Drosophila melanogaster

257 known processes

spn-E (Dmel_CG3158)

spindle E

(Aliases: fs(3)hls,homeless,spn-E/hls,hls,CG3158,Dmel\CG3158,fs(1)hls,Spn-E,spn E,spnE)

spn-E biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
meiosis i GO:0007127 59 0.996
meiotic cell cycle process GO:1903046 132 0.991
intracellular mrna localization GO:0008298 66 0.990
oocyte differentiation GO:0009994 145 0.985
regulation of pole plasm oskar mrna localization GO:0007317 27 0.982
transposition GO:0032196 13 0.982
negative regulation of transposition GO:0010529 12 0.982
pole plasm mrna localization GO:0019094 49 0.980
oocyte construction GO:0007308 112 0.980
oocyte development GO:0048599 124 0.977
chromosome organization GO:0051276 360 0.966
oocyte anterior posterior axis specification GO:0007314 72 0.964
karyosome formation GO:0030717 22 0.961
rna localization GO:0006403 115 0.957
germarium derived oocyte fate determination GO:0007294 26 0.950
germarium derived egg chamber formation GO:0007293 101 0.948
oocyte axis specification GO:0007309 108 0.943
germarium derived oocyte differentiation GO:0030706 29 0.940
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.936
meiotic chromosome segregation GO:0045132 59 0.925
meiotic nuclear division GO:0007126 151 0.922
Mouse
regulation of gene expression epigenetic GO:0040029 128 0.915
sister chromatid segregation GO:0000819 92 0.894
anterior posterior pattern specification GO:0009952 136 0.883
dna recombination GO:0006310 32 0.880
cell maturation GO:0048469 144 0.832
pole plasm assembly GO:0007315 61 0.825
posttranscriptional gene silencing GO:0016441 46 0.819
axis specification GO:0009798 167 0.816
negative regulation of gene expression GO:0010629 387 0.809
segmentation GO:0035282 207 0.803
meiotic cell cycle GO:0051321 171 0.797
Mouse
dorsal appendage formation GO:0046843 47 0.792
maternal determination of anterior posterior axis embryo GO:0008358 74 0.787
regulation of transposition GO:0010528 13 0.773
pole plasm oskar mrna localization GO:0045451 46 0.764
pole plasm rna localization GO:0007316 52 0.754
dna metabolic process GO:0006259 227 0.739
organelle fission GO:0048285 340 0.734
gene silencing GO:0016458 138 0.691
anterior posterior axis specification GO:0009948 109 0.682
anterior posterior axis specification embryo GO:0008595 103 0.680
cellular macromolecule localization GO:0070727 220 0.678
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.666
eggshell formation GO:0030703 105 0.657
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.656
negative regulation of biosynthetic process GO:0009890 277 0.628
targeting of mrna for destruction involved in rna interference GO:0030423 4 0.627
chorion containing eggshell formation GO:0007304 105 0.624
chromosome segregation GO:0007059 157 0.621
cellular nitrogen compound catabolic process GO:0044270 165 0.610
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.606
oocyte maturation GO:0001556 3 0.603
gene silencing by rna GO:0031047 57 0.598
embryonic axis specification GO:0000578 107 0.598
regulation of response to stress GO:0080134 200 0.591
regulation of oocyte development GO:0060281 27 0.573
negative regulation of cellular biosynthetic process GO:0031327 277 0.561
cell division GO:0051301 248 0.560
chromosome organization involved in meiosis GO:0070192 10 0.545
oocyte dorsal ventral axis specification GO:0007310 34 0.535
developmental maturation GO:0021700 172 0.512
positive regulation of nuclear transcribed mrna poly a tail shortening GO:0060213 4 0.504
regulation of mitotic cell cycle GO:0007346 190 0.503
blastoderm segmentation GO:0007350 159 0.502
negative regulation of dna recombination GO:0045910 2 0.489
nucleotide excision repair GO:0006289 8 0.486
eggshell chorion assembly GO:0007306 66 0.484
dna alkylation GO:0006305 4 0.473
Mouse
male gamete generation GO:0048232 201 0.457
Mouse
spindle organization GO:0007051 253 0.455
female germ line stem cell asymmetric division GO:0048132 14 0.455
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.442
negative regulation of cellular metabolic process GO:0031324 382 0.421
aromatic compound catabolic process GO:0019439 166 0.419
pole plasm protein localization GO:0007318 10 0.416
nuclear division GO:0000280 332 0.416
negative regulation of transcription dna templated GO:0045892 237 0.415
reciprocal dna recombination GO:0035825 19 0.412
tripartite regional subdivision GO:0007351 103 0.400
reciprocal meiotic recombination GO:0007131 19 0.386
nucleobase containing compound catabolic process GO:0034655 165 0.384
regulation of cell division GO:0051302 72 0.377
positive regulation of mrna catabolic process GO:0061014 5 0.373
mitotic spindle organization GO:0007052 220 0.350
regionalization GO:0003002 416 0.350
regulation of cell cycle process GO:0010564 181 0.345
pirna metabolic process GO:0034587 10 0.344
Mouse
regulation of meiosis GO:0040020 3 0.321
posttranscriptional regulation of gene expression GO:0010608 145 0.320
catabolic process GO:0009056 409 0.316
cellular macromolecule catabolic process GO:0044265 136 0.305
organelle assembly GO:0070925 198 0.302
dna repair GO:0006281 54 0.291
dna methylation or demethylation GO:0044728 4 0.289
Mouse
pronuclear migration GO:0035046 4 0.288
positive regulation of mrna processing GO:0050685 4 0.287
regulation of mrna 3 end processing GO:0031440 7 0.281
cellular catabolic process GO:0044248 372 0.279
organic cyclic compound catabolic process GO:1901361 168 0.273
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.272
male meiosis GO:0007140 52 0.266
Mouse
mitotic cell cycle phase transition GO:0044772 138 0.262
female meiotic division GO:0007143 70 0.262
cellular component assembly involved in morphogenesis GO:0010927 151 0.259
regulation of cell cycle GO:0051726 291 0.258
regulation of cell cycle phase transition GO:1901987 130 0.248
negative regulation of response to stimulus GO:0048585 258 0.244
dna modification GO:0006304 5 0.244
Mouse
mrna metabolic process GO:0016071 124 0.237
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.230
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.229
negative regulation of mitotic cell cycle GO:0045930 109 0.228
regulation of mitotic cell cycle phase transition GO:1901990 130 0.223
production of sirna involved in rna interference GO:0030422 11 0.212
immune system process GO:0002376 347 0.209
double strand break repair GO:0006302 26 0.203
negative regulation of rna biosynthetic process GO:1902679 240 0.202
meiotic sister chromatid segregation GO:0045144 6 0.197
microtubule organizing center organization GO:0031023 168 0.188
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.186
regulation of embryonic pattern specification GO:1902875 27 0.184
cellular response to dna damage stimulus GO:0006974 223 0.171
mrna catabolic process GO:0006402 33 0.169
oocyte microtubule cytoskeleton organization GO:0016325 35 0.169
female germ line cyst formation GO:0048135 42 0.158
germ line stem cell division GO:0042078 25 0.156
posttranscriptional gene silencing by rna GO:0035194 45 0.153
regulation of mrna processing GO:0050684 71 0.153
response to abiotic stimulus GO:0009628 341 0.151
regulation of oskar mrna translation GO:0046011 8 0.151
regulation of multi organism process GO:0043900 131 0.146
negative regulation of gene expression epigenetic GO:0045814 77 0.145
negative regulation of cell cycle process GO:0010948 109 0.144
chromatin silencing GO:0006342 76 0.144
negative regulation of oskar mrna translation GO:0007319 5 0.141
regulation of cell proliferation GO:0042127 163 0.138
embryonic pattern specification GO:0009880 174 0.136
meiotic chromosome separation GO:0051307 8 0.136
cell cycle phase transition GO:0044770 140 0.134
production of small rna involved in gene silencing by rna GO:0070918 15 0.134
single organism cellular localization GO:1902580 180 0.132
rna catabolic process GO:0006401 37 0.132
negative regulation of nucleic acid templated transcription GO:1903507 240 0.130
cytoplasm organization GO:0007028 64 0.128
regulation of nuclear division GO:0051783 58 0.126
regulation of cell differentiation GO:0045595 302 0.121
fertilization GO:0009566 26 0.117
Mouse
regulation of catabolic process GO:0009894 170 0.116
meiotic spindle organization GO:0000212 36 0.112
positive regulation of response to stimulus GO:0048584 323 0.108
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.104
spermatogenesis GO:0007283 200 0.096
Mouse
dsrna fragmentation GO:0031050 15 0.096
heterocycle catabolic process GO:0046700 166 0.095
mrna processing GO:0006397 104 0.090
rna processing GO:0006396 147 0.089
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.089
anatomical structure homeostasis GO:0060249 97 0.089
positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay GO:1900153 4 0.086
regulation of protein metabolic process GO:0051246 256 0.084
transcription from rna polymerase ii promoter GO:0006366 368 0.081
mitotic sister chromatid segregation GO:0000070 87 0.081
germarium derived female germ line cyst formation GO:0030727 42 0.081
germline stem cell asymmetric division GO:0098728 15 0.080
ovarian follicle cell development GO:0030707 248 0.078
programmed cell death GO:0012501 257 0.078
dna methylation GO:0006306 4 0.077
Mouse
dna biosynthetic process GO:0071897 24 0.076
spindle assembly involved in female meiosis GO:0007056 14 0.075
nuclear transcribed mrna catabolic process GO:0000956 24 0.075
regulation of cellular catabolic process GO:0031329 157 0.073
ribonucleoprotein complex subunit organization GO:0071826 28 0.072
mitotic dna integrity checkpoint GO:0044774 75 0.072
columnar cuboidal epithelial cell development GO:0002066 249 0.072
mitotic chromosome condensation GO:0007076 22 0.069
apoptotic process GO:0006915 159 0.069
ncrna metabolic process GO:0034660 43 0.069
Mouse
regulation of meiotic cell cycle GO:0051445 9 0.068
oocyte fate determination GO:0030716 27 0.068
negative regulation of rna metabolic process GO:0051253 251 0.067
ovarian fusome organization GO:0030723 11 0.067
cellular response to dsrna GO:0071359 15 0.067
response to other organism GO:0051707 293 0.063
organic substance catabolic process GO:1901575 308 0.062
positive regulation of hydrolase activity GO:0051345 78 0.060
negative regulation of cell differentiation GO:0045596 143 0.059
positive regulation of cellular catabolic process GO:0031331 95 0.059
response to dsrna GO:0043331 15 0.059
negative regulation of cell cycle phase transition GO:1901988 103 0.056
macromolecule catabolic process GO:0009057 161 0.054
double strand break repair via nonhomologous end joining GO:0006303 5 0.053
germ line cyst formation GO:0048134 44 0.053
synaptonemal complex organization GO:0070193 5 0.052
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.051
dorsal ventral pattern formation GO:0009953 133 0.049
negative regulation of cellular component organization GO:0051129 108 0.048
regulation of nervous system development GO:0051960 248 0.048
establishment or maintenance of cell polarity GO:0007163 167 0.047
cell death GO:0008219 279 0.046
death GO:0016265 284 0.044
dna catabolic process GO:0006308 16 0.044
positive regulation of defense response GO:0031349 59 0.044
regulation of cell development GO:0060284 215 0.044
meiosis ii GO:0007135 23 0.044
cell cycle checkpoint GO:0000075 95 0.044
positive regulation of mrna metabolic process GO:1903313 5 0.043
cellular protein complex assembly GO:0043623 71 0.043
rna 3 end processing GO:0031123 45 0.043
regulation of hydrolase activity GO:0051336 97 0.042
positive regulation of cellular biosynthetic process GO:0031328 316 0.042
cell proliferation GO:0008283 299 0.042
telomere organization GO:0032200 21 0.041
mitotic g2 dna damage checkpoint GO:0007095 69 0.040
g2 dna damage checkpoint GO:0031572 69 0.040
translation GO:0006412 69 0.038
regulation of mrna metabolic process GO:1903311 72 0.038
negative regulation of developmental process GO:0051093 201 0.038
epithelial cell differentiation GO:0030855 322 0.038
positive regulation of macromolecule metabolic process GO:0010604 405 0.037
spermatid development GO:0007286 98 0.036
protein complex assembly GO:0006461 200 0.036
immune response GO:0006955 246 0.036
regulation of anatomical structure morphogenesis GO:0022603 242 0.035
positive regulation of protein metabolic process GO:0051247 128 0.035
regulation of phosphorus metabolic process GO:0051174 210 0.034
mitotic recombination GO:0006312 2 0.034
regulation of multicellular organismal development GO:2000026 414 0.034
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.034
chromosome condensation GO:0030261 41 0.033
mrna polyadenylation GO:0006378 11 0.033
regulation of cellular protein metabolic process GO:0032268 243 0.032
chromatin organization GO:0006325 207 0.031
regulation of gene silencing GO:0060968 63 0.031
negative regulation of cell cycle GO:0045786 116 0.029
regulation of translation GO:0006417 56 0.029
defense response to other organism GO:0098542 225 0.029
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.029
protein localization GO:0008104 284 0.028
regulation of transcription by chromatin organization GO:0034401 3 0.028
regulation of chromatin silencing GO:0031935 36 0.028
regulation of defense response GO:0031347 102 0.027
regulation of hemocyte proliferation GO:0035206 37 0.027
establishment of nucleus localization GO:0040023 26 0.026
mitotic g2 m transition checkpoint GO:0044818 70 0.026
positive regulation of immune system process GO:0002684 68 0.025
regulation of organelle organization GO:0033043 196 0.025
positive regulation of cell cycle process GO:0090068 28 0.025
striated muscle cell development GO:0055002 50 0.025
spindle assembly GO:0051225 80 0.024
tube morphogenesis GO:0035239 191 0.024
pole cell formation GO:0007279 19 0.024
macromolecular complex assembly GO:0065003 256 0.024
cellular macromolecular complex assembly GO:0034622 153 0.024
stem cell development GO:0048864 79 0.024
protein complex biogenesis GO:0070271 201 0.023
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.023
nuclear envelope organization GO:0006998 7 0.023
negative regulation of cell division GO:0051782 17 0.023
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0030722 6 0.023
rna interference GO:0016246 27 0.022
regulation of immune response GO:0050776 118 0.022
response to bacterium GO:0009617 198 0.022
response to temperature stimulus GO:0009266 106 0.022
ribonucleoprotein complex assembly GO:0022618 23 0.021
positive regulation of atp catabolic process GO:1903291 3 0.021
intracellular signal transduction GO:0035556 300 0.021
positive regulation of signaling GO:0023056 243 0.020
ribonucleoside monophosphate metabolic process GO:0009161 51 0.020
telomere maintenance GO:0000723 21 0.020
response to external biotic stimulus GO:0043207 293 0.019
stem cell division GO:0017145 69 0.019
regulation of developmental growth GO:0048638 174 0.019
nucleus localization GO:0051647 34 0.019
negative regulation of protein metabolic process GO:0051248 85 0.019
meiotic sister chromatid cohesion GO:0051177 6 0.019
defense response to bacterium GO:0042742 178 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.019
phosphorylation GO:0016310 294 0.019
regulation of cell death GO:0010941 173 0.019
mitotic nuclear division GO:0007067 213 0.019
positive regulation of cell cycle GO:0045787 43 0.018
sex differentiation GO:0007548 81 0.018
regulation of cell maturation GO:1903429 27 0.018
epithelial cell development GO:0002064 274 0.018
positive regulation of translation GO:0045727 12 0.018
positive regulation of rna metabolic process GO:0051254 271 0.017
ribonucleoside monophosphate catabolic process GO:0009158 39 0.017
polarity specification of dorsal ventral axis GO:0009951 6 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.017
positive regulation of catabolic process GO:0009896 105 0.017
regulation of response to dna damage stimulus GO:2001020 23 0.017
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.017
digestive tract morphogenesis GO:0048546 127 0.017
small molecule metabolic process GO:0044281 305 0.017
negative regulation of multicellular organismal process GO:0051241 142 0.017
pole cell development GO:0007277 26 0.017
purine ribonucleotide catabolic process GO:0009154 109 0.017
regulation of apoptotic process GO:0042981 130 0.017
spindle assembly involved in meiosis GO:0090306 20 0.017
gland morphogenesis GO:0022612 145 0.017
single fertilization GO:0007338 24 0.017
response to hypoxia GO:0001666 53 0.016
response to decreased oxygen levels GO:0036293 58 0.016
organophosphate catabolic process GO:0046434 112 0.016
lateral inhibition GO:0046331 206 0.016
purine nucleoside monophosphate metabolic process GO:0009126 50 0.016
centriole assembly GO:0098534 24 0.016
myofibril assembly GO:0030239 36 0.016
dna conformation change GO:0071103 105 0.015
regulation of catalytic activity GO:0050790 185 0.015
digestive tract development GO:0048565 149 0.015
membrane disassembly GO:0030397 4 0.015
positive regulation of immune response GO:0050778 63 0.015
regulation of innate immune response GO:0045088 71 0.015
purine nucleoside monophosphate catabolic process GO:0009128 38 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.015
regulation of dna recombination GO:0000018 4 0.015
regulation of dna metabolic process GO:0051052 34 0.015
embryo development ending in birth or egg hatching GO:0009792 152 0.014
germ line stem cell maintenance GO:0030718 50 0.014
nucleoside monophosphate catabolic process GO:0009125 39 0.014
positive regulation of phosphate metabolic process GO:0045937 139 0.014
mitotic cell cycle checkpoint GO:0007093 88 0.014
response to biotic stimulus GO:0009607 294 0.014
developmental programmed cell death GO:0010623 138 0.014
regulation of double strand break repair GO:2000779 3 0.014
regulation of molecular function GO:0065009 217 0.014
oxoacid metabolic process GO:0043436 103 0.014
humoral immune response GO:0006959 117 0.014
response to oxygen containing compound GO:1901700 200 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
heterochromatin organization GO:0070828 25 0.013
purine nucleoside triphosphate metabolic process GO:0009144 119 0.013
development of primary sexual characteristics GO:0045137 50 0.013
endocytosis GO:0006897 310 0.012
negative regulation of cell communication GO:0010648 223 0.012
establishment of localization in cell GO:0051649 402 0.012
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
regulation of nucleocytoplasmic transport GO:0046822 35 0.012
regulation of reproductive process GO:2000241 54 0.012
regulation of signal transduction by p53 class mediator GO:1901796 1 0.012
cellular response to organic cyclic compound GO:0071407 32 0.012
non recombinational repair GO:0000726 7 0.012
establishment of spindle orientation GO:0051294 18 0.012
polarity specification of anterior posterior axis GO:0009949 5 0.012
meiotic chromosome condensation GO:0010032 3 0.012
nuclear migration GO:0007097 20 0.012
cystoblast division GO:0007282 10 0.012
positive regulation of dna endoreduplication GO:0032877 4 0.011
mitotic dna damage checkpoint GO:0044773 74 0.011
regulation of transposition rna mediated GO:0010525 3 0.011
spermatid differentiation GO:0048515 114 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
gliogenesis GO:0042063 80 0.011
regulation of cellular response to stress GO:0080135 89 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
maintenance of location in cell GO:0051651 28 0.011
nuclear transcribed mrna poly a tail shortening GO:0000289 12 0.011
organophosphate metabolic process GO:0019637 195 0.011
chromosome separation GO:0051304 42 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.011
negative regulation of transcription factor import into nucleus GO:0042992 4 0.011
cytoskeleton dependent cytokinesis GO:0061640 81 0.011
response to heat GO:0009408 63 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
cell fate determination GO:0001709 91 0.010
cellular protein modification process GO:0006464 438 0.010
atp catabolic process GO:0006200 38 0.010
positive regulation of innate immune response GO:0045089 38 0.010
stem cell differentiation GO:0048863 117 0.010
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.010
nucleoside metabolic process GO:0009116 127 0.010
lipid localization GO:0010876 54 0.010
response to nitrogen compound GO:1901698 90 0.010
microtubule anchoring GO:0034453 11 0.010

spn-E disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.050
cancer DOID:162 0 0.036
disease of cellular proliferation DOID:14566 0 0.036
thoracic cancer DOID:5093 0 0.011
organ system cancer DOID:0050686 0 0.011