Drosophila melanogaster

27 known processes

Wwox (Dmel_CG7221)

CG7221 gene product from transcript CG7221-RA

(Aliases: CG7221,Dmel\CG7221,DmWWOX,anon-EST:Posey177)

Wwox biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular protein modification process GO:0006464 438 0.198
protein modification process GO:0036211 438 0.166
small molecule metabolic process GO:0044281 305 0.071
response to biotic stimulus GO:0009607 294 0.065
phosphorylation GO:0016310 294 0.064
organonitrogen compound metabolic process GO:1901564 318 0.063
response to abiotic stimulus GO:0009628 341 0.059
response to other organism GO:0051707 293 0.058
response to external biotic stimulus GO:0043207 293 0.057
intracellular signal transduction GO:0035556 300 0.048
Mouse
actin filament based process GO:0030029 220 0.048
compound eye development GO:0048749 307 0.047
catabolic process GO:0009056 409 0.046
chromosome organization GO:0051276 360 0.043
regulation of catalytic activity GO:0050790 185 0.042
post embryonic appendage morphogenesis GO:0035120 385 0.041
imaginal disc derived appendage morphogenesis GO:0035114 395 0.041
single organism biosynthetic process GO:0044711 206 0.040
appendage development GO:0048736 401 0.040
response to bacterium GO:0009617 198 0.040
defense response GO:0006952 300 0.038
regulation of intracellular signal transduction GO:1902531 236 0.038
carbohydrate derivative metabolic process GO:1901135 217 0.034
neurological system process GO:0050877 358 0.034
single organism behavior GO:0044708 391 0.033
establishment of localization in cell GO:0051649 402 0.032
organic acid metabolic process GO:0006082 103 0.030
programmed cell death GO:0012501 257 0.030
Mouse
negative regulation of phosphorus metabolic process GO:0010563 45 0.029
imaginal disc derived wing morphogenesis GO:0007476 337 0.029
protein phosphorylation GO:0006468 169 0.029
immune system process GO:0002376 347 0.029
mapk cascade GO:0000165 107 0.029
regulation of phosphorus metabolic process GO:0051174 210 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.029
Mouse
positive regulation of signal transduction GO:0009967 223 0.029
Mouse
homeostatic process GO:0042592 199 0.028
wing disc morphogenesis GO:0007472 344 0.028
positive regulation of catalytic activity GO:0043085 118 0.028
organic substance catabolic process GO:1901575 308 0.028
transcription from rna polymerase ii promoter GO:0006366 368 0.027
Mouse
cellular catabolic process GO:0044248 372 0.027
regulation of cell death GO:0010941 173 0.027
Mouse
response to extracellular stimulus GO:0009991 116 0.027
immune response GO:0006955 246 0.026
negative regulation of cellular metabolic process GO:0031324 382 0.026
dephosphorylation GO:0016311 51 0.026
eye development GO:0001654 323 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.026
Mouse
defense response to other organism GO:0098542 225 0.025
positive regulation of signaling GO:0023056 243 0.025
Mouse
vesicle mediated transport GO:0016192 381 0.024
proteolysis GO:0006508 192 0.024
actin filament organization GO:0007015 126 0.024
positive regulation of phosphorus metabolic process GO:0010562 139 0.024
protein localization GO:0008104 284 0.023
signal transduction by phosphorylation GO:0023014 107 0.023
rna processing GO:0006396 147 0.023
single organism catabolic process GO:0044712 228 0.023
regulation of molecular function GO:0065009 217 0.023
regulation of hydrolase activity GO:0051336 97 0.023
eye morphogenesis GO:0048592 260 0.023
negative regulation of cell communication GO:0010648 223 0.023
Human
negative regulation of gene expression GO:0010629 387 0.023
organonitrogen compound catabolic process GO:1901565 128 0.021
sensory perception GO:0007600 196 0.021
carboxylic acid metabolic process GO:0019752 92 0.021
imaginal disc derived appendage development GO:0048737 399 0.021
cellular macromolecule localization GO:0070727 220 0.020
negative regulation of signal transduction GO:0009968 206 0.020
Human
sensory organ morphogenesis GO:0090596 260 0.020
regulation of cellular protein metabolic process GO:0032268 243 0.020
regulation of cellular amine metabolic process GO:0033238 3 0.020
oocyte differentiation GO:0009994 145 0.019
purine ribonucleotide metabolic process GO:0009150 145 0.019
positive regulation of molecular function GO:0044093 136 0.019
regulation of mapk cascade GO:0043408 92 0.019
ion transport GO:0006811 145 0.019
cell death GO:0008219 279 0.019
Mouse
sensory perception of chemical stimulus GO:0007606 116 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
positive regulation of cell death GO:0010942 69 0.019
Mouse
positive regulation of cell communication GO:0010647 250 0.018
Mouse
organic substance transport GO:0071702 257 0.018
appendage morphogenesis GO:0035107 397 0.018
oxoacid metabolic process GO:0043436 103 0.018
actin cytoskeleton organization GO:0030036 206 0.018
negative regulation of phosphate metabolic process GO:0045936 45 0.018
response to organophosphorus GO:0046683 2 0.018
response to oxygen containing compound GO:1901700 200 0.018
positive regulation of response to stimulus GO:0048584 323 0.017
Mouse
regionalization GO:0003002 416 0.017
germarium derived egg chamber formation GO:0007293 101 0.017
defense response to bacterium GO:0042742 178 0.017
positive regulation of phosphate metabolic process GO:0045937 139 0.017
taxis GO:0042330 304 0.017
response to organic substance GO:0010033 284 0.017
Human Mouse
cellular response to chemical stimulus GO:0070887 199 0.017
Human Mouse
response to nutrient levels GO:0031667 114 0.017
carbohydrate derivative biosynthetic process GO:1901137 85 0.017
synaptic transmission GO:0007268 288 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
metal ion transport GO:0030001 74 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.016
small gtpase mediated signal transduction GO:0007264 88 0.016
embryonic development via the syncytial blastoderm GO:0001700 148 0.016
regulation of programmed cell death GO:0043067 152 0.016
Mouse
secondary metabolic process GO:0019748 75 0.016
endocytosis GO:0006897 310 0.016
xenobiotic catabolic process GO:0042178 1 0.016
regulation of small gtpase mediated signal transduction GO:0051056 93 0.016
regulation of cell cycle GO:0051726 291 0.016
ribose phosphate metabolic process GO:0019693 145 0.016
nuclear division GO:0000280 332 0.015
regulation of phosphorylation GO:0042325 147 0.015
phagocytosis GO:0006909 215 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
Mouse
innate immune response GO:0045087 144 0.015
male gamete generation GO:0048232 201 0.015
macromolecule catabolic process GO:0009057 161 0.015
organelle assembly GO:0070925 198 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
Mouse
muscle organ development GO:0007517 127 0.015
regulation of proteolysis GO:0030162 87 0.015
compound eye morphogenesis GO:0001745 249 0.014
steroid catabolic process GO:0006706 1 0.014
cellular ketone metabolic process GO:0042180 24 0.014
purine containing compound metabolic process GO:0072521 155 0.014
regulation of endopeptidase activity GO:0052548 36 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
regulation of anatomical structure size GO:0090066 163 0.013
organelle fission GO:0048285 340 0.013
nitrogen compound transport GO:0071705 85 0.013
dendrite morphogenesis GO:0048813 199 0.013
regulation of protein metabolic process GO:0051246 256 0.013
aromatic compound catabolic process GO:0019439 166 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
regulation of cellular component biogenesis GO:0044087 201 0.013
segmentation GO:0035282 207 0.013
ribonucleoside triphosphate catabolic process GO:0009203 108 0.013
salivary gland morphogenesis GO:0007435 145 0.013
cellular response to dna damage stimulus GO:0006974 223 0.013
positive regulation of hydrolase activity GO:0051345 78 0.013
death GO:0016265 284 0.013
Mouse
exocrine system development GO:0035272 162 0.013
protein transport GO:0015031 155 0.013
membrane organization GO:0061024 112 0.013
spermatogenesis GO:0007283 200 0.013
heart process GO:0003015 37 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
organic cyclic compound catabolic process GO:1901361 168 0.012
negative regulation of signaling GO:0023057 219 0.012
Human
macromolecular complex assembly GO:0065003 256 0.012
secretion GO:0046903 109 0.012
neuromuscular junction development GO:0007528 149 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
nucleoside phosphate catabolic process GO:1901292 110 0.012
regulation of notch signaling pathway GO:0008593 100 0.012
anatomical structure homeostasis GO:0060249 97 0.012
regulation of localization GO:0032879 275 0.012
positive regulation of gene expression GO:0010628 290 0.012
Mouse
negative regulation of cell cycle GO:0045786 116 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
cellular homeostasis GO:0019725 80 0.012
regulation of organelle organization GO:0033043 196 0.012
purine nucleotide metabolic process GO:0006163 146 0.012
camera type eye development GO:0043010 4 0.012
muscle structure development GO:0061061 224 0.012
regulation of nervous system development GO:0051960 248 0.012
erk1 and erk2 cascade GO:0070371 39 0.012
defense response to gram negative bacterium GO:0050829 94 0.012
regulation of cell cycle process GO:0010564 181 0.011
regulation of immune system process GO:0002682 176 0.011
gene silencing GO:0016458 138 0.011
response to endogenous stimulus GO:0009719 119 0.011
Human Mouse
salivary gland development GO:0007431 162 0.011
gland morphogenesis GO:0022612 145 0.011
apoptotic process GO:0006915 159 0.011
Mouse
carbohydrate derivative catabolic process GO:1901136 118 0.011
nucleotide metabolic process GO:0009117 161 0.011
regulation of purine nucleotide metabolic process GO:1900542 62 0.011
heterocycle catabolic process GO:0046700 166 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
lipid metabolic process GO:0006629 121 0.011
response to lipopolysaccharide GO:0032496 4 0.011
gland development GO:0048732 191 0.011
negative regulation of nervous system development GO:0051961 92 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
response to temperature stimulus GO:0009266 106 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
embryonic pattern specification GO:0009880 174 0.011
peptidyl amino acid modification GO:0018193 105 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
covalent chromatin modification GO:0016569 106 0.011
regulation of transferase activity GO:0051338 58 0.011
meiotic cell cycle process GO:1903046 132 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
sensory perception of pain GO:0019233 4 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
rna localization GO:0006403 115 0.011
adult behavior GO:0030534 137 0.011
response to hexose GO:0009746 3 0.010
salivary gland histolysis GO:0035070 88 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
negative regulation of developmental process GO:0051093 201 0.010
sensory perception of smell GO:0007608 80 0.010
positive regulation of cellular biosynthetic process GO:0031328 316 0.010
Mouse
regulation of mitotic cell cycle GO:0007346 190 0.010
insecticide catabolic process GO:0046701 1 0.010
histone modification GO:0016570 106 0.010
vitamin metabolic process GO:0006766 2 0.010
cellular lipid metabolic process GO:0044255 83 0.010

Wwox disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
cardiovascular system disease DOID:1287 0 0.028
artery disease DOID:0050828 0 0.015
vascular disease DOID:178 0 0.015
nervous system disease DOID:863 0 0.015
hypertension DOID:10763 0 0.011
central nervous system disease DOID:331 0 0.010