Drosophila melanogaster

122 known processes

Sh (Dmel_CG12348)

Shaker

(Aliases: EKO,Dmel\CG12348,Sha,Shw,BcDNA:GH03046,V-I,SH,sh,CG17860,CG12348,CG7640,F-c,minisleep)

Sh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ion transport GO:0006811 145 0.489
cation transport GO:0006812 110 0.423
cation transmembrane transport GO:0098655 88 0.421
locomotory behavior GO:0007626 176 0.363
ion transmembrane transport GO:0034220 122 0.292
response to abiotic stimulus GO:0009628 341 0.167
synaptic transmission GO:0007268 288 0.158
learning GO:0007612 75 0.154
response to organic substance GO:0010033 284 0.143
Rat
adult behavior GO:0030534 137 0.138
single organism behavior GO:0044708 391 0.136
synapse organization GO:0050808 196 0.130
transmembrane transport GO:0055085 139 0.129
establishment of localization in cell GO:0051649 402 0.125
metal ion transport GO:0030001 74 0.109
Human Mouse Rat Fly
adult locomotory behavior GO:0008344 76 0.107
associative learning GO:0008306 65 0.104
sensory organ morphogenesis GO:0090596 260 0.100
axonogenesis GO:0007409 290 0.093
sleep GO:0030431 49 0.091
monovalent inorganic cation transport GO:0015672 40 0.085
Human Mouse Rat Fly
neurological system process GO:0050877 358 0.083
inorganic cation transmembrane transport GO:0098662 61 0.082
Human Mouse Rat Fly
eye development GO:0001654 323 0.077
telencephalon development GO:0021537 2 0.076
compound eye development GO:0048749 307 0.075
learning or memory GO:0007611 141 0.072
cognition GO:0050890 141 0.071
neuromuscular synaptic transmission GO:0007274 67 0.068
eye morphogenesis GO:0048592 260 0.061
protein complex biogenesis GO:0070271 201 0.060
Rat
forebrain development GO:0030900 2 0.060
response to light stimulus GO:0009416 124 0.059
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.058
regulation of synaptic transmission GO:0050804 69 0.055
cellular response to nutrient levels GO:0031669 62 0.050
homeostatic process GO:0042592 199 0.050
Rat
response to other organism GO:0051707 293 0.048
protein localization GO:0008104 284 0.048
cellular response to lipopolysaccharide GO:0071222 3 0.046
endocytosis GO:0006897 310 0.045
cell adhesion GO:0007155 136 0.044
circulatory system development GO:0072359 82 0.043
response to external biotic stimulus GO:0043207 293 0.042
response to sterol GO:0036314 34 0.041
negative regulation of cellular metabolic process GO:0031324 382 0.039
muscle structure development GO:0061061 224 0.038
developmental growth GO:0048589 280 0.037
anatomical structure homeostasis GO:0060249 97 0.037
protein complex assembly GO:0006461 200 0.037
Rat
axon development GO:0061564 297 0.037
photoreceptor cell differentiation GO:0046530 170 0.036
response to lipopolysaccharide GO:0032496 4 0.036
cellular response to chemical stimulus GO:0070887 199 0.036
organonitrogen compound metabolic process GO:1901564 318 0.035
cellular response to dna damage stimulus GO:0006974 223 0.035
dna metabolic process GO:0006259 227 0.035
response to alkaloid GO:0043279 26 0.035
eye photoreceptor cell differentiation GO:0001754 145 0.034
central nervous system development GO:0007417 201 0.033
vesicle mediated transport GO:0016192 381 0.033
response to alcohol GO:0097305 95 0.033
protein heterooligomerization GO:0051291 4 0.033
cellular response to molecule of bacterial origin GO:0071219 3 0.033
flight behavior GO:0007629 26 0.033
regulation of membrane potential GO:0042391 35 0.032
membrane depolarization GO:0051899 4 0.032
cellular homeostasis GO:0019725 80 0.032
Rat
eye photoreceptor cell development GO:0042462 81 0.032
circadian sleep wake cycle process GO:0022410 24 0.032
dna repair GO:0006281 54 0.031
regulation of nervous system development GO:0051960 248 0.031
response to insecticide GO:0017085 14 0.031
inorganic ion transmembrane transport GO:0098660 73 0.031
Human Mouse Rat Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.030
dendrite development GO:0016358 204 0.030
regulation of molecular function GO:0065009 217 0.030
circadian sleep wake cycle GO:0042745 28 0.029
circadian behavior GO:0048512 76 0.029
single organism biosynthetic process GO:0044711 206 0.029
cellular response to biotic stimulus GO:0071216 4 0.029
positive regulation of biosynthetic process GO:0009891 316 0.028
dendrite morphogenesis GO:0048813 199 0.028
macromolecular complex assembly GO:0065003 256 0.028
Rat
sensory perception of chemical stimulus GO:0007606 116 0.028
potassium ion transport GO:0006813 20 0.028
Human Mouse Rat Fly
heart development GO:0007507 82 0.028
neuron recognition GO:0008038 101 0.027
muscle organ development GO:0007517 127 0.027
circadian sleep wake cycle sleep GO:0050802 23 0.027
response to nitrogen compound GO:1901698 90 0.027
compound eye morphogenesis GO:0001745 249 0.027
organic substance transport GO:0071702 257 0.027
response to oxygen containing compound GO:1901700 200 0.026
Rat
cellular response to organic substance GO:0071310 132 0.025
mrna processing GO:0006397 104 0.025
phagocytosis GO:0006909 215 0.025
response to organonitrogen compound GO:0010243 75 0.025
axon guidance GO:0007411 233 0.024
positive regulation of rna biosynthetic process GO:1902680 266 0.024
response to toxic substance GO:0009636 22 0.024
establishment of protein localization GO:0045184 163 0.024
rhythmic process GO:0048511 106 0.024
muscle contraction GO:0006936 13 0.024
response to decreased oxygen levels GO:0036293 58 0.023
Rat
brain development GO:0007420 120 0.023
response to endogenous stimulus GO:0009719 119 0.023
nuclear division GO:0000280 332 0.023
behavioral response to ethanol GO:0048149 49 0.022
imaginal disc derived wing morphogenesis GO:0007476 337 0.022
biological adhesion GO:0022610 138 0.022
membrane organization GO:0061024 112 0.022
regulation of phosphorylation GO:0042325 147 0.022
response to oxidative stress GO:0006979 86 0.021
Rat
regulation of multicellular organismal development GO:2000026 414 0.021
regulation of localization GO:0032879 275 0.021
negative regulation of developmental process GO:0051093 201 0.021
organelle fission GO:0048285 340 0.021
single organism membrane organization GO:0044802 93 0.020
regulation of cell cycle GO:0051726 291 0.020
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
divalent metal ion transport GO:0070838 26 0.020
striated muscle cell differentiation GO:0051146 90 0.020
regulation of ion transport GO:0043269 39 0.020
regulation of transport GO:0051049 181 0.020
positive regulation of cellular biosynthetic process GO:0031328 316 0.020
protein transport GO:0015031 155 0.020
oxoacid metabolic process GO:0043436 103 0.019
aging GO:0007568 143 0.019
molting cycle GO:0042303 56 0.019
regulation of secretion GO:0051046 44 0.019
establishment or maintenance of cell polarity GO:0007163 167 0.019
response to organic cyclic compound GO:0014070 89 0.019
posttranscriptional regulation of gene expression GO:0010608 145 0.019
negative regulation of response to stimulus GO:0048585 258 0.019
developmental maturation GO:0021700 172 0.019
regulation of neuron differentiation GO:0045664 103 0.019
regulation of developmental growth GO:0048638 174 0.018
memory GO:0007613 94 0.018
meiotic cell cycle GO:0051321 171 0.018
secretion GO:0046903 109 0.018
chemotaxis GO:0006935 249 0.018
photoreceptor cell development GO:0042461 96 0.018
rna processing GO:0006396 147 0.018
regulation of cellular localization GO:0060341 136 0.018
carboxylic acid metabolic process GO:0019752 92 0.018
response to bacterium GO:0009617 198 0.018
response to oxygen levels GO:0070482 59 0.018
Rat
cell recognition GO:0008037 102 0.018
regulation of protein metabolic process GO:0051246 256 0.018
kidney development GO:0001822 3 0.018
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.018
compound eye photoreceptor development GO:0042051 78 0.017
body morphogenesis GO:0010171 2 0.017
negative regulation of gene expression GO:0010629 387 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
oocyte construction GO:0007308 112 0.017
appendage development GO:0048736 401 0.017
programmed cell death GO:0012501 257 0.017
response to nutrient levels GO:0031667 114 0.017
axis specification GO:0009798 167 0.017
synaptic growth at neuromuscular junction GO:0051124 119 0.016
positive regulation of gene expression GO:0010628 290 0.016
cellular response to external stimulus GO:0071496 66 0.016
appendage morphogenesis GO:0035107 397 0.016
negative regulation of signaling GO:0023057 219 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.015
regulation of cell differentiation GO:0045595 302 0.015
positive regulation of cell communication GO:0010647 250 0.015
antimicrobial humoral response GO:0019730 99 0.015
skeletal muscle organ development GO:0060538 48 0.015
hindbrain development GO:0030902 2 0.015
enzyme linked receptor protein signaling pathway GO:0007167 179 0.015
intracellular transport GO:0046907 228 0.015
regulation of mrna metabolic process GO:1903311 72 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
cellular response to decreased oxygen levels GO:0036294 30 0.015
camera type eye development GO:0043010 4 0.015
cellular response to starvation GO:0009267 61 0.015
segmentation GO:0035282 207 0.014
secretion by cell GO:0032940 101 0.014
multi multicellular organism process GO:0044706 123 0.014
cell maturation GO:0048469 144 0.014
regulation of neuron projection development GO:0010975 69 0.014
regulation of secretion by cell GO:1903530 39 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
organic acid metabolic process GO:0006082 103 0.014
response to ethanol GO:0045471 59 0.014
tube development GO:0035295 244 0.014
organic substance catabolic process GO:1901575 308 0.014
compound eye photoreceptor cell differentiation GO:0001751 140 0.014
neurotransmitter secretion GO:0007269 35 0.014
phosphorylation GO:0016310 294 0.014
multicellular organismal signaling GO:0035637 12 0.014
Human
cellular protein modification process GO:0006464 438 0.014
transmission of nerve impulse GO:0019226 12 0.014
negative regulation of rna biosynthetic process GO:1902679 240 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.013
negative regulation of notch signaling pathway GO:0045746 41 0.013
positive regulation of rna metabolic process GO:0051254 271 0.013
cell death GO:0008219 279 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
Rat
regulation of cellular ketone metabolic process GO:0010565 3 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.013
muscle system process GO:0003012 21 0.013
taxis GO:0042330 304 0.013
negative regulation of insulin secretion GO:0046676 1 0.013
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
positive regulation of exocytosis GO:0045921 4 0.013
carbohydrate derivative biosynthetic process GO:1901137 85 0.013
organonitrogen compound biosynthetic process GO:1901566 117 0.013
regulation of growth GO:0040008 233 0.013
microtubule organizing center organization GO:0031023 168 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
cell division GO:0051301 248 0.013
chemosensory behavior GO:0007635 106 0.013
intracellular signal transduction GO:0035556 300 0.013
regulation of mrna processing GO:0050684 71 0.012
regulation of catalytic activity GO:0050790 185 0.012
chemical homeostasis GO:0048878 92 0.012
Rat
embryo development ending in birth or egg hatching GO:0009792 152 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
negative regulation of signal transduction GO:0009968 206 0.012
regulation of cellular component size GO:0032535 98 0.012
regulation of transmembrane transport GO:0034762 27 0.012
catabolic process GO:0009056 409 0.012
amine metabolic process GO:0009308 12 0.012
calcium ion transport GO:0006816 24 0.012
embryonic pattern specification GO:0009880 174 0.012
muscle fiber development GO:0048747 12 0.012
response to organophosphorus GO:0046683 2 0.012
spinal cord development GO:0021510 1 0.012
mitotic nuclear division GO:0007067 213 0.012
positive regulation of signaling GO:0023056 243 0.012
tripartite regional subdivision GO:0007351 103 0.012
head development GO:0060322 135 0.012
neuron neuron synaptic transmission GO:0007270 14 0.012
oocyte axis specification GO:0007309 108 0.012
mrna splicing via spliceosome GO:0000398 73 0.012
growth GO:0040007 359 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
cellular amino acid metabolic process GO:0006520 61 0.012
sensory perception GO:0007600 196 0.012
regulation of response to stress GO:0080134 200 0.012
cellular response to carbohydrate stimulus GO:0071322 4 0.011
cytokinesis GO:0000910 90 0.011
purine containing compound metabolic process GO:0072521 155 0.011
anterior posterior axis specification GO:0009948 109 0.011
molting cycle process GO:0022404 29 0.011
regionalization GO:0003002 416 0.011
g protein coupled receptor signaling pathway GO:0007186 136 0.011
post embryonic appendage morphogenesis GO:0035120 385 0.011
retina development in camera type eye GO:0060041 4 0.011
notch signaling pathway GO:0007219 120 0.011
potassium ion transmembrane transport GO:0071805 18 0.011
Human Mouse Rat Fly
positive regulation of molecular function GO:0044093 136 0.011
synaptic transmission cholinergic GO:0007271 9 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
multicellular organism growth GO:0035264 46 0.011
regulation of synapse assembly GO:0051963 94 0.011
erbb signaling pathway GO:0038127 58 0.011
synaptic vesicle localization GO:0097479 53 0.011
sodium ion transport GO:0006814 22 0.011
response to wounding GO:0009611 94 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
negative regulation of homeostatic process GO:0032845 2 0.011
rna splicing via transesterification reactions GO:0000375 73 0.011
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.011
mitotic cytokinesis GO:0000281 50 0.011
olfactory behavior GO:0042048 97 0.011
multi organism behavior GO:0051705 175 0.011
negative regulation of cellular biosynthetic process GO:0031327 277 0.011
wing disc morphogenesis GO:0007472 344 0.011
gravitaxis GO:0042332 26 0.011
single organism catabolic process GO:0044712 228 0.011
macromolecule catabolic process GO:0009057 161 0.010
nucleoside phosphate metabolic process GO:0006753 162 0.010
mrna metabolic process GO:0016071 124 0.010
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.010
establishment of vesicle localization GO:0051650 51 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.010
response to radiation GO:0009314 155 0.010
asymmetric stem cell division GO:0098722 49 0.010
rna localization GO:0006403 115 0.010
sensory perception of smell GO:0007608 80 0.010
cellular ketone metabolic process GO:0042180 24 0.010
regulation of cell cycle process GO:0010564 181 0.010
Rat
inositol lipid mediated signaling GO:0048017 4 0.010

Sh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
Human
nervous system disease DOID:863 0 0.013
Human
disease of metabolism DOID:0014667 0 0.011
acquired metabolic disease DOID:0060158 0 0.011