Drosophila melanogaster

180 known processes

Cul-4 (Dmel_CG8711)

Cullin-4

(Aliases: CG8711,DMcul-4,Cul4,CUL4,Dmel\CG8711,dCul4,cul-4)

Cul-4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
epithelial cell differentiation GO:0030855 322 0.613
protein catabolic process GO:0030163 101 0.559
macromolecule catabolic process GO:0009057 161 0.462
cellular macromolecule catabolic process GO:0044265 136 0.374
Mouse
regulation of catabolic process GO:0009894 170 0.351
organelle fission GO:0048285 340 0.318
protein modification by small protein conjugation or removal GO:0070647 106 0.277
Human
protein ubiquitination GO:0016567 70 0.233
Human
histone modification GO:0016570 106 0.227
Human
ubiquitin dependent protein catabolic process GO:0006511 78 0.208
Mouse
body morphogenesis GO:0010171 2 0.201
cellular amino acid metabolic process GO:0006520 61 0.183
cell cycle phase transition GO:0044770 140 0.176
regulation of cellular ketone metabolic process GO:0010565 3 0.174
positive regulation of catabolic process GO:0009896 105 0.169
regulation of cell cycle process GO:0010564 181 0.162
histone acetylation GO:0016573 38 0.162
regulation of cellular amine metabolic process GO:0033238 3 0.155
single organism cellular localization GO:1902580 180 0.150
regulation of protein catabolic process GO:0042176 55 0.140
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.138
organic substance catabolic process GO:1901575 308 0.133
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.129
Mouse
transcription from rna polymerase ii promoter GO:0006366 368 0.124
regulation of cellular amino acid metabolic process GO:0006521 0 0.121
posttranscriptional gene silencing by rna GO:0035194 45 0.116
male gamete generation GO:0048232 201 0.115
covalent chromatin modification GO:0016569 106 0.107
Human
regulation of cell cycle phase transition GO:1901987 130 0.107
rna transport GO:0050658 46 0.106
mitotic dna damage checkpoint GO:0044773 74 0.104
cellular protein modification process GO:0006464 438 0.096
Human
mrna metabolic process GO:0016071 124 0.094
growth GO:0040007 359 0.093
protein complex biogenesis GO:0070271 201 0.087
positive regulation of protein metabolic process GO:0051247 128 0.082
carboxylic acid metabolic process GO:0019752 92 0.081
protein complex assembly GO:0006461 200 0.077
spermatid differentiation GO:0048515 114 0.074
cell proliferation GO:0008283 299 0.074
Mouse
chromatin remodeling GO:0006338 72 0.072
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.071
amine metabolic process GO:0009308 12 0.070
proteolysis GO:0006508 192 0.069
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.067
regulation of cellular protein metabolic process GO:0032268 243 0.060
nucleobase containing compound transport GO:0015931 56 0.060
posttranscriptional gene silencing GO:0016441 46 0.059
regulation of protein metabolic process GO:0051246 256 0.058
mrna catabolic process GO:0006402 33 0.057
regulation of cell morphogenesis GO:0022604 163 0.056
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.055
modification dependent protein catabolic process GO:0019941 78 0.053
Mouse
posttranscriptional regulation of gene expression GO:0010608 145 0.052
positive regulation of protein catabolic process GO:0045732 34 0.052
spermatid development GO:0007286 98 0.049
cellular macromolecular complex assembly GO:0034622 153 0.046
positive regulation of cellular protein metabolic process GO:0032270 118 0.045
positive regulation of macromolecule metabolic process GO:0010604 405 0.045
modification dependent macromolecule catabolic process GO:0043632 79 0.044
Mouse
cellular amine metabolic process GO:0044106 12 0.044
chromosome organization GO:0051276 360 0.044
Human
regulation of cell shape GO:0008360 113 0.043
catabolic process GO:0009056 409 0.043
protein modification process GO:0036211 438 0.042
Human
ovarian follicle cell development GO:0030707 248 0.041
regionalization GO:0003002 416 0.040
rna localization GO:0006403 115 0.040
cellular protein complex assembly GO:0043623 71 0.040
protein modification by small protein conjugation GO:0032446 79 0.038
Human
embryo development ending in birth or egg hatching GO:0009792 152 0.037
negative regulation of response to stimulus GO:0048585 258 0.036
columnar cuboidal epithelial cell development GO:0002066 249 0.036
regulation of mitotic cell cycle GO:0007346 190 0.036
positive regulation of signal transduction GO:0009967 223 0.036
organic acid metabolic process GO:0006082 103 0.035
regulation of catalytic activity GO:0050790 185 0.034
cellular ketone metabolic process GO:0042180 24 0.034
regulation of growth GO:0040008 233 0.033
positive regulation of nucleic acid templated transcription GO:1903508 266 0.032
establishment of rna localization GO:0051236 47 0.032
spermatogenesis GO:0007283 200 0.032
dna templated transcription initiation GO:0006352 25 0.031
vesicle mediated transport GO:0016192 381 0.031
oxoacid metabolic process GO:0043436 103 0.030
negative regulation of mitotic cell cycle GO:0045930 109 0.029
chaeta development GO:0022416 97 0.029
regulation of organelle organization GO:0033043 196 0.027
positive regulation of cellular catabolic process GO:0031331 95 0.027
peptidyl amino acid modification GO:0018193 105 0.027
ribonucleoprotein complex biogenesis GO:0022613 31 0.027
aging GO:0007568 143 0.026
small molecule metabolic process GO:0044281 305 0.026
protein targeting to nucleus GO:0044744 51 0.025
organic substance transport GO:0071702 257 0.025
single organism intracellular transport GO:1902582 207 0.024
regulation of cell development GO:0060284 215 0.024
gene silencing by rna GO:0031047 57 0.024
regulation of cellular catabolic process GO:0031329 157 0.023
proteasomal protein catabolic process GO:0010498 59 0.023
Mouse
gliogenesis GO:0042063 80 0.022
regulation of nervous system development GO:0051960 248 0.022
cellular cation homeostasis GO:0030003 38 0.022
peptidyl threonine phosphorylation GO:0018107 2 0.022
regulation of intracellular signal transduction GO:1902531 236 0.022
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.021
heterocycle catabolic process GO:0046700 166 0.021
nucleobase containing compound catabolic process GO:0034655 165 0.021
positive regulation of signaling GO:0023056 243 0.021
protein acetylation GO:0006473 39 0.021
nuclear transcribed mrna catabolic process GO:0000956 24 0.021
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.020
nucleocytoplasmic transport GO:0006913 72 0.020
imaginal disc pattern formation GO:0007447 91 0.020
positive regulation of cell communication GO:0010647 250 0.020
histone h2a acetylation GO:0043968 1 0.020
rna interference GO:0016246 27 0.020
mitotic nuclear division GO:0007067 213 0.020
cell growth GO:0016049 108 0.020
response to external biotic stimulus GO:0043207 293 0.020
regulation of protein complex assembly GO:0043254 42 0.019
wnt signaling pathway GO:0016055 98 0.019
reproductive structure development GO:0048608 74 0.018
single organism biosynthetic process GO:0044711 206 0.018
anterior posterior axis specification GO:0009948 109 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.018
protein localization to organelle GO:0033365 82 0.018
regulation of translation GO:0006417 56 0.018
translation GO:0006412 69 0.018
cytoplasmic transport GO:0016482 130 0.017
regulation of protein modification process GO:0031399 112 0.017
g protein coupled receptor signaling pathway GO:0007186 136 0.017
positive regulation of response to stimulus GO:0048584 323 0.017
regulation of proteolysis GO:0030162 87 0.017
stem cell differentiation GO:0048863 117 0.017
Mouse
meiotic cell cycle GO:0051321 171 0.017
nuclear export GO:0051168 24 0.017
adherens junction organization GO:0034332 27 0.017
negative regulation of protein metabolic process GO:0051248 85 0.016
cellular catabolic process GO:0044248 372 0.016
Mouse
positive regulation of cellular component organization GO:0051130 156 0.016
cell fate determination GO:0001709 91 0.016
negative regulation of growth GO:0045926 84 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
response to hypoxia GO:0001666 53 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
autophagic cell death GO:0048102 83 0.015
response to lipopolysaccharide GO:0032496 4 0.015
protein modification by small protein removal GO:0070646 28 0.015
response to radiation GO:0009314 155 0.015
Human
positive regulation of proteolysis GO:0045862 52 0.015
regulation of wnt signaling pathway GO:0030111 68 0.015
macromolecular complex assembly GO:0065003 256 0.015
regulation of hydrolase activity GO:0051336 97 0.015
regulation of cell cycle GO:0051726 291 0.014
organonitrogen compound metabolic process GO:1901564 318 0.014
regulation of mrna 3 end processing GO:0031440 7 0.014
sex differentiation GO:0007548 81 0.014
organelle inheritance GO:0048308 2 0.014
negative regulation of developmental process GO:0051093 201 0.013
Mouse
endocytosis GO:0006897 310 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
protein localization to nucleus GO:0034504 55 0.013
nucleic acid transport GO:0050657 46 0.013
cellular protein catabolic process GO:0044257 83 0.013
Mouse
positive regulation of hydrolase activity GO:0051345 78 0.013
regulation of protein phosphorylation GO:0001932 64 0.013
hematopoietic progenitor cell differentiation GO:0002244 1 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.013
larval development GO:0002164 104 0.013
protein localization GO:0008104 284 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
regulation of notch signaling pathway GO:0008593 100 0.012
rna catabolic process GO:0006401 37 0.012
positive regulation of protein modification process GO:0031401 58 0.012
wound healing GO:0042060 75 0.012
regulation of neurogenesis GO:0050767 158 0.012
compound eye development GO:0048749 307 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
defense response to other organism GO:0098542 225 0.011
jak stat cascade GO:0007259 49 0.011
protein transport GO:0015031 155 0.011
nephron epithelium development GO:0072009 3 0.011
response to other organism GO:0051707 293 0.011
protein dna complex assembly GO:0065004 63 0.011
protein import into nucleus GO:0006606 51 0.011
rna processing GO:0006396 147 0.011
chromatin modification GO:0016568 147 0.011
Human
regulation of cellular protein catabolic process GO:1903362 44 0.011
eggshell chorion gene amplification GO:0007307 9 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
formation of a compartment boundary GO:0060288 4 0.010
meiotic nuclear division GO:0007126 151 0.010
dsrna fragmentation GO:0031050 15 0.010
phosphorylation GO:0016310 294 0.010
phagocytosis GO:0006909 215 0.010
mitotic cell cycle phase transition GO:0044772 138 0.010
internal peptidyl lysine acetylation GO:0018393 38 0.010

Cul-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
disease of cellular proliferation DOID:14566 0 0.011