Drosophila melanogaster

22 known processes

Atg4 (Dmel_CG4428)

Autophagy-specific gene 4

(Aliases: Dmel\CG4428,atg4,CG4428)

Atg4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval midgut histolysis GO:0035069 22 0.942
regulation of autophagy GO:0010506 62 0.827
autophagy GO:0006914 108 0.782
autophagic vacuole assembly GO:0000045 2 0.764
Human Yeast
larval midgut cell programmed cell death GO:0035096 19 0.635
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.420
cellular response to starvation GO:0009267 61 0.398
Human Yeast
regulation of nurse cell apoptotic process GO:0045477 9 0.305
macroautophagy GO:0016236 42 0.292
Human Yeast
positive regulation of autophagy GO:0010508 21 0.288
cellular catabolic process GO:0044248 372 0.234
histolysis GO:0007559 102 0.221
Fly
catabolic process GO:0009056 409 0.206
regulation of tor signaling GO:0032006 21 0.192
regulation of cellular catabolic process GO:0031329 157 0.191
cellular response to extracellular stimulus GO:0031668 64 0.160
Human Yeast
regulation of catabolic process GO:0009894 170 0.150
cell death GO:0008219 279 0.149
Fly
response to starvation GO:0042594 97 0.147
Human Yeast
positive regulation of response to stimulus GO:0048584 323 0.143
response to oxygen containing compound GO:1901700 200 0.140
response to extracellular stimulus GO:0009991 116 0.135
Human Yeast
tissue death GO:0016271 102 0.127
Fly
inositol lipid mediated signaling GO:0048017 4 0.123
phosphatidylinositol mediated signaling GO:0048015 4 0.118
intracellular signal transduction GO:0035556 300 0.103
organelle assembly GO:0070925 198 0.102
Human Yeast
regulation of intracellular signal transduction GO:1902531 236 0.101
cellular response to external stimulus GO:0071496 66 0.098
Human Yeast
positive regulation of signaling GO:0023056 243 0.097
vesicle mediated transport GO:0016192 381 0.094
cellular response to nutrient levels GO:0031669 62 0.087
Human Yeast
protein localization GO:0008104 284 0.087
Yeast
response to nutrient levels GO:0031667 114 0.086
Human Yeast
positive regulation of catabolic process GO:0009896 105 0.083
establishment of localization in cell GO:0051649 402 0.083
Yeast
cellular protein modification process GO:0006464 438 0.075
Yeast
lipid modification GO:0030258 24 0.073
tor signaling GO:0031929 32 0.071
single organism catabolic process GO:0044712 228 0.067
Human Yeast
protein modification process GO:0036211 438 0.065
Yeast
developmental programmed cell death GO:0010623 138 0.063
Fly
death GO:0016265 284 0.060
Fly
negative regulation of signaling GO:0023057 219 0.058
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 4 0.057
aging GO:0007568 143 0.056
intracellular transport GO:0046907 228 0.055
Yeast
response to other organism GO:0051707 293 0.054
response to organonitrogen compound GO:0010243 75 0.054
response to organic substance GO:0010033 284 0.050
cellular response to chemical stimulus GO:0070887 199 0.050
lateral inhibition GO:0046331 206 0.049
regulation of protein metabolic process GO:0051246 256 0.048
negative regulation of signal transduction GO:0009968 206 0.047
protein secretion GO:0009306 45 0.046
response to alcohol GO:0097305 95 0.045
cellular response to oxidative stress GO:0034599 28 0.045
single organism biosynthetic process GO:0044711 206 0.042
small molecule metabolic process GO:0044281 305 0.042
developmental growth GO:0048589 280 0.042
carboxylic acid metabolic process GO:0019752 92 0.042
response to nitrogen compound GO:1901698 90 0.042
programmed cell death GO:0012501 257 0.041
Fly
endomembrane system organization GO:0010256 119 0.041
positive regulation of signal transduction GO:0009967 223 0.039
phagocytosis GO:0006909 215 0.039
establishment of protein localization GO:0045184 163 0.039
Yeast
cellular protein localization GO:0034613 160 0.038
Yeast
positive regulation of cell communication GO:0010647 250 0.037
negative regulation of intracellular signal transduction GO:1902532 57 0.037
organic substance transport GO:0071702 257 0.037
Yeast
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.035
nurse cell apoptotic process GO:0045476 17 0.035
growth GO:0040007 359 0.034
phosphorylation GO:0016310 294 0.033
anion homeostasis GO:0055081 3 0.032
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.032
regulation of localization GO:0032879 275 0.032
protein transport GO:0015031 155 0.032
Yeast
negative regulation of response to stimulus GO:0048585 258 0.032
regulation of phosphorus metabolic process GO:0051174 210 0.032
positive regulation of phosphorus metabolic process GO:0010562 139 0.031
endocytosis GO:0006897 310 0.031
organic substance catabolic process GO:1901575 308 0.030
regulation of response to external stimulus GO:0032101 115 0.030
immune system process GO:0002376 347 0.030
regulation of multi organism process GO:0043900 131 0.029
cytoplasmic transport GO:0016482 130 0.029
Yeast
apoptotic process GO:0006915 159 0.029
response to organic cyclic compound GO:0014070 89 0.029
gtp metabolic process GO:0046039 72 0.029
regulation of protein transport GO:0051223 57 0.028
multicellular organismal aging GO:0010259 140 0.028
imaginal disc derived wing morphogenesis GO:0007476 337 0.028
regulation of cellular protein metabolic process GO:0032268 243 0.028
response to endogenous stimulus GO:0009719 119 0.028
defense response GO:0006952 300 0.028
negative regulation of cell communication GO:0010648 223 0.028
organonitrogen compound metabolic process GO:1901564 318 0.027
regulation of response to stress GO:0080134 200 0.027
appendage development GO:0048736 401 0.027
response to biotic stimulus GO:0009607 294 0.027
lipid metabolic process GO:0006629 121 0.026
golgi vesicle transport GO:0048193 27 0.026
positive regulation of transcription dna templated GO:0045893 266 0.026
positive regulation of multicellular organismal process GO:0051240 143 0.025
regulation of phosphate metabolic process GO:0019220 210 0.025
organophosphate metabolic process GO:0019637 195 0.025
cellular response to endogenous stimulus GO:0071495 80 0.025
nitrogen compound transport GO:0071705 85 0.025
oxoacid metabolic process GO:0043436 103 0.024
determination of adult lifespan GO:0008340 137 0.024
positive regulation of intracellular signal transduction GO:1902533 116 0.024
regulation of secretion by cell GO:1903530 39 0.024
stress activated mapk cascade GO:0051403 52 0.023
organelle fission GO:0048285 340 0.023
embryonic morphogenesis GO:0048598 206 0.023
interspecies interaction between organisms GO:0044419 16 0.022
guanosine containing compound catabolic process GO:1901069 74 0.022
cell cell signaling involved in cell fate commitment GO:0045168 210 0.022
regulation of mapk cascade GO:0043408 92 0.022
maintenance of location GO:0051235 73 0.022
positive regulation of gene expression GO:0010628 290 0.022
single organism behavior GO:0044708 391 0.022
regulation of protein secretion GO:0050708 13 0.022
organic acid metabolic process GO:0006082 103 0.022
response to organophosphorus GO:0046683 2 0.022
single organism membrane fusion GO:0044801 42 0.022
regulation of cellular localization GO:0060341 136 0.021
single organism cellular localization GO:1902580 180 0.021
Yeast
apoptotic process involved in development GO:1902742 20 0.021
signal transduction by phosphorylation GO:0023014 107 0.020
regulation of response to biotic stimulus GO:0002831 63 0.020
actin cytoskeleton organization GO:0030036 206 0.020
regulation of cell differentiation GO:0045595 302 0.020
regulation of anatomical structure size GO:0090066 163 0.020
regulation of establishment of protein localization GO:0070201 61 0.020
response to external biotic stimulus GO:0043207 293 0.019
regulation of developmental growth GO:0048638 174 0.019
regulation of transport GO:0051049 181 0.019
membrane fusion GO:0061025 42 0.019
positive regulation of cell migration GO:0030335 2 0.019
mapk cascade GO:0000165 107 0.019
cell type specific apoptotic process GO:0097285 38 0.019
defense response to other organism GO:0098542 225 0.019
ribonucleoside metabolic process GO:0009119 127 0.019
regulation of immune system process GO:0002682 176 0.019
protein ubiquitination GO:0016567 70 0.019
cellular macromolecule localization GO:0070727 220 0.018
Yeast
positive regulation of tor signaling GO:0032008 13 0.018
negative regulation of cellular metabolic process GO:0031324 382 0.018
positive regulation of mapk cascade GO:0043410 63 0.018
imaginal disc derived appendage morphogenesis GO:0035114 395 0.018
guanosine containing compound metabolic process GO:1901068 74 0.018
protein complex biogenesis GO:0070271 201 0.018
wing disc morphogenesis GO:0007472 344 0.018
aggressive behavior GO:0002118 63 0.018
negative regulation of insulin receptor signaling pathway GO:0046627 11 0.017
positive regulation of phosphate metabolic process GO:0045937 139 0.017
regulation of protein localization GO:0032880 76 0.017
protein catabolic process GO:0030163 101 0.017
protein modification by small protein conjugation GO:0032446 79 0.017
single organism intracellular transport GO:1902582 207 0.017
Yeast
post embryonic appendage morphogenesis GO:0035120 385 0.017
macromolecular complex assembly GO:0065003 256 0.017
cellular lipid metabolic process GO:0044255 83 0.017
enzyme linked receptor protein signaling pathway GO:0007167 179 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
organic cyclic compound catabolic process GO:1901361 168 0.016
positive regulation of developmental process GO:0051094 143 0.016
cellular response to nitrogen compound GO:1901699 51 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.016
organic hydroxy compound metabolic process GO:1901615 83 0.016
positive regulation of programmed cell death GO:0043068 62 0.016
cell proliferation GO:0008283 299 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
secretion by cell GO:0032940 101 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.016
cellular response to oxygen containing compound GO:1901701 79 0.016
regulation of catalytic activity GO:0050790 185 0.015
response to hexose GO:0009746 3 0.015
macromolecule catabolic process GO:0009057 161 0.015
protein modification by small protein conjugation or removal GO:0070647 106 0.015
protein complex assembly GO:0006461 200 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
positive regulation of phosphorylation GO:0042327 87 0.015
appendage morphogenesis GO:0035107 397 0.015
regulation of secretion GO:0051046 44 0.015
inter male aggressive behavior GO:0002121 60 0.015
ras protein signal transduction GO:0007265 88 0.014
body morphogenesis GO:0010171 2 0.014
response to ethanol GO:0045471 59 0.014
vesicle localization GO:0051648 55 0.014
morphogenesis of an epithelium GO:0002009 276 0.014
phosphatidylinositol phosphorylation GO:0046854 10 0.014
cellular response to hormone stimulus GO:0032870 44 0.014
organelle localization GO:0051640 148 0.014
regulation of cell death GO:0010941 173 0.014
jnk cascade GO:0007254 50 0.014
nucleotide metabolic process GO:0009117 161 0.014
positive regulation of nurse cell apoptotic process GO:0045850 5 0.014
regulation of nervous system development GO:0051960 248 0.014
regulation of molecular function GO:0065009 217 0.014
sensory perception of smell GO:0007608 80 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
carbohydrate metabolic process GO:0005975 82 0.013
protein heterooligomerization GO:0051291 4 0.013
regulation of purine nucleotide catabolic process GO:0033121 48 0.013
organonitrogen compound catabolic process GO:1901565 128 0.013
regulation of phosphorylation GO:0042325 147 0.013
response to acid chemical GO:0001101 25 0.013
heterocycle catabolic process GO:0046700 166 0.013
regulation of protein modification process GO:0031399 112 0.013
gastrulation involving germ band extension GO:0010004 36 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
regulation of hydrolase activity GO:0051336 97 0.013
positive regulation of cell differentiation GO:0045597 64 0.013
cellular response to ethanol GO:0071361 4 0.013
regionalization GO:0003002 416 0.012
regulation of gtpase activity GO:0043087 44 0.012
triglyceride biosynthetic process GO:0019432 2 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
secretion GO:0046903 109 0.012
digestive tract development GO:0048565 149 0.012
actin filament organization GO:0007015 126 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
membrane organization GO:0061024 112 0.012
Yeast
positive regulation of rna biosynthetic process GO:1902680 266 0.012
regulation of growth GO:0040008 233 0.012
stress activated protein kinase signaling cascade GO:0031098 55 0.012
glycerophospholipid metabolic process GO:0006650 23 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
regulation of immune response GO:0050776 118 0.012
positive regulation of macromolecule metabolic process GO:0010604 405 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
organophosphate catabolic process GO:0046434 112 0.011
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.011
negative regulation of gene expression GO:0010629 387 0.011
cellular iron ion homeostasis GO:0006879 3 0.011
chaeta development GO:0022416 97 0.011
regulation of defense response GO:0031347 102 0.011
regulation of tube size GO:0035150 46 0.011
embryo development ending in birth or egg hatching GO:0009792 152 0.011
regulation of cell proliferation GO:0042127 163 0.011
response to insulin GO:0032868 29 0.011
cellular metal ion homeostasis GO:0006875 31 0.011
endosomal transport GO:0016197 44 0.011
intracellular protein transport GO:0006886 104 0.011
Yeast
positive regulation of nucleic acid templated transcription GO:1903508 266 0.011
positive regulation of cell motility GO:2000147 3 0.011
dendrite morphogenesis GO:0048813 199 0.011
translation GO:0006412 69 0.011
immune effector process GO:0002252 98 0.011
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
central nervous system development GO:0007417 201 0.011
cellular ketone metabolic process GO:0042180 24 0.011
positive regulation of biosynthetic process GO:0009891 316 0.011
cellular transition metal ion homeostasis GO:0046916 9 0.011
cell division GO:0051301 248 0.011
chemical homeostasis GO:0048878 92 0.011
transcription from rna polymerase ii promoter GO:0006366 368 0.011
rna localization GO:0006403 115 0.011
ribonucleotide metabolic process GO:0009259 145 0.011
spindle assembly GO:0051225 80 0.011
epithelial cell differentiation GO:0030855 322 0.011
imaginal disc derived appendage development GO:0048737 399 0.011
oxidation reduction process GO:0055114 123 0.011
cellular amine metabolic process GO:0044106 12 0.011
regulation of stress activated mapk cascade GO:0032872 41 0.010
response to inorganic substance GO:0010035 44 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.010
pyridine nucleotide metabolic process GO:0019362 2 0.010
positive regulation of cell death GO:0010942 69 0.010
protein processing GO:0016485 68 0.010
Yeast
carbohydrate derivative metabolic process GO:1901135 217 0.010
response to glucose GO:0009749 2 0.010
negative regulation of protein metabolic process GO:0051248 85 0.010
kidney development GO:0001822 3 0.010
positive regulation of multi organism process GO:0043902 40 0.010
regulation of cell cycle GO:0051726 291 0.010
positive regulation of apoptotic process GO:0043065 47 0.010
negative regulation of notch signaling pathway GO:0045746 41 0.010

Atg4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.268
disease of metabolism DOID:0014667 0 0.014
nervous system disease DOID:863 0 0.013
central nervous system disease DOID:331 0 0.012