Drosophila melanogaster

78 known processes

HP1e (Dmel_CG8120)

CG8120 gene product from transcript CG8120-RA

(Aliases: HP1E,CG8120,Dmel\CG8120)

HP1e biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of mitotic cell cycle phase transition GO:1901990 130 0.197
regulation of cell cycle phase transition GO:1901987 130 0.139
regulation of cell cycle process GO:0010564 181 0.084
negative regulation of mitotic cell cycle GO:0045930 109 0.081
negative regulation of cell cycle process GO:0010948 109 0.080
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.077
cell cycle phase transition GO:0044770 140 0.066
cell cycle checkpoint GO:0000075 95 0.063
negative regulation of cell cycle phase transition GO:1901988 103 0.059
regulation of protein metabolic process GO:0051246 256 0.058
organonitrogen compound metabolic process GO:1901564 318 0.057
regulation of mitotic cell cycle GO:0007346 190 0.054
organonitrogen compound biosynthetic process GO:1901566 117 0.050
rrna processing GO:0006364 3 0.049
regulation of cell cycle GO:0051726 291 0.049
mitotic cell cycle phase transition GO:0044772 138 0.049
olfactory learning GO:0008355 56 0.048
Worm
homeostatic process GO:0042592 199 0.043
regionalization GO:0003002 416 0.041
mitotic cell cycle checkpoint GO:0007093 88 0.041
sister chromatid segregation GO:0000819 92 0.040
regulation of molecular function GO:0065009 217 0.037
mitotic sister chromatid segregation GO:0000070 87 0.035
regulation of catabolic process GO:0009894 170 0.034
small gtpase mediated signal transduction GO:0007264 88 0.034
Worm
regulation of catalytic activity GO:0050790 185 0.032
regulation of cellular amine metabolic process GO:0033238 3 0.032
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.031
regulation of cellular protein metabolic process GO:0032268 243 0.031
regulation of intracellular signal transduction GO:1902531 236 0.031
Worm
single organism biosynthetic process GO:0044711 206 0.031
chromosome segregation GO:0007059 157 0.031
mitotic nuclear division GO:0007067 213 0.030
transcription from rna polymerase ii promoter GO:0006366 368 0.028
chromosome separation GO:0051304 42 0.028
cellular amide metabolic process GO:0043603 80 0.028
mitotic g2 m transition checkpoint GO:0044818 70 0.028
dna integrity checkpoint GO:0031570 81 0.027
regulation of phosphate metabolic process GO:0019220 210 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
mitotic dna integrity checkpoint GO:0044774 75 0.027
cellular response to dna damage stimulus GO:0006974 223 0.027
mitotic sister chromatid separation GO:0051306 30 0.027
single organism catabolic process GO:0044712 228 0.026
regulation of nervous system development GO:0051960 248 0.026
cell division GO:0051301 248 0.026
single organism behavior GO:0044708 391 0.026
Worm
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.025
regulation of response to stress GO:0080134 200 0.024
response to organic substance GO:0010033 284 0.024
g2 dna damage checkpoint GO:0031572 69 0.024
regulation of growth GO:0040008 233 0.023
Worm
response to starvation GO:0042594 97 0.023
positive regulation of catalytic activity GO:0043085 118 0.023
regulation of immune response GO:0050776 118 0.023
defense response to bacterium GO:0042742 178 0.023
peptide metabolic process GO:0006518 80 0.023
intracellular signal transduction GO:0035556 300 0.023
Worm
regulation of ras protein signal transduction GO:0046578 93 0.022
Worm
regulation of cellular ketone metabolic process GO:0010565 3 0.022
regulation of cellular catabolic process GO:0031329 157 0.022
developmental growth GO:0048589 280 0.022
Worm
protein complex assembly GO:0006461 200 0.022
oxoacid metabolic process GO:0043436 103 0.021
growth GO:0040007 359 0.021
Worm
dna damage checkpoint GO:0000077 78 0.021
regulation of cellular localization GO:0060341 136 0.021
positive regulation of molecular function GO:0044093 136 0.021
establishment of localization in cell GO:0051649 402 0.021
positive regulation of signaling GO:0023056 243 0.021
ras protein signal transduction GO:0007265 88 0.021
Worm
kidney development GO:0001822 3 0.020
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.020
embryonic pattern specification GO:0009880 174 0.020
body morphogenesis GO:0010171 2 0.020
small molecule metabolic process GO:0044281 305 0.020
regulation of mitotic sister chromatid segregation GO:0033047 28 0.020
endocytosis GO:0006897 310 0.020
muscle structure development GO:0061061 224 0.020
response to other organism GO:0051707 293 0.020
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.019
protein modification process GO:0036211 438 0.019
macromolecular complex assembly GO:0065003 256 0.019
regulation of proteasomal protein catabolic process GO:0061136 39 0.019
peptide biosynthetic process GO:0043043 42 0.019
amine metabolic process GO:0009308 12 0.019
positive regulation of proteolysis GO:0045862 52 0.019
positive regulation of phosphate metabolic process GO:0045937 139 0.019
regulation of programmed cell death GO:0043067 152 0.019
protein dna complex subunit organization GO:0071824 86 0.019
negative regulation of response to stimulus GO:0048585 258 0.018
Worm
response to abiotic stimulus GO:0009628 341 0.018
cellular catabolic process GO:0044248 372 0.018
programmed cell death GO:0012501 257 0.018
Worm
regulation of sister chromatid segregation GO:0033045 28 0.018
nephron development GO:0072006 3 0.018
response to nutrient levels GO:0031667 114 0.018
organelle fission GO:0048285 340 0.017
cognition GO:0050890 141 0.017
Worm
positive regulation of apoptotic signaling pathway GO:2001235 4 0.017
metaphase anaphase transition of cell cycle GO:0044784 28 0.017
mating GO:0007618 120 0.017
regulation of cell division GO:0051302 72 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
response to oxygen containing compound GO:1901700 200 0.017
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.017
retina development in camera type eye GO:0060041 4 0.017
protein transport GO:0015031 155 0.016
organophosphate metabolic process GO:0019637 195 0.016
regulation of mitotic sister chromatid separation GO:0010965 28 0.016
cytokinesis GO:0000910 90 0.016
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.016
protein complex biogenesis GO:0070271 201 0.016
vesicle mediated transport GO:0016192 381 0.016
response to temperature stimulus GO:0009266 106 0.016
response to endogenous stimulus GO:0009719 119 0.016
cellular response to heat GO:0034605 24 0.016
regulation of chromosome segregation GO:0051983 32 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
eye development GO:0001654 323 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
carbohydrate derivative biosynthetic process GO:1901137 85 0.015
organelle assembly GO:0070925 198 0.015
cellular protein modification process GO:0006464 438 0.015
associative learning GO:0008306 65 0.015
Worm
negative regulation of cell cycle GO:0045786 116 0.015
positive regulation of protein metabolic process GO:0051247 128 0.015
protein catabolic process GO:0030163 101 0.015
response to biotic stimulus GO:0009607 294 0.015
axis specification GO:0009798 167 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.015
regulation of proteolysis GO:0030162 87 0.015
regulation of phosphorus metabolic process GO:0051174 210 0.015
multi multicellular organism process GO:0044706 123 0.015
defense response to other organism GO:0098542 225 0.015
regulation of cell death GO:0010941 173 0.015
negative regulation of chromosome segregation GO:0051985 14 0.015
mapk cascade GO:0000165 107 0.014
response to external biotic stimulus GO:0043207 293 0.014
organic substance transport GO:0071702 257 0.014
neuromuscular junction development GO:0007528 149 0.014
negative regulation of cell division GO:0051782 17 0.014
mitotic dna damage checkpoint GO:0044773 74 0.014
compound eye morphogenesis GO:0001745 249 0.014
chromosome organization GO:0051276 360 0.014
protein maturation GO:0051604 71 0.014
regulation of immune system process GO:0002682 176 0.014
wing disc morphogenesis GO:0007472 344 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.014
rna processing GO:0006396 147 0.014
regulation of cell development GO:0060284 215 0.014
respiratory system development GO:0060541 213 0.014
imaginal disc derived wing morphogenesis GO:0007476 337 0.014
positive regulation of response to stimulus GO:0048584 323 0.013
mitotic g2 dna damage checkpoint GO:0007095 69 0.013
dna metabolic process GO:0006259 227 0.013
regulation of mitosis GO:0007088 56 0.013
protein localization GO:0008104 284 0.013
response to heat GO:0009408 63 0.013
lipid localization GO:0010876 54 0.013
synapse organization GO:0050808 196 0.013
regulation of protein transport GO:0051223 57 0.013
chemosensory behavior GO:0007635 106 0.013
Worm
ion transport GO:0006811 145 0.013
production of molecular mediator of immune response GO:0002440 46 0.013
camera type eye development GO:0043010 4 0.013
positive regulation of cellular biosynthetic process GO:0031328 316 0.013
negative regulation of catabolic process GO:0009895 36 0.013
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.013
blastoderm segmentation GO:0007350 159 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
cellular protein catabolic process GO:0044257 83 0.013
regulation of innate immune response GO:0045088 71 0.013
kidney epithelium development GO:0072073 3 0.013
innate immune response GO:0045087 144 0.013
cellular homeostasis GO:0019725 80 0.012
monocarboxylic acid transport GO:0015718 3 0.012
glutathione metabolic process GO:0006749 37 0.012
spindle organization GO:0007051 253 0.012
catabolic process GO:0009056 409 0.012
positive regulation of intracellular signal transduction GO:1902533 116 0.012
modification dependent protein catabolic process GO:0019941 78 0.012
positive regulation of cell communication GO:0010647 250 0.012
positive regulation of signal transduction GO:0009967 223 0.012
regulation of organelle organization GO:0033043 196 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
regulation of transport GO:0051049 181 0.012
carboxylic acid metabolic process GO:0019752 92 0.012
regulation of phosphorylation GO:0042325 147 0.012
cell fate determination GO:0001709 91 0.012
positive regulation of macromolecule metabolic process GO:0010604 405 0.012
single organism intracellular transport GO:1902582 207 0.012
cell proliferation GO:0008283 299 0.012
compound eye development GO:0048749 307 0.012
positive regulation of cell motility GO:2000147 3 0.012
hematopoietic progenitor cell differentiation GO:0002244 1 0.012
locomotory behavior GO:0007626 176 0.012
positive regulation of immune response GO:0050778 63 0.012
organic acid metabolic process GO:0006082 103 0.012
response to hexose GO:0009746 3 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.012
regulation of cellular protein catabolic process GO:1903362 44 0.012
forebrain development GO:0030900 2 0.012
cellular amine metabolic process GO:0044106 12 0.012
cation transmembrane transport GO:0098655 88 0.011
nephron tubule development GO:0072080 3 0.011
modification dependent macromolecule catabolic process GO:0043632 79 0.011
immune response regulating signaling pathway GO:0002764 2 0.011
response to extracellular stimulus GO:0009991 116 0.011
eye photoreceptor cell differentiation GO:0001754 145 0.011
response to glucose GO:0009749 2 0.011
compound eye photoreceptor cell differentiation GO:0001751 140 0.011
regulation of multi organism process GO:0043900 131 0.011
segmentation GO:0035282 207 0.011
regulation of mapk cascade GO:0043408 92 0.011
dna templated transcription initiation GO:0006352 25 0.011
intracellular transport GO:0046907 228 0.011
proteolysis GO:0006508 192 0.011
secondary metabolite catabolic process GO:0090487 1 0.011
sensory perception of chemical stimulus GO:0007606 116 0.011
mitotic spindle organization GO:0007052 220 0.011
proteasomal protein catabolic process GO:0010498 59 0.011
negative regulation of sister chromatid segregation GO:0033046 13 0.011
sensory organ morphogenesis GO:0090596 260 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
olfactory behavior GO:0042048 97 0.011
Worm
negative regulation of multicellular organismal process GO:0051241 142 0.011
Worm
negative regulation of organelle organization GO:0010639 56 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
spinal cord development GO:0021510 1 0.011
response to lipopolysaccharide GO:0032496 4 0.011
oxidation reduction process GO:0055114 123 0.011
protein processing GO:0016485 68 0.011
positive regulation of programmed cell death GO:0043068 62 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
golgi organization GO:0007030 66 0.011
germarium derived egg chamber formation GO:0007293 101 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
membrane organization GO:0061024 112 0.011
protein heterooligomerization GO:0051291 4 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
learning GO:0007612 75 0.011
Worm
regulation of nuclear division GO:0051783 58 0.011
response to monosaccharide GO:0034284 4 0.011
erk1 and erk2 cascade GO:0070371 39 0.011
chromatin remodeling GO:0006338 72 0.011
multicellular organismal aging GO:0010259 140 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
aging GO:0007568 143 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.011
nephron morphogenesis GO:0072028 3 0.010
regulation of protein complex assembly GO:0043254 42 0.010
phagocytosis GO:0006909 215 0.010
secretion by cell GO:0032940 101 0.010
centrosome duplication GO:0051298 121 0.010
carbohydrate metabolic process GO:0005975 82 0.010
appendage morphogenesis GO:0035107 397 0.010
organophosphate catabolic process GO:0046434 112 0.010
negative regulation of epithelial cell proliferation GO:0050680 4 0.010
regulation of multicellular organismal development GO:2000026 414 0.010
Worm
cell junction organization GO:0034330 57 0.010
carbohydrate derivative metabolic process GO:1901135 217 0.010
reproductive system development GO:0061458 74 0.010
Worm
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.010
endomembrane system organization GO:0010256 119 0.010

HP1e disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
musculoskeletal system disease DOID:17 0 0.014
nervous system disease DOID:863 0 0.012
hypertension DOID:10763 0 0.010
artery disease DOID:0050828 0 0.010
vascular disease DOID:178 0 0.010
essential hypertension DOID:10825 0 0.010
cardiovascular system disease DOID:1287 0 0.010