Drosophila melanogaster

66 known processes

Tie (Dmel_CG7525)

Tie-like receptor tyrosine kinase

(Aliases: tie,DPR1,Dmel\CG7525,RTK,CG7525)

Tie biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
death GO:0016265 284 0.118
regulation of cell development GO:0060284 215 0.088
cell proliferation GO:0008283 299 0.086
detection of chemical stimulus GO:0009593 93 0.082
cellular protein modification process GO:0006464 438 0.079
response to abiotic stimulus GO:0009628 341 0.075
response to extracellular stimulus GO:0009991 116 0.073
detection of stimulus GO:0051606 156 0.070
chromosome organization GO:0051276 360 0.069
protein modification process GO:0036211 438 0.069
regulation of cell death GO:0010941 173 0.068
homeostatic process GO:0042592 199 0.067
cell death GO:0008219 279 0.065
positive regulation of lipid storage GO:0010884 4 0.064
negative regulation of developmental process GO:0051093 201 0.056
programmed cell death GO:0012501 257 0.052
axonogenesis GO:0007409 290 0.052
regulation of nervous system development GO:0051960 248 0.051
positive regulation of macromolecule metabolic process GO:0010604 405 0.050
tissue death GO:0016271 102 0.050
cellular response to radiation GO:0071478 52 0.049
appendage morphogenesis GO:0035107 397 0.048
cellular response to abiotic stimulus GO:0071214 58 0.047
response to radiation GO:0009314 155 0.047
imaginal disc derived wing morphogenesis GO:0007476 337 0.046
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.046
phosphorylation GO:0016310 294 0.044
post embryonic appendage morphogenesis GO:0035120 385 0.044
negative regulation of cellular biosynthetic process GO:0031327 277 0.044
organic cyclic compound catabolic process GO:1901361 168 0.044
appendage development GO:0048736 401 0.043
organic substance catabolic process GO:1901575 308 0.042
regulation of multicellular organismal development GO:2000026 414 0.042
single organism biosynthetic process GO:0044711 206 0.042
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.040
taxis GO:0042330 304 0.039
regulation of cell differentiation GO:0045595 302 0.038
multicellular organismal aging GO:0010259 140 0.037
salivary gland morphogenesis GO:0007435 145 0.036
regulation of neuron differentiation GO:0045664 103 0.036
transcription from rna polymerase ii promoter GO:0006366 368 0.036
positive regulation of gene expression GO:0010628 290 0.035
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.035
negative regulation of cellular metabolic process GO:0031324 382 0.035
exocrine system development GO:0035272 162 0.034
pigment metabolic process involved in pigmentation GO:0043474 33 0.033
regulation of molecular function GO:0065009 217 0.033
cell motility GO:0048870 251 0.033
small molecule metabolic process GO:0044281 305 0.032
axon development GO:0061564 297 0.032
intracellular signal transduction GO:0035556 300 0.032
negative regulation of gene expression GO:0010629 387 0.032
nucleobase containing compound catabolic process GO:0034655 165 0.032
response to lipopolysaccharide GO:0032496 4 0.032
acetylcholine metabolic process GO:0008291 2 0.031
body morphogenesis GO:0010171 2 0.031
regulation of neurogenesis GO:0050767 158 0.031
negative regulation of nervous system development GO:0051961 92 0.031
regulation of intracellular signal transduction GO:1902531 236 0.030
regulation of cellular protein metabolic process GO:0032268 243 0.030
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.030
cellular response to dna damage stimulus GO:0006974 223 0.030
regulation of mitotic cell cycle GO:0007346 190 0.029
developmental pigmentation GO:0048066 68 0.029
organic substance transport GO:0071702 257 0.029
response to biotic stimulus GO:0009607 294 0.029
aging GO:0007568 143 0.029
developmental programmed cell death GO:0010623 138 0.029
catabolic process GO:0009056 409 0.029
response to light stimulus GO:0009416 124 0.028
developmental growth GO:0048589 280 0.028
cellular catabolic process GO:0044248 372 0.028
organelle assembly GO:0070925 198 0.028
pigmentation GO:0043473 75 0.028
response to organophosphorus GO:0046683 2 0.027
response to nutrient levels GO:0031667 114 0.027
positive regulation of molecular function GO:0044093 136 0.027
response to other organism GO:0051707 293 0.027
cellular nitrogen compound catabolic process GO:0044270 165 0.027
cellular macromolecule localization GO:0070727 220 0.027
aromatic compound catabolic process GO:0019439 166 0.027
macromolecular complex assembly GO:0065003 256 0.026
protein phosphorylation GO:0006468 169 0.026
organelle fission GO:0048285 340 0.026
nuclear division GO:0000280 332 0.026
chromosome segregation GO:0007059 157 0.026
eye pigment biosynthetic process GO:0006726 32 0.025
positive regulation of catalytic activity GO:0043085 118 0.025
negative regulation of rna biosynthetic process GO:1902679 240 0.025
positive regulation of phosphate metabolic process GO:0045937 139 0.025
macromolecule catabolic process GO:0009057 161 0.025
cholesterol transport GO:0030301 2 0.025
response to bacterium GO:0009617 198 0.025
regulation of transport GO:0051049 181 0.025
protein complex assembly GO:0006461 200 0.025
imaginal disc derived appendage morphogenesis GO:0035114 395 0.024
regulation of phosphorus metabolic process GO:0051174 210 0.024
central nervous system development GO:0007417 201 0.024
vitamin metabolic process GO:0006766 2 0.024
cellular response to chemical stimulus GO:0070887 199 0.024
regulation of catalytic activity GO:0050790 185 0.024
neuron projection guidance GO:0097485 241 0.024
rhodopsin metabolic process GO:0046154 10 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.024
defense response to other organism GO:0098542 225 0.024
cellular response to uv GO:0034644 12 0.024
carbohydrate derivative metabolic process GO:1901135 217 0.023
negative regulation of rna metabolic process GO:0051253 251 0.023
regulation of cellular component biogenesis GO:0044087 201 0.023
regulation of response to stress GO:0080134 200 0.023
immune system process GO:0002376 347 0.023
vesicle mediated transport GO:0016192 381 0.023
organonitrogen compound metabolic process GO:1901564 318 0.023
regionalization GO:0003002 416 0.023
regulation of localization GO:0032879 275 0.023
negative regulation of cell development GO:0010721 62 0.023
gliogenesis GO:0042063 80 0.023
lipid metabolic process GO:0006629 121 0.023
regulation of programmed cell death GO:0043067 152 0.022
protein complex biogenesis GO:0070271 201 0.022
pigment metabolic process GO:0042440 84 0.022
axon guidance GO:0007411 233 0.022
cellular amine metabolic process GO:0044106 12 0.021
gland morphogenesis GO:0022612 145 0.021
single organism intracellular transport GO:1902582 207 0.021
negative regulation of transcription dna templated GO:0045892 237 0.021
positive regulation of nervous system development GO:0051962 69 0.021
regulation of lipid storage GO:0010883 22 0.021
epithelial cell migration GO:0010631 148 0.021
chromatin organization GO:0006325 207 0.021
wing disc morphogenesis GO:0007472 344 0.021
response to external biotic stimulus GO:0043207 293 0.021
negative regulation of response to stimulus GO:0048585 258 0.021
phototransduction GO:0007602 52 0.021
salivary gland cell autophagic cell death GO:0035071 83 0.021
nucleoside phosphate catabolic process GO:1901292 110 0.020
salivary gland development GO:0007431 162 0.020
regulation of phosphorylation GO:0042325 147 0.020
dna metabolic process GO:0006259 227 0.020
ethanolamine containing compound metabolic process GO:0042439 4 0.020
detection of abiotic stimulus GO:0009582 66 0.020
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.020
heterocycle catabolic process GO:0046700 166 0.020
imaginal disc derived appendage development GO:0048737 399 0.020
cuticle development GO:0042335 86 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.019
phagocytosis GO:0006909 215 0.019
epithelial cell differentiation GO:0030855 322 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.019
immune response regulating signaling pathway GO:0002764 2 0.019
salivary gland histolysis GO:0035070 88 0.019
ovarian follicle cell development GO:0030707 248 0.019
regulation of cell cycle GO:0051726 291 0.019
morphogenesis of an epithelium GO:0002009 276 0.019
apoptotic process GO:0006915 159 0.019
purine ribonucleotide metabolic process GO:0009150 145 0.019
skin development GO:0043588 65 0.019
regulation of cellular catabolic process GO:0031329 157 0.019
positive regulation of cell development GO:0010720 61 0.019
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
negative regulation of multicellular organismal process GO:0051241 142 0.019
regulation of anatomical structure size GO:0090066 163 0.018
negative regulation of biosynthetic process GO:0009890 277 0.018
amine metabolic process GO:0009308 12 0.018
regulation of cellular response to stress GO:0080135 89 0.018
cellular response to lipopolysaccharide GO:0071222 3 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
positive regulation of cell communication GO:0010647 250 0.018
regulation of mitotic cell cycle phase transition GO:1901990 130 0.018
cell cycle phase transition GO:0044770 140 0.018
negative regulation of cell communication GO:0010648 223 0.018
positive regulation of cell migration GO:0030335 2 0.018
regulation of apoptotic process GO:0042981 130 0.017
cellular response to organic substance GO:0071310 132 0.017
positive regulation of multicellular organismal process GO:0051240 143 0.017
regulation of epithelial cell differentiation GO:0030856 4 0.017
regulation of protein metabolic process GO:0051246 256 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
ras protein signal transduction GO:0007265 88 0.017
cellular macromolecule catabolic process GO:0044265 136 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
ovarian follicle cell migration GO:0007297 121 0.017
negative regulation of cell cycle phase transition GO:1901988 103 0.017
negative regulation of signal transduction GO:0009968 206 0.017
neurological system process GO:0050877 358 0.017
meiotic cell cycle GO:0051321 171 0.017
cellular response to molecule of bacterial origin GO:0071219 3 0.017
lateral inhibition GO:0046331 206 0.017
lipid biosynthetic process GO:0008610 46 0.016
single organism cellular localization GO:1902580 180 0.016
histolysis GO:0007559 102 0.016
regulation of immune system process GO:0002682 176 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.016
lipid localization GO:0010876 54 0.016
positive regulation of protein metabolic process GO:0051247 128 0.016
response to temperature stimulus GO:0009266 106 0.016
cellular homeostasis GO:0019725 80 0.016
ameboidal type cell migration GO:0001667 151 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
kidney development GO:0001822 3 0.016
positive regulation of cellular component organization GO:0051130 156 0.016
actin filament based process GO:0030029 220 0.016
positive regulation of cell proliferation GO:0008284 47 0.016
eye pigment metabolic process GO:0042441 33 0.016
single organism catabolic process GO:0044712 228 0.016
endocytosis GO:0006897 310 0.016
regulation of cell proliferation GO:0042127 163 0.016
cellular response to biotic stimulus GO:0071216 4 0.016
actin cytoskeleton organization GO:0030036 206 0.015
negative regulation of cellular component organization GO:0051129 108 0.015
regulation of rna splicing GO:0043484 69 0.015
negative regulation of programmed cell death GO:0043069 72 0.015
response to ionizing radiation GO:0010212 32 0.015
anion homeostasis GO:0055081 3 0.015
segmentation GO:0035282 207 0.015
positive regulation of cell differentiation GO:0045597 64 0.015
organonitrogen compound catabolic process GO:1901565 128 0.015
spindle assembly GO:0051225 80 0.015
autophagic cell death GO:0048102 83 0.015
protein localization GO:0008104 284 0.015
chemotaxis GO:0006935 249 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
cellular lipid metabolic process GO:0044255 83 0.015
response to uv GO:0009411 24 0.015
cellular component assembly involved in morphogenesis GO:0010927 151 0.015
peptidyl amino acid modification GO:0018193 105 0.015
androgen metabolic process GO:0008209 1 0.015
regulation of organelle organization GO:0033043 196 0.014
response to oxygen containing compound GO:1901700 200 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.014
pigment biosynthetic process GO:0046148 36 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
cell adhesion GO:0007155 136 0.014
jak stat cascade GO:0007259 49 0.014
positive regulation of neurogenesis GO:0050769 41 0.014
connective tissue development GO:0061448 3 0.014
protein catabolic process GO:0030163 101 0.014
cell recognition GO:0008037 102 0.014
ribonucleotide catabolic process GO:0009261 109 0.014
epidermal cell differentiation GO:0009913 51 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
regulation of catabolic process GO:0009894 170 0.014
tetraterpenoid metabolic process GO:0016108 1 0.014
intracellular transport GO:0046907 228 0.014
axis specification GO:0009798 167 0.014
ribonucleoside triphosphate catabolic process GO:0009203 108 0.014
tissue migration GO:0090130 155 0.014
negative regulation of homeostatic process GO:0032845 2 0.014
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.014
defense response to gram negative bacterium GO:0050829 94 0.014
sterol homeostasis GO:0055092 4 0.014
compound eye development GO:0048749 307 0.014
small gtpase mediated signal transduction GO:0007264 88 0.014
response to organic substance GO:0010033 284 0.014
purine nucleotide metabolic process GO:0006163 146 0.014
g protein coupled receptor signaling pathway GO:0007186 136 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
determination of adult lifespan GO:0008340 137 0.014
cellular response to oxygen containing compound GO:1901701 79 0.013
positive regulation of phosphorylation GO:0042327 87 0.013
negative regulation of nucleic acid templated transcription GO:1903507 240 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
chitin based cuticle development GO:0040003 49 0.013
tissue morphogenesis GO:0048729 297 0.013
carboxylic acid metabolic process GO:0019752 92 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
regulation of protein modification process GO:0031399 112 0.013
immune response GO:0006955 246 0.013
anatomical structure homeostasis GO:0060249 97 0.013
negative regulation of mitotic cell cycle GO:0045930 109 0.013
nucleoside triphosphate catabolic process GO:0009143 108 0.013
cellular response to light stimulus GO:0071482 37 0.013
negative regulation of apoptotic process GO:0043066 63 0.013
cell division GO:0051301 248 0.013
hair cell differentiation GO:0035315 47 0.013
regulation of cell projection organization GO:0031344 92 0.013
gene silencing GO:0016458 138 0.013
photoreceptor cell development GO:0042461 96 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.013
ribonucleoside metabolic process GO:0009119 127 0.013
chromatin modification GO:0016568 147 0.013
xenobiotic catabolic process GO:0042178 1 0.013
growth GO:0040007 359 0.013
imaginal disc pattern formation GO:0007447 91 0.013
organic acid metabolic process GO:0006082 103 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
response to endogenous stimulus GO:0009719 119 0.013
cellular ketone metabolic process GO:0042180 24 0.013
localization of cell GO:0051674 257 0.013
chemical homeostasis GO:0048878 92 0.013
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
organophosphate catabolic process GO:0046434 112 0.012
endomembrane system organization GO:0010256 119 0.012
purine containing compound catabolic process GO:0072523 112 0.012
positive regulation of signal transduction GO:0009967 223 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
developmental maturation GO:0021700 172 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
adult behavior GO:0030534 137 0.012
mitotic nuclear division GO:0007067 213 0.012
cell junction organization GO:0034330 57 0.012
ribonucleoside monophosphate catabolic process GO:0009158 39 0.012
negative regulation of signaling GO:0023057 219 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
regulation of cellular component size GO:0032535 98 0.012
histone modification GO:0016570 106 0.012
organophosphate metabolic process GO:0019637 195 0.012
regulation of cell substrate adhesion GO:0010810 2 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
positive regulation of neuron differentiation GO:0045666 26 0.012
negative regulation of cell cycle GO:0045786 116 0.012
positive regulation of response to stimulus GO:0048584 323 0.012
establishment of protein localization GO:0045184 163 0.012
muscle adaptation GO:0043500 1 0.012
positive regulation of signaling GO:0023056 243 0.012
purine containing compound metabolic process GO:0072521 155 0.012
steroid catabolic process GO:0006706 1 0.012
microtubule organizing center organization GO:0031023 168 0.012
open tracheal system development GO:0007424 204 0.012
positive regulation of rna biosynthetic process GO:1902680 266 0.012
nucleoside catabolic process GO:0009164 112 0.011
forebrain development GO:0030900 2 0.011
negative regulation of cell cycle process GO:0010948 109 0.011
eye pigmentation GO:0048069 43 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
lipid storage GO:0019915 38 0.011
oxoacid metabolic process GO:0043436 103 0.011
regulation of cell cycle phase transition GO:1901987 130 0.011
humoral immune response GO:0006959 117 0.011
negative regulation of intracellular signal transduction GO:1902532 57 0.011
fat soluble vitamin metabolic process GO:0006775 1 0.011
respiratory system development GO:0060541 213 0.011
defense response to bacterium GO:0042742 178 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
vitamin biosynthetic process GO:0009110 1 0.011
peptidyl tyrosine modification GO:0018212 24 0.011
hormone catabolic process GO:0042447 3 0.011
response to organic cyclic compound GO:0014070 89 0.011
organic hydroxy compound metabolic process GO:1901615 83 0.011
spindle organization GO:0007051 253 0.011
membrane organization GO:0061024 112 0.011
positive regulation of cell motility GO:2000147 3 0.011
rna processing GO:0006396 147 0.011
regulation of endocytosis GO:0030100 37 0.011
regulation of vesicle mediated transport GO:0060627 59 0.011
chromosome separation GO:0051304 42 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
regulation of embryonic development GO:0045995 68 0.011
response to oxidative stress GO:0006979 86 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
epidermis development GO:0008544 65 0.011
negative regulation of cell death GO:0060548 81 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
response to glucose GO:0009749 2 0.011
establishment of organelle localization GO:0051656 122 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
cell projection assembly GO:0030031 94 0.011
ion transport GO:0006811 145 0.010
substrate adhesion dependent cell spreading GO:0034446 2 0.010
negative regulation of cell differentiation GO:0045596 143 0.010
blastoderm segmentation GO:0007350 159 0.010
dorsal ventral pattern formation GO:0009953 133 0.010
tripartite regional subdivision GO:0007351 103 0.010
negative regulation of cellular protein metabolic process GO:0032269 85 0.010
regulation of purine nucleotide metabolic process GO:1900542 62 0.010
embryonic pattern specification GO:0009880 174 0.010
defense response GO:0006952 300 0.010
positive regulation of hydrolase activity GO:0051345 78 0.010
hindbrain development GO:0030902 2 0.010
nucleotide metabolic process GO:0009117 161 0.010
purine nucleoside triphosphate catabolic process GO:0009146 108 0.010
covalent chromatin modification GO:0016569 106 0.010
eye development GO:0001654 323 0.010
establishment of localization in cell GO:0051649 402 0.010
regulation of response to dna damage stimulus GO:2001020 23 0.010
purine ribonucleoside catabolic process GO:0046130 112 0.010
epithelial cell development GO:0002064 274 0.010
cellular protein localization GO:0034613 160 0.010
male gamete generation GO:0048232 201 0.010
nucleoside metabolic process GO:0009116 127 0.010

Tie disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
nervous system disease DOID:863 0 0.020
renal tubular transport disease DOID:447 0 0.020
kidney disease DOID:557 0 0.020
urinary system disease DOID:18 0 0.020
disease of metabolism DOID:0014667 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
cardiovascular system disease DOID:1287 0 0.011
organ system cancer DOID:0050686 0 0.010