Drosophila melanogaster

52 known processes

Nak (Dmel_CG10637)

Numb-associated kinase

(Aliases: nak,CG10637,Dmel\CG10637)

Nak biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
microtubule organizing center organization GO:0031023 168 0.383
cellular protein modification process GO:0006464 438 0.297
Human Yeast Mouse Rat
centrosome organization GO:0051297 163 0.223
regulation of cell differentiation GO:0045595 302 0.151
imaginal disc derived appendage morphogenesis GO:0035114 395 0.107
homeostatic process GO:0042592 199 0.094
negative regulation of gene expression GO:0010629 387 0.090
regulation of cell development GO:0060284 215 0.074
regulation of nervous system development GO:0051960 248 0.069
positive regulation of dendrite morphogenesis GO:0050775 9 0.069
regulation of notch signaling pathway GO:0008593 100 0.067
Human
adult locomotory behavior GO:0008344 76 0.066
regulation of phosphorylation GO:0042325 147 0.066
negative regulation of cell communication GO:0010648 223 0.060
regulation of cellular localization GO:0060341 136 0.058
response to abiotic stimulus GO:0009628 341 0.055
rho protein signal transduction GO:0007266 14 0.054
protein modification process GO:0036211 438 0.051
Human Yeast Mouse Rat
death GO:0016265 284 0.050
catabolic process GO:0009056 409 0.050
imaginal disc derived wing morphogenesis GO:0007476 337 0.049
protein phosphorylation GO:0006468 169 0.047
Human Yeast Mouse Rat
regulation of microtubule cytoskeleton organization GO:0070507 41 0.045
negative regulation of developmental process GO:0051093 201 0.044
negative regulation of cellular metabolic process GO:0031324 382 0.042
spermatogenesis GO:0007283 200 0.042
centrosome cycle GO:0007098 137 0.042
response to starvation GO:0042594 97 0.040
regulation of nurse cell apoptotic process GO:0045477 9 0.040
regulation of neuron differentiation GO:0045664 103 0.039
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.038
spermatid differentiation GO:0048515 114 0.038
positive regulation of signaling GO:0023056 243 0.038
Human
microtubule polymerization or depolymerization GO:0031109 39 0.037
phosphorylation GO:0016310 294 0.036
Human Yeast Mouse Rat
single organism cellular localization GO:1902580 180 0.035
response to nutrient levels GO:0031667 114 0.034
heterochromatin organization GO:0070828 25 0.034
regulation of intracellular signal transduction GO:1902531 236 0.034
protein complex disassembly GO:0043241 36 0.034
cell cell signaling involved in cell fate commitment GO:0045168 210 0.033
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.033
regulation of neurogenesis GO:0050767 158 0.032
negative regulation of rna biosynthetic process GO:1902679 240 0.032
positive regulation of cellular biosynthetic process GO:0031328 316 0.031
developmental maturation GO:0021700 172 0.031
oocyte development GO:0048599 124 0.031
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.030
endocytosis GO:0006897 310 0.030
negative regulation of cell differentiation GO:0045596 143 0.029
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.029
protein transport GO:0015031 155 0.028
single organism intracellular transport GO:1902582 207 0.027
transmembrane transport GO:0055085 139 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.026
regulation of microtubule based process GO:0032886 49 0.026
cellular catabolic process GO:0044248 372 0.026
vesicle mediated transport GO:0016192 381 0.025
regulation of cellular catabolic process GO:0031329 157 0.025
immune effector process GO:0002252 98 0.025
developmental programmed cell death GO:0010623 138 0.024
negative regulation of microtubule depolymerization GO:0007026 21 0.024
nucleocytoplasmic transport GO:0006913 72 0.024
response to oxygen containing compound GO:1901700 200 0.023
positive regulation of signal transduction GO:0009967 223 0.023
Human
tube morphogenesis GO:0035239 191 0.023
maintenance of location GO:0051235 73 0.022
autophagic cell death GO:0048102 83 0.022
regulation of hydrolase activity GO:0051336 97 0.022
negative regulation of multicellular organismal process GO:0051241 142 0.022
regulation of localization GO:0032879 275 0.022
organonitrogen compound metabolic process GO:1901564 318 0.022
response to heat GO:0009408 63 0.022
salivary gland histolysis GO:0035070 88 0.022
meiosis i GO:0007127 59 0.021
regulation of phosphorus metabolic process GO:0051174 210 0.021
negative regulation of signal transduction GO:0009968 206 0.021
negative regulation of protein metabolic process GO:0051248 85 0.021
oocyte differentiation GO:0009994 145 0.021
positive regulation of response to stimulus GO:0048584 323 0.021
Human
regulation of transferase activity GO:0051338 58 0.021
carbohydrate derivative metabolic process GO:1901135 217 0.021
cell cycle checkpoint GO:0000075 95 0.021
cell maturation GO:0048469 144 0.020
regulation of phosphate metabolic process GO:0019220 210 0.020
mapk cascade GO:0000165 107 0.020
oxoacid metabolic process GO:0043436 103 0.020
response to extracellular stimulus GO:0009991 116 0.020
protein complex assembly GO:0006461 200 0.020
negative regulation of cell development GO:0010721 62 0.020
microtubule depolymerization GO:0007019 25 0.019
negative regulation of cellular protein metabolic process GO:0032269 85 0.019
regulation of microtubule depolymerization GO:0031114 24 0.019
pigment cell differentiation GO:0050931 3 0.018
dna integrity checkpoint GO:0031570 81 0.018
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.018
detection of stimulus GO:0051606 156 0.018
positive regulation of cellular catabolic process GO:0031331 95 0.018
regulation of transport GO:0051049 181 0.018
multi organism reproductive behavior GO:0044705 121 0.018
atp catabolic process GO:0006200 38 0.018
positive regulation of exocytosis GO:0045921 4 0.018
dna damage checkpoint GO:0000077 78 0.017
purine nucleotide metabolic process GO:0006163 146 0.017
positive regulation of jun kinase activity GO:0043507 4 0.017
meiotic cell cycle process GO:1903046 132 0.017
cell cycle phase transition GO:0044770 140 0.017
gene silencing GO:0016458 138 0.017
positive regulation of cellular protein metabolic process GO:0032270 118 0.017
cellular protein complex disassembly GO:0043624 35 0.017
protein complex biogenesis GO:0070271 201 0.017
imaginal disc derived wing vein specification GO:0007474 48 0.017
intracellular transport GO:0046907 228 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.016
organic acid metabolic process GO:0006082 103 0.016
meiotic chromosome segregation GO:0045132 59 0.016
regulation of organ morphogenesis GO:2000027 78 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
regulation of gtp catabolic process GO:0033124 44 0.015
negative regulation of response to stimulus GO:0048585 258 0.015
carbohydrate derivative catabolic process GO:1901136 118 0.015
digestive tract development GO:0048565 149 0.015
regulation of catalytic activity GO:0050790 185 0.015
Mouse
apoptotic process GO:0006915 159 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.015
spermatid development GO:0007286 98 0.015
regulation of protein complex disassembly GO:0043244 29 0.015
chromatin remodeling GO:0006338 72 0.015
chromosome condensation GO:0030261 41 0.015
tissue death GO:0016271 102 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.014
cellular pigmentation GO:0033059 12 0.014
organelle localization GO:0051640 148 0.014
regulation of multi organism process GO:0043900 131 0.014
multicellular organismal aging GO:0010259 140 0.014
regulation of protein phosphorylation GO:0001932 64 0.014
cellular amide metabolic process GO:0043603 80 0.014
skeletal muscle organ development GO:0060538 48 0.014
positive regulation of nervous system development GO:0051962 69 0.014
cellular response to oxygen containing compound GO:1901701 79 0.014
protein targeting to nucleus GO:0044744 51 0.014
tube development GO:0035295 244 0.014
telomere maintenance GO:0000723 21 0.013
regulation of hemocyte proliferation GO:0035206 37 0.013
response to monosaccharide GO:0034284 4 0.013
negative regulation of transcription dna templated GO:0045892 237 0.013
organic substance transport GO:0071702 257 0.013
centrosome duplication GO:0051298 121 0.013
protein modification by small protein conjugation or removal GO:0070647 106 0.013
regulation of cell cycle GO:0051726 291 0.013
germarium derived egg chamber formation GO:0007293 101 0.013
positive regulation of cell differentiation GO:0045597 64 0.013
heterocycle catabolic process GO:0046700 166 0.013
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
dna geometric change GO:0032392 16 0.013
purine ribonucleoside metabolic process GO:0046128 127 0.013
positive regulation of rac gtpase activity GO:0032855 8 0.013
programmed cell death GO:0012501 257 0.012
purine ribonucleoside catabolic process GO:0046130 112 0.012
protein alkylation GO:0008213 43 0.012
positive regulation of apoptotic process GO:0043065 47 0.012
ras protein signal transduction GO:0007265 88 0.012
response to endogenous stimulus GO:0009719 119 0.012
regulation of mapk cascade GO:0043408 92 0.012
cell death GO:0008219 279 0.012
chromatin organization GO:0006325 207 0.012
small molecule metabolic process GO:0044281 305 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
organic substance catabolic process GO:1901575 308 0.012
regulation of rho protein signal transduction GO:0035023 20 0.012
peptidyl amino acid modification GO:0018193 105 0.012
regulation of vesicle mediated transport GO:0060627 59 0.012
regulation of heterochromatin assembly GO:0031445 8 0.012
methylation GO:0032259 47 0.012
mitotic cell cycle checkpoint GO:0007093 88 0.012
intracellular signal transduction GO:0035556 300 0.012
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
endomembrane system organization GO:0010256 119 0.011
cellular response to starvation GO:0009267 61 0.011
single organism catabolic process GO:0044712 228 0.011
regulation of proteolysis GO:0030162 87 0.011
regulation of endocytosis GO:0030100 37 0.011
positive regulation of rna biosynthetic process GO:1902680 266 0.011
rna catabolic process GO:0006401 37 0.011
signal transduction in response to dna damage GO:0042770 3 0.011
polyol biosynthetic process GO:0046173 3 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.011
positive regulation of cell development GO:0010720 61 0.011
negative regulation of erbb signaling pathway GO:1901185 29 0.011
macromolecular complex assembly GO:0065003 256 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
cellular response to abiotic stimulus GO:0071214 58 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
nucleoside metabolic process GO:0009116 127 0.011
dna methylation or demethylation GO:0044728 4 0.011
regulation of reproductive process GO:2000241 54 0.011
immune system process GO:0002376 347 0.011
negative regulation of biosynthetic process GO:0009890 277 0.011
actin filament based process GO:0030029 220 0.010
Yeast
organ formation GO:0048645 39 0.010
gtp metabolic process GO:0046039 72 0.010
protein processing GO:0016485 68 0.010
small gtpase mediated signal transduction GO:0007264 88 0.010
regulation of intracellular transport GO:0032386 64 0.010
divalent metal ion transport GO:0070838 26 0.010
pigmentation GO:0043473 75 0.010
cytoplasmic transport GO:0016482 130 0.010
positive regulation of cell communication GO:0010647 250 0.010
Human
cellular macromolecular complex assembly GO:0034622 153 0.010
innate immune response GO:0045087 144 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.010
regulation of small gtpase mediated signal transduction GO:0051056 93 0.010
ribonucleoside catabolic process GO:0042454 112 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010

Nak disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
kidney disease DOID:557 0 0.011
urinary system disease DOID:18 0 0.011