Drosophila melanogaster

95 known processes

ntc (Dmel_CG10855)

nutcracker

(Aliases: CG10855,Dmel\CG10855)

ntc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sperm individualization GO:0007291 48 0.927
spermatid development GO:0007286 98 0.767
spermatid differentiation GO:0048515 114 0.498
spermatogenesis GO:0007283 200 0.443
male gamete generation GO:0048232 201 0.397
cellularization GO:0007349 90 0.267
cellular response to dna damage stimulus GO:0006974 223 0.184
protein modification by small protein conjugation or removal GO:0070647 106 0.179
protein localization GO:0008104 284 0.146
lateral inhibition GO:0046331 206 0.146
single organism biosynthetic process GO:0044711 206 0.140
protein catabolic process GO:0030163 101 0.133
synaptic growth at neuromuscular junction GO:0051124 119 0.126
neuromuscular junction development GO:0007528 149 0.118
cellular macromolecule catabolic process GO:0044265 136 0.115
cellular catabolic process GO:0044248 372 0.115
nuclear division GO:0000280 332 0.113
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.110
cellular protein catabolic process GO:0044257 83 0.099
regulation of cellular component biogenesis GO:0044087 201 0.095
modification dependent macromolecule catabolic process GO:0043632 79 0.094
ubiquitin dependent protein catabolic process GO:0006511 78 0.088
posttranscriptional regulation of gene expression GO:0010608 145 0.088
synapse assembly GO:0007416 143 0.085
response to external biotic stimulus GO:0043207 293 0.084
organic substance catabolic process GO:1901575 308 0.084
negative regulation of developmental growth GO:0048640 64 0.084
catabolic process GO:0009056 409 0.078
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.078
defense response to bacterium GO:0042742 178 0.071
protein modification process GO:0036211 438 0.069
microtubule organizing center organization GO:0031023 168 0.067
regulation of synapse assembly GO:0051963 94 0.065
protein ubiquitination GO:0016567 70 0.064
negative regulation of developmental process GO:0051093 201 0.064
response to bacterium GO:0009617 198 0.062
negative regulation of response to stimulus GO:0048585 258 0.062
defense response to other organism GO:0098542 225 0.060
small molecule metabolic process GO:0044281 305 0.060
cell death GO:0008219 279 0.060
regulation of synapse structure and activity GO:0050803 128 0.060
proteolysis GO:0006508 192 0.059
negative regulation of cellular metabolic process GO:0031324 382 0.058
regulation of multicellular organismal development GO:2000026 414 0.058
programmed cell death GO:0012501 257 0.058
negative regulation of nervous system development GO:0051961 92 0.058
protein modification by small protein conjugation GO:0032446 79 0.057
response to other organism GO:0051707 293 0.057
negative regulation of rna metabolic process GO:0051253 251 0.056
modification dependent protein catabolic process GO:0019941 78 0.056
regulation of microtubule based process GO:0032886 49 0.055
regulation of phosphorus metabolic process GO:0051174 210 0.052
posttranscriptional gene silencing by rna GO:0035194 45 0.052
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.052
regulation of response to stress GO:0080134 200 0.051
cell cell signaling involved in cell fate commitment GO:0045168 210 0.051
centrosome organization GO:0051297 163 0.047
proteasomal protein catabolic process GO:0010498 59 0.047
intracellular signal transduction GO:0035556 300 0.047
chromatin organization GO:0006325 207 0.046
macromolecule catabolic process GO:0009057 161 0.046
response to biotic stimulus GO:0009607 294 0.046
defense response to gram negative bacterium GO:0050829 94 0.045
enzyme linked receptor protein signaling pathway GO:0007167 179 0.045
regulation of nervous system development GO:0051960 248 0.045
signal transduction by phosphorylation GO:0023014 107 0.045
synapse organization GO:0050808 196 0.044
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.044
carboxylic acid metabolic process GO:0019752 92 0.043
immune system process GO:0002376 347 0.042
regulation of gene expression epigenetic GO:0040029 128 0.042
stress activated protein kinase signaling cascade GO:0031098 55 0.042
regulation of mitotic cell cycle GO:0007346 190 0.042
developmental programmed cell death GO:0010623 138 0.041
regulation of programmed cell death GO:0043067 152 0.041
forebrain development GO:0030900 2 0.041
regulation of intracellular signal transduction GO:1902531 236 0.041
organophosphate metabolic process GO:0019637 195 0.041
chromatin silencing GO:0006342 76 0.041
negative regulation of multicellular organismal process GO:0051241 142 0.040
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.039
positive regulation of proteolysis GO:0045862 52 0.039
cell maturation GO:0048469 144 0.039
immune response GO:0006955 246 0.038
negative regulation of cell communication GO:0010648 223 0.037
developmental growth GO:0048589 280 0.037
positive regulation of macromolecule metabolic process GO:0010604 405 0.037
ribose phosphate metabolic process GO:0019693 145 0.037
regulation of synapse organization GO:0050807 110 0.036
vesicle mediated transport GO:0016192 381 0.035
negative regulation of gene expression epigenetic GO:0045814 77 0.035
endocytosis GO:0006897 310 0.035
negative regulation of cellular biosynthetic process GO:0031327 277 0.034
cellular protein modification process GO:0006464 438 0.034
histone modification GO:0016570 106 0.034
regulation of cell cycle GO:0051726 291 0.034
cellular response to nitrogen compound GO:1901699 51 0.033
cellular protein complex assembly GO:0043623 71 0.033
negative regulation of intracellular signal transduction GO:1902532 57 0.033
negative regulation of nucleic acid templated transcription GO:1903507 240 0.033
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.033
negative regulation of programmed cell death GO:0043069 72 0.032
respiratory system development GO:0060541 213 0.032
negative regulation of cell death GO:0060548 81 0.032
negative regulation of signaling GO:0023057 219 0.032
negative regulation of cell cycle process GO:0010948 109 0.031
negative regulation of biosynthetic process GO:0009890 277 0.031
negative regulation of rna biosynthetic process GO:1902679 240 0.031
oxoacid metabolic process GO:0043436 103 0.031
regulation of localization GO:0032879 275 0.030
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.030
negative regulation of signal transduction GO:0009968 206 0.030
organic acid metabolic process GO:0006082 103 0.029
negative regulation of synapse assembly GO:0051964 39 0.029
organonitrogen compound metabolic process GO:1901564 318 0.029
mitotic cell cycle phase transition GO:0044772 138 0.029
defense response GO:0006952 300 0.029
gene silencing GO:0016458 138 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
regulation of cell death GO:0010941 173 0.028
chromosome organization GO:0051276 360 0.028
mitotic dna damage checkpoint GO:0044773 74 0.027
nucleoside phosphate metabolic process GO:0006753 162 0.027
cellular macromolecule localization GO:0070727 220 0.027
regulation of cellular ketone metabolic process GO:0010565 3 0.027
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.027
negative regulation of cellular component organization GO:0051129 108 0.026
covalent chromatin modification GO:0016569 106 0.026
regulation of cellular amine metabolic process GO:0033238 3 0.026
positive regulation of signaling GO:0023056 243 0.025
g2 dna damage checkpoint GO:0031572 69 0.025
regulation of cytoskeleton organization GO:0051493 89 0.025
cellular response to endogenous stimulus GO:0071495 80 0.025
chromatin modification GO:0016568 147 0.025
ion transmembrane transport GO:0034220 122 0.025
single organism catabolic process GO:0044712 228 0.025
regulation of mapk cascade GO:0043408 92 0.024
positive regulation of cell communication GO:0010647 250 0.024
regulation of cell cycle phase transition GO:1901987 130 0.024
regulation of pole plasm oskar mrna localization GO:0007317 27 0.024
response to peptide hormone GO:0043434 29 0.024
positive regulation of cellular amine metabolic process GO:0033240 0 0.023
carbohydrate derivative metabolic process GO:1901135 217 0.023
pole plasm assembly GO:0007315 61 0.023
transmembrane transport GO:0055085 139 0.023
response to oxygen containing compound GO:1901700 200 0.023
stress activated mapk cascade GO:0051403 52 0.023
posttranscriptional gene silencing GO:0016441 46 0.023
negative regulation of apoptotic process GO:0043066 63 0.023
cellular nitrogen compound catabolic process GO:0044270 165 0.023
positive regulation of protein metabolic process GO:0051247 128 0.023
lipid metabolic process GO:0006629 121 0.023
negative regulation of transcription dna templated GO:0045892 237 0.023
regulation of microtubule cytoskeleton organization GO:0070507 41 0.022
negative regulation of mapk cascade GO:0043409 23 0.022
purine ribonucleoside metabolic process GO:0046128 127 0.022
cellular protein localization GO:0034613 160 0.022
regulation of apoptotic process GO:0042981 130 0.022
regulation of gene silencing GO:0060968 63 0.022
eye photoreceptor cell differentiation GO:0001754 145 0.022
regulation of phosphate metabolic process GO:0019220 210 0.022
wing disc morphogenesis GO:0007472 344 0.022
response to nitrogen compound GO:1901698 90 0.022
death GO:0016265 284 0.021
dna conformation change GO:0071103 105 0.021
organelle fission GO:0048285 340 0.021
regulation of growth GO:0040008 233 0.021
positive regulation of cellular component organization GO:0051130 156 0.021
gland morphogenesis GO:0022612 145 0.021
regulation of catabolic process GO:0009894 170 0.020
neural precursor cell proliferation GO:0061351 75 0.020
negative regulation of gene expression GO:0010629 387 0.020
small gtpase mediated signal transduction GO:0007264 88 0.020
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.020
growth GO:0040007 359 0.020
maternal determination of anterior posterior axis embryo GO:0008358 74 0.020
salivary gland development GO:0007431 162 0.020
rna processing GO:0006396 147 0.019
phosphorylation GO:0016310 294 0.019
localization of cell GO:0051674 257 0.019
regulation of multi organism process GO:0043900 131 0.019
post embryonic appendage morphogenesis GO:0035120 385 0.019
rna interference GO:0016246 27 0.019
purine ribonucleotide metabolic process GO:0009150 145 0.019
positive regulation of cellular protein metabolic process GO:0032270 118 0.019
nucleobase containing compound catabolic process GO:0034655 165 0.019
autophagic cell death GO:0048102 83 0.019
regulation of phosphorylation GO:0042325 147 0.019
cellular response to hormone stimulus GO:0032870 44 0.019
heterocycle catabolic process GO:0046700 166 0.019
jnk cascade GO:0007254 50 0.019
negative regulation of phosphate metabolic process GO:0045936 45 0.019
phagocytosis GO:0006909 215 0.018
translation GO:0006412 69 0.018
single organism carbohydrate metabolic process GO:0044723 72 0.018
ribonucleoside metabolic process GO:0009119 127 0.018
negative regulation of growth GO:0045926 84 0.018
epithelial cell differentiation GO:0030855 322 0.018
organic cyclic compound catabolic process GO:1901361 168 0.018
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.018
cellular response to peptide hormone stimulus GO:0071375 28 0.018
response to organonitrogen compound GO:0010243 75 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.018
purine nucleotide catabolic process GO:0006195 109 0.018
negative regulation of cell cycle phase transition GO:1901988 103 0.018
purine nucleoside triphosphate catabolic process GO:0009146 108 0.018
mitotic nuclear division GO:0007067 213 0.018
regulation of organelle organization GO:0033043 196 0.017
cellular ketone metabolic process GO:0042180 24 0.017
positive regulation of gene expression GO:0010628 290 0.017
protein complex assembly GO:0006461 200 0.017
regulation of cell cycle process GO:0010564 181 0.017
oocyte axis specification GO:0007309 108 0.017
regulation of cellular localization GO:0060341 136 0.017
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.017
exocrine system development GO:0035272 162 0.017
purine nucleoside triphosphate metabolic process GO:0009144 119 0.017
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.017
cellular response to organic substance GO:0071310 132 0.017
carbohydrate derivative catabolic process GO:1901136 118 0.017
establishment of protein localization GO:0045184 163 0.017
protein k48 linked ubiquitination GO:0070936 3 0.017
regulation of anatomical structure size GO:0090066 163 0.017
cellular amine metabolic process GO:0044106 12 0.016
apoptotic process GO:0006915 159 0.016
response to insulin GO:0032868 29 0.016
regulation of cellular protein metabolic process GO:0032268 243 0.016
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
cell growth GO:0016049 108 0.016
regionalization GO:0003002 416 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
male courtship behavior GO:0008049 63 0.016
telencephalon development GO:0021537 2 0.016
purine containing compound catabolic process GO:0072523 112 0.016
positive regulation of catabolic process GO:0009896 105 0.016
salivary gland cell autophagic cell death GO:0035071 83 0.016
organophosphate catabolic process GO:0046434 112 0.016
dna damage checkpoint GO:0000077 78 0.016
mitotic cell cycle checkpoint GO:0007093 88 0.016
nucleotide metabolic process GO:0009117 161 0.016
macromolecular complex disassembly GO:0032984 37 0.016
rna localization GO:0006403 115 0.016
glycosyl compound catabolic process GO:1901658 112 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
response to glucose GO:0009749 2 0.016
ras protein signal transduction GO:0007265 88 0.016
oocyte construction GO:0007308 112 0.016
regulation of innate immune response GO:0045088 71 0.016
regulation of proteolysis GO:0030162 87 0.016
positive regulation of apoptotic signaling pathway GO:2001235 4 0.016
sensory perception of sound GO:0007605 56 0.016
anion homeostasis GO:0055081 3 0.015
salivary gland morphogenesis GO:0007435 145 0.015
regulation of embryonic pattern specification GO:1902875 27 0.015
columnar cuboidal epithelial cell development GO:0002066 249 0.015
purine containing compound metabolic process GO:0072521 155 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.015
positive regulation of phosphate metabolic process GO:0045937 139 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
positive regulation of signal transduction GO:0009967 223 0.015
positive regulation of cell motility GO:2000147 3 0.015
salivary gland histolysis GO:0035070 88 0.015
cellular response to peptide GO:1901653 28 0.015
regulation of jnk cascade GO:0046328 40 0.015
cellular response to chemical stimulus GO:0070887 199 0.015
regulation of protein stability GO:0031647 43 0.015
nucleotide catabolic process GO:0009166 109 0.015
cellular lipid metabolic process GO:0044255 83 0.015
nucleoside triphosphate metabolic process GO:0009141 120 0.015
amine metabolic process GO:0009308 12 0.015
regulation of cell differentiation GO:0045595 302 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
purine nucleotide metabolic process GO:0006163 146 0.015
purine nucleoside catabolic process GO:0006152 112 0.014
mitotic dna integrity checkpoint GO:0044774 75 0.014
response to peptide GO:1901652 29 0.014
dna integrity checkpoint GO:0031570 81 0.014
cytoplasmic transport GO:0016482 130 0.014
regulation of molecular function GO:0065009 217 0.014
response to organic substance GO:0010033 284 0.014
camera type eye development GO:0043010 4 0.014
cytoplasm organization GO:0007028 64 0.014
positive regulation of biosynthetic process GO:0009891 316 0.014
purine ribonucleoside catabolic process GO:0046130 112 0.014
alternative mrna splicing via spliceosome GO:0000380 60 0.014
benzene containing compound metabolic process GO:0042537 3 0.014
developmental maturation GO:0021700 172 0.014
positive regulation of cell cycle GO:0045787 43 0.014
protein import into nucleus GO:0006606 51 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
dna metabolic process GO:0006259 227 0.013
anterior posterior pattern specification GO:0009952 136 0.013
establishment of localization in cell GO:0051649 402 0.013
response to lipopolysaccharide GO:0032496 4 0.013
body morphogenesis GO:0010171 2 0.013
cell cycle checkpoint GO:0000075 95 0.013
regulation of insulin receptor signaling pathway GO:0046626 17 0.013
nucleus organization GO:0006997 45 0.013
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
secondary metabolic process GO:0019748 75 0.013
sterol homeostasis GO:0055092 4 0.013
sensory organ morphogenesis GO:0090596 260 0.013
oocyte differentiation GO:0009994 145 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
negative regulation of cell cycle GO:0045786 116 0.013
regulation of ras protein signal transduction GO:0046578 93 0.013
regulation of immune response GO:0050776 118 0.013
mrna processing GO:0006397 104 0.013
negative regulation of phosphorus metabolic process GO:0010563 45 0.013
aromatic compound catabolic process GO:0019439 166 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.013
regulation of protein catabolic process GO:0042176 55 0.012
sperm axoneme assembly GO:0007288 13 0.012
mitotic sister chromatid separation GO:0051306 30 0.012
response to hormone GO:0009725 45 0.012
courtship behavior GO:0007619 68 0.012
spindle organization GO:0007051 253 0.012
protein transport GO:0015031 155 0.012
anterior posterior axis specification embryo GO:0008595 103 0.012
tissue death GO:0016271 102 0.012
regulation of neural precursor cell proliferation GO:2000177 35 0.012
imaginal disc derived wing morphogenesis GO:0007476 337 0.012
regulation of oocyte development GO:0060281 27 0.012
cellular protein complex disassembly GO:0043624 35 0.012
microtubule based movement GO:0007018 51 0.012
regulation of cell development GO:0060284 215 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.012
response to hexose GO:0009746 3 0.012
cellular homeostasis GO:0019725 80 0.012
organic substance transport GO:0071702 257 0.012
axis specification GO:0009798 167 0.012
actin filament based process GO:0030029 220 0.012
cholesterol transport GO:0030301 2 0.012
innate immune response GO:0045087 144 0.012
erbb signaling pathway GO:0038127 58 0.012
ribonucleoside catabolic process GO:0042454 112 0.012
cholesterol homeostasis GO:0042632 3 0.012
regulation of chromatin silencing GO:0031935 36 0.012
kidney development GO:0001822 3 0.012
regulation of erbb signaling pathway GO:1901184 42 0.012
xenobiotic catabolic process GO:0042178 1 0.012
cell cycle phase transition GO:0044770 140 0.012
response to copper ion GO:0046688 4 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
open tracheal system development GO:0007424 204 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
nucleoside metabolic process GO:0009116 127 0.011
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.011
regulation of reproductive process GO:2000241 54 0.011
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
gland development GO:0048732 191 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
positive regulation of response to stimulus GO:0048584 323 0.011
synaptic transmission GO:0007268 288 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
establishment of organelle localization GO:0051656 122 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
glycoprotein metabolic process GO:0009100 41 0.011
organic hydroxy compound metabolic process GO:1901615 83 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.011
carbohydrate metabolic process GO:0005975 82 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
oocyte development GO:0048599 124 0.011
nuclear import GO:0051170 51 0.011
tube development GO:0035295 244 0.011
oocyte anterior posterior axis specification GO:0007314 72 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
intracellular mrna localization GO:0008298 66 0.011
protein localization to organelle GO:0033365 82 0.011
cognition GO:0050890 141 0.011
negative regulation of stress activated mapk cascade GO:0032873 19 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
organelle localization GO:0051640 148 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
response to light stimulus GO:0009416 124 0.011
regulation of neurogenesis GO:0050767 158 0.011
response to monosaccharide GO:0034284 4 0.011
necrotic cell death GO:0070265 1 0.011
homeostatic process GO:0042592 199 0.011
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.011
embryonic pattern specification GO:0009880 174 0.011
cell recognition GO:0008037 102 0.011
mitotic g2 dna damage checkpoint GO:0007095 69 0.011
tube morphogenesis GO:0035239 191 0.010
regulation of cellular protein catabolic process GO:1903362 44 0.010
cellular response to external stimulus GO:0071496 66 0.010
sperm mitochondrion organization GO:0030382 7 0.010
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.010
organonitrogen compound catabolic process GO:1901565 128 0.010
regulation of protein metabolic process GO:0051246 256 0.010
cellular macromolecular complex assembly GO:0034622 153 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.010
negative regulation of cell development GO:0010721 62 0.010
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.010
neuroblast proliferation GO:0007405 74 0.010
biological adhesion GO:0022610 138 0.010
regulation of stress activated mapk cascade GO:0032872 41 0.010
cell proliferation GO:0008283 299 0.010
regulation of cellular response to oxidative stress GO:1900407 4 0.010

ntc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.013
disease of metabolism DOID:0014667 0 0.013
organ system cancer DOID:0050686 0 0.012
carbohydrate metabolism disease DOID:0050013 0 0.012
glucose metabolism disease DOID:4194 0 0.012
acquired metabolic disease DOID:0060158 0 0.012
inherited metabolic disorder DOID:655 0 0.011
nervous system disease DOID:863 0 0.010