Drosophila melanogaster

144 known processes

alpha-Spec (Dmel_CG1977)

alpha Spectrin

(Aliases: l(3)62Bd,dre3,alpha-spectrin,Spec,l(3)dre3,l(3)04276,alfa-Spec,Dmel\CG1977,spectrin,anon-EST:fe2E2,alphaSp,alpha-spec,alpha-Sp,alpha-Spect,alpha,CG1977,alpha-Spc,alpha-Spe,l(3)alpha-Spec,klo,3A9,alphaSpec)

alpha-Spec biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
germarium derived female germ line cyst formation GO:0030727 42 0.965
axon development GO:0061564 297 0.943
oocyte differentiation GO:0009994 145 0.930
oocyte development GO:0048599 124 0.872
germarium derived egg chamber formation GO:0007293 101 0.863
establishment of localization in cell GO:0051649 402 0.819
synaptic transmission GO:0007268 288 0.749
organelle localization GO:0051640 148 0.744
neuromuscular junction development GO:0007528 149 0.708
axonogenesis GO:0007409 290 0.707
regulation of multicellular organismal development GO:2000026 414 0.692
catabolic process GO:0009056 409 0.640
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.615
pole plasm assembly GO:0007315 61 0.592
female germ line cyst formation GO:0048135 42 0.576
actin filament based process GO:0030029 220 0.573
negative regulation of protein complex disassembly GO:0043242 23 0.560
establishment of organelle localization GO:0051656 122 0.557
regulation of cellular component biogenesis GO:0044087 201 0.537
cell proliferation GO:0008283 299 0.506
regulation of synapse organization GO:0050807 110 0.490
pole plasm oskar mrna localization GO:0045451 46 0.477
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.476
establishment or maintenance of cell polarity GO:0007163 167 0.439
regulation of synapse assembly GO:0051963 94 0.417
oocyte axis specification GO:0007309 108 0.405
germ line cyst formation GO:0048134 44 0.391
body morphogenesis GO:0010171 2 0.385
oocyte anterior posterior axis specification GO:0007314 72 0.362
sensory organ morphogenesis GO:0090596 260 0.348
regulation of oocyte development GO:0060281 27 0.343
microtubule depolymerization GO:0007019 25 0.339
oocyte construction GO:0007308 112 0.333
pole plasm mrna localization GO:0019094 49 0.327
synaptic growth at neuromuscular junction GO:0051124 119 0.325
membrane organization GO:0061024 112 0.322
locomotory behavior GO:0007626 176 0.317
regulation of growth GO:0040008 233 0.312
synaptic vesicle fusion to presynaptic membrane GO:0031629 7 0.301
synaptic vesicle recycling GO:0036465 28 0.296
eye morphogenesis GO:0048592 260 0.295
positive regulation of cellular component organization GO:0051130 156 0.294
regulation of cell differentiation GO:0045595 302 0.289
growth GO:0040007 359 0.281
regulation of nervous system development GO:0051960 248 0.270
synaptic vesicle transport GO:0048489 50 0.263
positive regulation of macromolecule metabolic process GO:0010604 405 0.257
regulation of vesicle mediated transport GO:0060627 59 0.249
developmental growth GO:0048589 280 0.240
organic substance catabolic process GO:1901575 308 0.239
signal release GO:0023061 49 0.235
regulation of cytoskeleton organization GO:0051493 89 0.230
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.229
cellular component disassembly GO:0022411 46 0.220
mrna metabolic process GO:0016071 124 0.215
negative regulation of cellular metabolic process GO:0031324 382 0.212
regulation of secretion by cell GO:1903530 39 0.206
regulation of cell development GO:0060284 215 0.203
compound eye morphogenesis GO:0001745 249 0.203
central nervous system development GO:0007417 201 0.196
establishment of vesicle localization GO:0051650 51 0.190
maintenance of presynaptic active zone structure GO:0048790 8 0.190
learning or memory GO:0007611 141 0.182
vesicle mediated transport GO:0016192 381 0.182
cytoskeleton dependent intracellular transport GO:0030705 44 0.179
negative regulation of cell communication GO:0010648 223 0.179
positive regulation of biosynthetic process GO:0009891 316 0.175
protein complex disassembly GO:0043241 36 0.172
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.170
regulation of organelle organization GO:0033043 196 0.165
protein modification process GO:0036211 438 0.165
negative regulation of protein depolymerization GO:1901880 23 0.161
regulation of microtubule cytoskeleton organization GO:0070507 41 0.152
synapse assembly GO:0007416 143 0.151
regulation of cellular localization GO:0060341 136 0.148
macromolecular complex disassembly GO:0032984 37 0.143
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.137
neuron projection guidance GO:0097485 241 0.136
cellular macromolecular complex assembly GO:0034622 153 0.134
pole plasm rna localization GO:0007316 52 0.133
protein depolymerization GO:0051261 31 0.131
cellular protein complex assembly GO:0043623 71 0.131
compound eye development GO:0048749 307 0.130
regulation of microtubule based process GO:0032886 49 0.123
photoreceptor cell differentiation GO:0046530 170 0.120
single organism intracellular transport GO:1902582 207 0.120
cognition GO:0050890 141 0.117
vesicle organization GO:0016050 44 0.113
secretion GO:0046903 109 0.110
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 8 0.106
cytoplasm organization GO:0007028 64 0.105
single organism membrane organization GO:0044802 93 0.104
posttranscriptional gene silencing by rna GO:0035194 45 0.103
positive regulation of cellular biosynthetic process GO:0031328 316 0.103
rna localization GO:0006403 115 0.099
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.098
protein localization to plasma membrane GO:0072659 13 0.098
positive regulation of organelle organization GO:0010638 65 0.094
morphogenesis of follicular epithelium GO:0016333 36 0.094
asymmetric protein localization GO:0008105 33 0.092
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.090
epithelial cell development GO:0002064 274 0.090
negative regulation of cellular biosynthetic process GO:0031327 277 0.090
associative learning GO:0008306 65 0.090
neurological system process GO:0050877 358 0.087
regulation of gene expression epigenetic GO:0040029 128 0.085
positive regulation of protein metabolic process GO:0051247 128 0.083
single organism cellular localization GO:1902580 180 0.083
regulation of localization GO:0032879 275 0.082
heterocycle catabolic process GO:0046700 166 0.081
endoplasmic reticulum organization GO:0007029 13 0.081
regulation of transport GO:0051049 181 0.080
molting cycle GO:0042303 56 0.079
secretion by cell GO:0032940 101 0.078
negative regulation of gene expression GO:0010629 387 0.077
multicellular organismal reproductive behavior GO:0033057 110 0.076
protein modification by small protein conjugation GO:0032446 79 0.076
organonitrogen compound metabolic process GO:1901564 318 0.076
membrane fusion GO:0061025 42 0.075
actin filament polymerization GO:0030041 27 0.075
positive regulation of axonogenesis GO:0050772 2 0.075
intracellular transport GO:0046907 228 0.074
microtubule polymerization or depolymerization GO:0031109 39 0.073
transcription from rna polymerase ii promoter GO:0006366 368 0.073
notch signaling pathway GO:0007219 120 0.071
response to biotic stimulus GO:0009607 294 0.071
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.070
regulation of secretion GO:0051046 44 0.069
forebrain development GO:0030900 2 0.069
small molecule metabolic process GO:0044281 305 0.069
microtubule based transport GO:0010970 42 0.068
regulation of actin filament based process GO:0032970 42 0.068
chemotaxis GO:0006935 249 0.067
ovarian follicle cell development GO:0030707 248 0.066
eye development GO:0001654 323 0.066
regulation of cell death GO:0010941 173 0.066
posttranscriptional regulation of gene expression GO:0010608 145 0.065
regulation of protein complex assembly GO:0043254 42 0.065
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.064
axon cargo transport GO:0008088 29 0.063
positive regulation of rna metabolic process GO:0051254 271 0.061
positive regulation of secretion by cell GO:1903532 20 0.061
memory GO:0007613 94 0.061
negative regulation of nervous system development GO:0051961 92 0.061
multi organism behavior GO:0051705 175 0.061
oviposition GO:0018991 19 0.061
macroautophagy GO:0016236 42 0.060
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.058
cellular catabolic process GO:0044248 372 0.057
protein ubiquitination GO:0016567 70 0.056
organic substance transport GO:0071702 257 0.055
organelle assembly GO:0070925 198 0.052
maternal determination of anterior posterior axis embryo GO:0008358 74 0.052
germarium derived oocyte fate determination GO:0007294 26 0.051
macromolecular complex assembly GO:0065003 256 0.051
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.051
nucleus localization GO:0051647 34 0.051
anterior posterior axis specification GO:0009948 109 0.051
negative regulation of cellular component organization GO:0051129 108 0.050
nucleobase containing compound catabolic process GO:0034655 165 0.050
protein localization GO:0008104 284 0.049
cell division GO:0051301 248 0.049
cell maturation GO:0048469 144 0.048
negative regulation of synapse assembly GO:0051964 39 0.048
actin cytoskeleton organization GO:0030036 206 0.047
negative regulation of multicellular organismal process GO:0051241 142 0.047
developmental programmed cell death GO:0010623 138 0.047
single organism membrane fusion GO:0044801 42 0.047
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.047
single organism behavior GO:0044708 391 0.046
aromatic compound catabolic process GO:0019439 166 0.046
regulation of multi organism process GO:0043900 131 0.046
cation homeostasis GO:0055080 51 0.046
regulation of reproductive process GO:2000241 54 0.045
defense response GO:0006952 300 0.045
positive regulation of cell projection organization GO:0031346 29 0.044
tube development GO:0035295 244 0.044
positive regulation of cell communication GO:0010647 250 0.043
protein catabolic process GO:0030163 101 0.043
cellular ion homeostasis GO:0006873 39 0.043
cellular nitrogen compound catabolic process GO:0044270 165 0.043
golgi vesicle transport GO:0048193 27 0.043
negative regulation of epithelial cell proliferation GO:0050680 4 0.043
establishment of synaptic vesicle localization GO:0097480 50 0.042
positive regulation of cellular component biogenesis GO:0044089 80 0.042
oocyte maturation GO:0001556 3 0.042
tripartite regional subdivision GO:0007351 103 0.041
positive regulation of gene expression GO:0010628 290 0.041
regulation of synaptic transmission GO:0050804 69 0.041
positive regulation of developmental process GO:0051094 143 0.041
blastoderm segmentation GO:0007350 159 0.040
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.040
regulation of neurogenesis GO:0050767 158 0.040
negative regulation of developmental process GO:0051093 201 0.039
cellular ketone metabolic process GO:0042180 24 0.039
regulation of microtubule depolymerization GO:0031114 24 0.038
plasma membrane organization GO:0007009 26 0.038
positive regulation of transport GO:0051050 92 0.038
macromolecule catabolic process GO:0009057 161 0.038
chromosome segregation GO:0007059 157 0.038
branching involved in open tracheal system development GO:0060446 45 0.038
regulation of protein complex disassembly GO:0043244 29 0.038
organic cyclic compound catabolic process GO:1901361 168 0.037
positive regulation of response to stimulus GO:0048584 323 0.037
positive regulation of nucleic acid templated transcription GO:1903508 266 0.037
establishment of protein localization to membrane GO:0090150 11 0.036
regulation of cell proliferation GO:0042127 163 0.036
intracellular mrna localization GO:0008298 66 0.036
regulation of protein depolymerization GO:1901879 27 0.036
positive regulation of signaling GO:0023056 243 0.036
spindle localization GO:0051653 22 0.035
epithelial cell differentiation GO:0030855 322 0.035
actin polymerization or depolymerization GO:0008154 31 0.034
adult locomotory behavior GO:0008344 76 0.034
cell recognition GO:0008037 102 0.034
regulation of erbb signaling pathway GO:1901184 42 0.033
regulation of mitotic cell cycle GO:0007346 190 0.033
regulation of nurse cell apoptotic process GO:0045477 9 0.033
negative regulation of signaling GO:0023057 219 0.032
multi multicellular organism process GO:0044706 123 0.032
synapse organization GO:0050808 196 0.032
organophosphate catabolic process GO:0046434 112 0.032
positive regulation of cell development GO:0010720 61 0.032
phosphorylation GO:0016310 294 0.032
cation transport GO:0006812 110 0.032
response to external biotic stimulus GO:0043207 293 0.031
nitrogen compound transport GO:0071705 85 0.030
camera type eye morphogenesis GO:0048593 2 0.030
positive regulation of transcription dna templated GO:0045893 266 0.029
response to organic substance GO:0010033 284 0.029
protein complex assembly GO:0006461 200 0.029
chemosensory behavior GO:0007635 106 0.028
synaptic vesicle priming GO:0016082 1 0.028
positive regulation of nervous system development GO:0051962 69 0.028
positive regulation of multicellular organismal process GO:0051240 143 0.028
regulation of notch signaling pathway GO:0008593 100 0.028
ameboidal type cell migration GO:0001667 151 0.028
establishment of nucleus localization GO:0040023 26 0.028
carbohydrate derivative metabolic process GO:1901135 217 0.028
amine metabolic process GO:0009308 12 0.028
regulation of hemocyte proliferation GO:0035206 37 0.027
asymmetric cell division GO:0008356 37 0.027
ventral cord development GO:0007419 16 0.027
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.027
synaptic vesicle endocytosis GO:0048488 28 0.027
cell adhesion GO:0007155 136 0.027
developmental maturation GO:0021700 172 0.027
taxis GO:0042330 304 0.027
negative regulation of response to stimulus GO:0048585 258 0.026
protein complex biogenesis GO:0070271 201 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.026
regulation of cell maturation GO:1903429 27 0.025
positive regulation of axon guidance GO:1902669 1 0.025
negative regulation of microtubule depolymerization GO:0007026 21 0.025
cell migration GO:0016477 238 0.024
neurotransmitter transport GO:0006836 37 0.024
border follicle cell migration GO:0007298 113 0.024
homeostatic process GO:0042592 199 0.024
mapk cascade GO:0000165 107 0.023
oocyte dorsal ventral axis specification GO:0007310 34 0.023
enzyme linked receptor protein signaling pathway GO:0007167 179 0.023
regulation of response to stress GO:0080134 200 0.023
mitotic nuclear division GO:0007067 213 0.023
ribonucleoside metabolic process GO:0009119 127 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.023
negative regulation of notch signaling pathway GO:0045746 41 0.023
regulation of actin polymerization or depolymerization GO:0008064 27 0.023
chromosome organization GO:0051276 360 0.023
substrate adhesion dependent cell spreading GO:0034446 2 0.023
regulation of programmed cell death GO:0043067 152 0.023
tissue morphogenesis GO:0048729 297 0.022
phosphatidylinositol phosphorylation GO:0046854 10 0.022
regulation of phosphatase activity GO:0010921 3 0.022
negative regulation of organelle organization GO:0010639 56 0.022
regulation of embryonic pattern specification GO:1902875 27 0.022
microtubule based movement GO:0007018 51 0.022
positive regulation of receptor mediated endocytosis GO:0048260 7 0.021
oxoacid metabolic process GO:0043436 103 0.021
meiotic nuclear division GO:0007126 151 0.021
cellularization GO:0007349 90 0.021
vesicle fusion GO:0006906 19 0.021
carboxylic acid metabolic process GO:0019752 92 0.021
gene silencing GO:0016458 138 0.021
regulation of intracellular signal transduction GO:1902531 236 0.020
striated muscle cell differentiation GO:0051146 90 0.020
endocytosis GO:0006897 310 0.020
regulation of epithelial cell proliferation GO:0050678 4 0.020
cellular macromolecule localization GO:0070727 220 0.020
response to reactive oxygen species GO:0000302 24 0.020
mrna processing GO:0006397 104 0.020
regulation of cell substrate adhesion GO:0010810 2 0.019
regulation of protein polymerization GO:0032271 28 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 16 0.019
metal ion transport GO:0030001 74 0.019
cellular macromolecule catabolic process GO:0044265 136 0.019
cellular protein modification process GO:0006464 438 0.019
positive regulation of signal transduction GO:0009967 223 0.019
anterior posterior axis specification embryo GO:0008595 103 0.019
neurotransmitter secretion GO:0007269 35 0.019
hindbrain development GO:0030902 2 0.019
vesicle localization GO:0051648 55 0.019
spinal cord development GO:0021510 1 0.019
cytoplasmic transport GO:0016482 130 0.019
single organism catabolic process GO:0044712 228 0.019
organelle fission GO:0048285 340 0.019
ovarian follicle cell migration GO:0007297 121 0.018
regulation of endocytosis GO:0030100 37 0.018
photoreceptor cell axon guidance GO:0072499 23 0.018
endomembrane system organization GO:0010256 119 0.018
cell cycle g1 s phase transition GO:0044843 31 0.018
regulation of protein metabolic process GO:0051246 256 0.018
establishment of spindle localization GO:0051293 22 0.017
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.017
morphogenesis of an epithelium GO:0002009 276 0.017
response to starvation GO:0042594 97 0.017
long term memory GO:0007616 62 0.017
epithelium migration GO:0090132 148 0.016
protein polymerization GO:0051258 42 0.016
regulation of actin cytoskeleton organization GO:0032956 42 0.016
negative regulation of rna metabolic process GO:0051253 251 0.016
reproductive behavior GO:0019098 122 0.016
response to organic cyclic compound GO:0014070 89 0.016
negative regulation of nucleic acid templated transcription GO:1903507 240 0.016
axis specification GO:0009798 167 0.016
glial cell development GO:0021782 27 0.016
protein modification by small protein conjugation or removal GO:0070647 106 0.016
nucleus organization GO:0006997 45 0.016
establishment of protein localization to plasma membrane GO:0090002 9 0.016
cytokinesis GO:0000910 90 0.015
imaginal disc growth GO:0007446 37 0.015
conditioned taste aversion GO:0001661 3 0.015
skeletal muscle fiber development GO:0048741 3 0.015
ribonucleotide metabolic process GO:0009259 145 0.015
tissue migration GO:0090130 155 0.015
cell death GO:0008219 279 0.015
axon guidance GO:0007411 233 0.015
positive regulation of growth GO:0045927 75 0.015
regulation of lamellipodium assembly GO:0010591 15 0.015
ribonucleoprotein complex subunit organization GO:0071826 28 0.015
muscle tissue development GO:0060537 30 0.014
single organism carbohydrate metabolic process GO:0044723 72 0.014
regulation of system process GO:0044057 36 0.014
regulation of cell projection organization GO:0031344 92 0.014
cellular homeostasis GO:0019725 80 0.014
establishment of mitochondrion localization GO:0051654 7 0.014
positive regulation of developmental pigmentation GO:0048087 5 0.014
positive regulation of cell cycle GO:0045787 43 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
embryonic pattern specification GO:0009880 174 0.014
learning GO:0007612 75 0.014
positive regulation of exocytosis GO:0045921 4 0.014
eye antennal disc development GO:0035214 60 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.013
negative regulation of cell cycle GO:0045786 116 0.013
membrane budding GO:0006900 4 0.013
meiotic cell cycle GO:0051321 171 0.013
ovarian follicle cell stalk formation GO:0030713 17 0.013
cell cycle arrest GO:0007050 4 0.013
sensory perception of chemical stimulus GO:0007606 116 0.013
determination of adult lifespan GO:0008340 137 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.013
positive regulation of protein localization to plasma membrane GO:1903078 3 0.013
negative regulation of hormone biosynthetic process GO:0032353 1 0.013
organic hydroxy compound metabolic process GO:1901615 83 0.012
response to oxygen containing compound GO:1901700 200 0.012
anterior posterior pattern specification GO:0009952 136 0.012
regulation of mapk cascade GO:0043408 92 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.012
regulation of phosphorus metabolic process GO:0051174 210 0.012
response to lipopolysaccharide GO:0032496 4 0.012
brain development GO:0007420 120 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
membrane tubulation GO:0097320 4 0.012
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.012
cell cell signaling involved in cell fate commitment GO:0045168 210 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
regulation of neuron death GO:1901214 26 0.012
cellular response to chemical stimulus GO:0070887 199 0.012
protein transport GO:0015031 155 0.012
cortical actin cytoskeleton organization GO:0030866 24 0.012
response to alkaloid GO:0043279 26 0.012
larval development GO:0002164 104 0.012
cellular amine metabolic process GO:0044106 12 0.012
regulation of translation GO:0006417 56 0.011
muscle organ development GO:0007517 127 0.011
carbohydrate metabolic process GO:0005975 82 0.011
regulation of pole plasm oskar mrna localization GO:0007317 27 0.011
positive regulation of filopodium assembly GO:0051491 15 0.011
sex differentiation GO:0007548 81 0.011
organic acid metabolic process GO:0006082 103 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
positive regulation of axon extension GO:0045773 2 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
phagocytosis GO:0006909 215 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
purine nucleoside monophosphate metabolic process GO:0009126 50 0.011
oocyte microtubule cytoskeleton organization GO:0016325 35 0.011
regulation of neuron differentiation GO:0045664 103 0.011
rna splicing GO:0008380 83 0.010
response to toxic substance GO:0009636 22 0.010
positive regulation of neurogenesis GO:0050769 41 0.010
developmental growth involved in morphogenesis GO:0060560 65 0.010
negative regulation of rna biosynthetic process GO:1902679 240 0.010
regulation of developmental growth GO:0048638 174 0.010

alpha-Spec disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.177
cardiovascular system disease DOID:1287 0 0.055
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
musculoskeletal system disease DOID:17 0 0.016
organ system cancer DOID:0050686 0 0.012