Drosophila melanogaster

149 known processes

cbt (Dmel_CG4427)

cabut

(Aliases: Cabut,EP(2)2237,dTIEG,Cabot,CG4427,EP2237,Dmel\CG4427)

cbt biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic morphogenesis GO:0048598 206 0.883
dorsal closure GO:0007391 79 0.878
morphogenesis of an epithelium GO:0002009 276 0.847
morphogenesis of embryonic epithelium GO:0016331 94 0.565
head involution GO:0008258 35 0.544
embryonic development via the syncytial blastoderm GO:0001700 148 0.518
tissue morphogenesis GO:0048729 297 0.487
cellular response to chemical stimulus GO:0070887 199 0.487
Rat
regulation of intracellular signal transduction GO:1902531 236 0.411
appendage development GO:0048736 401 0.361
Fly
enzyme linked receptor protein signaling pathway GO:0007167 179 0.302
organonitrogen compound metabolic process GO:1901564 318 0.266
gland morphogenesis GO:0022612 145 0.258
cell division GO:0051301 248 0.227
oxoacid metabolic process GO:0043436 103 0.222
response to light stimulus GO:0009416 124 0.214
homeostatic process GO:0042592 199 0.206
negative regulation of cell communication GO:0010648 223 0.201
intracellular signal transduction GO:0035556 300 0.183
vesicle mediated transport GO:0016192 381 0.170
Worm
regulation of phosphate metabolic process GO:0019220 210 0.166
regulation of cellular response to stress GO:0080135 89 0.161
chaeta development GO:0022416 97 0.160
negative regulation of gene expression GO:0010629 387 0.159
organic acid metabolic process GO:0006082 103 0.153
positive regulation of phosphate metabolic process GO:0045937 139 0.152
post embryonic appendage morphogenesis GO:0035120 385 0.149
Fly
negative regulation of signal transduction GO:0009968 206 0.149
programmed cell death GO:0012501 257 0.148
imaginal disc derived wing morphogenesis GO:0007476 337 0.147
endocytosis GO:0006897 310 0.141
Worm
regulation of cell proliferation GO:0042127 163 0.129
Human
glycosyl compound catabolic process GO:1901658 112 0.127
imaginal disc derived appendage morphogenesis GO:0035114 395 0.123
Fly
cell maturation GO:0048469 144 0.122
establishment of localization in cell GO:0051649 402 0.120
autophagy GO:0006914 108 0.119
negative regulation of response to stimulus GO:0048585 258 0.110
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.109
Worm Fly
embryo development ending in birth or egg hatching GO:0009792 152 0.108
wing disc morphogenesis GO:0007472 344 0.106
salivary gland cell autophagic cell death GO:0035071 83 0.105
digestive tract development GO:0048565 149 0.102
Fly
actin filament organization GO:0007015 126 0.102
carboxylic acid metabolic process GO:0019752 92 0.100
appendage morphogenesis GO:0035107 397 0.098
Fly
regulation of programmed cell death GO:0043067 152 0.095
Human Worm
regulation of cell death GO:0010941 173 0.095
Human Worm
single organism biosynthetic process GO:0044711 206 0.085
cell death GO:0008219 279 0.083
actin cytoskeleton organization GO:0030036 206 0.083
response to organic substance GO:0010033 284 0.082
Rat
regulation of response to stress GO:0080134 200 0.081
regulation of neuron projection development GO:0010975 69 0.081
regulation of immune system process GO:0002682 176 0.078
Mouse
death GO:0016265 284 0.077
regulation of cellular ketone metabolic process GO:0010565 3 0.077
cellular response to abiotic stimulus GO:0071214 58 0.074
regulation of catabolic process GO:0009894 170 0.074
cell fate determination GO:0001709 91 0.074
negative regulation of cell differentiation GO:0045596 143 0.074
Mouse
regulation of cell cycle GO:0051726 291 0.073
peptidyl amino acid modification GO:0018193 105 0.073
regulation of phosphorylation GO:0042325 147 0.072
phosphorylation GO:0016310 294 0.070
immune response GO:0006955 246 0.067
purine nucleoside triphosphate metabolic process GO:0009144 119 0.065
exocrine system development GO:0035272 162 0.065
imaginal disc derived appendage development GO:0048737 399 0.065
Fly
cellular response to starvation GO:0009267 61 0.063
Mouse
regulation of cellular localization GO:0060341 136 0.062
positive regulation of cell proliferation GO:0008284 47 0.062
carbohydrate homeostasis GO:0033500 12 0.057
polysaccharide biosynthetic process GO:0000271 7 0.057
cellular response to organic substance GO:0071310 132 0.056
Rat
negative regulation of rna metabolic process GO:0051253 251 0.055
protein phosphorylation GO:0006468 169 0.054
stress activated mapk cascade GO:0051403 52 0.053
protein localization GO:0008104 284 0.052
cellular response to molecule of bacterial origin GO:0071219 3 0.052
regulation of cellular amino acid metabolic process GO:0006521 0 0.051
positive regulation of protein metabolic process GO:0051247 128 0.051
regulation of secretion by cell GO:1903530 39 0.049
histolysis GO:0007559 102 0.049
gene silencing GO:0016458 138 0.048
salivary gland development GO:0007431 162 0.048
establishment of organelle localization GO:0051656 122 0.048
actin filament based process GO:0030029 220 0.047
cell proliferation GO:0008283 299 0.046
Human
negative regulation of smoothened signaling pathway GO:0045879 16 0.046
neuroblast proliferation GO:0007405 74 0.046
regulation of multicellular organismal development GO:2000026 414 0.045
Mouse
positive regulation of transcription dna templated GO:0045893 266 0.045
Worm Fly
mesoderm development GO:0007498 78 0.045
compound eye development GO:0048749 307 0.044
response to radiation GO:0009314 155 0.044
regulation of epithelial cell differentiation GO:0030856 4 0.044
stress activated protein kinase signaling cascade GO:0031098 55 0.044
positive regulation of cellular amine metabolic process GO:0033240 0 0.044
defense response to other organism GO:0098542 225 0.044
Fly
salivary gland histolysis GO:0035070 88 0.044
digestive tract morphogenesis GO:0048546 127 0.042
Fly
salivary gland morphogenesis GO:0007435 145 0.041
cardiac cell fate determination GO:0060913 3 0.041
small molecule metabolic process GO:0044281 305 0.041
positive regulation of rna biosynthetic process GO:1902680 266 0.040
Worm Fly
synapse assembly GO:0007416 143 0.040
positive regulation of developmental process GO:0051094 143 0.039
Mouse
rhythmic process GO:0048511 106 0.039
Mouse Rat
positive regulation of phosphorus metabolic process GO:0010562 139 0.039
compound eye morphogenesis GO:0001745 249 0.039
cellular amino acid metabolic process GO:0006520 61 0.039
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.038
tissue death GO:0016271 102 0.038
cellular ketone metabolic process GO:0042180 24 0.037
response to external biotic stimulus GO:0043207 293 0.037
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.036
response to bacterium GO:0009617 198 0.036
regulation of mitotic cell cycle GO:0007346 190 0.035
response to oxidative stress GO:0006979 86 0.035
regulation of anatomical structure morphogenesis GO:0022603 242 0.034
mapk cascade GO:0000165 107 0.034
negative regulation of wnt signaling pathway GO:0030178 28 0.034
regulation of molecular function GO:0065009 217 0.033
immune response regulating signaling pathway GO:0002764 2 0.033
regulation of cell development GO:0060284 215 0.033
female germ line stem cell asymmetric division GO:0048132 14 0.032
establishment or maintenance of cell polarity GO:0007163 167 0.032
glucose homeostasis GO:0042593 6 0.032
negative regulation of insulin secretion GO:0046676 1 0.032
body morphogenesis GO:0010171 2 0.032
Worm
organelle assembly GO:0070925 198 0.032
regulation of response to dna damage stimulus GO:2001020 23 0.032
negative regulation of signaling GO:0023057 219 0.032
carboxylic acid transport GO:0046942 18 0.031
negative regulation of developmental process GO:0051093 201 0.031
Mouse
organ formation GO:0048645 39 0.031
cortical cytoskeleton organization GO:0030865 29 0.030
purine nucleoside catabolic process GO:0006152 112 0.030
regulation of response to external stimulus GO:0032101 115 0.030
ribonucleotide metabolic process GO:0009259 145 0.030
negative regulation of cellular metabolic process GO:0031324 382 0.030
regulation of cellular component biogenesis GO:0044087 201 0.030
positive regulation of signaling GO:0023056 243 0.030
regulation of gtpase activity GO:0043087 44 0.030
regulation of cellular catabolic process GO:0031329 157 0.030
purine nucleoside metabolic process GO:0042278 127 0.029
neurological system process GO:0050877 358 0.029
peptidyl threonine phosphorylation GO:0018107 2 0.029
positive regulation of catabolic process GO:0009896 105 0.029
catabolic process GO:0009056 409 0.029
regulation of cellular amine metabolic process GO:0033238 3 0.028
regionalization GO:0003002 416 0.028
nitrogen compound transport GO:0071705 85 0.028
single organism behavior GO:0044708 391 0.028
protein modification process GO:0036211 438 0.027
regulation of actin filament based process GO:0032970 42 0.027
posttranscriptional regulation of gene expression GO:0010608 145 0.027
cellular protein localization GO:0034613 160 0.027
regulation of synapse assembly GO:0051963 94 0.027
synaptic growth at neuromuscular junction GO:0051124 119 0.026
gastrulation GO:0007369 70 0.026
Fly
signal transduction by phosphorylation GO:0023014 107 0.026
ras protein signal transduction GO:0007265 88 0.026
regulation of notch signaling pathway GO:0008593 100 0.025
negative regulation of transcription dna templated GO:0045892 237 0.025
eye morphogenesis GO:0048592 260 0.025
response to oxygen containing compound GO:1901700 200 0.025
Rat
autophagic cell death GO:0048102 83 0.025
larval development GO:0002164 104 0.025
Worm
regulation of protein metabolic process GO:0051246 256 0.025
regulation of epithelial cell proliferation GO:0050678 4 0.025
positive regulation of cellular biosynthetic process GO:0031328 316 0.024
Worm Fly
response to endogenous stimulus GO:0009719 119 0.024
Rat
cellular component assembly involved in morphogenesis GO:0010927 151 0.024
defense response GO:0006952 300 0.024
Fly
jnk cascade GO:0007254 50 0.024
cytokinesis GO:0000910 90 0.024
regulation of stem cell proliferation GO:0072091 40 0.024
transcription from rna polymerase ii promoter GO:0006366 368 0.024
response to other organism GO:0051707 293 0.023
Fly
enteroendocrine cell differentiation GO:0035883 1 0.023
synapse organization GO:0050808 196 0.023
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.023
cellular catabolic process GO:0044248 372 0.023
regulation of nervous system development GO:0051960 248 0.023
positive regulation of macromolecule metabolic process GO:0010604 405 0.023
Worm Fly
eye development GO:0001654 323 0.023
regulation of cell differentiation GO:0045595 302 0.022
Mouse
germline stem cell asymmetric division GO:0098728 15 0.022
germ band shortening GO:0007390 19 0.021
dendrite development GO:0016358 204 0.021
formation of primary germ layer GO:0001704 24 0.021
regulation of organ morphogenesis GO:2000027 78 0.021
cellular response to oxygen containing compound GO:1901701 79 0.021
Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.021
Worm Fly
response to glucose GO:0009749 2 0.021
single organism intracellular transport GO:1902582 207 0.021
establishment of protein localization GO:0045184 163 0.021
small gtpase mediated signal transduction GO:0007264 88 0.021
negative regulation of programmed cell death GO:0043069 72 0.021
negative regulation of hormone biosynthetic process GO:0032353 1 0.021
columnar cuboidal epithelial cell development GO:0002066 249 0.020
dendrite morphogenesis GO:0048813 199 0.020
response to wounding GO:0009611 94 0.020
positive regulation of cell communication GO:0010647 250 0.020
positive regulation of developmental growth GO:0048639 62 0.020
cellular protein modification process GO:0006464 438 0.020
regulation of ras protein signal transduction GO:0046578 93 0.020
response to starvation GO:0042594 97 0.020
Mouse
regulation of jnk cascade GO:0046328 40 0.019
neural precursor cell proliferation GO:0061351 75 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
negative regulation of kinase activity GO:0033673 16 0.019
positive regulation of cell differentiation GO:0045597 64 0.019
Mouse
heterocycle catabolic process GO:0046700 166 0.019
defense response to bacterium GO:0042742 178 0.019
digestive system development GO:0055123 149 0.019
Fly
spindle organization GO:0007051 253 0.018
positive regulation of phosphorylation GO:0042327 87 0.018
positive regulation of cell motility GO:2000147 3 0.018
developmental maturation GO:0021700 172 0.018
ribonucleoside metabolic process GO:0009119 127 0.018
anion transport GO:0006820 41 0.018
maintenance of location GO:0051235 73 0.018
maintenance of protein location in cell GO:0032507 26 0.018
positive regulation of response to stimulus GO:0048584 323 0.018
rna processing GO:0006396 147 0.018
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.017
polysaccharide metabolic process GO:0005976 11 0.017
centrosome organization GO:0051297 163 0.017
mrna processing GO:0006397 104 0.017
positive regulation of protein modification process GO:0031401 58 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.017
negative regulation of autophagy GO:0010507 16 0.017
multi organism behavior GO:0051705 175 0.017
positive regulation of apoptotic process GO:0043065 47 0.017
Human Worm
regulation of localization GO:0032879 275 0.017
maintenance of location in cell GO:0051651 28 0.017
positive regulation of cell migration GO:0030335 2 0.017
germ line stem cell division GO:0042078 25 0.017
organelle localization GO:0051640 148 0.017
microtubule organizing center organization GO:0031023 168 0.017
secretion by cell GO:0032940 101 0.016
single organismal cell cell adhesion GO:0016337 45 0.016
regulation of protein modification process GO:0031399 112 0.016
heart process GO:0003015 37 0.016
response to abiotic stimulus GO:0009628 341 0.016
positive regulation of gene expression GO:0010628 290 0.016
Worm Fly
formation of anatomical boundary GO:0048859 37 0.016
positive regulation of cellular component biogenesis GO:0044089 80 0.016
chorion containing eggshell formation GO:0007304 105 0.016
regulation of ion transport GO:0043269 39 0.016
single organism cellular localization GO:1902580 180 0.016
regulation of gene expression epigenetic GO:0040029 128 0.016
negative regulation of multicellular organismal process GO:0051241 142 0.015
stem cell proliferation GO:0072089 88 0.015
regulation of cytoskeleton organization GO:0051493 89 0.015
localization of cell GO:0051674 257 0.015
immune system process GO:0002376 347 0.015
Mouse
regulation of immune response GO:0050776 118 0.015
intracellular transport GO:0046907 228 0.015
positive regulation of signal transduction GO:0009967 223 0.015
negative regulation of phosphorylation GO:0042326 35 0.015
cytoskeleton dependent intracellular transport GO:0030705 44 0.015
gliogenesis GO:0042063 80 0.015
phagocytosis GO:0006909 215 0.015
response to lipopolysaccharide GO:0032496 4 0.015
growth GO:0040007 359 0.015
positive regulation of multicellular organism growth GO:0040018 21 0.015
positive regulation of growth GO:0045927 75 0.015
anatomical structure homeostasis GO:0060249 97 0.015
regulation of autophagy GO:0010506 62 0.015
nephron development GO:0072006 3 0.014
positive regulation of molecular function GO:0044093 136 0.014
epidermal growth factor receptor signaling pathway GO:0007173 58 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.014
negative regulation of nervous system development GO:0051961 92 0.014
regulation of response to wounding GO:1903034 19 0.014
regulation of wnt signaling pathway GO:0030111 68 0.014
limb development GO:0060173 1 0.014
regulation of nucleoside metabolic process GO:0009118 50 0.014
regulation of mapk cascade GO:0043408 92 0.014
erbb signaling pathway GO:0038127 58 0.014
positive regulation of catalytic activity GO:0043085 118 0.014
cellular response to lipopolysaccharide GO:0071222 3 0.014
regulation of bmp signaling pathway GO:0030510 23 0.014
regulation of small gtpase mediated signal transduction GO:0051056 93 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
gland development GO:0048732 191 0.013
multicellular organismal aging GO:0010259 140 0.013
Worm
detection of stimulus GO:0051606 156 0.013
dna biosynthetic process GO:0071897 24 0.013
mrna splicing via spliceosome GO:0000398 73 0.013
ion transport GO:0006811 145 0.013
negative regulation of apoptotic process GO:0043066 63 0.013
biological adhesion GO:0022610 138 0.013
regulation of embryonic development GO:0045995 68 0.013
regulation of synapse organization GO:0050807 110 0.013
ameboidal type cell migration GO:0001667 151 0.013
regulation of hemocyte proliferation GO:0035206 37 0.013
positive regulation of secretion by cell GO:1903532 20 0.013
protein polymerization GO:0051258 42 0.013
amine metabolic process GO:0009308 12 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
negative regulation of small gtpase mediated signal transduction GO:0051058 13 0.013
endodermal cell differentiation GO:0035987 3 0.013
actin filament polymerization GO:0030041 27 0.013
cellular response to ethanol GO:0071361 4 0.013
sensory organ morphogenesis GO:0090596 260 0.013
microtubule based movement GO:0007018 51 0.012
positive regulation of lipid biosynthetic process GO:0046889 3 0.012
intracellular protein transport GO:0006886 104 0.012
regulation of protein phosphorylation GO:0001932 64 0.012
positive regulation of intracellular signal transduction GO:1902533 116 0.012
dephosphorylation GO:0016311 51 0.012
carbohydrate derivative metabolic process GO:1901135 217 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
cellular response to radiation GO:0071478 52 0.012
regulation of nucleotide catabolic process GO:0030811 48 0.012
tube morphogenesis GO:0035239 191 0.012
Fly
cell cycle phase transition GO:0044770 140 0.012
Human
carbohydrate biosynthetic process GO:0016051 17 0.012
response to monosaccharide GO:0034284 4 0.012
developmental programmed cell death GO:0010623 138 0.012
actin filament bundle organization GO:0061572 28 0.012
chaeta morphogenesis GO:0008407 42 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.011
regulation of synapse structure and activity GO:0050803 128 0.011
feeding behavior GO:0007631 50 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
actin polymerization or depolymerization GO:0008154 31 0.011
negative regulation of intracellular signal transduction GO:1902532 57 0.011
regulation of response to biotic stimulus GO:0002831 63 0.011
embryonic hemopoiesis GO:0035162 26 0.011
regulation of neuroblast proliferation GO:1902692 34 0.011
positive regulation of cellular catabolic process GO:0031331 95 0.011
organic substance transport GO:0071702 257 0.011
smoothened signaling pathway GO:0007224 49 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
purine containing compound metabolic process GO:0072521 155 0.011
notch signaling pathway GO:0007219 120 0.011
response to transforming growth factor beta GO:0071559 18 0.011
developmental growth GO:0048589 280 0.011
actin cytoskeleton reorganization GO:0031532 22 0.011
aging GO:0007568 143 0.011
Worm
cellular macromolecule localization GO:0070727 220 0.011
regulation of transferase activity GO:0051338 58 0.011
purine nucleotide catabolic process GO:0006195 109 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
translation GO:0006412 69 0.010
purine ribonucleoside metabolic process GO:0046128 127 0.010
regulation of polysaccharide biosynthetic process GO:0032885 1 0.010
chemical homeostasis GO:0048878 92 0.010
gene silencing by rna GO:0031047 57 0.010
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.010
smad protein import into nucleus GO:0007184 11 0.010
divalent inorganic cation homeostasis GO:0072507 29 0.010
nucleoside phosphate catabolic process GO:1901292 110 0.010
immune system development GO:0002520 57 0.010
Mouse
nucleoside phosphate metabolic process GO:0006753 162 0.010

cbt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.027
disease of anatomical entity DOID:7 0 0.027
eye and adnexa disease DOID:1492 0 0.027
nervous system disease DOID:863 0 0.027
eye disease DOID:5614 0 0.027
disease of metabolism DOID:0014667 0 0.016
carbohydrate metabolism disease DOID:0050013 0 0.016
acquired metabolic disease DOID:0060158 0 0.016
diabetes mellitus DOID:9351 0 0.014
glucose metabolism disease DOID:4194 0 0.014
inherited metabolic disorder DOID:655 0 0.012
cardiovascular system disease DOID:1287 0 0.010