Drosophila melanogaster

56 known processes

fray (Dmel_CG7693)

frayed

(Aliases: STE20-like/SPAK,l(3)07551,dSTRAD,lag,Dmel\CG7693,4624,CG7693)

fray biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of signaling GO:0023057 219 0.432
embryonic development via the syncytial blastoderm GO:0001700 148 0.296
negative regulation of cell communication GO:0010648 223 0.197
imaginal disc derived appendage morphogenesis GO:0035114 395 0.169
organonitrogen compound metabolic process GO:1901564 318 0.165
embryonic morphogenesis GO:0048598 206 0.160
tube morphogenesis GO:0035239 191 0.148
Worm
eye morphogenesis GO:0048592 260 0.141
imaginal disc derived appendage development GO:0048737 399 0.128
eye development GO:0001654 323 0.127
regionalization GO:0003002 416 0.119
cellular protein modification process GO:0006464 438 0.114
Human Mouse Rat Worm
organic acid metabolic process GO:0006082 103 0.111
embryo development ending in birth or egg hatching GO:0009792 152 0.106
immune system process GO:0002376 347 0.090
asymmetric stem cell division GO:0098722 49 0.088
carboxylic acid metabolic process GO:0019752 92 0.087
compound eye development GO:0048749 307 0.081
peptidyl threonine phosphorylation GO:0018107 2 0.078
Human Mouse Worm
small molecule metabolic process GO:0044281 305 0.078
sevenless signaling pathway GO:0045500 4 0.075
digestive tract morphogenesis GO:0048546 127 0.071
stem cell division GO:0017145 69 0.070
neuroblast division GO:0055057 35 0.068
imaginal disc derived wing morphogenesis GO:0007476 337 0.067
ras protein signal transduction GO:0007265 88 0.067
protein modification process GO:0036211 438 0.064
Human Mouse Rat Worm
tissue morphogenesis GO:0048729 297 0.064
Worm
memory GO:0007613 94 0.062
regulation of phosphate metabolic process GO:0019220 210 0.062
Mouse
regulation of catalytic activity GO:0050790 185 0.062
hemopoiesis GO:0030097 46 0.061
positive regulation of catalytic activity GO:0043085 118 0.059
digestive tract development GO:0048565 149 0.057
establishment of localization in cell GO:0051649 402 0.057
single organism behavior GO:0044708 391 0.056
appendage morphogenesis GO:0035107 397 0.055
wing disc morphogenesis GO:0007472 344 0.054
anatomical structure homeostasis GO:0060249 97 0.054
developmental growth GO:0048589 280 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.053
negative regulation of signal transduction GO:0009968 206 0.052
positive regulation of molecular function GO:0044093 136 0.051
regulation of mitotic cell cycle phase transition GO:1901990 130 0.051
post embryonic appendage morphogenesis GO:0035120 385 0.051
endocytosis GO:0006897 310 0.050
short term memory GO:0007614 19 0.049
neurological system process GO:0050877 358 0.049
synapse assembly GO:0007416 143 0.049
localization of cell GO:0051674 257 0.049
positive regulation of gtpase activity GO:0043547 43 0.047
regulation of cell cycle GO:0051726 291 0.047
programmed cell death GO:0012501 257 0.047
regulation of cellular catabolic process GO:0031329 157 0.047
death GO:0016265 284 0.046
small gtpase mediated signal transduction GO:0007264 88 0.046
cell death GO:0008219 279 0.044
segmentation GO:0035282 207 0.044
guanosine containing compound metabolic process GO:1901068 74 0.043
oxoacid metabolic process GO:0043436 103 0.043
regulation of ras protein signal transduction GO:0046578 93 0.042
negative regulation of cellular protein metabolic process GO:0032269 85 0.042
Mouse
regulation of small gtpase mediated signal transduction GO:0051056 93 0.042
cell cell signaling involved in cell fate commitment GO:0045168 210 0.042
positive regulation of nucleotide catabolic process GO:0030813 46 0.042
homeostatic process GO:0042592 199 0.041
Mouse
regulation of nucleotide metabolic process GO:0006140 62 0.040
tube development GO:0035295 244 0.040
Worm
vesicle organization GO:0016050 44 0.040
apoptotic process GO:0006915 159 0.040
negative regulation of response to stimulus GO:0048585 258 0.039
response to abiotic stimulus GO:0009628 341 0.039
Mouse
regulation of phosphorus metabolic process GO:0051174 210 0.038
Mouse
cellular ketone metabolic process GO:0042180 24 0.038
regulation of intracellular signal transduction GO:1902531 236 0.037
intracellular transport GO:0046907 228 0.037
sensory organ morphogenesis GO:0090596 260 0.037
regulation of cellular protein metabolic process GO:0032268 243 0.036
Mouse
compound eye morphogenesis GO:0001745 249 0.036
positive regulation of macromolecule metabolic process GO:0010604 405 0.036
appendage development GO:0048736 401 0.036
cell motility GO:0048870 251 0.035
proteasomal protein catabolic process GO:0010498 59 0.035
histone modification GO:0016570 106 0.035
gastrulation with mouth forming first GO:0001703 36 0.035
regulation of nucleoside metabolic process GO:0009118 50 0.035
learning or memory GO:0007611 141 0.034
catabolic process GO:0009056 409 0.034
protein phosphorylation GO:0006468 169 0.034
Human Mouse Rat Worm
rubidium ion transport GO:0035826 1 0.034
Human Mouse
actin cytoskeleton organization GO:0030036 206 0.033
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.033
positive regulation of transport GO:0051050 92 0.033
Rat
positive regulation of hydrolase activity GO:0051345 78 0.033
regulation of cell cycle phase transition GO:1901987 130 0.033
gland development GO:0048732 191 0.033
regulation of hydrolase activity GO:0051336 97 0.033
purine nucleoside catabolic process GO:0006152 112 0.033
gastrulation GO:0007369 70 0.033
cellular amine metabolic process GO:0044106 12 0.032
somatic stem cell division GO:0048103 37 0.032
actin filament based process GO:0030029 220 0.031
cell growth GO:0016049 108 0.031
leg disc development GO:0035218 92 0.031
myotube cell development GO:0014904 3 0.030
eye photoreceptor cell differentiation GO:0001754 145 0.030
regulation of apoptotic process GO:0042981 130 0.030
protein transport GO:0015031 155 0.029
somatic muscle development GO:0007525 66 0.029
phosphorylation GO:0016310 294 0.028
Human Mouse Rat Worm
positive regulation of response to stimulus GO:0048584 323 0.028
regulation of cellular amine metabolic process GO:0033238 3 0.028
activation of cysteine type endopeptidase activity GO:0097202 17 0.028
regulation of nervous system development GO:0051960 248 0.028
positive regulation of nucleoside metabolic process GO:0045979 47 0.028
organelle assembly GO:0070925 198 0.027
positive regulation of nucleic acid templated transcription GO:1903508 266 0.027
negative regulation of protein metabolic process GO:0051248 85 0.026
Mouse
cellular protein localization GO:0034613 160 0.026
imaginal disc derived wing vein specification GO:0007474 48 0.026
regulation of growth GO:0040008 233 0.026
cellular amino acid metabolic process GO:0006520 61 0.026
macromolecule catabolic process GO:0009057 161 0.026
imaginal disc derived leg morphogenesis GO:0007480 80 0.026
immune system development GO:0002520 57 0.026
regulation of protein modification process GO:0031399 112 0.026
Mouse
single organism cellular localization GO:1902580 180 0.025
camera type eye development GO:0043010 4 0.025
regulation of purine nucleotide metabolic process GO:1900542 62 0.024
nucleoside phosphate metabolic process GO:0006753 162 0.024
regulation of gtp catabolic process GO:0033124 44 0.024
gland morphogenesis GO:0022612 145 0.024
regulation of mitotic cell cycle GO:0007346 190 0.024
regulation of vesicle mediated transport GO:0060627 59 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.023
vesicle mediated transport GO:0016192 381 0.023
establishment or maintenance of cell polarity GO:0007163 167 0.023
regulation of phosphorylation GO:0042325 147 0.023
Mouse
positive regulation of signaling GO:0023056 243 0.023
mitotic spindle organization GO:0007052 220 0.023
enzyme linked receptor protein signaling pathway GO:0007167 179 0.023
mitotic dna integrity checkpoint GO:0044774 75 0.023
cellular response to dna damage stimulus GO:0006974 223 0.023
regulation of transport GO:0051049 181 0.022
Human Mouse Rat
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.022
negative regulation of cell cycle phase transition GO:1901988 103 0.022
regulation of gtpase activity GO:0043087 44 0.022
gastrulation involving germ band extension GO:0010004 36 0.022
regulation of protein phosphorylation GO:0001932 64 0.022
Mouse
cytokinesis GO:0000910 90 0.022
regulation of organ morphogenesis GO:2000027 78 0.022
response to radiation GO:0009314 155 0.022
intracellular signal transduction GO:0035556 300 0.022
Human Mouse
purine nucleoside triphosphate metabolic process GO:0009144 119 0.022
organic substance catabolic process GO:1901575 308 0.022
negative regulation of cellular metabolic process GO:0031324 382 0.022
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.022
regulation of synapse structure and activity GO:0050803 128 0.022
cognition GO:0050890 141 0.021
periodic partitioning GO:0007365 29 0.021
asymmetric neuroblast division GO:0055059 33 0.021
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.021
photoreceptor cell differentiation GO:0046530 170 0.021
cellular catabolic process GO:0044248 372 0.021
single organism membrane fusion GO:0044801 42 0.020
notch signaling pathway GO:0007219 120 0.020
positive regulation of phosphate metabolic process GO:0045937 139 0.020
wnt signaling pathway GO:0016055 98 0.020
negative regulation of apoptotic process GO:0043066 63 0.020
eye photoreceptor cell development GO:0042462 81 0.020
dephosphorylation GO:0016311 51 0.020
morphogenesis of an epithelium GO:0002009 276 0.020
Worm
positive regulation of cell communication GO:0010647 250 0.020
positive regulation of cellular catabolic process GO:0031331 95 0.020
regulation of developmental growth GO:0048638 174 0.020
neuronal stem cell division GO:0036445 35 0.020
mitotic cell cycle checkpoint GO:0007093 88 0.020
mitotic nuclear division GO:0007067 213 0.019
response to endogenous stimulus GO:0009719 119 0.019
epithelial cell differentiation GO:0030855 322 0.019
lateral inhibition GO:0046331 206 0.019
germ line stem cell niche homeostasis GO:0060250 5 0.019
regulation of nucleotide catabolic process GO:0030811 48 0.019
response to organic substance GO:0010033 284 0.019
purine nucleotide metabolic process GO:0006163 146 0.019
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.019
regulation of r7 cell differentiation GO:0045676 15 0.019
purine nucleoside metabolic process GO:0042278 127 0.019
dna damage checkpoint GO:0000077 78 0.019
regulation of cellular component biogenesis GO:0044087 201 0.019
regulation of cellular ketone metabolic process GO:0010565 3 0.019
negative regulation of programmed cell death GO:0043069 72 0.018
establishment of planar polarity GO:0001736 87 0.018
cytoplasmic transport GO:0016482 130 0.018
exocrine system development GO:0035272 162 0.018
hematopoietic or lymphoid organ development GO:0048534 57 0.018
regulation of actin polymerization or depolymerization GO:0008064 27 0.018
regulation of programmed cell death GO:0043067 152 0.018
positive regulation of rna metabolic process GO:0051254 271 0.018
cell migration GO:0016477 238 0.018
protein processing GO:0016485 68 0.018
negative regulation of intracellular signal transduction GO:1902532 57 0.018
positive regulation of developmental process GO:0051094 143 0.018
positive regulation of peptidase activity GO:0010952 29 0.017
erk1 and erk2 cascade GO:0070371 39 0.017
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.017
nuclear division GO:0000280 332 0.017
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.017
protein catabolic process GO:0030163 101 0.017
blastoderm segmentation GO:0007350 159 0.017
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.017
regulation of immune system process GO:0002682 176 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
peptidyl amino acid modification GO:0018193 105 0.017
Human Mouse Worm
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
peptidyl threonine modification GO:0018210 3 0.016
Human Mouse Worm
carbohydrate derivative metabolic process GO:1901135 217 0.016
adult somatic muscle development GO:0007527 14 0.016
urogenital system development GO:0001655 72 0.016
negative regulation of protein tyrosine kinase activity GO:0061099 5 0.016
phagocytosis GO:0006909 215 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.016
digestive system development GO:0055123 149 0.016
negative regulation of catabolic process GO:0009895 36 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.016
single organism intracellular transport GO:1902582 207 0.016
compound eye photoreceptor cell differentiation GO:0001751 140 0.016
cell fate determination GO:0001709 91 0.016
developmental growth involved in morphogenesis GO:0060560 65 0.016
microtubule based transport GO:0010970 42 0.016
positive regulation of developmental growth GO:0048639 62 0.016
organic substance transport GO:0071702 257 0.015
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
organelle fission GO:0048285 340 0.015
positive regulation of photoreceptor cell differentiation GO:0046534 12 0.015
vesicle fusion GO:0006906 19 0.015
muscle organ development GO:0007517 127 0.015
regulation of cellular protein catabolic process GO:1903362 44 0.015
positive regulation of rna biosynthetic process GO:1902680 266 0.015
negative regulation of photoreceptor cell differentiation GO:0046533 8 0.015
regulation of proteolysis GO:0030162 87 0.015
erbb signaling pathway GO:0038127 58 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.015
negative regulation of smoothened signaling pathway GO:0045879 16 0.015
compound eye photoreceptor development GO:0042051 78 0.015
regulation of lipid transport GO:0032368 3 0.015
purine ribonucleotide catabolic process GO:0009154 109 0.015
centriole replication GO:0007099 24 0.015
regulation of cell cycle process GO:0010564 181 0.015
regulation of anatomical structure morphogenesis GO:0022603 242 0.015
organonitrogen compound catabolic process GO:1901565 128 0.015
purine containing compound catabolic process GO:0072523 112 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
growth GO:0040007 359 0.014
regulation of multicellular organism growth GO:0040014 40 0.014
positive regulation of signal transduction GO:0009967 223 0.014
axon guidance GO:0007411 233 0.014
organic cyclic compound catabolic process GO:1901361 168 0.014
purine ribonucleotide metabolic process GO:0009150 145 0.014
body morphogenesis GO:0010171 2 0.014
regulation of cytoskeleton organization GO:0051493 89 0.014
cell division GO:0051301 248 0.014
negative regulation of transferase activity GO:0051348 18 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
negative regulation of epithelial cell migration GO:0010633 1 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
cell cell junction assembly GO:0007043 38 0.014
head involution GO:0008258 35 0.014
dorsal ventral pattern formation GO:0009953 133 0.014
regulation of molecular function GO:0065009 217 0.014
Human Mouse
regulation of photoreceptor cell differentiation GO:0046532 34 0.014
inorganic cation transmembrane transport GO:0098662 61 0.014
Human Mouse
head development GO:0060322 135 0.014
positive regulation of cellular biosynthetic process GO:0031328 316 0.014
phototransduction GO:0007602 52 0.014
nucleocytoplasmic transport GO:0006913 72 0.014
regulation of embryonic development GO:0045995 68 0.014
single organism biosynthetic process GO:0044711 206 0.013
tissue death GO:0016271 102 0.013
cellular response to growth factor stimulus GO:0071363 30 0.013
taxis GO:0042330 304 0.013
chromosome organization GO:0051276 360 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
protein maturation GO:0051604 71 0.013
negative regulation of erbb signaling pathway GO:1901185 29 0.013
smad protein import into nucleus GO:0007184 11 0.013
single organismal cell cell adhesion GO:0016337 45 0.013
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.013
cytoskeleton dependent cytokinesis GO:0061640 81 0.013
positive regulation of cell cycle g2 m phase transition GO:1902751 2 0.013
positive regulation of gtp catabolic process GO:0033126 43 0.013
negative regulation of phosphorylation GO:0042326 35 0.013
Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.013
nucleoside triphosphate metabolic process GO:0009141 120 0.013
developmental cell growth GO:0048588 52 0.013
ubiquitin dependent protein catabolic process GO:0006511 78 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.013
nucleoside metabolic process GO:0009116 127 0.013
microtubule organizing center organization GO:0031023 168 0.013
water homeostasis GO:0030104 3 0.013
negative regulation of r7 cell differentiation GO:0045677 2 0.013
convergent extension GO:0060026 2 0.012
embryonic pattern specification GO:0009880 174 0.012
compound eye retinal cell programmed cell death GO:0046667 23 0.012
regulation of catabolic process GO:0009894 170 0.012
transcription from rna polymerase ii promoter GO:0006366 368 0.012
mitotic g2 m transition checkpoint GO:0044818 70 0.012
cellular macromolecule localization GO:0070727 220 0.012
reproductive behavior GO:0019098 122 0.012
salivary gland development GO:0007431 162 0.012
regulation of purine nucleotide catabolic process GO:0033121 48 0.012
regulation of neurogenesis GO:0050767 158 0.012
cell cycle phase transition GO:0044770 140 0.012
regulation of mapk cascade GO:0043408 92 0.012
regulation of rhodopsin mediated signaling pathway GO:0022400 17 0.012
regulation of cell proliferation GO:0042127 163 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
response to glucose GO:0009749 2 0.012
aromatic compound catabolic process GO:0019439 166 0.012
canonical wnt signaling pathway GO:0060070 21 0.012
regulation of transferase activity GO:0051338 58 0.012
sulfur compound metabolic process GO:0006790 59 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
positive regulation of protein metabolic process GO:0051247 128 0.012
olfactory learning GO:0008355 56 0.012
cuticle pattern formation GO:0035017 27 0.012
establishment of protein localization GO:0045184 163 0.012
regulation of defense response GO:0031347 102 0.012
Mouse
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.012
cell junction assembly GO:0034329 42 0.012
torc1 signaling GO:0038202 12 0.012
guanosine containing compound catabolic process GO:1901069 74 0.012
regulation of protein metabolic process GO:0051246 256 0.012
Mouse
amine metabolic process GO:0009308 12 0.012
ameboidal type cell migration GO:0001667 151 0.011
axis specification GO:0009798 167 0.011
negative regulation of gene expression GO:0010629 387 0.011
regulation of kinase activity GO:0043549 53 0.011
mapk cascade GO:0000165 107 0.011
regulation of reproductive process GO:2000241 54 0.011
ribonucleoside triphosphate catabolic process GO:0009203 108 0.011
positive regulation of cell motility GO:2000147 3 0.011
heterocycle catabolic process GO:0046700 166 0.011
cell cycle checkpoint GO:0000075 95 0.011
positive regulation of growth GO:0045927 75 0.011
skeletal muscle fiber development GO:0048741 3 0.011
regulation of erk1 and erk2 cascade GO:0070372 39 0.011
endomembrane system organization GO:0010256 119 0.011
salivary gland cell autophagic cell death GO:0035071 83 0.011
cellular lipid metabolic process GO:0044255 83 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.011
regulation of proteasomal protein catabolic process GO:0061136 39 0.011
carbohydrate derivative catabolic process GO:1901136 118 0.011
gtp metabolic process GO:0046039 72 0.011
larval development GO:0002164 104 0.011
endosomal transport GO:0016197 44 0.011
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 4 0.011
negative regulation of cytoskeleton organization GO:0051494 30 0.011
olfactory behavior GO:0042048 97 0.011
negative regulation of proteolysis GO:0045861 31 0.011
negative regulation of protein phosphorylation GO:0001933 17 0.011
Mouse
regulation of protein catabolic process GO:0042176 55 0.011
axis elongation GO:0003401 3 0.011
antennal morphogenesis GO:0048800 14 0.011
biological adhesion GO:0022610 138 0.011
regulation of rho protein signal transduction GO:0035023 20 0.011
epithelial cell development GO:0002064 274 0.011
wnt signaling pathway planar cell polarity pathway GO:0060071 6 0.011
negative regulation of notch signaling pathway GO:0045746 41 0.010
regulation of protein kinase activity GO:0045859 51 0.010
positive regulation of ras gtpase activity GO:0032320 36 0.010
forebrain development GO:0030900 2 0.010
rho protein signal transduction GO:0007266 14 0.010
photoreceptor cell fate commitment GO:0046552 41 0.010
cellular response to organic substance GO:0071310 132 0.010
negative regulation of epithelial cell proliferation GO:0050680 4 0.010
mitotic sister chromatid separation GO:0051306 30 0.010
cell aging GO:0007569 2 0.010
columnar cuboidal epithelial cell development GO:0002066 249 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
leg disc morphogenesis GO:0007478 80 0.010
gtp catabolic process GO:0006184 72 0.010
posttranscriptional regulation of gene expression GO:0010608 145 0.010
stem cell differentiation GO:0048863 117 0.010
r7 cell fate commitment GO:0007465 12 0.010

fray disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.015
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.012