Drosophila melanogaster

103 known processes

twin (Dmel_CG31137)

CG31137 gene product from transcript CG31137-RB

(Aliases: BEST:GH20274,CG17741,CT39331,twn,Dmel\CG31137,CG5534,CCR4,ccr4,CG31137)

twin biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
female germ line stem cell asymmetric division GO:0048132 14 0.881
germline stem cell asymmetric division GO:0098728 15 0.812
germ line stem cell division GO:0042078 25 0.692
regulation of cellular component biogenesis GO:0044087 201 0.570
Human
macromolecule catabolic process GO:0009057 161 0.439
cell division GO:0051301 248 0.424
germarium derived egg chamber formation GO:0007293 101 0.412
female germ line stem cell maintenance GO:0036099 8 0.298
female meiotic division GO:0007143 70 0.280
synapse organization GO:0050808 196 0.251
vesicle mediated transport GO:0016192 381 0.230
negative regulation of gene expression GO:0010629 387 0.193
germ line stem cell maintenance GO:0030718 50 0.192
ovarian fusome organization GO:0030723 11 0.177
organelle fission GO:0048285 340 0.175
positive regulation of biosynthetic process GO:0009891 316 0.172
nuclear division GO:0000280 332 0.170
establishment of localization in cell GO:0051649 402 0.169
regulation of growth GO:0040008 233 0.168
Worm
regulation of synapse organization GO:0050807 110 0.160
rna processing GO:0006396 147 0.156
negative regulation of developmental process GO:0051093 201 0.156
asymmetric stem cell division GO:0098722 49 0.148
regulation of organelle organization GO:0033043 196 0.146
Human
catabolic process GO:0009056 409 0.141
fusome organization GO:0045478 13 0.132
negative regulation of response to stimulus GO:0048585 258 0.132
oocyte development GO:0048599 124 0.127
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.124
regulation of multicellular organismal development GO:2000026 414 0.120
cellular macromolecule catabolic process GO:0044265 136 0.117
response to other organism GO:0051707 293 0.116
protein modification process GO:0036211 438 0.115
actin filament based process GO:0030029 220 0.112
male gamete generation GO:0048232 201 0.110
appendage morphogenesis GO:0035107 397 0.109
imaginal disc derived appendage development GO:0048737 399 0.107
meiotic cell cycle GO:0051321 171 0.106
regulation of synapse assembly GO:0051963 94 0.105
protein modification by small protein conjugation or removal GO:0070647 106 0.101
stem cell division GO:0017145 69 0.101
post embryonic appendage morphogenesis GO:0035120 385 0.100
negative regulation of cell cycle phase transition GO:1901988 103 0.099
negative regulation of protein metabolic process GO:0051248 85 0.096
spermatid differentiation GO:0048515 114 0.094
positive regulation of macromolecule metabolic process GO:0010604 405 0.093
meiotic nuclear division GO:0007126 151 0.092
oocyte differentiation GO:0009994 145 0.091
blastoderm segmentation GO:0007350 159 0.090
regulation of mitotic cell cycle GO:0007346 190 0.090
organic cyclic compound catabolic process GO:1901361 168 0.088
oocyte construction GO:0007308 112 0.082
negative regulation of cellular metabolic process GO:0031324 382 0.080
posttranscriptional gene silencing by rna GO:0035194 45 0.080
organic substance catabolic process GO:1901575 308 0.080
microtubule bundle formation GO:0001578 27 0.077
negative regulation of synapse assembly GO:0051964 39 0.075
regulation of actin cytoskeleton organization GO:0032956 42 0.074
rna catabolic process GO:0006401 37 0.074
oocyte microtubule cytoskeleton organization GO:0016325 35 0.073
gene silencing by rna GO:0031047 57 0.073
female germline ring canal formation GO:0007301 9 0.072
positive regulation of cellular component organization GO:0051130 156 0.072
Human
oocyte axis specification GO:0007309 108 0.072
imaginal disc derived appendage morphogenesis GO:0035114 395 0.070
regulation of synapse structure and activity GO:0050803 128 0.070
cellular catabolic process GO:0044248 372 0.069
positive regulation of nucleic acid templated transcription GO:1903508 266 0.069
purine ribonucleoside catabolic process GO:0046130 112 0.069
chromosome segregation GO:0007059 157 0.069
mitotic nuclear division GO:0007067 213 0.068
body morphogenesis GO:0010171 2 0.068
phagocytosis GO:0006909 215 0.066
chaeta development GO:0022416 97 0.065
stem cell maintenance GO:0019827 67 0.064
imaginal disc derived wing morphogenesis GO:0007476 337 0.064
spermatogenesis GO:0007283 200 0.063
positive regulation of signal transduction GO:0009967 223 0.063
actin cytoskeleton organization GO:0030036 206 0.060
endocytosis GO:0006897 310 0.058
response to external biotic stimulus GO:0043207 293 0.058
maternal determination of anterior posterior axis embryo GO:0008358 74 0.057
regulation of protein catabolic process GO:0042176 55 0.056
synaptic growth at neuromuscular junction GO:0051124 119 0.055
appendage development GO:0048736 401 0.054
regulation of cell differentiation GO:0045595 302 0.054
regulation of translation GO:0006417 56 0.053
cystoblast division GO:0007282 10 0.053
stem cell development GO:0048864 79 0.053
cell cycle phase transition GO:0044770 140 0.053
cytokinesis GO:0000910 90 0.049
negative regulation of mitotic cell cycle GO:0045930 109 0.049
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.049
neuromuscular junction development GO:0007528 149 0.049
regulation of cell cycle GO:0051726 291 0.048
regulation of oocyte development GO:0060281 27 0.048
negative regulation of cellular component organization GO:0051129 108 0.047
response to organic substance GO:0010033 284 0.047
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.047
positive regulation of transcription dna templated GO:0045893 266 0.046
germline ring canal formation GO:0030725 13 0.045
posttranscriptional regulation of gene expression GO:0010608 145 0.045
carbohydrate derivative metabolic process GO:1901135 217 0.044
maintenance of location GO:0051235 73 0.044
chromosome organization GO:0051276 360 0.043
actin filament organization GO:0007015 126 0.042
regulation of cellular protein metabolic process GO:0032268 243 0.042
heterochromatin organization GO:0070828 25 0.042
chromosome localization GO:0050000 20 0.041
regulation of cell cycle phase transition GO:1901987 130 0.041
aromatic compound catabolic process GO:0019439 166 0.041
cell cycle checkpoint GO:0000075 95 0.040
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.040
negative regulation of organelle organization GO:0010639 56 0.040
oocyte anterior posterior axis specification GO:0007314 72 0.039
regulation of protein complex assembly GO:0043254 42 0.039
synapse assembly GO:0007416 143 0.038
nucleoside phosphate metabolic process GO:0006753 162 0.038
developmental maturation GO:0021700 172 0.037
carbohydrate derivative catabolic process GO:1901136 118 0.037
negative regulation of cellular protein metabolic process GO:0032269 85 0.037
spermatid development GO:0007286 98 0.037
cell death GO:0008219 279 0.037
ovarian nurse cell to oocyte transport GO:0007300 27 0.037
meiotic cell cycle process GO:1903046 132 0.037
negative regulation of cell differentiation GO:0045596 143 0.036
nucleobase containing small molecule metabolic process GO:0055086 174 0.035
embryo development ending in birth or egg hatching GO:0009792 152 0.035
Worm
negative regulation of protein depolymerization GO:1901880 23 0.035
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.034
homeostatic process GO:0042592 199 0.034
mitotic cell cycle checkpoint GO:0007093 88 0.033
cellular macromolecule localization GO:0070727 220 0.033
wing disc morphogenesis GO:0007472 344 0.033
dna conformation change GO:0071103 105 0.032
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.032
ribonucleoside triphosphate metabolic process GO:0009199 119 0.032
negative regulation of cell cycle GO:0045786 116 0.031
dna metabolic process GO:0006259 227 0.031
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.031
sensory organ morphogenesis GO:0090596 260 0.031
adult behavior GO:0030534 137 0.031
positive regulation of response to stimulus GO:0048584 323 0.030
organophosphate catabolic process GO:0046434 112 0.030
mrna processing GO:0006397 104 0.029
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.029
bmp signaling pathway GO:0030509 27 0.029
organic substance transport GO:0071702 257 0.029
centrosome duplication GO:0051298 121 0.029
positive regulation of rna biosynthetic process GO:1902680 266 0.028
regulation of protein complex disassembly GO:0043244 29 0.028
negative regulation of cell communication GO:0010648 223 0.028
purine nucleoside triphosphate metabolic process GO:0009144 119 0.028
regulation of protein metabolic process GO:0051246 256 0.028
regulation of cell death GO:0010941 173 0.028
purine ribonucleotide catabolic process GO:0009154 109 0.027
positive regulation of cellular component biogenesis GO:0044089 80 0.027
Human
nucleoside triphosphate metabolic process GO:0009141 120 0.027
nucleobase containing compound catabolic process GO:0034655 165 0.027
purine ribonucleotide metabolic process GO:0009150 145 0.027
proteolysis GO:0006508 192 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.026
embryonic axis specification GO:0000578 107 0.026
mrna catabolic process GO:0006402 33 0.026
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.026
purine nucleoside triphosphate catabolic process GO:0009146 108 0.026
purine nucleotide metabolic process GO:0006163 146 0.026
positive regulation of developmental process GO:0051094 143 0.026
Worm
regulation of transport GO:0051049 181 0.026
positive regulation of cellular biosynthetic process GO:0031328 316 0.026
translation GO:0006412 69 0.026
cellular homeostasis GO:0019725 80 0.026
positive regulation of rna metabolic process GO:0051254 271 0.025
ribose phosphate metabolic process GO:0019693 145 0.025
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.025
ribonucleoside monophosphate catabolic process GO:0009158 39 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.025
negative regulation of growth GO:0045926 84 0.025
organonitrogen compound metabolic process GO:1901564 318 0.024
protein modification by small protein removal GO:0070646 28 0.024
ncrna metabolic process GO:0034660 43 0.024
establishment of protein localization GO:0045184 163 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.024
heterocycle catabolic process GO:0046700 166 0.024
sister chromatid segregation GO:0000819 92 0.024
single organism catabolic process GO:0044712 228 0.023
cellular protein localization GO:0034613 160 0.023
regulation of cytoskeleton organization GO:0051493 89 0.023
actin filament bundle organization GO:0061572 28 0.023
protein maturation GO:0051604 71 0.023
regulation of cell cycle process GO:0010564 181 0.023
mrna metabolic process GO:0016071 124 0.023
regulation of protein depolymerization GO:1901879 27 0.022
digestive tract morphogenesis GO:0048546 127 0.022
glycosyl compound metabolic process GO:1901657 127 0.022
learning or memory GO:0007611 141 0.022
response to oxygen containing compound GO:1901700 200 0.022
protein catabolic process GO:0030163 101 0.022
response to bacterium GO:0009617 198 0.022
compound eye development GO:0048749 307 0.022
positive regulation of cytoskeleton organization GO:0051495 21 0.022
positive regulation of translation GO:0045727 12 0.021
spindle elongation GO:0051231 83 0.021
regulation of developmental growth GO:0048638 174 0.021
Worm
response to dsrna GO:0043331 15 0.021
negative regulation of cytoskeleton organization GO:0051494 30 0.020
maintenance of protein location in cell GO:0032507 26 0.020
negative regulation of signal transduction GO:0009968 206 0.020
negative regulation of cell cycle process GO:0010948 109 0.020
eye morphogenesis GO:0048592 260 0.020
response to abiotic stimulus GO:0009628 341 0.020
negative regulation of multicellular organismal process GO:0051241 142 0.020
cellular response to heat GO:0034605 24 0.019
negative regulation of programmed cell death GO:0043069 72 0.019
maintenance of protein location GO:0045185 28 0.019
regulation of proteolysis GO:0030162 87 0.019
protein processing GO:0016485 68 0.019
cellular protein catabolic process GO:0044257 83 0.019
regulation of actin polymerization or depolymerization GO:0008064 27 0.019
ribonucleoside triphosphate catabolic process GO:0009203 108 0.019
small molecule metabolic process GO:0044281 305 0.019
regulation of nervous system development GO:0051960 248 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
establishment of chromosome localization GO:0051303 20 0.018
purine containing compound metabolic process GO:0072521 155 0.018
taxis GO:0042330 304 0.018
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.018
negative regulation of signaling GO:0023057 219 0.018
gene silencing GO:0016458 138 0.018
establishment of rna localization GO:0051236 47 0.018
cellular response to organic substance GO:0071310 132 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.018
rrna processing GO:0006364 3 0.018
developmental growth GO:0048589 280 0.018
Worm
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.018
regulation of meiosis GO:0040020 3 0.018
ribonucleotide catabolic process GO:0009261 109 0.018
positive regulation of signaling GO:0023056 243 0.018
mitochondrion degradation GO:0000422 8 0.018
positive regulation of cell communication GO:0010647 250 0.017
regulation of apoptotic process GO:0042981 130 0.017
meiosis i GO:0007127 59 0.017
regulation of mrna catabolic process GO:0061013 5 0.017
immune system process GO:0002376 347 0.017
regulation of peptidase activity GO:0052547 39 0.017
negative regulation of cell death GO:0060548 81 0.017
ubiquitin dependent protein catabolic process GO:0006511 78 0.017
regulation of proteasomal protein catabolic process GO:0061136 39 0.017
nucleotide catabolic process GO:0009166 109 0.017
protein localization GO:0008104 284 0.017
mrna 3 end processing GO:0031124 28 0.017
regulation of nuclear division GO:0051783 58 0.017
protein transport GO:0015031 155 0.017
asymmetric cell division GO:0008356 37 0.016
glycosyl compound catabolic process GO:1901658 112 0.016
intracellular transport GO:0046907 228 0.016
stem cell differentiation GO:0048863 117 0.016
regulation of embryonic development GO:0045995 68 0.016
posttranscriptional gene silencing GO:0016441 46 0.016
regulation of catabolic process GO:0009894 170 0.016
cell motility GO:0048870 251 0.016
regulation of cell division GO:0051302 72 0.016
response to temperature stimulus GO:0009266 106 0.016
cell fate determination GO:0001709 91 0.016
purine nucleotide catabolic process GO:0006195 109 0.016
regulation of pole plasm oskar mrna localization GO:0007317 27 0.016
negative regulation of wnt signaling pathway GO:0030178 28 0.015
positive regulation of gene expression GO:0010628 290 0.015
phosphorylation GO:0016310 294 0.015
macromolecular complex assembly GO:0065003 256 0.015
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.015
regulation of programmed cell death GO:0043067 152 0.015
cellular protein modification process GO:0006464 438 0.015
death GO:0016265 284 0.015
regulation of cellular localization GO:0060341 136 0.015
somatic muscle development GO:0007525 66 0.014
microtubule based movement GO:0007018 51 0.014
cell proliferation GO:0008283 299 0.014
Human Mouse
ribonucleoside metabolic process GO:0009119 127 0.014
microtubule depolymerization GO:0007019 25 0.014
nucleoside triphosphate catabolic process GO:0009143 108 0.014
regulation of cellular protein catabolic process GO:1903362 44 0.014
stem cell proliferation GO:0072089 88 0.014
nucleoside catabolic process GO:0009164 112 0.014
negative regulation of catabolic process GO:0009895 36 0.014
segmentation GO:0035282 207 0.014
regulation of mrna metabolic process GO:1903311 72 0.014
intercellular bridge organization GO:0043063 14 0.014
centrosome cycle GO:0007098 137 0.014
cellular protein complex disassembly GO:0043624 35 0.014
female germ line cyst formation GO:0048135 42 0.014
mitotic cell cycle phase transition GO:0044772 138 0.014
small rna loading onto risc GO:0070922 6 0.014
purine ribonucleoside metabolic process GO:0046128 127 0.014
ovarian follicle cell migration GO:0007297 121 0.013
regulation of cellular component size GO:0032535 98 0.013
germarium derived female germ line cyst encapsulation GO:0030708 8 0.013
anatomical structure homeostasis GO:0060249 97 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
anterior posterior pattern specification GO:0009952 136 0.013
germarium derived oocyte fate determination GO:0007294 26 0.013
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.013
cellular protein complex assembly GO:0043623 71 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.013
memory GO:0007613 94 0.013
organelle assembly GO:0070925 198 0.013
Human
ribonucleoside catabolic process GO:0042454 112 0.013
atp metabolic process GO:0046034 49 0.013
positive regulation of hydrolase activity GO:0051345 78 0.013
regulation of mitosis GO:0007088 56 0.013
proteasomal protein catabolic process GO:0010498 59 0.012
mesenchymal cell differentiation GO:0048762 1 0.012
purine nucleoside catabolic process GO:0006152 112 0.012
lipid storage GO:0019915 38 0.012
endomembrane system organization GO:0010256 119 0.012
axis specification GO:0009798 167 0.012
alternative mrna splicing via spliceosome GO:0000380 60 0.012
single organism biosynthetic process GO:0044711 206 0.012
protein ubiquitination GO:0016567 70 0.012
regulation of embryonic pattern specification GO:1902875 27 0.012
extracellular structure organization GO:0043062 46 0.012
protein modification by small protein conjugation GO:0032446 79 0.012
negative regulation of translation GO:0017148 28 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.012
negative regulation of protein processing GO:0010955 31 0.012
cytoplasm organization GO:0007028 64 0.012
regulation of mitotic cell cycle phase transition GO:1901990 130 0.012
skeletal muscle organ development GO:0060538 48 0.011
karyosome formation GO:0030717 22 0.011
lipid metabolic process GO:0006629 121 0.011
cellular response to dsrna GO:0071359 15 0.011
mitotic spindle organization GO:0007052 220 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
nuclear transport GO:0051169 72 0.011
regulation of localization GO:0032879 275 0.011
muscle structure development GO:0061061 224 0.011
regulation of phosphatase activity GO:0010921 3 0.011
ameboidal type cell migration GO:0001667 151 0.011
nucleoside metabolic process GO:0009116 127 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
regulation of hemocyte proliferation GO:0035206 37 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
protein k48 linked ubiquitination GO:0070936 3 0.011
regulation of cell growth GO:0001558 43 0.011
germarium derived oocyte differentiation GO:0030706 29 0.011
protein depolymerization GO:0051261 31 0.011
intracellular protein transport GO:0006886 104 0.011
nucleotide metabolic process GO:0009117 161 0.011
positive regulation of cellular catabolic process GO:0031331 95 0.010
regulation of endocytosis GO:0030100 37 0.010
negative regulation of cellular response to oxidative stress GO:1900408 1 0.010
mitotic spindle stabilization GO:0043148 6 0.010
long term memory GO:0007616 62 0.010
ovarian follicle cell development GO:0030707 248 0.010
modification dependent protein catabolic process GO:0019941 78 0.010
carbohydrate metabolic process GO:0005975 82 0.010
purine containing compound catabolic process GO:0072523 112 0.010
regulation of rna splicing GO:0043484 69 0.010
negative regulation of molecular function GO:0044092 51 0.010
cellular macromolecular complex assembly GO:0034622 153 0.010
Human
appendage segmentation GO:0035285 26 0.010
actin filament bundle assembly GO:0051017 26 0.010
regulation of membrane depolarization GO:0003254 1 0.010
regulation of anatomical structure size GO:0090066 163 0.010
cell aging GO:0007569 2 0.010
cellular response to nitrogen compound GO:1901699 51 0.010

twin disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012