Drosophila melanogaster

9 known processes

HLH4C (Dmel_CG3052)

Helix loop helix protein 4C

(Aliases: CG3052,DroNHLH,EG:84H4.2,bHLH36,Dmel\CG3052)

HLH4C biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of rna biosynthetic process GO:1902679 240 0.253
photoreceptor cell differentiation GO:0046530 170 0.174
epithelial cell development GO:0002064 274 0.157
regulation of cell cycle GO:0051726 291 0.121
eye antennal disc morphogenesis GO:0007455 34 0.121
response to oxygen containing compound GO:1901700 200 0.117
synaptic transmission GO:0007268 288 0.101
embryonic morphogenesis GO:0048598 206 0.093
negative regulation of rna metabolic process GO:0051253 251 0.090
compound eye development GO:0048749 307 0.089
membrane fusion GO:0061025 42 0.088
taxis GO:0042330 304 0.084
cell migration GO:0016477 238 0.083
sensory organ morphogenesis GO:0090596 260 0.075
organelle fission GO:0048285 340 0.072
telencephalon development GO:0021537 2 0.070
vesicle mediated transport GO:0016192 381 0.070
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.069
Human Fly
chaeta development GO:0022416 97 0.069
axon development GO:0061564 297 0.065
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.065
Human Fly
macromolecular complex assembly GO:0065003 256 0.063
localization of cell GO:0051674 257 0.060
axon guidance GO:0007411 233 0.060
negative regulation of cellular biosynthetic process GO:0031327 277 0.058
negative regulation of gene expression GO:0010629 387 0.054
intracellular transport GO:0046907 228 0.053
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.052
immune system process GO:0002376 347 0.051
regulation of cellular localization GO:0060341 136 0.049
Fly
positive regulation of rna metabolic process GO:0051254 271 0.048
Human Fly
compound eye morphogenesis GO:0001745 249 0.048
mitotic spindle organization GO:0007052 220 0.047
axonogenesis GO:0007409 290 0.046
chemotaxis GO:0006935 249 0.043
anterior posterior pattern specification GO:0009952 136 0.042
cell motility GO:0048870 251 0.042
nuclear division GO:0000280 332 0.042
segmentation GO:0035282 207 0.042
tube morphogenesis GO:0035239 191 0.040
dendrite development GO:0016358 204 0.040
positive regulation of rna biosynthetic process GO:1902680 266 0.039
Human Fly
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.039
regulation of organelle organization GO:0033043 196 0.037
cellular protein localization GO:0034613 160 0.037
positive regulation of transport GO:0051050 92 0.036
Fly
cell fate determination GO:0001709 91 0.035
chaeta morphogenesis GO:0008407 42 0.034
compound eye photoreceptor cell differentiation GO:0001751 140 0.034
regulation of cell development GO:0060284 215 0.034
cellular macromolecular complex assembly GO:0034622 153 0.034
regulation of neuron differentiation GO:0045664 103 0.033
forebrain development GO:0030900 2 0.033
gland development GO:0048732 191 0.033
secretion by cell GO:0032940 101 0.031
Fly
negative regulation of nucleic acid templated transcription GO:1903507 240 0.031
protein localization GO:0008104 284 0.031
gland morphogenesis GO:0022612 145 0.031
positive regulation of exocytosis GO:0045921 4 0.030
neuron projection guidance GO:0097485 241 0.029
negative regulation of transcription dna templated GO:0045892 237 0.029
homeostatic process GO:0042592 199 0.028
establishment of protein localization GO:0045184 163 0.028
establishment of localization in cell GO:0051649 402 0.028
Fly
regulation of synapse structure and activity GO:0050803 128 0.027
eye photoreceptor cell differentiation GO:0001754 145 0.026
regulation of multicellular organismal development GO:2000026 414 0.025
positive regulation of organelle organization GO:0010638 65 0.025
hindbrain development GO:0030902 2 0.025
regulation of nervous system development GO:0051960 248 0.024
negative regulation of biosynthetic process GO:0009890 277 0.024
exocytosis GO:0006887 28 0.024
regionalization GO:0003002 416 0.024
tube development GO:0035295 244 0.024
epithelial cell morphogenesis GO:0003382 25 0.024
nucleoside phosphate biosynthetic process GO:1901293 34 0.023
metal ion homeostasis GO:0055065 44 0.023
brain development GO:0007420 120 0.023
negative regulation of developmental process GO:0051093 201 0.022
digestive system development GO:0055123 149 0.022
dorsal appendage formation GO:0046843 47 0.022
regulation of synaptic transmission GO:0050804 69 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.021
regulation of behavior GO:0050795 75 0.021
axis specification GO:0009798 167 0.021
cellular response to chemical stimulus GO:0070887 199 0.021
negative regulation of nervous system development GO:0051961 92 0.021
ion homeostasis GO:0050801 55 0.021
spinal cord development GO:0021510 1 0.021
regulation of mitotic cell cycle GO:0007346 190 0.021
regulation of vesicle mediated transport GO:0060627 59 0.020
smoothened signaling pathway GO:0007224 49 0.020
positive regulation of growth GO:0045927 75 0.020
dephosphorylation GO:0016311 51 0.020
epithelial cell differentiation GO:0030855 322 0.020
Fly
microtubule based movement GO:0007018 51 0.020
regulation of epithelial cell differentiation GO:0030856 4 0.019
regulation of cell cycle process GO:0010564 181 0.019
oocyte differentiation GO:0009994 145 0.019
appendage development GO:0048736 401 0.019
negative regulation of gene expression epigenetic GO:0045814 77 0.019
positive regulation of signaling GO:0023056 243 0.019
Fly
spindle organization GO:0007051 253 0.018
germarium derived egg chamber formation GO:0007293 101 0.018
developmental maturation GO:0021700 172 0.018
mitotic cell cycle phase transition GO:0044772 138 0.017
positive regulation of cyclase activity GO:0031281 9 0.017
negative regulation of cellular metabolic process GO:0031324 382 0.016
cellular macromolecule localization GO:0070727 220 0.016
regulation of cellular component size GO:0032535 98 0.016
regulation of neuroblast proliferation GO:1902692 34 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
regulation of cell differentiation GO:0045595 302 0.016
negative regulation of cellular component organization GO:0051129 108 0.016
gastrulation GO:0007369 70 0.015
cell maturation GO:0048469 144 0.015
regulation of catalytic activity GO:0050790 185 0.015
response to organic substance GO:0010033 284 0.015
single organism intracellular transport GO:1902582 207 0.015
ribose phosphate metabolic process GO:0019693 145 0.015
morphogenesis of a branching structure GO:0001763 45 0.015
secretion GO:0046903 109 0.014
Fly
positive regulation of nucleic acid templated transcription GO:1903508 266 0.014
Human Fly
nucleoside phosphate metabolic process GO:0006753 162 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.014
regulation of molecular function GO:0065009 217 0.014
olfactory behavior GO:0042048 97 0.014
protein dna complex subunit organization GO:0071824 86 0.014
eye morphogenesis GO:0048592 260 0.014
photoreceptor cell development GO:0042461 96 0.014
negative regulation of mitotic cell cycle GO:0045930 109 0.014
inorganic cation transmembrane transport GO:0098662 61 0.013
single organism biosynthetic process GO:0044711 206 0.013
endodermal cell fate commitment GO:0001711 3 0.013
body morphogenesis GO:0010171 2 0.013
regulation of lyase activity GO:0051339 14 0.013
ovarian follicle cell development GO:0030707 248 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
Fly
tripartite regional subdivision GO:0007351 103 0.013
mitochondrion organization GO:0007005 65 0.013
negative regulation of cell cycle process GO:0010948 109 0.013
embryonic axis specification GO:0000578 107 0.013
digestive tract development GO:0048565 149 0.013
regulation of protein stability GO:0031647 43 0.013
chemosensory behavior GO:0007635 106 0.013
mitotic g2 m transition checkpoint GO:0044818 70 0.013
regulation of mitotic cell cycle phase transition GO:1901990 130 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
regulation of mitosis GO:0007088 56 0.013
embryonic pattern specification GO:0009880 174 0.013
endodermal cell differentiation GO:0035987 3 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
negative regulation of multicellular organismal process GO:0051241 142 0.013
regulation of transport GO:0051049 181 0.013
Fly
phosphatidylinositol mediated signaling GO:0048015 4 0.012
hindgut morphogenesis GO:0007442 58 0.012
lymph gland development GO:0048542 28 0.012
g2 dna damage checkpoint GO:0031572 69 0.012
metal ion transport GO:0030001 74 0.012
positive regulation of developmental growth GO:0048639 62 0.012
neuron fate commitment GO:0048663 50 0.012
organ formation GO:0048645 39 0.012
organelle fusion GO:0048284 46 0.012
spinal cord dorsal ventral patterning GO:0021513 1 0.012
hindgut development GO:0061525 58 0.012
single organism behavior GO:0044708 391 0.012
cellular protein complex assembly GO:0043623 71 0.012
modification dependent protein catabolic process GO:0019941 78 0.012
neuron fate specification GO:0048665 12 0.012
anatomical structure homeostasis GO:0060249 97 0.012
larval behavior GO:0030537 42 0.012
cellular carbohydrate metabolic process GO:0044262 22 0.012
eye photoreceptor cell development GO:0042462 81 0.012
stem cell differentiation GO:0048863 117 0.012
neuroblast proliferation GO:0007405 74 0.012
apical constriction GO:0003383 18 0.012
anterior posterior axis specification embryo GO:0008595 103 0.012
female meiotic division GO:0007143 70 0.011
spinal cord patterning GO:0021511 1 0.011
positive regulation of multicellular organismal process GO:0051240 143 0.011
protein polymerization GO:0051258 42 0.011
salivary gland morphogenesis GO:0007435 145 0.011
exocrine system development GO:0035272 162 0.011
dna templated transcription initiation GO:0006352 25 0.011
protein ubiquitination GO:0016567 70 0.011
neuron recognition GO:0008038 101 0.011
epidermal growth factor receptor signaling pathway GO:0007173 58 0.011
response to mechanical stimulus GO:0009612 28 0.011
macromolecule catabolic process GO:0009057 161 0.011
negative regulation of insulin secretion GO:0046676 1 0.011
wnt signaling pathway GO:0016055 98 0.011
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.011
maintenance of protein location in cell GO:0032507 26 0.011
cell recognition GO:0008037 102 0.011
response to biotic stimulus GO:0009607 294 0.011
maintenance of location GO:0051235 73 0.011
Worm
chemical homeostasis GO:0048878 92 0.011
dendrite morphogenesis GO:0048813 199 0.011
antennal morphogenesis GO:0048800 14 0.011
eye antennal disc development GO:0035214 60 0.011
mesoderm development GO:0007498 78 0.011
regulation of neurogenesis GO:0050767 158 0.011
camera type eye morphogenesis GO:0048593 2 0.011
rna processing GO:0006396 147 0.011
tissue morphogenesis GO:0048729 297 0.011
cellular divalent inorganic cation homeostasis GO:0072503 23 0.010
regulation of neuron projection development GO:0010975 69 0.010
regulation of localization GO:0032879 275 0.010
Fly
nucleus localization GO:0051647 34 0.010
regulation of cyclase activity GO:0031279 13 0.010
cyclic purine nucleotide metabolic process GO:0052652 25 0.010
cell fate commitment involved in pattern specification GO:0060581 31 0.010
positive regulation of signal transduction GO:0009967 223 0.010
regulation of anatomical structure size GO:0090066 163 0.010
cgmp biosynthetic process GO:0006182 8 0.010
leg disc development GO:0035218 92 0.010
regulation of cellular amine metabolic process GO:0033238 3 0.010
peptide metabolic process GO:0006518 80 0.010

HLH4C disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027