Drosophila melanogaster

69 known processes

Nek2 (Dmel_CG17256)

CG17256 gene product from transcript CG17256-RA

(Aliases: Dmel\CG17256,NEK2,DmNek2,Dm Nek2,CG17256)

Nek2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
centrosome cycle GO:0007098 137 0.976
Human
centrosome organization GO:0051297 163 0.915
Human
centrosome duplication GO:0051298 121 0.862
microtubule organizing center organization GO:0031023 168 0.761
Human
mitotic spindle organization GO:0007052 220 0.678
Mouse
spindle organization GO:0007051 253 0.674
Mouse
mitotic nuclear division GO:0007067 213 0.638
organelle localization GO:0051640 148 0.527
mitotic spindle stabilization GO:0043148 6 0.330
regulation of cell cycle GO:0051726 291 0.325
mitotic sister chromatid segregation GO:0000070 87 0.292
Mouse
single fertilization GO:0007338 24 0.239
protein complex assembly GO:0006461 200 0.235
Mouse
sister chromatid segregation GO:0000819 92 0.234
Mouse
regulation of mitotic cell cycle GO:0007346 190 0.224
regulation of mitosis GO:0007088 56 0.204
microtubule anchoring GO:0034453 11 0.195
Human
regulation of microtubule cytoskeleton organization GO:0070507 41 0.186
Human
microtubule based movement GO:0007018 51 0.181
negative regulation of cell cycle GO:0045786 116 0.169
nucleus localization GO:0051647 34 0.164
protein complex biogenesis GO:0070271 201 0.157
Mouse
macromolecular complex assembly GO:0065003 256 0.155
Mouse
spindle assembly involved in mitosis GO:0090307 50 0.148
Mouse
single organism intracellular transport GO:1902582 207 0.147
organelle assembly GO:0070925 198 0.147
Mouse
pronuclear migration GO:0035046 4 0.135
cytoskeleton dependent cytokinesis GO:0061640 81 0.131
developmental maturation GO:0021700 172 0.130
cytokinesis GO:0000910 90 0.130
attachment of spindle microtubules to kinetochore GO:0008608 5 0.130
Human
cell division GO:0051301 248 0.128
maintenance of location in cell GO:0051651 28 0.126
Human
mitotic cell cycle embryonic GO:0045448 38 0.126
protein localization GO:0008104 284 0.125
Human
oocyte differentiation GO:0009994 145 0.123
meiotic cytokinesis GO:0033206 33 0.121
nuclear division GO:0000280 332 0.118
meiotic spindle organization GO:0000212 36 0.112
cellular macromolecule localization GO:0070727 220 0.111
Human
asymmetric cell division GO:0008356 37 0.103
regulation of cell division GO:0051302 72 0.101
regulation of microtubule based process GO:0032886 49 0.097
Human
growth GO:0040007 359 0.094
regulation of cytoskeleton organization GO:0051493 89 0.093
Human
regulation of phosphorus metabolic process GO:0051174 210 0.092
cytoskeleton dependent intracellular transport GO:0030705 44 0.092
single organism cellular localization GO:1902580 180 0.086
cell maturation GO:0048469 144 0.084
maintenance of protein location in cell GO:0032507 26 0.083
Human
regulation of mitotic cell cycle phase transition GO:1901990 130 0.081
cytokinetic process GO:0032506 27 0.081
establishment of localization in cell GO:0051649 402 0.081
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.078
regulation of synapse assembly GO:0051963 94 0.077
mitotic spindle midzone assembly GO:0051256 1 0.076
regulation of spindle elongation GO:0032887 1 0.075
regulation of cell cycle phase transition GO:1901987 130 0.075
spindle assembly involved in meiosis GO:0090306 20 0.074
regulation of mitotic sister chromatid segregation GO:0033047 28 0.072
establishment or maintenance of cell polarity GO:0007163 167 0.065
regulation of organelle organization GO:0033043 196 0.064
positive regulation of developmental process GO:0051094 143 0.064
centrosome separation GO:0051299 20 0.063
Human
regulation of developmental growth GO:0048638 174 0.063
intracellular protein transport GO:0006886 104 0.062
regulation of growth GO:0040008 233 0.061
mitotic spindle elongation GO:0000022 81 0.061
open tracheal system development GO:0007424 204 0.061
appendage morphogenesis GO:0035107 397 0.059
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.059
Mouse
negative regulation of mitotic cell cycle GO:0045930 109 0.058
purine nucleoside metabolic process GO:0042278 127 0.057
regulation of mitotic spindle organization GO:0060236 9 0.057
compound eye development GO:0048749 307 0.055
cellular macromolecular complex assembly GO:0034622 153 0.054
positive regulation of protein localization to nucleus GO:1900182 21 0.053
spermatogenesis GO:0007283 200 0.053
nucleobase containing small molecule metabolic process GO:0055086 174 0.052
mitotic cell cycle checkpoint GO:0007093 88 0.052
male meiosis cytokinesis GO:0007112 26 0.051
regulation of intracellular transport GO:0032386 64 0.051
organelle fission GO:0048285 340 0.050
sensory perception of mechanical stimulus GO:0050954 72 0.050
nuclear migration GO:0007097 20 0.049
positive regulation of phosphorus metabolic process GO:0010562 139 0.049
chromosome segregation GO:0007059 157 0.047
Human Mouse
endomembrane system organization GO:0010256 119 0.046
axis specification GO:0009798 167 0.046
establishment of organelle localization GO:0051656 122 0.044
regulation of spindle organization GO:0090224 17 0.044
intracellular transport GO:0046907 228 0.044
mitotic sister chromatid separation GO:0051306 30 0.044
protein localization to nucleus GO:0034504 55 0.041
protein phosphorylation GO:0006468 169 0.041
female meiotic division GO:0007143 70 0.041
intracellular signal transduction GO:0035556 300 0.041
carbohydrate derivative metabolic process GO:1901135 217 0.041
spindle assembly involved in female meiosis GO:0007056 14 0.040
regulation of synapse organization GO:0050807 110 0.040
establishment of cell polarity GO:0030010 40 0.040
microtubule polymerization or depolymerization GO:0031109 39 0.040
female meiosis i GO:0007144 8 0.040
oocyte dorsal ventral axis specification GO:0007310 34 0.039
establishment of chromosome localization GO:0051303 20 0.039
regulation of protein metabolic process GO:0051246 256 0.039
purine containing compound catabolic process GO:0072523 112 0.039
phosphorylation GO:0016310 294 0.039
small molecule metabolic process GO:0044281 305 0.038
imaginal disc derived appendage development GO:0048737 399 0.038
nucleocytoplasmic transport GO:0006913 72 0.038
regulation of multicellular organismal development GO:2000026 414 0.038
organophosphate metabolic process GO:0019637 195 0.038
catabolic process GO:0009056 409 0.038
single organism biosynthetic process GO:0044711 206 0.037
endocytosis GO:0006897 310 0.037
nucleotide catabolic process GO:0009166 109 0.036
meiotic nuclear division GO:0007126 151 0.035
chromosome movement towards spindle pole GO:0051305 4 0.035
purine ribonucleotide catabolic process GO:0009154 109 0.035
regulation of mitotic sister chromatid separation GO:0010965 28 0.035
dephosphorylation GO:0016311 51 0.035
neuronal stem cell division GO:0036445 35 0.035
mitotic centrosome separation GO:0007100 8 0.035
organic substance catabolic process GO:1901575 308 0.034
dendrite morphogenesis GO:0048813 199 0.034
protein transport GO:0015031 155 0.034
mitotic cell cycle phase transition GO:0044772 138 0.034
microtubule polymerization GO:0046785 15 0.034
protein localization to organelle GO:0033365 82 0.033
ribose phosphate metabolic process GO:0019693 145 0.033
positive regulation of transport GO:0051050 92 0.033
positive regulation of multicellular organismal process GO:0051240 143 0.033
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.033
carbohydrate derivative catabolic process GO:1901136 118 0.032
spindle assembly GO:0051225 80 0.032
Mouse
cellular protein localization GO:0034613 160 0.032
Human
positive regulation of transcription factor import into nucleus GO:0042993 19 0.032
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.032
positive regulation of protein transport GO:0051222 37 0.031
mitotic cytokinesis GO:0000281 50 0.031
protein dna complex assembly GO:0065004 63 0.031
cellular nitrogen compound catabolic process GO:0044270 165 0.031
regionalization GO:0003002 416 0.031
regulation of cellular localization GO:0060341 136 0.031
Human
response to heat GO:0009408 63 0.030
gastrulation GO:0007369 70 0.030
glycosyl compound metabolic process GO:1901657 127 0.030
wnt signaling pathway GO:0016055 98 0.030
equator specification GO:0045317 4 0.030
regulation of protein import into nucleus GO:0042306 28 0.030
regulation of cytoplasmic transport GO:1903649 47 0.030
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.029
male gamete generation GO:0048232 201 0.029
protein import GO:0017038 55 0.029
maintenance of protein location GO:0045185 28 0.029
Human
purine nucleoside triphosphate catabolic process GO:0009146 108 0.028
nuclear transport GO:0051169 72 0.028
centriole assembly GO:0098534 24 0.028
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.028
positive regulation of phosphate metabolic process GO:0045937 139 0.028
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.027
cytoplasmic transport GO:0016482 130 0.027
myotube differentiation GO:0014902 46 0.027
single organism nuclear import GO:1902593 51 0.027
developmental growth GO:0048589 280 0.027
mitotic chromosome condensation GO:0007076 22 0.027
single organism catabolic process GO:0044712 228 0.027
golgi organization GO:0007030 66 0.027
protein polymerization GO:0051258 42 0.026
regulation of intracellular protein transport GO:0033157 46 0.026
muscle organ development GO:0007517 127 0.026
regulation of nuclear division GO:0051783 58 0.026
neuron remodeling GO:0016322 29 0.026
regulation of cytokinesis GO:0032465 3 0.026
meiosis i GO:0007127 59 0.026
ribonucleoside triphosphate catabolic process GO:0009203 108 0.026
dorsal ventral pattern formation GO:0009953 133 0.025
response to organophosphorus GO:0046683 2 0.025
nucleoside triphosphate catabolic process GO:0009143 108 0.025
ribonucleoside catabolic process GO:0042454 112 0.024
regulation of hydrolase activity GO:0051336 97 0.024
regulation of catalytic activity GO:0050790 185 0.024
organonitrogen compound catabolic process GO:1901565 128 0.024
positive regulation of response to stimulus GO:0048584 323 0.024
regulation of mapk cascade GO:0043408 92 0.024
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.024
positive regulation of intracellular protein transport GO:0090316 30 0.024
organic substance transport GO:0071702 257 0.024
regulation of transcription factor import into nucleus GO:0042990 22 0.024
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.023
regulation of protein localization to nucleus GO:1900180 29 0.023
nucleoside phosphate catabolic process GO:1901292 110 0.022
positive regulation of signaling GO:0023056 243 0.022
negative regulation of cell cycle process GO:0010948 109 0.022
metaphase anaphase transition of cell cycle GO:0044784 28 0.022
negative regulation of cellular component organization GO:0051129 108 0.022
Human
regulation of nucleocytoplasmic transport GO:0046822 35 0.022
heterocycle catabolic process GO:0046700 166 0.022
purine ribonucleoside catabolic process GO:0046130 112 0.022
purine containing compound metabolic process GO:0072521 155 0.022
neurological system process GO:0050877 358 0.022
fat soluble vitamin metabolic process GO:0006775 1 0.022
regulation of embryonic development GO:0045995 68 0.022
purine nucleotide catabolic process GO:0006195 109 0.022
programmed cell death GO:0012501 257 0.022
cellular protein complex assembly GO:0043623 71 0.021
glycosyl compound catabolic process GO:1901658 112 0.021
jnk cascade GO:0007254 50 0.021
centriole centriole cohesion GO:0010457 5 0.021
Human
regulation of mitotic spindle elongation GO:0032888 1 0.021
organophosphate catabolic process GO:0046434 112 0.021
maintenance of location GO:0051235 73 0.021
Human
cellular response to abiotic stimulus GO:0071214 58 0.021
digestive tract morphogenesis GO:0048546 127 0.021
positive regulation of mitotic metaphase anaphase transition GO:0045842 10 0.021
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.020
protein import into nucleus GO:0006606 51 0.020
regulation of cell cycle process GO:0010564 181 0.020
negative regulation of developmental process GO:0051093 201 0.020
proteasomal protein catabolic process GO:0010498 59 0.020
microtubule based transport GO:0010970 42 0.020
establishment of protein localization GO:0045184 163 0.020
regulation of intracellular signal transduction GO:1902531 236 0.020
positive regulation of catalytic activity GO:0043085 118 0.020
ribonucleoside triphosphate metabolic process GO:0009199 119 0.019
regulation of nervous system development GO:0051960 248 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
tube development GO:0035295 244 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.019
rna 3 end processing GO:0031123 45 0.019
neuroblast proliferation GO:0007405 74 0.019
cell adhesion GO:0007155 136 0.019
spindle midzone assembly GO:0051255 4 0.019
spindle assembly involved in female meiosis i GO:0007057 5 0.019
nucleoside triphosphate metabolic process GO:0009141 120 0.018
actin filament based process GO:0030029 220 0.018
regulation of localization GO:0032879 275 0.018
Human
cell cell signaling involved in cell fate commitment GO:0045168 210 0.018
cilium organization GO:0044782 41 0.018
positive regulation of nfat protein import into nucleus GO:0051533 16 0.018
embryonic pattern specification GO:0009880 174 0.018
vesicle mediated transport GO:0016192 381 0.018
dendrite development GO:0016358 204 0.018
protein targeting GO:0006605 64 0.018
ribonucleotide metabolic process GO:0009259 145 0.018
synaptic transmission GO:0007268 288 0.018
microtubule bundle formation GO:0001578 27 0.018
spindle elongation GO:0051231 83 0.018
aromatic compound catabolic process GO:0019439 166 0.018
sensory perception GO:0007600 196 0.018
segmentation GO:0035282 207 0.018
ribonucleotide catabolic process GO:0009261 109 0.018
purine ribonucleotide metabolic process GO:0009150 145 0.018
nucleoside phosphate metabolic process GO:0006753 162 0.017
mitotic g2 dna damage checkpoint GO:0007095 69 0.017
sensory organ precursor cell division GO:0045035 10 0.017
nuclear import GO:0051170 51 0.017
mitotic g2 m transition checkpoint GO:0044818 70 0.017
establishment of nucleus localization GO:0040023 26 0.017
cell death GO:0008219 279 0.017
cell motility GO:0048870 251 0.017
actin filament organization GO:0007015 126 0.017
axonogenesis GO:0007409 290 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.017
organonitrogen compound metabolic process GO:1901564 318 0.017
localization of cell GO:0051674 257 0.017
regulation of transport GO:0051049 181 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.016
mapk cascade GO:0000165 107 0.016
forebrain development GO:0030900 2 0.016
negative regulation of cell cycle g2 m phase transition GO:1902750 8 0.016
eggshell formation GO:0030703 105 0.016
axon development GO:0061564 297 0.016
cellular protein modification process GO:0006464 438 0.016
embryonic morphogenesis GO:0048598 206 0.016
positive regulation of intracellular transport GO:0032388 42 0.016
stem cell division GO:0017145 69 0.016
regulation of epithelial cell proliferation GO:0050678 4 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.015
regulation of protein localization GO:0032880 76 0.015
Human
regulation of microtubule depolymerization GO:0031114 24 0.015
cell growth GO:0016049 108 0.015
response to temperature stimulus GO:0009266 106 0.015
purine ribonucleoside metabolic process GO:0046128 127 0.015
blastoderm segmentation GO:0007350 159 0.015
nucleotide metabolic process GO:0009117 161 0.015
positive regulation of protein metabolic process GO:0051247 128 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.015
regulation of locomotion GO:0040012 42 0.015
wing disc morphogenesis GO:0007472 344 0.015
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 8 0.015
salivary gland cell autophagic cell death GO:0035071 83 0.015
negative regulation of cell cycle phase transition GO:1901988 103 0.015
mitotic sister chromatid cohesion GO:0007064 6 0.015
chromosome separation GO:0051304 42 0.015
gtp metabolic process GO:0046039 72 0.015
regulation of molecular function GO:0065009 217 0.015
Mouse
negative regulation of microtubule depolymerization GO:0007026 21 0.015
eye photoreceptor cell differentiation GO:0001754 145 0.014
Zebrafish
neural precursor cell proliferation GO:0061351 75 0.014
cellular catabolic process GO:0044248 372 0.014
regulation of centrosome cycle GO:0046605 7 0.014
macromolecule catabolic process GO:0009057 161 0.014
purine nucleotide metabolic process GO:0006163 146 0.014
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 10 0.014
neuromuscular junction development GO:0007528 149 0.014
establishment of protein localization to organelle GO:0072594 62 0.014
mitotic metaphase plate congression GO:0007080 13 0.014
embryonic development via the syncytial blastoderm GO:0001700 148 0.014
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.014
compound eye morphogenesis GO:0001745 249 0.014
appendage development GO:0048736 401 0.014
dna conformation change GO:0071103 105 0.014
organic cyclic compound catabolic process GO:1901361 168 0.014
positive regulation of catabolic process GO:0009896 105 0.013
regulation of phosphorylation GO:0042325 147 0.013
cellular protein complex disassembly GO:0043624 35 0.013
establishment of spindle orientation GO:0051294 18 0.013
germarium derived egg chamber formation GO:0007293 101 0.013
synapse organization GO:0050808 196 0.013
spindle assembly involved in male meiosis GO:0007053 5 0.013
dna integrity checkpoint GO:0031570 81 0.013
skeletal muscle organ development GO:0060538 48 0.013
g2 m transition of mitotic cell cycle GO:0000086 19 0.013
negative regulation of phosphorus metabolic process GO:0010563 45 0.013
negative regulation of growth GO:0045926 84 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
regulation of cell morphogenesis GO:0022604 163 0.013
carboxylic acid metabolic process GO:0019752 92 0.013
eye morphogenesis GO:0048592 260 0.013
Zebrafish
regulation of cell development GO:0060284 215 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.012
cystoblast division GO:0007282 10 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
regulation of protein phosphorylation GO:0001932 64 0.012
oocyte axis specification GO:0007309 108 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
synaptic growth at neuromuscular junction GO:0051124 119 0.012
regulation of purine nucleotide catabolic process GO:0033121 48 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
regulation of neuron projection development GO:0010975 69 0.012
response to biotic stimulus GO:0009607 294 0.012
asymmetric neuroblast division GO:0055059 33 0.012
cytokinetic cell separation GO:0000920 1 0.012
regulation of response to stress GO:0080134 200 0.012
lipid metabolic process GO:0006629 121 0.012
regulation of gtp catabolic process GO:0033124 44 0.012
negative regulation of phosphorylation GO:0042326 35 0.012
immune response activating signal transduction GO:0002757 2 0.012
formation of anatomical boundary GO:0048859 37 0.012
response to radiation GO:0009314 155 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
regulation of nucleotide metabolic process GO:0006140 62 0.011
regulation of anatomical structure size GO:0090066 163 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
negative regulation of rna metabolic process GO:0051253 251 0.011
regulation of protein transport GO:0051223 57 0.011
regulation of proteolysis GO:0030162 87 0.011
tripartite regional subdivision GO:0007351 103 0.011
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9 0.011
endomitotic cell cycle GO:0007113 7 0.011
synapse assembly GO:0007416 143 0.011
nucleoside metabolic process GO:0009116 127 0.011
phagocytosis GO:0006909 215 0.011
digestive tract development GO:0048565 149 0.011
positive regulation of protein kinase activity GO:0045860 25 0.011
regulation of programmed cell death GO:0043067 152 0.011
cell cycle checkpoint GO:0000075 95 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
nucleoside catabolic process GO:0009164 112 0.011
response to ionizing radiation GO:0010212 32 0.011
negative regulation of developmental growth GO:0048640 64 0.011
negative regulation of nucleic acid templated transcription GO:1903507 240 0.011
response to oxidative stress GO:0006979 86 0.011
single organism cell adhesion GO:0098602 47 0.011
nucleoside monophosphate catabolic process GO:0009125 39 0.011
protein modification process GO:0036211 438 0.011
chromosome localization GO:0050000 20 0.011
regulation of establishment of protein localization GO:0070201 61 0.011
regulation of protein targeting GO:1903533 29 0.011
regulation of kinase activity GO:0043549 53 0.011
photoreceptor cell development GO:0042461 96 0.010
Zebrafish
regulation of catabolic process GO:0009894 170 0.010
oocyte maturation GO:0001556 3 0.010
negative regulation of phosphate metabolic process GO:0045936 45 0.010
actin cytoskeleton organization GO:0030036 206 0.010
regulation of neurogenesis GO:0050767 158 0.010
segment polarity determination GO:0007367 25 0.010
protein targeting to nucleus GO:0044744 51 0.010
chemotaxis GO:0006935 249 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.010
cellular lipid metabolic process GO:0044255 83 0.010
cell migration GO:0016477 238 0.010
negative regulation of gene expression GO:0010629 387 0.010

Nek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.023
cancer DOID:162 0 0.018
organ system cancer DOID:0050686 0 0.018