Drosophila melanogaster

7 known processes

Pros28.1 (Dmel_CG3422)

Proteasome 28kD subunit 1

(Aliases: Pros28,PROS-28.1,Prosalpha4,alpha4,3422,PROS-Dm28.1,pros28.1,alpha4_dm,PSA4_DROME,Dmel\CG3422,28.1Pros,PROSA-28.1,CG3422,Pros-Dm28.1,a4)

Pros28.1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.705
Yeast
modification dependent macromolecule catabolic process GO:0043632 79 0.705
Yeast
mitotic spindle elongation GO:0000022 81 0.669
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.597
Yeast
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.463
proteolysis GO:0006508 192 0.403
Yeast
modification dependent protein catabolic process GO:0019941 78 0.397
Yeast
cellular response to dna damage stimulus GO:0006974 223 0.323
cellular protein catabolic process GO:0044257 83 0.307
Yeast
cellular catabolic process GO:0044248 372 0.298
Yeast
proteasomal protein catabolic process GO:0010498 59 0.287
Yeast
protein catabolic process GO:0030163 101 0.271
Yeast
catabolic process GO:0009056 409 0.256
Yeast
ubiquitin dependent protein catabolic process GO:0006511 78 0.235
Yeast
chromosome organization GO:0051276 360 0.224
macromolecule catabolic process GO:0009057 161 0.211
Yeast
multicellular organismal aging GO:0010259 140 0.183
organic substance catabolic process GO:1901575 308 0.175
Yeast
aging GO:0007568 143 0.153
programmed cell death GO:0012501 257 0.146
protein complex assembly GO:0006461 200 0.141
proteasome assembly GO:0043248 2 0.139
mitotic spindle organization GO:0007052 220 0.129
purine ribonucleotide catabolic process GO:0009154 109 0.123
microtubule organizing center organization GO:0031023 168 0.114
cellular macromolecule catabolic process GO:0044265 136 0.111
Yeast
death GO:0016265 284 0.111
cell death GO:0008219 279 0.107
positive regulation of nucleic acid templated transcription GO:1903508 266 0.101
protein complex biogenesis GO:0070271 201 0.095
spindle organization GO:0007051 253 0.088
organelle assembly GO:0070925 198 0.087
centrosome organization GO:0051297 163 0.080
carboxylic acid metabolic process GO:0019752 92 0.079
cell proliferation GO:0008283 299 0.072
organic acid metabolic process GO:0006082 103 0.072
determination of adult lifespan GO:0008340 137 0.070
dna repair GO:0006281 54 0.070
purine ribonucleotide metabolic process GO:0009150 145 0.066
apoptotic process GO:0006915 159 0.064
nucleoside metabolic process GO:0009116 127 0.062
macromolecular complex assembly GO:0065003 256 0.058
positive regulation of gene expression GO:0010628 290 0.058
positive regulation of transcription dna templated GO:0045893 266 0.054
organonitrogen compound metabolic process GO:1901564 318 0.050
mitotic nuclear division GO:0007067 213 0.049
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.049
positive regulation of biosynthetic process GO:0009891 316 0.049
single organism catabolic process GO:0044712 228 0.049
small molecule metabolic process GO:0044281 305 0.048
body morphogenesis GO:0010171 2 0.048
dna templated transcription initiation GO:0006352 25 0.048
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.047
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.046
purine nucleoside catabolic process GO:0006152 112 0.043
dna metabolic process GO:0006259 227 0.042
organelle fission GO:0048285 340 0.042
purine ribonucleoside metabolic process GO:0046128 127 0.042
response to organic substance GO:0010033 284 0.040
oxoacid metabolic process GO:0043436 103 0.039
spindle elongation GO:0051231 83 0.039
cellular modified amino acid metabolic process GO:0006575 45 0.036
purine containing compound metabolic process GO:0072521 155 0.036
single organism behavior GO:0044708 391 0.036
positive regulation of rna metabolic process GO:0051254 271 0.035
embryo development ending in birth or egg hatching GO:0009792 152 0.035
peptide metabolic process GO:0006518 80 0.034
positive regulation of macromolecule metabolic process GO:0010604 405 0.034
nuclear division GO:0000280 332 0.034
nucleoside phosphate metabolic process GO:0006753 162 0.034
protein dna complex assembly GO:0065004 63 0.033
cellular nitrogen compound catabolic process GO:0044270 165 0.033
ribonucleoside catabolic process GO:0042454 112 0.032
positive regulation of rna biosynthetic process GO:1902680 266 0.032
nucleotide catabolic process GO:0009166 109 0.031
homeostatic process GO:0042592 199 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.030
response to inorganic substance GO:0010035 44 0.030
response to organic cyclic compound GO:0014070 89 0.030
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
purine nucleoside triphosphate catabolic process GO:0009146 108 0.030
carbohydrate derivative metabolic process GO:1901135 217 0.030
cellular homeostasis GO:0019725 80 0.029
mitotic cell cycle phase transition GO:0044772 138 0.028
single organism biosynthetic process GO:0044711 206 0.028
glycosyl compound metabolic process GO:1901657 127 0.027
response to organonitrogen compound GO:0010243 75 0.025
nucleoside phosphate catabolic process GO:1901292 110 0.025
cellular ion homeostasis GO:0006873 39 0.024
cellular protein complex assembly GO:0043623 71 0.024
regulation of cellular ketone metabolic process GO:0010565 3 0.024
carbohydrate derivative catabolic process GO:1901136 118 0.023
chromatin modification GO:0016568 147 0.023
positive regulation of proteolysis GO:0045862 52 0.022
ribonucleotide catabolic process GO:0009261 109 0.022
transcription from rna polymerase ii promoter GO:0006366 368 0.022
nucleotide excision repair GO:0006289 8 0.022
regulation of protein catabolic process GO:0042176 55 0.021
ribonucleotide metabolic process GO:0009259 145 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
small molecule biosynthetic process GO:0044283 37 0.020
regulation of cellular protein metabolic process GO:0032268 243 0.020
lateral inhibition GO:0046331 206 0.020
nucleoside catabolic process GO:0009164 112 0.020
pigmentation GO:0043473 75 0.020
purine ribonucleoside catabolic process GO:0046130 112 0.020
chromatin organization GO:0006325 207 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.020
response to nitrogen compound GO:1901698 90 0.020
organonitrogen compound catabolic process GO:1901565 128 0.020
developmental maturation GO:0021700 172 0.019
nucleobase containing small molecule metabolic process GO:0055086 174 0.019
regulation of cellular component biogenesis GO:0044087 201 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
response to other organism GO:0051707 293 0.019
negative regulation of programmed cell death GO:0043069 72 0.019
ribose phosphate metabolic process GO:0019693 145 0.018
neurological system process GO:0050877 358 0.018
cellular macromolecular complex assembly GO:0034622 153 0.018
positive regulation of cellular component biogenesis GO:0044089 80 0.018
regulation of molecular function GO:0065009 217 0.018
negative regulation of cellular component organization GO:0051129 108 0.018
nucleoside triphosphate metabolic process GO:0009141 120 0.017
protein modification by small protein conjugation or removal GO:0070647 106 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.017
purine nucleoside metabolic process GO:0042278 127 0.017
larval development GO:0002164 104 0.017
negative regulation of gene expression GO:0010629 387 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
cellular response to chemical stimulus GO:0070887 199 0.017
membrane fusion GO:0061025 42 0.017
regulation of cellular catabolic process GO:0031329 157 0.016
negative regulation of cellular metabolic process GO:0031324 382 0.016
ribonucleoside triphosphate catabolic process GO:0009203 108 0.016
regulation of proteasomal protein catabolic process GO:0061136 39 0.016
cellular cation homeostasis GO:0030003 38 0.016
inorganic ion transmembrane transport GO:0098660 73 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
heterocycle catabolic process GO:0046700 166 0.015
spindle assembly involved in mitosis GO:0090307 50 0.015
regulation of catalytic activity GO:0050790 185 0.015
nucleotide metabolic process GO:0009117 161 0.015
purine containing compound catabolic process GO:0072523 112 0.015
response to oxygen containing compound GO:1901700 200 0.015
response to biotic stimulus GO:0009607 294 0.014
response to endogenous stimulus GO:0009719 119 0.014
regulation of proteolysis GO:0030162 87 0.014
negative regulation of nucleic acid templated transcription GO:1903507 240 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.014
forebrain development GO:0030900 2 0.014
cellular chemical homeostasis GO:0055082 40 0.014
response to external biotic stimulus GO:0043207 293 0.014
organophosphate catabolic process GO:0046434 112 0.014
negative regulation of cell death GO:0060548 81 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
aromatic compound catabolic process GO:0019439 166 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
posttranscriptional regulation of gene expression GO:0010608 145 0.013
ribonucleoside metabolic process GO:0009119 127 0.013
regulation of sequestering of calcium ion GO:0051282 3 0.012
protein localization GO:0008104 284 0.012
organophosphate metabolic process GO:0019637 195 0.012
regulation of catabolic process GO:0009894 170 0.012
response to abiotic stimulus GO:0009628 341 0.012
eye pigment biosynthetic process GO:0006726 32 0.012
ion transport GO:0006811 145 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.012
gene silencing GO:0016458 138 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.012
positive regulation of cellular catabolic process GO:0031331 95 0.011
intracellular signal transduction GO:0035556 300 0.011
cation transmembrane transport GO:0098655 88 0.011
regulation of protein modification process GO:0031399 112 0.011
positive regulation of cellular protein catabolic process GO:1903364 24 0.011
regulation of localization GO:0032879 275 0.011
response to oxidative stress GO:0006979 86 0.011
sister chromatid segregation GO:0000819 92 0.011
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.010
spindle assembly GO:0051225 80 0.010
organonitrogen compound biosynthetic process GO:1901566 117 0.010
imaginal disc derived appendage morphogenesis GO:0035114 395 0.010
glycosyl compound catabolic process GO:1901658 112 0.010
protein modification process GO:0036211 438 0.010
camera type eye development GO:0043010 4 0.010
positive regulation of binding GO:0051099 4 0.010
regulation of cellular localization GO:0060341 136 0.010

Pros28.1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036