Drosophila melanogaster

157 known processes

Parg (Dmel_CG2864)

Poly(ADP-ribose) glycohydrolase

(Aliases: CG2864,parg,HD10914,PARG,EG:114E2.1,Dmel\CG2864)

Parg biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of gene expression GO:0010629 387 0.798
positive regulation of macromolecule metabolic process GO:0010604 405 0.583
positive regulation of cellular biosynthetic process GO:0031328 316 0.441
nuclear body organization GO:0030575 6 0.301
central nervous system development GO:0007417 201 0.296
negative regulation of cellular biosynthetic process GO:0031327 277 0.267
response to abiotic stimulus GO:0009628 341 0.267
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.256
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.239
response to temperature stimulus GO:0009266 106 0.237
negative regulation of rna biosynthetic process GO:1902679 240 0.228
brain development GO:0007420 120 0.223
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.222
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.213
cognition GO:0050890 141 0.201
organelle fission GO:0048285 340 0.195
Worm
negative regulation of rna metabolic process GO:0051253 251 0.180
positive regulation of transcription dna templated GO:0045893 266 0.179
female germ line stem cell asymmetric division GO:0048132 14 0.178
gene silencing GO:0016458 138 0.175
head development GO:0060322 135 0.170
sensory organ morphogenesis GO:0090596 260 0.169
positive regulation of biosynthetic process GO:0009891 316 0.163
germ line stem cell maintenance GO:0030718 50 0.153
male mating behavior GO:0060179 70 0.149
ovarian follicle cell development GO:0030707 248 0.144
dorsal ventral pattern formation GO:0009953 133 0.144
chromatin organization GO:0006325 207 0.141
eye development GO:0001654 323 0.134
learning or memory GO:0007611 141 0.133
appendage development GO:0048736 401 0.124
negative regulation of biosynthetic process GO:0009890 277 0.123
chromosome organization GO:0051276 360 0.115
cellular response to heat GO:0034605 24 0.114
positive regulation of nucleic acid templated transcription GO:1903508 266 0.112
regulation of response to stress GO:0080134 200 0.109
anatomical structure homeostasis GO:0060249 97 0.099
negative regulation of cellular metabolic process GO:0031324 382 0.097
positive regulation of rna metabolic process GO:0051254 271 0.097
germ line stem cell division GO:0042078 25 0.094
positive regulation of rna biosynthetic process GO:1902680 266 0.092
forebrain development GO:0030900 2 0.088
associative learning GO:0008306 65 0.088
response to other organism GO:0051707 293 0.085
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.084
negative regulation of transcription dna templated GO:0045892 237 0.084
regulation of anatomical structure morphogenesis GO:0022603 242 0.081
chemosensory behavior GO:0007635 106 0.079
compound eye development GO:0048749 307 0.079
learning GO:0007612 75 0.079
meiotic nuclear division GO:0007126 151 0.078
Worm
mushroom body development GO:0016319 70 0.075
regulation of protein metabolic process GO:0051246 256 0.072
response to heat GO:0009408 63 0.070
appendage morphogenesis GO:0035107 397 0.070
columnar cuboidal epithelial cell development GO:0002066 249 0.069
regionalization GO:0003002 416 0.068
positive regulation of gene expression GO:0010628 290 0.068
spermatogenesis GO:0007283 200 0.068
organic hydroxy compound metabolic process GO:1901615 83 0.067
protein modification process GO:0036211 438 0.066
negative regulation of nucleic acid templated transcription GO:1903507 240 0.064
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.061
nuclear division GO:0000280 332 0.060
Worm
defense response GO:0006952 300 0.059
homeostatic process GO:0042592 199 0.059
immune response GO:0006955 246 0.059
single organism behavior GO:0044708 391 0.057
gene silencing by mirna GO:0035195 22 0.055
germline stem cell asymmetric division GO:0098728 15 0.055
nucleus organization GO:0006997 45 0.054
locomotory behavior GO:0007626 176 0.051
response to oxygen containing compound GO:1901700 200 0.050
positive regulation of immune response GO:0050778 63 0.049
regulation of cellular response to oxidative stress GO:1900407 4 0.049
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.049
defense response to bacterium GO:0042742 178 0.049
circadian rhythm GO:0007623 105 0.048
response to sterol GO:0036314 34 0.048
adult behavior GO:0030534 137 0.047
multicellular organismal reproductive behavior GO:0033057 110 0.045
telomere organization GO:0032200 21 0.045
molting cycle chitin based cuticle GO:0007591 56 0.044
posttranscriptional regulation of gene expression GO:0010608 145 0.043
negative regulation of neuron death GO:1901215 18 0.043
lipid localization GO:0010876 54 0.043
morphogenesis of an epithelium GO:0002009 276 0.042
gene silencing by rna GO:0031047 57 0.042
negative regulation of intracellular signal transduction GO:1902532 57 0.042
rna processing GO:0006396 147 0.041
telencephalon development GO:0021537 2 0.041
multi multicellular organism process GO:0044706 123 0.041
regulation of chromatin organization GO:1902275 32 0.040
wing disc morphogenesis GO:0007472 344 0.039
mitotic spindle organization GO:0007052 220 0.039
stem cell maintenance GO:0019827 67 0.038
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.038
transcription from rna polymerase ii promoter GO:0006366 368 0.038
eggshell formation GO:0030703 105 0.038
response to organic substance GO:0010033 284 0.038
posttranscriptional gene silencing by rna GO:0035194 45 0.038
camera type eye development GO:0043010 4 0.037
response to oxygen radical GO:0000305 3 0.037
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.036
ovarian follicle cell stalk formation GO:0030713 17 0.036
response to external biotic stimulus GO:0043207 293 0.036
Mouse
response to ecdysone GO:0035075 34 0.035
positive regulation of multi organism process GO:0043902 40 0.035
response to superoxide GO:0000303 3 0.034
lipid metabolic process GO:0006629 121 0.034
positive regulation of apoptotic signaling pathway GO:2001235 4 0.034
negative regulation of cellular response to oxidative stress GO:1900408 1 0.033
regulation of chromosome organization GO:0033044 64 0.033
organophosphate metabolic process GO:0019637 195 0.033
cellular response to chemical stimulus GO:0070887 199 0.032
carbohydrate metabolic process GO:0005975 82 0.032
regulation of response to oxidative stress GO:1902882 4 0.032
regulation of innate immune response GO:0045088 71 0.031
histone modification GO:0016570 106 0.030
mating behavior GO:0007617 106 0.030
developmental growth involved in morphogenesis GO:0060560 65 0.030
retina development in camera type eye GO:0060041 4 0.030
rna splicing GO:0008380 83 0.029
positive regulation of response to extracellular stimulus GO:0032106 8 0.029
eye morphogenesis GO:0048592 260 0.029
camera type eye morphogenesis GO:0048593 2 0.028
cell death GO:0008219 279 0.028
response to endogenous stimulus GO:0009719 119 0.028
positive regulation of signaling GO:0023056 243 0.028
male sex differentiation GO:0046661 25 0.028
response to inorganic substance GO:0010035 44 0.028
regulation of cellular protein metabolic process GO:0032268 243 0.028
circulatory system process GO:0003013 37 0.028
multi organism behavior GO:0051705 175 0.026
cellular response to organic substance GO:0071310 132 0.026
regulation of circadian rhythm GO:0042752 49 0.026
imaginal disc derived appendage morphogenesis GO:0035114 395 0.026
immune system process GO:0002376 347 0.026
positive regulation of autophagy GO:0010508 21 0.026
inter male aggressive behavior GO:0002121 60 0.026
neural precursor cell proliferation GO:0061351 75 0.026
regulation of immune response GO:0050776 118 0.026
organic substance transport GO:0071702 257 0.025
organic acid metabolic process GO:0006082 103 0.025
circulatory system development GO:0072359 82 0.025
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.025
regulation of programmed cell death GO:0043067 152 0.025
translation GO:0006412 69 0.024
tissue death GO:0016271 102 0.024
response to ionizing radiation GO:0010212 32 0.024
imaginal disc pattern formation GO:0007447 91 0.024
chromatin silencing GO:0006342 76 0.024
eggshell chorion assembly GO:0007306 66 0.024
positive regulation of defense response GO:0031349 59 0.023
taxis GO:0042330 304 0.023
cellular protein modification process GO:0006464 438 0.023
intracellular signal transduction GO:0035556 300 0.022
response to dsrna GO:0043331 15 0.022
apoptotic process GO:0006915 159 0.022
regulation of chromatin modification GO:1903308 28 0.022
aging GO:0007568 143 0.022
negative regulation of cellular component organization GO:0051129 108 0.022
post embryonic appendage morphogenesis GO:0035120 385 0.021
ion transport GO:0006811 145 0.021
positive regulation of cell death GO:0010942 69 0.021
gonad development GO:0008406 50 0.021
aggressive behavior GO:0002118 63 0.020
imaginal disc derived appendage development GO:0048737 399 0.020
germarium derived female germ line cyst encapsulation GO:0030708 8 0.020
regulation of cell death GO:0010941 173 0.020
single organism carbohydrate metabolic process GO:0044723 72 0.020
positive regulation of antimicrobial humoral response GO:0002760 28 0.020
positive regulation of protein metabolic process GO:0051247 128 0.020
organonitrogen compound metabolic process GO:1901564 318 0.020
positive regulation of signal transduction GO:0009967 223 0.019
cellular component assembly involved in morphogenesis GO:0010927 151 0.019
female meiotic division GO:0007143 70 0.019
adult locomotory behavior GO:0008344 76 0.019
production of small rna involved in gene silencing by rna GO:0070918 15 0.018
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.018
cellular protein localization GO:0034613 160 0.018
double strand break repair GO:0006302 26 0.018
chaeta development GO:0022416 97 0.018
regulation of proteolysis GO:0030162 87 0.018
asymmetric stem cell division GO:0098722 49 0.018
regulation of cell morphogenesis GO:0022604 163 0.018
negative regulation of programmed cell death GO:0043069 72 0.018
oocyte maturation GO:0001556 3 0.018
chromatin modification GO:0016568 147 0.018
regulation of gene expression epigenetic GO:0040029 128 0.017
response to light stimulus GO:0009416 124 0.017
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.017
cellular response to organic cyclic compound GO:0071407 32 0.017
organonitrogen compound biosynthetic process GO:1901566 117 0.017
cellular response to starvation GO:0009267 61 0.017
cellular homeostasis GO:0019725 80 0.017
protein heterooligomerization GO:0051291 4 0.017
humoral immune response GO:0006959 117 0.017
regulation of microtubule based process GO:0032886 49 0.017
brain morphogenesis GO:0048854 16 0.017
positive regulation of response to stimulus GO:0048584 323 0.017
response to bacterium GO:0009617 198 0.017
Mouse
embryo development ending in birth or egg hatching GO:0009792 152 0.016
cell proliferation GO:0008283 299 0.016
positive regulation of macroautophagy GO:0016239 8 0.016
telomere maintenance GO:0000723 21 0.016
male gamete generation GO:0048232 201 0.016
aromatic compound catabolic process GO:0019439 166 0.016
innate immune response GO:0045087 144 0.016
enzyme linked receptor protein signaling pathway GO:0007167 179 0.016
regulation of cell cycle GO:0051726 291 0.016
negative regulation of response to oxidative stress GO:1902883 1 0.016
negative regulation of organelle organization GO:0010639 56 0.016
male courtship behavior GO:0008049 63 0.016
posttranscriptional gene silencing GO:0016441 46 0.016
apoptotic process involved in morphogenesis GO:0060561 3 0.016
sex differentiation GO:0007548 81 0.016
oxidation reduction process GO:0055114 123 0.016
autophagic cell death GO:0048102 83 0.016
neuron apoptotic process GO:0051402 17 0.015
dorsal appendage formation GO:0046843 47 0.015
atp metabolic process GO:0046034 49 0.015
negative regulation of developmental process GO:0051093 201 0.015
embryonic development via the syncytial blastoderm GO:0001700 148 0.015
chromosome separation GO:0051304 42 0.015
regulation of gene silencing GO:0060968 63 0.015
eye antennal disc development GO:0035214 60 0.015
regulation of organelle organization GO:0033043 196 0.015
cellular response to metal ion GO:0071248 6 0.015
covalent chromatin modification GO:0016569 106 0.015
neuron death GO:0070997 27 0.015
cell cycle checkpoint GO:0000075 95 0.015
ncrna metabolic process GO:0034660 43 0.015
peptide metabolic process GO:0006518 80 0.014
programmed cell death GO:0012501 257 0.014
cellular response to reactive oxygen species GO:0034614 14 0.014
organelle assembly GO:0070925 198 0.014
regulation of antimicrobial humoral response GO:0002759 50 0.014
negative regulation of neural precursor cell proliferation GO:2000178 27 0.014
cellular catabolic process GO:0044248 372 0.014
regulation of neuron death GO:1901214 26 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
histolysis GO:0007559 102 0.014
regulation of microtubule cytoskeleton organization GO:0070507 41 0.014
ribonucleoside metabolic process GO:0009119 127 0.014
cardiovascular system development GO:0072358 82 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.014
neurological system process GO:0050877 358 0.014
response to alcohol GO:0097305 95 0.014
epithelial cell development GO:0002064 274 0.014
regulation of neuron differentiation GO:0045664 103 0.014
chromosome segregation GO:0007059 157 0.014
Worm
regulation of cell projection organization GO:0031344 92 0.014
cellular amide metabolic process GO:0043603 80 0.014
rhythmic process GO:0048511 106 0.013
stress activated protein kinase signaling cascade GO:0031098 55 0.013
memory GO:0007613 94 0.013
antimicrobial humoral response GO:0019730 99 0.013
regulation of defense response to virus by host GO:0050691 10 0.013
regulation of jnk cascade GO:0046328 40 0.013
wing disc dorsal ventral pattern formation GO:0048190 47 0.013
regulation of behavior GO:0050795 75 0.013
secondary metabolic process GO:0019748 75 0.013
developmental programmed cell death GO:0010623 138 0.013
regulation of synaptic transmission GO:0050804 69 0.013
regulation of dna templated transcription in response to stress GO:0043620 4 0.013
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.012
single organism catabolic process GO:0044712 228 0.012
developmental cell growth GO:0048588 52 0.012
organic substance catabolic process GO:1901575 308 0.012
chaeta morphogenesis GO:0008407 42 0.012
negative regulation of cell death GO:0060548 81 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
negative regulation of neuron apoptotic process GO:0043524 14 0.012
response to oxidative stress GO:0006979 86 0.012
olfactory behavior GO:0042048 97 0.012
positive regulation of response to external stimulus GO:0032103 44 0.012
terminal button organization GO:0072553 19 0.012
cellular response to growth factor stimulus GO:0071363 30 0.012
single organism biosynthetic process GO:0044711 206 0.012
mitotic sister chromatid segregation GO:0000070 87 0.012
protein glycosylation GO:0006486 32 0.012
compound eye morphogenesis GO:0001745 249 0.012
positive regulation of cellular catabolic process GO:0031331 95 0.012
limb development GO:0060173 1 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.012
organic cyclic compound catabolic process GO:1901361 168 0.011
chromatin assembly GO:0031497 48 0.011
cellular response to abiotic stimulus GO:0071214 58 0.011
mrna metabolic process GO:0016071 124 0.011
positive regulation of immune system process GO:0002684 68 0.011
response to biotic stimulus GO:0009607 294 0.011
Mouse
proteolysis GO:0006508 192 0.011
regulation of catalytic activity GO:0050790 185 0.011
vesicle mediated transport GO:0016192 381 0.011
regulation of macroautophagy GO:0016241 15 0.011
phagocytosis GO:0006909 215 0.011
fertilization GO:0009566 26 0.011
stress activated mapk cascade GO:0051403 52 0.011
positive regulation of innate immune response GO:0045089 38 0.011
generation of precursor metabolites and energy GO:0006091 42 0.011
protein transport GO:0015031 155 0.011
alternative mrna splicing via spliceosome GO:0000380 60 0.011
glial cell differentiation GO:0010001 35 0.011
dna conformation change GO:0071103 105 0.011
germarium derived egg chamber formation GO:0007293 101 0.011
positive regulation of neuron apoptotic process GO:0043525 1 0.011
response to organic cyclic compound GO:0014070 89 0.011
muscle tissue morphogenesis GO:0060415 2 0.011
regulation of bmp signaling pathway GO:0030510 23 0.011
cellular response to dsrna GO:0071359 15 0.011
positive regulation of antibacterial peptide production GO:0002803 20 0.010
regulation of cellular localization GO:0060341 136 0.010
defense response to gram negative bacterium GO:0050829 94 0.010
dendrite morphogenesis GO:0048813 199 0.010
endocytosis GO:0006897 310 0.010
dsrna fragmentation GO:0031050 15 0.010
salivary gland histolysis GO:0035070 88 0.010
reproductive system development GO:0061458 74 0.010
carbohydrate derivative biosynthetic process GO:1901137 85 0.010
positive regulation of defense response to bacterium GO:1900426 23 0.010
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.010

Parg disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org