanogaster

91 known processes

msl-1 (Dmel_CG10385)

male-specific lethal 1

(Aliases: Msl-1,MSL-1,MSL1,MSL3,msl,km(2)B,CG10385,kmB,i94,MSL,Dmel\CG10385,mls-1,msl1,Msl 1-3,Msl1)

msl-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone h4 k16 acetylation GO:0043984 4 0.981
Human
peptidyl lysine modification GO:0018205 57 0.707
Human
protein acetylation GO:0006473 39 0.551
Human
histone h4 acetylation GO:0043967 13 0.535
Human
regulation of chromatin silencing GO:0031935 36 0.506
regulation of gene silencing GO:0060968 63 0.450
gene silencing GO:0016458 138 0.449
positive regulation of gene expression GO:0010628 290 0.399
positive regulation of rna biosynthetic process GO:1902680 266 0.365
protein modification by small protein conjugation GO:0032446 79 0.362
regulation of gene expression epigenetic GO:0040029 128 0.349
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.340
positive regulation of rna metabolic process GO:0051254 271 0.324
negative regulation of gene expression GO:0010629 387 0.323
covalent chromatin modification GO:0016569 106 0.323
Human
positive regulation of biosynthetic process GO:0009891 316 0.284
chromatin modification GO:0016568 147 0.248
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.241
positive regulation of proteolysis GO:0045862 52 0.214
chromosome organization GO:0051276 360 0.213
Human
internal peptidyl lysine acetylation GO:0018393 38 0.206
Human
positive regulation of cellular biosynthetic process GO:0031328 316 0.199
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.193
negative regulation of cellular biosynthetic process GO:0031327 277 0.190
chromatin organization GO:0006325 207 0.173
Human
localization of cell GO:0051674 257 0.169
histone acetylation GO:0016573 38 0.151
Human
protein modification by small protein conjugation or removal GO:0070647 106 0.150
chromatin silencing GO:0006342 76 0.133
dosage compensation GO:0007549 16 0.126
cell migration GO:0016477 238 0.125
rna processing GO:0006396 147 0.117
positive regulation of endopeptidase activity GO:0010950 26 0.115
negative regulation of biosynthetic process GO:0009890 277 0.112
histone modification GO:0016570 106 0.111
Human
negative regulation of nucleic acid templated transcription GO:1903507 240 0.108
protein modification process GO:0036211 438 0.105
Human
response to oxidative stress GO:0006979 86 0.099
protein acylation GO:0043543 42 0.095
Human
peptidyl lysine acetylation GO:0018394 39 0.093
Human
internal protein amino acid acetylation GO:0006475 38 0.093
Human
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.091
cellular macromolecule localization GO:0070727 220 0.091
immune system process GO:0002376 347 0.085
negative regulation of rna metabolic process GO:0051253 251 0.084
regulation of cellular ketone metabolic process GO:0010565 3 0.084
ommochrome biosynthetic process GO:0006727 19 0.080
anterograde synaptic vesicle transport GO:0048490 3 0.080
epithelium migration GO:0090132 148 0.080
cellular pigmentation GO:0033059 12 0.078
positive regulation of nucleic acid templated transcription GO:1903508 266 0.070
regulation of protein acetylation GO:1901983 7 0.068
negative regulation of neuron death GO:1901215 18 0.067
body morphogenesis GO:0010171 2 0.066
regulation of notch signaling pathway GO:0008593 100 0.065
macromolecular complex assembly GO:0065003 256 0.065
rna splicing GO:0008380 83 0.065
cellular response to abiotic stimulus GO:0071214 58 0.064
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.064
positive regulation of transcription dna templated GO:0045893 266 0.062
single organism cellular localization GO:1902580 180 0.062
negative regulation of transcription dna templated GO:0045892 237 0.061
negative regulation of gene expression epigenetic GO:0045814 77 0.060
endocytosis GO:0006897 310 0.060
protein localization to organelle GO:0033365 82 0.057
chromatin remodeling GO:0006338 72 0.057
regulation of synapse organization GO:0050807 110 0.056
peptidyl amino acid modification GO:0018193 105 0.055
Human
ameboidal type cell migration GO:0001667 151 0.054
regulation of apoptotic process GO:0042981 130 0.053
regulation of chromatin organization GO:1902275 32 0.052
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.052
negative regulation of chromatin silencing GO:0031936 9 0.051
mrna splicing via spliceosome GO:0000398 73 0.049
epithelial cell development GO:0002064 274 0.049
zymogen activation GO:0031638 20 0.049
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.049
regulation of programmed cell death GO:0043067 152 0.048
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.047
chromatin assembly or disassembly GO:0006333 52 0.044
cellular protein modification process GO:0006464 438 0.043
Human
negative regulation of molecular function GO:0044092 51 0.041
growth GO:0040007 359 0.041
carboxylic acid metabolic process GO:0019752 92 0.040
ovarian follicle cell migration GO:0007297 121 0.039
transcription from rna polymerase ii promoter GO:0006366 368 0.039
homeostatic process GO:0042592 199 0.038
ocellus pigment metabolic process GO:0046158 19 0.038
positive regulation of peptidase activity GO:0010952 29 0.038
mrna metabolic process GO:0016071 124 0.037
autophagy GO:0006914 108 0.037
positive regulation of response to stimulus GO:0048584 323 0.036
establishment of localization in cell GO:0051649 402 0.036
regulation of response to stress GO:0080134 200 0.035
negative regulation of rna biosynthetic process GO:1902679 240 0.034
regulation of chromatin modification GO:1903308 28 0.034
male gamete generation GO:0048232 201 0.032
establishment of organelle localization GO:0051656 122 0.032
regulation of cellular amino acid metabolic process GO:0006521 0 0.031
organelle localization GO:0051640 148 0.031
modification dependent macromolecule catabolic process GO:0043632 79 0.031
regulation of cellular amine metabolic process GO:0033238 3 0.030
protein dna complex subunit organization GO:0071824 86 0.030
regulation of synapse structure and activity GO:0050803 128 0.030
cellular catabolic process GO:0044248 372 0.030
regulation of proteolysis GO:0030162 87 0.030
regulation of autophagy GO:0010506 62 0.030
regulation of cell proliferation GO:0042127 163 0.030
regulation of mrna processing GO:0050684 71 0.030
notch signaling pathway GO:0007219 120 0.029
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.029
amine metabolic process GO:0009308 12 0.029
negative regulation of signal transduction GO:0009968 206 0.028
hematopoietic or lymphoid organ development GO:0048534 57 0.027
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.027
negative regulation of cell communication GO:0010648 223 0.027
programmed cell death GO:0012501 257 0.026
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.026
vesicle localization GO:0051648 55 0.026
tissue migration GO:0090130 155 0.026
regulation of mrna metabolic process GO:1903311 72 0.026
regulation of rna splicing GO:0043484 69 0.025
regulation of steroid metabolic process GO:0019218 2 0.025
regulation of organelle organization GO:0033043 196 0.024
cellular response to dna damage stimulus GO:0006974 223 0.024
actin filament based process GO:0030029 220 0.023
negative regulation of response to stimulus GO:0048585 258 0.023
phagocytosis GO:0006909 215 0.023
synaptic transmission GO:0007268 288 0.022
positive regulation of cell communication GO:0010647 250 0.022
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.022
regionalization GO:0003002 416 0.022
cellular response to chemical stimulus GO:0070887 199 0.021
death GO:0016265 284 0.021
regulation of meiosis GO:0040020 3 0.021
cell death GO:0008219 279 0.020
cell division GO:0051301 248 0.020
determination of adult lifespan GO:0008340 137 0.020
regulation of protein metabolic process GO:0051246 256 0.020
cytoplasmic transport GO:0016482 130 0.020
ocellus pigmentation GO:0033060 19 0.020
epithelial cell migration GO:0010631 148 0.020
immune system development GO:0002520 57 0.019
regulation of cellular protein metabolic process GO:0032268 243 0.019
notch receptor processing GO:0007220 13 0.019
rna splicing via transesterification reactions GO:0000375 73 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
negative regulation of programmed cell death GO:0043069 72 0.019
gene silencing by rna GO:0031047 57 0.019
enzyme linked receptor protein signaling pathway GO:0007167 179 0.018
vesicle mediated transport GO:0016192 381 0.018
anterograde axon cargo transport GO:0008089 6 0.018
oxoacid metabolic process GO:0043436 103 0.018
cytokinesis GO:0000910 90 0.018
germ cell migration GO:0008354 43 0.017
cellular amine metabolic process GO:0044106 12 0.017
organic acid metabolic process GO:0006082 103 0.017
germarium derived egg chamber formation GO:0007293 101 0.017
proteolysis GO:0006508 192 0.017
regulation of mrna splicing via spliceosome GO:0048024 64 0.017
eye pigment granule organization GO:0008057 12 0.017
dna integrity checkpoint GO:0031570 81 0.017
negative regulation of notch signaling pathway GO:0045746 41 0.017
smoothened signaling pathway GO:0007224 49 0.016
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.016
regulation of proteasomal protein catabolic process GO:0061136 39 0.016
regulation of growth GO:0040008 233 0.016
activation of cysteine type endopeptidase activity GO:0097202 17 0.016
ovarian follicle cell development GO:0030707 248 0.016
regulation of peptidase activity GO:0052547 39 0.016
macromolecule catabolic process GO:0009057 161 0.016
cellular ketone metabolic process GO:0042180 24 0.015
cellular homeostasis GO:0019725 80 0.015
negative regulation of gene silencing by rna GO:0060967 9 0.015
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.015
hemopoiesis GO:0030097 46 0.015
regulation of histone acetylation GO:0035065 7 0.015
cytoskeleton dependent intracellular transport GO:0030705 44 0.015
eye development GO:0001654 323 0.015
alternative mrna splicing via spliceosome GO:0000380 60 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.014
protein transport GO:0015031 155 0.014
compound eye development GO:0048749 307 0.014
regulation of cell death GO:0010941 173 0.014
eye pigment metabolic process GO:0042441 33 0.014
regulation of cysteine type endopeptidase activity GO:2000116 27 0.014
proteasomal protein catabolic process GO:0010498 59 0.014
embryo development ending in birth or egg hatching GO:0009792 152 0.014
columnar cuboidal epithelial cell development GO:0002066 249 0.014
response to ionizing radiation GO:0010212 32 0.013
connective tissue development GO:0061448 3 0.013
organic substance transport GO:0071702 257 0.013
cell growth GO:0016049 108 0.013
anatomical structure homeostasis GO:0060249 97 0.013
dna damage checkpoint GO:0000077 78 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.012
wing disc morphogenesis GO:0007472 344 0.012
cell motility GO:0048870 251 0.012
regulation of mitotic cell cycle GO:0007346 190 0.012
cellular divalent inorganic cation homeostasis GO:0072503 23 0.012
negative regulation of bmp signaling pathway GO:0030514 12 0.012
establishment of protein localization GO:0045184 163 0.012
response to abiotic stimulus GO:0009628 341 0.012
photoreceptor cell fate commitment GO:0046552 41 0.012
protein ubiquitination GO:0016567 70 0.012
regulation of cell cycle GO:0051726 291 0.012
imaginal disc derived leg segmentation GO:0036011 26 0.011
regulation of nervous system development GO:0051960 248 0.011
ommochrome metabolic process GO:0046152 19 0.011
ribonucleoprotein complex biogenesis GO:0022613 31 0.011
negative regulation of cellular response to oxidative stress GO:1900408 1 0.011
regulation of histone modification GO:0031056 20 0.011
protein localization GO:0008104 284 0.011
imaginal disc fusion thorax closure GO:0046529 19 0.011
response to hypoxia GO:0001666 53 0.011
multicellular organismal aging GO:0010259 140 0.011
negative regulation of neuron apoptotic process GO:0043524 14 0.011
rrna processing GO:0006364 3 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.011
regulation of macroautophagy GO:0016241 15 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.011
pigment granule organization GO:0048753 12 0.010
cellular macromolecular complex assembly GO:0034622 153 0.010
positive regulation of cell death GO:0010942 69 0.010

msl-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.014