Drosophila melanogaster

88 known processes

Nacalpha (Dmel_CG8759)

Nascent polypeptide associated complex protein alpha subunit

(Aliases: alpha-NAC,NAC,NACalpha,alphaNAC,l(2)04329,Dmel\CG8759,CG8759,aic)

Nacalpha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis GO:0006508 192 0.593
regulation of localization GO:0032879 275 0.477
macromolecular complex assembly GO:0065003 256 0.369
dendrite development GO:0016358 204 0.340
positive regulation of biosynthetic process GO:0009891 316 0.329
Mouse
regulation of embryonic development GO:0045995 68 0.291
positive regulation of response to stimulus GO:0048584 323 0.256
response to abiotic stimulus GO:0009628 341 0.247
single organism catabolic process GO:0044712 228 0.223
regulation of multicellular organismal development GO:2000026 414 0.216
regulation of embryonic pattern specification GO:1902875 27 0.205
regulation of translation GO:0006417 56 0.200
regulation of cell differentiation GO:0045595 302 0.195
protein complex biogenesis GO:0070271 201 0.192
death GO:0016265 284 0.190
Mouse
translation GO:0006412 69 0.178
positive regulation of cell communication GO:0010647 250 0.173
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.156
Mouse
brain development GO:0007420 120 0.145
regulation of cell death GO:0010941 173 0.140
Mouse
intracellular transport GO:0046907 228 0.138
body morphogenesis GO:0010171 2 0.136
Worm
regulation of cellular ketone metabolic process GO:0010565 3 0.135
head development GO:0060322 135 0.126
positive regulation of developmental process GO:0051094 143 0.123
Mouse
organophosphate metabolic process GO:0019637 195 0.121
positive regulation of signaling GO:0023056 243 0.120
cell proliferation GO:0008283 299 0.115
Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.115
vesicle mediated transport GO:0016192 381 0.111
positive regulation of multicellular organismal process GO:0051240 143 0.109
Mouse
small molecule metabolic process GO:0044281 305 0.109
purine ribonucleotide catabolic process GO:0009154 109 0.107
regulation of cellular component biogenesis GO:0044087 201 0.105
dendrite morphogenesis GO:0048813 199 0.105
carboxylic acid metabolic process GO:0019752 92 0.097
programmed cell death GO:0012501 257 0.097
Mouse
regulation of oocyte development GO:0060281 27 0.095
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.095
Mouse
positive regulation of gene expression GO:0010628 290 0.093
Mouse
intracellular signal transduction GO:0035556 300 0.088
regulation of neurogenesis GO:0050767 158 0.086
axon development GO:0061564 297 0.084
organic substance catabolic process GO:1901575 308 0.083
cellular ketone metabolic process GO:0042180 24 0.081
cell death GO:0008219 279 0.081
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.081
Mouse
regulation of cellular localization GO:0060341 136 0.079
regulation of protein metabolic process GO:0051246 256 0.075
regulation of mrna splicing via spliceosome GO:0048024 64 0.074
purine nucleoside catabolic process GO:0006152 112 0.072
cellular catabolic process GO:0044248 372 0.072
nucleotide metabolic process GO:0009117 161 0.071
regulation of apoptotic process GO:0042981 130 0.070
Mouse
negative regulation of gene expression GO:0010629 387 0.068
Mouse
apoptotic process GO:0006915 159 0.065
Mouse
positive regulation of signal transduction GO:0009967 223 0.063
nucleotide catabolic process GO:0009166 109 0.063
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.062
Mouse
organonitrogen compound metabolic process GO:1901564 318 0.062
translational initiation GO:0006413 11 0.061
appendage morphogenesis GO:0035107 397 0.060
regulation of transport GO:0051049 181 0.060
negative regulation of cellular metabolic process GO:0031324 382 0.059
Mouse
protein localization GO:0008104 284 0.058
rna localization GO:0006403 115 0.057
cytoplasmic transport GO:0016482 130 0.056
endocytosis GO:0006897 310 0.055
tissue morphogenesis GO:0048729 297 0.055
reproductive structure development GO:0048608 74 0.054
Worm
dna metabolic process GO:0006259 227 0.054
glycosyl compound metabolic process GO:1901657 127 0.053
organelle assembly GO:0070925 198 0.052
Zebrafish
purine ribonucleoside metabolic process GO:0046128 127 0.051
cellular protein localization GO:0034613 160 0.051
ribose phosphate metabolic process GO:0019693 145 0.051
establishment of protein localization GO:0045184 163 0.051
pole plasm mrna localization GO:0019094 49 0.049
nuclear division GO:0000280 332 0.049
Worm
positive regulation of macromolecule metabolic process GO:0010604 405 0.048
Mouse
organic substance transport GO:0071702 257 0.048
posttranscriptional regulation of gene expression GO:0010608 145 0.047
carbohydrate derivative catabolic process GO:1901136 118 0.046
tube morphogenesis GO:0035239 191 0.046
carbohydrate derivative metabolic process GO:1901135 217 0.046
post embryonic appendage morphogenesis GO:0035120 385 0.046
rna splicing via transesterification reactions GO:0000375 73 0.045
purine nucleotide metabolic process GO:0006163 146 0.044
histolysis GO:0007559 102 0.044
protein dna complex subunit organization GO:0071824 86 0.043
response to temperature stimulus GO:0009266 106 0.043
membrane organization GO:0061024 112 0.043
central nervous system development GO:0007417 201 0.043
taxis GO:0042330 304 0.042
negative regulation of programmed cell death GO:0043069 72 0.042
Mouse
purine ribonucleoside catabolic process GO:0046130 112 0.042
purine nucleoside metabolic process GO:0042278 127 0.041
positive regulation of rna biosynthetic process GO:1902680 266 0.041
Mouse
single organism carbohydrate metabolic process GO:0044723 72 0.041
cell adhesion GO:0007155 136 0.041
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.040
Mouse
purine containing compound catabolic process GO:0072523 112 0.040
positive regulation of cell proliferation GO:0008284 47 0.040
Mouse
positive regulation of rna metabolic process GO:0051254 271 0.038
Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.038
Mouse
positive regulation of protein metabolic process GO:0051247 128 0.038
protein complex assembly GO:0006461 200 0.038
gland morphogenesis GO:0022612 145 0.037
negative regulation of biosynthetic process GO:0009890 277 0.037
Mouse
axonogenesis GO:0007409 290 0.036
negative regulation of rna metabolic process GO:0051253 251 0.035
Mouse
cellular lipid metabolic process GO:0044255 83 0.035
cellular macromolecule localization GO:0070727 220 0.034
neurological system process GO:0050877 358 0.034
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.034
organic cyclic compound catabolic process GO:1901361 168 0.034
tube development GO:0035295 244 0.033
tissue death GO:0016271 102 0.033
regulation of cell proliferation GO:0042127 163 0.033
Mouse
regionalization GO:0003002 416 0.032
exocrine system development GO:0035272 162 0.032
purine containing compound metabolic process GO:0072521 155 0.032
salivary gland development GO:0007431 162 0.032
protein targeting GO:0006605 64 0.032
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.031
phagocytosis GO:0006909 215 0.031
regulation of programmed cell death GO:0043067 152 0.031
Mouse
regulation of molecular function GO:0065009 217 0.031
oxoacid metabolic process GO:0043436 103 0.031
reproductive system development GO:0061458 74 0.031
Worm
gliogenesis GO:0042063 80 0.030
rna processing GO:0006396 147 0.030
ribonucleoside triphosphate catabolic process GO:0009203 108 0.030
regulation of cellular catabolic process GO:0031329 157 0.029
purine nucleoside triphosphate metabolic process GO:0009144 119 0.029
protein transport GO:0015031 155 0.029
negative regulation of developmental process GO:0051093 201 0.029
catabolic process GO:0009056 409 0.029
glycosyl compound catabolic process GO:1901658 112 0.028
regulation of rna splicing GO:0043484 69 0.028
regulation of intracellular signal transduction GO:1902531 236 0.028
heterocycle catabolic process GO:0046700 166 0.028
actin filament based process GO:0030029 220 0.028
Zebrafish
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.027
organophosphate catabolic process GO:0046434 112 0.027
single organism cellular localization GO:1902580 180 0.027
nucleoside catabolic process GO:0009164 112 0.027
salivary gland cell autophagic cell death GO:0035071 83 0.026
purine nucleoside triphosphate catabolic process GO:0009146 108 0.026
intracellular receptor signaling pathway GO:0030522 19 0.026
morphogenesis of an epithelium GO:0002009 276 0.026
nucleoside phosphate metabolic process GO:0006753 162 0.026
salivary gland histolysis GO:0035070 88 0.026
organelle fission GO:0048285 340 0.025
Worm
cell redox homeostasis GO:0045454 5 0.025
salivary gland morphogenesis GO:0007435 145 0.025
determination of adult lifespan GO:0008340 137 0.025
Worm
regulation of cell maturation GO:1903429 27 0.025
nucleobase containing small molecule metabolic process GO:0055086 174 0.024
mitotic spindle organization GO:0007052 220 0.024
establishment of localization in cell GO:0051649 402 0.024
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.024
appendage development GO:0048736 401 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.023
regulation of cellular protein metabolic process GO:0032268 243 0.023
imaginal disc derived appendage development GO:0048737 399 0.023
purine nucleoside monophosphate metabolic process GO:0009126 50 0.023
protein processing GO:0016485 68 0.023
negative regulation of signaling GO:0023057 219 0.022
positive regulation of intracellular signal transduction GO:1902533 116 0.022
regulation of phosphorus metabolic process GO:0051174 210 0.022
regulation of pole plasm oskar mrna localization GO:0007317 27 0.022
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.022
Mouse
establishment or maintenance of cell polarity GO:0007163 167 0.022
regulation of cellular amine metabolic process GO:0033238 3 0.021
homeostatic process GO:0042592 199 0.021
biological adhesion GO:0022610 138 0.021
mrna splicing via spliceosome GO:0000398 73 0.021
response to starvation GO:0042594 97 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.020
retinal metabolic process GO:0042574 2 0.020
regulation of mrna processing GO:0050684 71 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.020
Mouse
oxidation reduction process GO:0055114 123 0.020
immune response GO:0006955 246 0.020
positive regulation of immune system process GO:0002684 68 0.019
autophagic cell death GO:0048102 83 0.019
spindle assembly involved in mitosis GO:0090307 50 0.019
wing disc morphogenesis GO:0007472 344 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
maintenance of location GO:0051235 73 0.019
Worm
striated muscle myosin thick filament assembly GO:0071688 3 0.019
immune system process GO:0002376 347 0.019
nucleosome organization GO:0034728 59 0.019
positive regulation of cellular protein metabolic process GO:0032270 118 0.019
positive regulation of transport GO:0051050 92 0.019
gland development GO:0048732 191 0.019
positive regulation of phosphorylation GO:0042327 87 0.018
cellular homeostasis GO:0019725 80 0.018
negative regulation of transcription dna templated GO:0045892 237 0.018
Mouse
protein maturation GO:0051604 71 0.018
regulation of response to stress GO:0080134 200 0.018
response to extracellular stimulus GO:0009991 116 0.018
nucleoside triphosphate catabolic process GO:0009143 108 0.018
ribonucleoside triphosphate metabolic process GO:0009199 119 0.018
regulation of proteolysis GO:0030162 87 0.018
negative regulation of response to stimulus GO:0048585 258 0.018
imaginal disc derived appendage morphogenesis GO:0035114 395 0.018
lipid metabolic process GO:0006629 121 0.017
negative regulation of signal transduction GO:0009968 206 0.017
cell aging GO:0007569 2 0.017
notch signaling pathway GO:0007219 120 0.017
purine ribonucleotide metabolic process GO:0009150 145 0.017
intracellular mrna localization GO:0008298 66 0.017
cellular amine metabolic process GO:0044106 12 0.017
dorsal ventral pattern formation GO:0009953 133 0.017
rrna processing GO:0006364 3 0.016
protein modification by small protein conjugation GO:0032446 79 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.016
regulation of cell development GO:0060284 215 0.016
regulation of protein modification process GO:0031399 112 0.016
response to bacterium GO:0009617 198 0.016
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.016
response to other organism GO:0051707 293 0.016
organic acid metabolic process GO:0006082 103 0.016
multicellular organismal aging GO:0010259 140 0.016
Worm
regulation of purine nucleotide metabolic process GO:1900542 62 0.015
nucleobase containing compound catabolic process GO:0034655 165 0.015
cardiovascular system development GO:0072358 82 0.015
Mouse
positive regulation of neurogenesis GO:0050769 41 0.015
nucleoside metabolic process GO:0009116 127 0.015
response to external biotic stimulus GO:0043207 293 0.015
lipid storage GO:0019915 38 0.015
Worm
negative regulation of cell communication GO:0010648 223 0.015
carbohydrate metabolic process GO:0005975 82 0.015
cellular response to dna damage stimulus GO:0006974 223 0.014
ribonucleoside metabolic process GO:0009119 127 0.014
response to nutrient levels GO:0031667 114 0.014
generation of precursor metabolites and energy GO:0006091 42 0.014
larval development GO:0002164 104 0.014
Worm
positive regulation of ion transmembrane transporter activity GO:0032414 4 0.014
glial cell proliferation GO:0014009 13 0.014
chromatin organization GO:0006325 207 0.014
nucleocytoplasmic transport GO:0006913 72 0.014
cell cycle checkpoint GO:0000075 95 0.014
mitotic nuclear division GO:0007067 213 0.014
negative regulation of molecular function GO:0044092 51 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
cellular macromolecular complex assembly GO:0034622 153 0.013
establishment of protein localization to organelle GO:0072594 62 0.013
response to biotic stimulus GO:0009607 294 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
Mouse
aromatic compound catabolic process GO:0019439 166 0.013
negative regulation of cell death GO:0060548 81 0.013
Mouse
jak stat cascade GO:0007259 49 0.013
muscle structure development GO:0061061 224 0.013
Zebrafish Mouse
spindle organization GO:0007051 253 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
neuron projection guidance GO:0097485 241 0.013
regulation of catabolic process GO:0009894 170 0.013
fluid transport GO:0042044 19 0.012
intracellular protein transport GO:0006886 104 0.012
regulation of transmembrane transporter activity GO:0022898 6 0.012
regulation of nervous system development GO:0051960 248 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
developmental programmed cell death GO:0010623 138 0.012
circulatory system development GO:0072359 82 0.012
Mouse
ribonucleoprotein complex assembly GO:0022618 23 0.012
cellular amino acid metabolic process GO:0006520 61 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
amine metabolic process GO:0009308 12 0.012
tripartite regional subdivision GO:0007351 103 0.012
regulation of behavior GO:0050795 75 0.012
negative regulation of cell cycle GO:0045786 116 0.012
developmental growth GO:0048589 280 0.012
Mouse
apoptotic signaling pathway GO:0097190 27 0.012
regulation of catalytic activity GO:0050790 185 0.012
mrna processing GO:0006397 104 0.011
protein dna complex assembly GO:0065004 63 0.011
sesquiterpenoid metabolic process GO:0006714 3 0.011
stem cell differentiation GO:0048863 117 0.011
regulation of mrna metabolic process GO:1903311 72 0.011
atp metabolic process GO:0046034 49 0.011
mrna metabolic process GO:0016071 124 0.011
response to water deprivation GO:0009414 4 0.011
centrosome duplication GO:0051298 121 0.011
nucleoside monophosphate metabolic process GO:0009123 52 0.011
multi organism behavior GO:0051705 175 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
ribonucleotide metabolic process GO:0009259 145 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.011
Mouse
eye development GO:0001654 323 0.011
stem cell maintenance GO:0019827 67 0.010
response to decreased oxygen levels GO:0036293 58 0.010
single organism intracellular transport GO:1902582 207 0.010
nucleoside triphosphate metabolic process GO:0009141 120 0.010
growth GO:0040007 359 0.010
Mouse
oocyte construction GO:0007308 112 0.010
regulation of neuron differentiation GO:0045664 103 0.010
negative regulation of apoptotic process GO:0043066 63 0.010
Mouse
anterior posterior axis specification GO:0009948 109 0.010

Nacalpha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.114
musculoskeletal system disease DOID:17 0 0.114
muscular disease DOID:0080000 0 0.017
muscle tissue disease DOID:66 0 0.017