Drosophila melanogaster

58 known processes

Spn5 (Dmel_CG18525)

Serine protease inhibitor 5

(Aliases: Spn88Ea,Dmel\CG18525,Sp5,spn5,sp5,CG18525)

Spn5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
immune response GO:0006955 246 0.157
defense response GO:0006952 300 0.147
response to external biotic stimulus GO:0043207 293 0.139
organonitrogen compound metabolic process GO:1901564 318 0.116
cellular protein modification process GO:0006464 438 0.110
regulation of defense response GO:0031347 102 0.099
response to bacterium GO:0009617 198 0.092
imaginal disc derived appendage development GO:0048737 399 0.088
negative regulation of response to stimulus GO:0048585 258 0.087
response to other organism GO:0051707 293 0.087
endocytosis GO:0006897 310 0.080
negative regulation of signaling GO:0023057 219 0.080
response to biotic stimulus GO:0009607 294 0.078
steroid catabolic process GO:0006706 1 0.078
regulation of protein metabolic process GO:0051246 256 0.076
cell adhesion GO:0007155 136 0.074
negative regulation of signal transduction GO:0009968 206 0.073
defense response to bacterium GO:0042742 178 0.073
regulation of cellular protein metabolic process GO:0032268 243 0.071
negative regulation of cell communication GO:0010648 223 0.064
vesicle mediated transport GO:0016192 381 0.064
cellular amino acid metabolic process GO:0006520 61 0.064
negative regulation of catalytic activity GO:0043086 42 0.062
regulation of multi organism process GO:0043900 131 0.059
regulation of cell projection organization GO:0031344 92 0.056
defense response to other organism GO:0098542 225 0.056
negative regulation of cell development GO:0010721 62 0.052
immune system process GO:0002376 347 0.051
regionalization GO:0003002 416 0.051
homeostatic process GO:0042592 199 0.049
defense response to fungus GO:0050832 48 0.049
lateral inhibition GO:0046331 206 0.048
defense response to gram negative bacterium GO:0050829 94 0.047
innate immune response GO:0045087 144 0.047
phagocytosis GO:0006909 215 0.047
regulation of neuron projection development GO:0010975 69 0.046
regulation of catalytic activity GO:0050790 185 0.046
cell cell signaling involved in cell fate commitment GO:0045168 210 0.046
response to abiotic stimulus GO:0009628 341 0.045
amine metabolic process GO:0009308 12 0.043
negative regulation of cellular component organization GO:0051129 108 0.042
protein maturation GO:0051604 71 0.042
regulation of nervous system development GO:0051960 248 0.040
appendage development GO:0048736 401 0.040
negative regulation of cellular protein metabolic process GO:0032269 85 0.040
regulation of cellular amine metabolic process GO:0033238 3 0.039
hormone metabolic process GO:0042445 33 0.038
regulation of localization GO:0032879 275 0.037
regulation of neuron differentiation GO:0045664 103 0.037
regulation of cell differentiation GO:0045595 302 0.036
establishment of glial blood brain barrier GO:0060857 14 0.036
biological adhesion GO:0022610 138 0.036
cellular response to chemical stimulus GO:0070887 199 0.036
response to lipopolysaccharide GO:0032496 4 0.036
organic acid metabolic process GO:0006082 103 0.036
organic substance transport GO:0071702 257 0.035
imaginal disc derived wing morphogenesis GO:0007476 337 0.035
regulation of intracellular signal transduction GO:1902531 236 0.035
oxoacid metabolic process GO:0043436 103 0.034
humoral immune response GO:0006959 117 0.033
regulation of peptidase activity GO:0052547 39 0.033
negative regulation of cellular metabolic process GO:0031324 382 0.033
regulation of immune system process GO:0002682 176 0.032
cellular response to hormone stimulus GO:0032870 44 0.032
cellular ketone metabolic process GO:0042180 24 0.032
regulation of response to biotic stimulus GO:0002831 63 0.032
body morphogenesis GO:0010171 2 0.032
neurological system process GO:0050877 358 0.032
response to fungus GO:0009620 50 0.032
regulation of multicellular organismal development GO:2000026 414 0.032
phosphorylation GO:0016310 294 0.032
appendage morphogenesis GO:0035107 397 0.031
negative regulation of protein metabolic process GO:0051248 85 0.031
imaginal disc derived appendage morphogenesis GO:0035114 395 0.031
regulation of response to external stimulus GO:0032101 115 0.030
cell proliferation GO:0008283 299 0.030
protein phosphorylation GO:0006468 169 0.030
negative regulation of multicellular organismal process GO:0051241 142 0.029
positive regulation of signaling GO:0023056 243 0.029
antimicrobial humoral response GO:0019730 99 0.029
cellular amine metabolic process GO:0044106 12 0.029
mapk cascade GO:0000165 107 0.029
forebrain development GO:0030900 2 0.029
response to wounding GO:0009611 94 0.028
signal transduction by phosphorylation GO:0023014 107 0.028
regulation of phosphorus metabolic process GO:0051174 210 0.028
negative regulation of gene expression GO:0010629 387 0.028
regulation of cell development GO:0060284 215 0.027
cellular response to endogenous stimulus GO:0071495 80 0.027
cellular macromolecule localization GO:0070727 220 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
regulation of neurogenesis GO:0050767 158 0.027
wing disc morphogenesis GO:0007472 344 0.027
negative regulation of neurogenesis GO:0050768 53 0.027
glycosyl compound catabolic process GO:1901658 112 0.026
regulation of immune response GO:0050776 118 0.026
protein processing GO:0016485 68 0.026
regulation of mapk cascade GO:0043408 92 0.026
regulation of cellular ketone metabolic process GO:0010565 3 0.026
mushroom body development GO:0016319 70 0.025
secretion by cell GO:0032940 101 0.025
peptide metabolic process GO:0006518 80 0.025
cation transport GO:0006812 110 0.025
regulation of cell substrate adhesion GO:0010810 2 0.025
protein modification process GO:0036211 438 0.024
regulation of hydrolase activity GO:0051336 97 0.024
detection of stimulus GO:0051606 156 0.024
proteolysis GO:0006508 192 0.024
eye development GO:0001654 323 0.024
cellular response to organic substance GO:0071310 132 0.024
establishment of localization in cell GO:0051649 402 0.024
small molecule metabolic process GO:0044281 305 0.024
positive regulation of cell communication GO:0010647 250 0.024
post embryonic appendage morphogenesis GO:0035120 385 0.024
intracellular signal transduction GO:0035556 300 0.023
single organism behavior GO:0044708 391 0.023
aging GO:0007568 143 0.023
sensory perception GO:0007600 196 0.023
regulation of proteolysis GO:0030162 87 0.022
negative regulation of immune system process GO:0002683 50 0.022
regulation of molecular function GO:0065009 217 0.021
signal release GO:0023061 49 0.021
hormone catabolic process GO:0042447 3 0.021
peptidyl amino acid modification GO:0018193 105 0.021
programmed cell death GO:0012501 257 0.021
protein localization GO:0008104 284 0.021
negative regulation of developmental process GO:0051093 201 0.021
response to organic substance GO:0010033 284 0.020
carboxylic acid metabolic process GO:0019752 92 0.020
regulation of phosphate metabolic process GO:0019220 210 0.020
ribonucleoside catabolic process GO:0042454 112 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.020
negative regulation of molecular function GO:0044092 51 0.020
anatomical structure homeostasis GO:0060249 97 0.019
cell death GO:0008219 279 0.019
chemotaxis GO:0006935 249 0.019
open tracheal system development GO:0007424 204 0.019
regulation of hormone levels GO:0010817 40 0.019
androgen metabolic process GO:0008209 1 0.018
immune response activating signal transduction GO:0002757 2 0.018
negative regulation of response to external stimulus GO:0032102 22 0.018
cell cell junction organization GO:0045216 55 0.018
immune response regulating signaling pathway GO:0002764 2 0.018
organic cyclic compound catabolic process GO:1901361 168 0.018
neuron projection guidance GO:0097485 241 0.017
camera type eye development GO:0043010 4 0.017
ion transport GO:0006811 145 0.017
positive regulation of response to stimulus GO:0048584 323 0.017
regulation of tube size open tracheal system GO:0035151 43 0.017
regulation of cellular localization GO:0060341 136 0.017
actin cytoskeleton organization GO:0030036 206 0.016
regulation of cell adhesion GO:0030155 27 0.016
developmental programmed cell death GO:0010623 138 0.016
embryonic pattern specification GO:0009880 174 0.016
death GO:0016265 284 0.016
antifungal humoral response GO:0019732 12 0.016
aromatic compound catabolic process GO:0019439 166 0.016
axis specification GO:0009798 167 0.016
actin filament based process GO:0030029 220 0.016
telencephalon development GO:0021537 2 0.016
central nervous system development GO:0007417 201 0.016
cellular protein localization GO:0034613 160 0.016
growth GO:0040007 359 0.016
g protein coupled receptor signaling pathway GO:0007186 136 0.015
ras protein signal transduction GO:0007265 88 0.015
regulation of cell proliferation GO:0042127 163 0.015
response to nutrient levels GO:0031667 114 0.015
taxis GO:0042330 304 0.015
regulation of protein modification process GO:0031399 112 0.015
regulation of membrane potential GO:0042391 35 0.015
negative regulation of nervous system development GO:0051961 92 0.015
kidney development GO:0001822 3 0.015
compound eye development GO:0048749 307 0.015
negative regulation of cell differentiation GO:0045596 143 0.015
nitrogen compound transport GO:0071705 85 0.015
substrate adhesion dependent cell spreading GO:0034446 2 0.015
head development GO:0060322 135 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.015
cell cycle phase transition GO:0044770 140 0.015
tube development GO:0035295 244 0.015
carbohydrate derivative metabolic process GO:1901135 217 0.014
negative regulation of protein processing GO:0010955 31 0.014
negative regulation of defense response GO:0031348 35 0.014
regulation of protein serine threonine kinase activity GO:0071900 25 0.014
regulation of antimicrobial humoral response GO:0002759 50 0.014
ribonucleotide metabolic process GO:0009259 145 0.014
cell cell junction assembly GO:0007043 38 0.014
negative regulation of phosphate metabolic process GO:0045936 45 0.014
response to endogenous stimulus GO:0009719 119 0.014
response to hormone GO:0009725 45 0.014
wound healing GO:0042060 75 0.014
tissue morphogenesis GO:0048729 297 0.014
nucleoside triphosphate catabolic process GO:0009143 108 0.014
segmentation GO:0035282 207 0.014
cuticle development GO:0042335 86 0.014
cellular catabolic process GO:0044248 372 0.014
tube morphogenesis GO:0035239 191 0.014
respiratory system development GO:0060541 213 0.014
lipid metabolic process GO:0006629 121 0.014
regulation of cell morphogenesis GO:0022604 163 0.013
multicellular organismal aging GO:0010259 140 0.013
chemical homeostasis GO:0048878 92 0.013
developmental maturation GO:0021700 172 0.013
chitin based cuticle sclerotization GO:0007593 19 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
regulation of phosphorylation GO:0042325 147 0.013
regulation of protein processing GO:0070613 32 0.013
catabolic process GO:0009056 409 0.013
regulation of catabolic process GO:0009894 170 0.013
embryonic axis specification GO:0000578 107 0.013
extracellular structure organization GO:0043062 46 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
regulation of secretion GO:0051046 44 0.013
positive regulation of signal transduction GO:0009967 223 0.013
carbohydrate metabolic process GO:0005975 82 0.013
activation of innate immune response GO:0002218 4 0.013
detection of external stimulus GO:0009581 66 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
positive regulation of cell motility GO:2000147 3 0.013
positive regulation of transport GO:0051050 92 0.012
single organism cell adhesion GO:0098602 47 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
response to oxygen containing compound GO:1901700 200 0.012
developmental growth GO:0048589 280 0.012
dendrite development GO:0016358 204 0.012
embryonic morphogenesis GO:0048598 206 0.012
regulation of response to stress GO:0080134 200 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
response to copper ion GO:0046688 4 0.012
organic substance catabolic process GO:1901575 308 0.012
single organism biosynthetic process GO:0044711 206 0.012
nucleoside catabolic process GO:0009164 112 0.012
glycoprotein metabolic process GO:0009100 41 0.012
apical junction assembly GO:0043297 32 0.012
cellular cation homeostasis GO:0030003 38 0.011
mesenchymal cell development GO:0014031 1 0.011
heterocycle catabolic process GO:0046700 166 0.011
regulation of secretion by cell GO:1903530 39 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
single organism catabolic process GO:0044712 228 0.011
adult behavior GO:0030534 137 0.011
salivary gland development GO:0007431 162 0.011
regulation of tube architecture open tracheal system GO:0035152 68 0.011
regulation of cell death GO:0010941 173 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
cell junction organization GO:0034330 57 0.011
positive regulation of cellular component biogenesis GO:0044089 80 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
embryo development ending in birth or egg hatching GO:0009792 152 0.011
regeneration GO:0031099 16 0.011
organophosphate catabolic process GO:0046434 112 0.011
establishment of blood brain barrier GO:0060856 16 0.011
determination of adult lifespan GO:0008340 137 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
regulation of immune effector process GO:0002697 52 0.011
cell motility GO:0048870 251 0.011
negative regulation of proteolysis GO:0045861 31 0.010
regulation of growth GO:0040008 233 0.010
purine nucleoside catabolic process GO:0006152 112 0.010
detection of abiotic stimulus GO:0009582 66 0.010
spinal cord development GO:0021510 1 0.010
nucleoside metabolic process GO:0009116 127 0.010
olfactory behavior GO:0042048 97 0.010
purine nucleoside triphosphate catabolic process GO:0009146 108 0.010
cellular nitrogen compound catabolic process GO:0044270 165 0.010
nucleotide metabolic process GO:0009117 161 0.010
response to organonitrogen compound GO:0010243 75 0.010
synaptic transmission GO:0007268 288 0.010
chemosensory behavior GO:0007635 106 0.010
hormone mediated signaling pathway GO:0009755 16 0.010
dephosphorylation GO:0016311 51 0.010
response to starvation GO:0042594 97 0.010

Spn5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.051
nervous system disease DOID:863 0 0.015
disease of metabolism DOID:0014667 0 0.013
sensory system disease DOID:0050155 0 0.012
musculoskeletal system disease DOID:17 0 0.010
connective tissue disease DOID:65 0 0.010
eye and adnexa disease DOID:1492 0 0.010
renal tubular transport disease DOID:447 0 0.010
kidney disease DOID:557 0 0.010
urinary system disease DOID:18 0 0.010