Drosophila melanogaster

126 known processes

lea (Dmel_CG5481)

leak

(Aliases: Robo 2,CT17326,Robo2,Dmel\CG5481,clone 1.75,Robo-2,ROBO2,D-robo2,CG14347,D-Robo2,robo-2,anon-EST:Liang-1.75,dRobo-2,CG14348,robo2,CG5481,CG5574)

lea biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
motor neuron axon guidance GO:0008045 58 1.000
Fly
axon choice point recognition GO:0016198 26 0.996
Zebrafish Mouse Rat Fly
ventral cord development GO:0007419 16 0.996
salivary gland boundary specification GO:0007432 8 0.994
axon development GO:0061564 297 0.991
dorsal ventral axon guidance GO:0033563 2 0.991
Worm
axon midline choice point recognition GO:0016199 26 0.988
Zebrafish Mouse Rat Fly
regulation of cell differentiation GO:0045595 302 0.988
Human Zebrafish Rat Fly
regulation of dendrite morphogenesis GO:0048814 28 0.984
Rat
central nervous system development GO:0007417 201 0.980
dendrite guidance GO:0070983 21 0.971
Fly
growth GO:0040007 359 0.967
Zebrafish Mouse
neuron projection guidance GO:0097485 241 0.958
axon guidance GO:0007411 233 0.955
neuron recognition GO:0008038 101 0.944
negative regulation of growth GO:0045926 84 0.929
Zebrafish
substrate dependent cell migration GO:0006929 3 0.925
Human
central nervous system projection neuron axonogenesis GO:0021952 6 0.925
Zebrafish
central complex development GO:0048036 9 0.917
retinal ganglion cell axon guidance GO:0031290 12 0.917
Zebrafish Mouse
regulation of axon extension involved in axon guidance GO:0048841 4 0.915
Zebrafish
dendrite development GO:0016358 204 0.910
Rat Fly
cardioblast cell fate commitment GO:0042684 14 0.906
axon extension involved in axon guidance GO:0048846 10 0.906
Zebrafish
regulation of axon guidance GO:1902667 10 0.901
Zebrafish
axonogenesis GO:0007409 290 0.899
regionalization GO:0003002 416 0.891
regulation of epithelial cell migration GO:0010632 12 0.884
regulation of cell development GO:0060284 215 0.880
Human Zebrafish Rat Fly
regulation of apoptotic process GO:0042981 130 0.860
Human
cell recognition GO:0008037 102 0.844
regulation of cell death GO:0010941 173 0.837
Human
positive regulation of axonogenesis GO:0050772 2 0.823
Human
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.822
tube development GO:0035295 244 0.818
brain development GO:0007420 120 0.811
respiratory system development GO:0060541 213 0.808
negative regulation of transcription dna templated GO:0045892 237 0.789
regulation of multicellular organismal development GO:2000026 414 0.788
axon extension GO:0048675 32 0.783
Zebrafish
negative regulation of developmental growth GO:0048640 64 0.782
Zebrafish
circulatory system development GO:0072359 82 0.768
tissue migration GO:0090130 155 0.754
positive regulation of cellular biosynthetic process GO:0031328 316 0.751
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.750
ameboidal type cell migration GO:0001667 151 0.738
apoptotic process GO:0006915 159 0.729
Human
glial cell migration GO:0008347 31 0.726
epithelial cell migration open tracheal system GO:0007427 32 0.719
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.711
regulation of neuron projection development GO:0010975 69 0.707
Human Zebrafish Rat Fly
cardiac cell fate commitment GO:0060911 17 0.697
regulation of response to external stimulus GO:0032101 115 0.692
Human Zebrafish
cardioblast differentiation GO:0010002 20 0.674
open tracheal system development GO:0007424 204 0.671
salivary gland development GO:0007431 162 0.666
neuroblast fate commitment GO:0014017 19 0.657
kidney epithelium development GO:0072073 3 0.650
Human Mouse
embryonic organ development GO:0048568 50 0.638
developmental cell growth GO:0048588 52 0.635
Zebrafish
heart development GO:0007507 82 0.635
telencephalon development GO:0021537 2 0.621
Human Mouse
cell projection assembly GO:0030031 94 0.612
Zebrafish
positive regulation of signaling GO:0023056 243 0.606
Zebrafish
cardiocyte differentiation GO:0035051 29 0.601
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.599
mushroom body development GO:0016319 70 0.590
heart morphogenesis GO:0003007 32 0.587
positive regulation of macromolecule metabolic process GO:0010604 405 0.586
Human
convergent extension GO:0060026 2 0.585
Zebrafish
developmental growth involved in morphogenesis GO:0060560 65 0.582
Zebrafish Mouse
regulation of developmental growth GO:0048638 174 0.574
Zebrafish
olfactory bulb axon guidance GO:0071678 3 0.562
localization of cell GO:0051674 257 0.562
regulation of programmed cell death GO:0043067 152 0.560
Human
renal system development GO:0072001 72 0.558
Human Mouse
head development GO:0060322 135 0.553
cardiovascular system development GO:0072358 82 0.546
negative regulation of signaling GO:0023057 219 0.545
Human
cell motility GO:0048870 251 0.541
negative regulation of axon extension GO:0030517 3 0.540
Zebrafish
gonad development GO:0008406 50 0.516
muscle structure development GO:0061061 224 0.515
programmed cell death GO:0012501 257 0.513
Human
formation of anatomical boundary GO:0048859 37 0.496
organ formation GO:0048645 39 0.496
stem cell differentiation GO:0048863 117 0.493
internal protein amino acid acetylation GO:0006475 38 0.492
regulation of axonogenesis GO:0050770 32 0.491
Human Zebrafish
regulation of cell morphogenesis GO:0022604 163 0.482
Human Zebrafish Rat
filopodium assembly GO:0046847 33 0.476
Zebrafish
death GO:0016265 284 0.473
Human
forebrain development GO:0030900 2 0.463
Human Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.459
Human
catabolic process GO:0009056 409 0.456
anterior posterior pattern specification GO:0009952 136 0.456
negative regulation of gene expression GO:0010629 387 0.455
positive regulation of cell differentiation GO:0045597 64 0.452
Human
embryonic development via the syncytial blastoderm GO:0001700 148 0.449
positive regulation of gene expression GO:0010628 290 0.444
synapse assembly GO:0007416 143 0.436
Zebrafish
outflow tract morphogenesis GO:0003151 4 0.432
cardioblast cell fate specification GO:0042685 9 0.425
regulation of cell growth GO:0001558 43 0.425
Zebrafish
neuron migration GO:0001764 5 0.417
negative regulation of cellular biosynthetic process GO:0031327 277 0.412
positive regulation of neurogenesis GO:0050769 41 0.412
Human
intracellular signal transduction GO:0035556 300 0.409
Zebrafish
positive regulation of cell projection organization GO:0031346 29 0.405
Human
negative regulation of nucleic acid templated transcription GO:1903507 240 0.405
regulation of cellular component biogenesis GO:0044087 201 0.403
Zebrafish
segmentation GO:0035282 207 0.401
heart formation GO:0060914 6 0.401
Zebrafish
muscle organ development GO:0007517 127 0.397
activation of cysteine type endopeptidase activity GO:0097202 17 0.396
Human
negative regulation of cell communication GO:0010648 223 0.394
Human
epithelial tube morphogenesis GO:0060562 88 0.392
Mouse
dendrite morphogenesis GO:0048813 199 0.390
Rat Fly
positive regulation of rna biosynthetic process GO:1902680 266 0.386
reproductive system development GO:0061458 74 0.385
positive regulation of multicellular organismal process GO:0051240 143 0.385
Human
morphogenesis of a branching epithelium GO:0061138 45 0.381
response to endogenous stimulus GO:0009719 119 0.378
Human
regulation of synapse assembly GO:0051963 94 0.375
Zebrafish
positive regulation of transcription dna templated GO:0045893 266 0.375
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.364
cell fate specification GO:0001708 71 0.363
regulation of small gtpase mediated signal transduction GO:0051056 93 0.353
Zebrafish
regulation of nervous system development GO:0051960 248 0.351
Human Zebrafish Rat Fly
regulation of cell proliferation GO:0042127 163 0.350
Human Mouse
exocrine system development GO:0035272 162 0.348
cell migration GO:0016477 238 0.342
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.342
Human
small gtpase mediated signal transduction GO:0007264 88 0.340
Zebrafish
regulation of intracellular signal transduction GO:1902531 236 0.337
Zebrafish
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.334
regulation of cell projection organization GO:0031344 92 0.334
Human Zebrafish Rat Fly
synapse organization GO:0050808 196 0.333
Zebrafish
sex differentiation GO:0007548 81 0.331
positive regulation of nervous system development GO:0051962 69 0.328
Human
lamellipodium organization GO:0097581 21 0.325
Zebrafish
cardiac cell fate specification GO:0060912 10 0.324
regulation of photoreceptor cell axon guidance GO:2000289 5 0.317
startle response GO:0001964 16 0.314
Fly
gastrulation GO:0007369 70 0.312
negative regulation of developmental process GO:0051093 201 0.302
Human Zebrafish
regulation of localization GO:0032879 275 0.298
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.294
regulation of cysteine type endopeptidase activity GO:2000116 27 0.294
Human
negative regulation of biosynthetic process GO:0009890 277 0.291
central nervous system neuron differentiation GO:0021953 8 0.286
Human Zebrafish Mouse
regulation of cell size GO:0008361 63 0.282
Zebrafish
chemotaxis GO:0006935 249 0.277
brain morphogenesis GO:0048854 16 0.274
Fly
positive regulation of molecular function GO:0044093 136 0.274
Human
formation of organ boundary GO:0010160 30 0.272
developmental growth GO:0048589 280 0.269
Zebrafish Mouse
tissue morphogenesis GO:0048729 297 0.263
Zebrafish Mouse
cellular response to chemical stimulus GO:0070887 199 0.263
Human Mouse
response to organic substance GO:0010033 284 0.251
Human
stem cell fate commitment GO:0048865 25 0.250
taxis GO:0042330 304 0.249
reproductive structure development GO:0048608 74 0.246
positive regulation of cell motility GO:2000147 3 0.242
regulation of synapse organization GO:0050807 110 0.234
Zebrafish
cell proliferation GO:0008283 299 0.228
Human Mouse
regulation of growth GO:0040008 233 0.228
Zebrafish
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.226
Human Zebrafish Rat
regulation of organelle organization GO:0033043 196 0.217
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.215
neuroblast development GO:0014019 13 0.213
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.212
roundabout signaling pathway GO:0035385 4 0.211
Human Fly
negative regulation of apoptotic process GO:0043066 63 0.209
peptidyl lysine acetylation GO:0018394 39 0.206
neuron fate specification GO:0048665 12 0.205
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.203
ras protein signal transduction GO:0007265 88 0.199
Zebrafish
neuroblast differentiation GO:0014016 29 0.193
negative regulation of response to external stimulus GO:0032102 22 0.191
Human Zebrafish
chromosome organization GO:0051276 360 0.190
appendage development GO:0048736 401 0.186
regulation of neuron differentiation GO:0045664 103 0.185
Human Zebrafish Rat Fly
positive regulation of axon guidance GO:1902669 1 0.183
embryo development ending in birth or egg hatching GO:0009792 152 0.181
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.175
Human
neuroblast fate specification GO:0014018 2 0.173
embryonic heart tube development GO:0035050 22 0.167
negative regulation of synapse assembly GO:0051964 39 0.166
Zebrafish
positive regulation of cell adhesion GO:0045785 10 0.163
cell maturation GO:0048469 144 0.162
negative regulation of rna biosynthetic process GO:1902679 240 0.158
malpighian tubule development GO:0072002 64 0.156
transcription from rna polymerase ii promoter GO:0006366 368 0.153
positive regulation of intracellular signal transduction GO:1902533 116 0.148
Zebrafish
regulation of anatomical structure morphogenesis GO:0022603 242 0.145
Human Zebrafish Rat
imaginal disc derived appendage development GO:0048737 399 0.145
germ cell migration GO:0008354 43 0.141
anterior posterior axis specification GO:0009948 109 0.141
positive regulation of developmental process GO:0051094 143 0.140
Human
leg disc development GO:0035218 92 0.140
regulation of cell substrate adhesion GO:0010810 2 0.139
Zebrafish
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.136
positive regulation of proteolysis GO:0045862 52 0.135
Human
neuron projection extension involved in neuron projection guidance GO:1902284 10 0.135
Zebrafish
negative regulation of cell death GO:0060548 81 0.134
proteolysis GO:0006508 192 0.133
Human
neuron projection extension GO:1990138 32 0.132
Zebrafish
malpighian tubule morphogenesis GO:0007443 44 0.131
cell fate determination GO:0001709 91 0.128
epidermis development GO:0008544 65 0.127
eye photoreceptor cell fate commitment GO:0042706 37 0.126
cellular ketone metabolic process GO:0042180 24 0.124
regulation of synapse structure and activity GO:0050803 128 0.123
Zebrafish
negative regulation of chemotaxis GO:0050922 1 0.121
Human Zebrafish
body morphogenesis GO:0010171 2 0.121
urogenital system development GO:0001655 72 0.120
Human Mouse
regulation of protein metabolic process GO:0051246 256 0.120
Human
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.118
Human
epithelial cell migration GO:0010631 148 0.117
regulation of hydrolase activity GO:0051336 97 0.117
Human
negative regulation of response to stimulus GO:0048585 258 0.116
Human Zebrafish
dendrite self avoidance GO:0070593 8 0.116
cardiac cell fate determination GO:0060913 3 0.116
positive regulation of nucleic acid templated transcription GO:1903508 266 0.115
regulation of cell migration GO:0030334 22 0.115
determination of ventral identity GO:0048264 1 0.114
Zebrafish
spinal cord development GO:0021510 1 0.112
Rat
positive regulation of hydrolase activity GO:0051345 78 0.111
Human
chromatin organization GO:0006325 207 0.110
positive regulation of axon extension GO:0045773 2 0.109
embryonic pattern specification GO:0009880 174 0.109
leg disc proximal distal pattern formation GO:0007479 9 0.108
positive regulation of cellular component organization GO:0051130 156 0.107
Human
regulation of locomotion GO:0040012 42 0.107
mesodermal cell migration GO:0008078 7 0.107
morphogenesis of an epithelium GO:0002009 276 0.106
Zebrafish Mouse
central nervous system neuron axonogenesis GO:0021955 7 0.103
Zebrafish
positive regulation of cell cell adhesion GO:0022409 9 0.103
determination of dorsal ventral asymmetry GO:0048262 3 0.101
Zebrafish
positive regulation of cell migration GO:0030335 2 0.101
chromatin modification GO:0016568 147 0.101
terminal region determination GO:0007362 25 0.101
blastoderm segmentation GO:0007350 159 0.100
photoreceptor cell axon guidance GO:0072499 23 0.098
Fly
negative regulation of rna metabolic process GO:0051253 251 0.097
anterior commissure morphogenesis GO:0021960 2 0.096
epithelium migration GO:0090132 148 0.096
actin polymerization or depolymerization GO:0008154 31 0.093
organic substance catabolic process GO:1901575 308 0.092
imaginal disc derived appendage morphogenesis GO:0035114 395 0.091
positive regulation of cell death GO:0010942 69 0.090
Human
axonal defasciculation GO:0007414 12 0.090
gland morphogenesis GO:0022612 145 0.089
Mouse
positive regulation of ras protein signal transduction GO:0046579 43 0.089
Zebrafish
positive regulation of rna metabolic process GO:0051254 271 0.089
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.088
camera type eye development GO:0043010 4 0.087
positive regulation of cell development GO:0010720 61 0.087
Human
regulation of photoreceptor cell differentiation GO:0046532 34 0.084
digestive tract development GO:0048565 149 0.084
humoral immune response GO:0006959 117 0.083
response to biotic stimulus GO:0009607 294 0.082
digestive system development GO:0055123 149 0.080
cell migration involved in gastrulation GO:0042074 9 0.078
single organism cell adhesion GO:0098602 47 0.078
camera type eye morphogenesis GO:0048593 2 0.077
gland development GO:0048732 191 0.077
embryonic morphogenesis GO:0048598 206 0.076
negative regulation of multicellular organismal process GO:0051241 142 0.076
Human Zebrafish
sensory organ morphogenesis GO:0090596 260 0.076
regulation of ras protein signal transduction GO:0046578 93 0.075
Zebrafish
kidney development GO:0001822 3 0.074
Human Mouse
endocytosis GO:0006897 310 0.073
purine ribonucleotide catabolic process GO:0009154 109 0.072
phosphatidylinositol mediated signaling GO:0048015 4 0.072
response to other organism GO:0051707 293 0.072
negative regulation of cell differentiation GO:0045596 143 0.071
Zebrafish
negative regulation of nervous system development GO:0051961 92 0.071
Zebrafish
regulation of extent of cell growth GO:0061387 8 0.071
Zebrafish
response to wounding GO:0009611 94 0.070
cell death GO:0008219 279 0.070
Human
small molecule metabolic process GO:0044281 305 0.070
regulation of proteolysis GO:0030162 87 0.070
Human
signal transduction in response to dna damage GO:0042770 3 0.069
enzyme linked receptor protein signaling pathway GO:0007167 179 0.068
regulation of neurogenesis GO:0050767 158 0.067
Human Zebrafish Rat Fly
digestive tract morphogenesis GO:0048546 127 0.067
positive regulation of cell morphogenesis involved in differentiation GO:0010770 12 0.066
Human
positive regulation of cell communication GO:0010647 250 0.065
Zebrafish
synaptic target recognition GO:0008039 45 0.065
negative regulation of neurogenesis GO:0050768 53 0.064
Zebrafish
regulation of catalytic activity GO:0050790 185 0.064
Human
appendage morphogenesis GO:0035107 397 0.062
cardioblast cell fate determination GO:0007510 3 0.062
development of primary sexual characteristics GO:0045137 50 0.062
biological adhesion GO:0022610 138 0.061
regulation of anatomical structure size GO:0090066 163 0.060
Zebrafish
skin development GO:0043588 65 0.060
positive regulation of response to stimulus GO:0048584 323 0.059
Zebrafish
response to organic cyclic compound GO:0014070 89 0.059
oocyte anterior posterior axis specification GO:0007314 72 0.058
single organismal cell cell adhesion GO:0016337 45 0.057
nucleoside phosphate catabolic process GO:1901292 110 0.056
photoreceptor cell fate commitment GO:0046552 41 0.056
cell division GO:0051301 248 0.055
oocyte axis specification GO:0007309 108 0.055
gliogenesis GO:0042063 80 0.055
response to alcohol GO:0097305 95 0.054
regulation of embryonic development GO:0045995 68 0.054
organonitrogen compound metabolic process GO:1901564 318 0.054
salivary gland morphogenesis GO:0007435 145 0.054
regulation of circadian rhythm GO:0042752 49 0.053
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.053
wound healing GO:0042060 75 0.053
regulation of phosphatase activity GO:0010921 3 0.053
positive regulation of cellular protein metabolic process GO:0032270 118 0.052
Human
regulation of endocytosis GO:0030100 37 0.051
regulation of rac protein signal transduction GO:0035020 3 0.051
Zebrafish
cellular catabolic process GO:0044248 372 0.051
columnar cuboidal epithelial cell development GO:0002066 249 0.050
nucleotide catabolic process GO:0009166 109 0.049
anatomical structure homeostasis GO:0060249 97 0.049
Fly
neuron death GO:0070997 27 0.049
positive regulation of endopeptidase activity GO:0010950 26 0.048
Human
zymogen activation GO:0031638 20 0.048
Human
axonal fasciculation GO:0007413 12 0.048
Zebrafish
regulation of epithelial cell differentiation GO:0030856 4 0.048
cellular nitrogen compound catabolic process GO:0044270 165 0.047
positive regulation of signal transduction GO:0009967 223 0.047
Zebrafish
negative regulation of cellular metabolic process GO:0031324 382 0.047
cellular homeostasis GO:0019725 80 0.047
Fly
negative regulation of cellular component organization GO:0051129 108 0.047
Zebrafish
anterior posterior axis specification embryo GO:0008595 103 0.047
cell growth GO:0016049 108 0.047
Zebrafish
regulation of protein acetylation GO:1901983 7 0.046
tripartite regional subdivision GO:0007351 103 0.046
single organism biosynthetic process GO:0044711 206 0.046
branching involved in open tracheal system development GO:0060446 45 0.046
regulation of cellular component movement GO:0051270 42 0.045
positive regulation of peptidase activity GO:0010952 29 0.045
Human
positive regulation of programmed cell death GO:0043068 62 0.045
Human
mesodermal cell fate commitment GO:0001710 7 0.045
protein catabolic process GO:0030163 101 0.045
response to external biotic stimulus GO:0043207 293 0.045
negative regulation of rho protein signal transduction GO:0035024 1 0.045
cell matrix adhesion GO:0007160 6 0.044
Zebrafish
regulation of cell motility GO:2000145 23 0.044
eye photoreceptor cell differentiation GO:0001754 145 0.044
gonad morphogenesis GO:0035262 7 0.044
spiracle morphogenesis open tracheal system GO:0035277 22 0.044
organic cyclic compound catabolic process GO:1901361 168 0.043
ocellus development GO:0008056 4 0.043
peripheral nervous system development GO:0007422 52 0.043
cell substrate adhesion GO:0031589 10 0.042
Zebrafish
mesoderm development GO:0007498 78 0.042
dorsal ventral pattern formation GO:0009953 133 0.042
Zebrafish
formation of primary germ layer GO:0001704 24 0.042
morphogenesis of embryonic epithelium GO:0016331 94 0.041
protein modification process GO:0036211 438 0.040
brain segmentation GO:0035284 5 0.040
positive regulation of protein metabolic process GO:0051247 128 0.040
Human
embryonic axis specification GO:0000578 107 0.040
embryonic hemopoiesis GO:0035162 26 0.040
positive regulation of locomotion GO:0040017 8 0.040
neuron fate commitment GO:0048663 50 0.039
central nervous system segmentation GO:0035283 5 0.039
dorsal closure GO:0007391 79 0.039
regulation of lamellipodium assembly GO:0010591 15 0.039
epithelial cell differentiation GO:0030855 322 0.039
regulation of chemotaxis GO:0050920 12 0.038
Human Zebrafish
skeletal muscle organ development GO:0060538 48 0.037
glial cell differentiation GO:0010001 35 0.037
mesoderm formation GO:0001707 21 0.037
response to ethanol GO:0045471 59 0.035
gonadal mesoderm development GO:0007506 8 0.035
regulation of molecular function GO:0065009 217 0.035
Human
positive regulation of catabolic process GO:0009896 105 0.034
ectodermal placode development GO:0071696 4 0.034
purine nucleoside triphosphate catabolic process GO:0009146 108 0.034
positive regulation of apoptotic process GO:0043065 47 0.033
Human
branching morphogenesis of an epithelial tube GO:0048754 45 0.033
positive regulation of neuron projection development GO:0010976 14 0.033
Human
regulation of axon extension GO:0030516 8 0.033
Zebrafish
extrinsic apoptotic signaling pathway GO:0097191 1 0.033
inositol lipid mediated signaling GO:0048017 4 0.033
nephron tubule morphogenesis GO:0072078 3 0.032
ribonucleotide catabolic process GO:0009261 109 0.032
covalent chromatin modification GO:0016569 106 0.032
pole plasm oskar mrna localization GO:0045451 46 0.031
hindgut development GO:0061525 58 0.031
eye development GO:0001654 323 0.031
actin filament bundle organization GO:0061572 28 0.031
positive regulation of cellular component biogenesis GO:0044089 80 0.030
pharynx development GO:0060465 1 0.030
regulation of cellular component size GO:0032535 98 0.030
Zebrafish
cellular response to endogenous stimulus GO:0071495 80 0.029
Human
neuron apoptotic process GO:0051402 17 0.029
internal peptidyl lysine acetylation GO:0018393 38 0.029
positive regulation of biosynthetic process GO:0009891 316 0.029
vesicle mediated transport GO:0016192 381 0.028
actin filament polymerization GO:0030041 27 0.028
antimicrobial humoral response GO:0019730 99 0.028
mesoderm morphogenesis GO:0048332 22 0.028
developmental maturation GO:0021700 172 0.028
central nervous system neuron development GO:0021954 8 0.028
Human Zebrafish Mouse
regulation of neuron death GO:1901214 26 0.027
apoptotic signaling pathway GO:0097190 27 0.027
stem cell fate specification GO:0048866 2 0.027
regulation of chromatin modification GO:1903308 28 0.027
regulation of neuron apoptotic process GO:0043523 16 0.026
negative regulation of programmed cell death GO:0043069 72 0.026
positive regulation of neuron differentiation GO:0045666 26 0.025
Human
neuroblast division GO:0055057 35 0.025
single organism catabolic process GO:0044712 228 0.025
regulation of cell cycle GO:0051726 291 0.025
negative regulation of phosphatase activity GO:0010923 3 0.025
neuroepithelial cell differentiation GO:0060563 6 0.024
regulation of cellular amine metabolic process GO:0033238 3 0.024
photoreceptor cell differentiation GO:0046530 170 0.024
garland nephrocyte differentiation GO:0061321 3 0.024
positive regulation of cell substrate adhesion GO:0010811 1 0.024
Zebrafish
protein acylation GO:0043543 42 0.023
negative regulation of cell development GO:0010721 62 0.023
Zebrafish
cortical actin cytoskeleton organization GO:0030866 24 0.023
cell adhesion GO:0007155 136 0.023
amnioserosa maintenance GO:0046665 5 0.023
immune effector process GO:0002252 98 0.023
tube morphogenesis GO:0035239 191 0.023
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.022
regulation of stem cell proliferation GO:0072091 40 0.022
hindbrain development GO:0030902 2 0.022
synaptic growth at neuromuscular junction GO:0051124 119 0.022
embryonic organ morphogenesis GO:0048562 5 0.022
negative regulation of signal transduction GO:0009968 206 0.022
Human
positive regulation of developmental growth GO:0048639 62 0.022
cellular protein modification process GO:0006464 438 0.021
macromolecular complex assembly GO:0065003 256 0.021
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.021
retina morphogenesis in camera type eye GO:0060042 2 0.021
cellular response to hormone stimulus GO:0032870 44 0.021
Human
compound eye morphogenesis GO:0001745 249 0.021
regulation of cellular ketone metabolic process GO:0010565 3 0.021
stem cell division GO:0017145 69 0.021
lamellipodium assembly GO:0030032 21 0.020
Zebrafish
protein processing GO:0016485 68 0.020
Human
positive regulation of cellular catabolic process GO:0031331 95 0.020
phosphorylation GO:0016310 294 0.020
nucleoside metabolic process GO:0009116 127 0.020
immune system process GO:0002376 347 0.020
collateral sprouting GO:0048668 3 0.020
positive regulation of rho gtpase activity GO:0032321 19 0.020
apoptotic process involved in morphogenesis GO:0060561 3 0.020
regulation of cellular protein metabolic process GO:0032268 243 0.019
Human
locomotory behavior GO:0007626 176 0.019
Fly
nephron epithelium development GO:0072009 3 0.019
regulation of response to wounding GO:1903034 19 0.019
regulation of rho protein signal transduction GO:0035023 20 0.019
epidermal cell differentiation GO:0009913 51 0.019
immune response GO:0006955 246 0.019
macromolecule catabolic process GO:0009057 161 0.019
response to organonitrogen compound GO:0010243 75 0.019
regulation of response to stress GO:0080134 200 0.019
negative regulation of cell projection organization GO:0031345 13 0.019
Zebrafish
regulation of behavior GO:0050795 75 0.019
Human Zebrafish
actin cytoskeleton organization GO:0030036 206 0.019
regulation of dendrite development GO:0050773 37 0.019
Rat Fly
regulation of mitotic cell cycle GO:0007346 190 0.019
hindgut morphogenesis GO:0007442 58 0.018
positive regulation of gtpase activity GO:0043547 43 0.018
antimicrobial peptide production GO:0002775 46 0.018
negative regulation of cell proliferation GO:0008285 69 0.018
Human Mouse
positive regulation of phosphate metabolic process GO:0045937 139 0.018
nucleoside triphosphate catabolic process GO:0009143 108 0.018
regulation of histone modification GO:0031056 20 0.018
dna conformation change GO:0071103 105 0.018
response to lipid GO:0033993 38 0.018
ribonucleoside triphosphate catabolic process GO:0009203 108 0.018
embryonic epithelial tube formation GO:0001838 6 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
negative regulation of intracellular signal transduction GO:1902532 57 0.017
histone modification GO:0016570 106 0.017
mesenchymal cell development GO:0014031 1 0.017
parallel actin filament bundle assembly GO:0030046 2 0.017
nucleobase containing compound catabolic process GO:0034655 165 0.017
induction of programmed cell death by hormones GO:0035081 12 0.017
positive chemotaxis GO:0050918 4 0.017
Mouse
leg disc morphogenesis GO:0007478 80 0.017

lea disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.216
Human
nervous system disease DOID:863 0 0.045
cancer DOID:162 0 0.033
disease of cellular proliferation DOID:14566 0 0.033
congenital heart disease DOID:1682 0 0.024
heart disease DOID:114 0 0.024
cardiovascular system disease DOID:1287 0 0.024
urinary system disease DOID:18 0 0.023
Human
sensory system disease DOID:0050155 0 0.023
eye and adnexa disease DOID:1492 0 0.023
eye disease DOID:5614 0 0.019