Drosophila melanogaster

74 known processes

AIF (Dmel_CG7263)

Apoptosis inducing factor

(Aliases: DmAIF,CG7263,Dmel\CG7263)

AIF biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response to fungus GO:0050832 48 0.396
response to external biotic stimulus GO:0043207 293 0.355
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.338
eye development GO:0001654 323 0.293
regulation of lamellipodium organization GO:1902743 15 0.258
endocytosis GO:0006897 310 0.210
Worm
homeostatic process GO:0042592 199 0.185
transcription from rna polymerase ii promoter GO:0006366 368 0.181
response to other organism GO:0051707 293 0.157
response to fungus GO:0009620 50 0.155
tube morphogenesis GO:0035239 191 0.146
defense response GO:0006952 300 0.137
defense response to other organism GO:0098542 225 0.123
positive regulation of biosynthetic process GO:0009891 316 0.112
programmed cell death GO:0012501 257 0.108
nucleotide metabolic process GO:0009117 161 0.093
enzyme linked receptor protein signaling pathway GO:0007167 179 0.093
protein modification process GO:0036211 438 0.090
regulation of immune response GO:0050776 118 0.075
embryo development ending in birth or egg hatching GO:0009792 152 0.075
Worm
sensory organ morphogenesis GO:0090596 260 0.075
digestive tract development GO:0048565 149 0.072
gonad development GO:0008406 50 0.070
digestive tract morphogenesis GO:0048546 127 0.068
protein modification by small protein conjugation GO:0032446 79 0.063
catabolic process GO:0009056 409 0.062
Mouse Worm
cell death GO:0008219 279 0.059
anatomical structure homeostasis GO:0060249 97 0.056
positive regulation of rna metabolic process GO:0051254 271 0.056
vesicle mediated transport GO:0016192 381 0.054
Worm
sex differentiation GO:0007548 81 0.052
cellular protein modification process GO:0006464 438 0.052
purine ribonucleotide metabolic process GO:0009150 145 0.051
negative regulation of immune system process GO:0002683 50 0.051
macromolecule catabolic process GO:0009057 161 0.048
Mouse Worm
regulation of catalytic activity GO:0050790 185 0.048
positive regulation of response to stimulus GO:0048584 323 0.047
development of primary sexual characteristics GO:0045137 50 0.043
protein catabolic process GO:0030163 101 0.043
regulation of cell death GO:0010941 173 0.042
Mouse
positive regulation of growth GO:0045927 75 0.042
ribonucleoside triphosphate metabolic process GO:0009199 119 0.041
digestive system development GO:0055123 149 0.040
positive regulation of atp catabolic process GO:1903291 3 0.039
positive regulation of rna biosynthetic process GO:1902680 266 0.039
organelle fusion GO:0048284 46 0.039
organophosphate metabolic process GO:0019637 195 0.039
regulation of immune system process GO:0002682 176 0.036
positive regulation of catabolic process GO:0009896 105 0.036
purine nucleoside metabolic process GO:0042278 127 0.034
gastrulation GO:0007369 70 0.034
negative regulation of cellular metabolic process GO:0031324 382 0.033
tube development GO:0035295 244 0.032
purine nucleoside monophosphate metabolic process GO:0009126 50 0.032
positive regulation of nucleic acid templated transcription GO:1903508 266 0.032
columnar cuboidal epithelial cell development GO:0002066 249 0.031
death GO:0016265 284 0.031
ion transport GO:0006811 145 0.031
single organism behavior GO:0044708 391 0.031
negative regulation of programmed cell death GO:0043069 72 0.031
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
innate immune response GO:0045087 144 0.029
phagocytosis GO:0006909 215 0.029
lipid biosynthetic process GO:0008610 46 0.029
regulation of intracellular signal transduction GO:1902531 236 0.028
negative regulation of nucleic acid templated transcription GO:1903507 240 0.028
reproductive structure development GO:0048608 74 0.028
positive regulation of developmental growth GO:0048639 62 0.028
nucleoside triphosphate catabolic process GO:0009143 108 0.027
organic substance transport GO:0071702 257 0.027
protein complex assembly GO:0006461 200 0.027
leucine transport GO:0015820 3 0.027
regulation of defense response GO:0031347 102 0.027
phosphatidylinositol mediated signaling GO:0048015 4 0.026
regulation of catabolic process GO:0009894 170 0.026
Mouse
detection of stimulus involved in sensory perception GO:0050906 92 0.025
multicellular organismal aging GO:0010259 140 0.025
regulation of growth GO:0040008 233 0.025
protein modification by small protein conjugation or removal GO:0070647 106 0.025
glutamate secretion GO:0014047 1 0.025
positive regulation of cell communication GO:0010647 250 0.024
purine nucleotide metabolic process GO:0006163 146 0.024
membrane disassembly GO:0030397 4 0.024
regulation of phosphate metabolic process GO:0019220 210 0.024
atp metabolic process GO:0046034 49 0.024
regulation of molecular function GO:0065009 217 0.023
negative regulation of cell death GO:0060548 81 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.023
endomembrane system organization GO:0010256 119 0.023
hematopoietic progenitor cell differentiation GO:0002244 1 0.022
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.022
imaginal disc derived leg morphogenesis GO:0007480 80 0.022
regulation of anatomical structure morphogenesis GO:0022603 242 0.022
oxidation reduction process GO:0055114 123 0.022
positive regulation of signal transduction GO:0009967 223 0.021
reproductive system development GO:0061458 74 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.021
regulation of response to stress GO:0080134 200 0.021
glycosyl compound metabolic process GO:1901657 127 0.020
glycosyl compound catabolic process GO:1901658 112 0.020
secretion by cell GO:0032940 101 0.020
Worm
chemical homeostasis GO:0048878 92 0.020
positive regulation of cellular catabolic process GO:0031331 95 0.020
positive regulation of multicellular organismal process GO:0051240 143 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.020
defense response to gram negative bacterium GO:0050829 94 0.020
cell type specific apoptotic process GO:0097285 38 0.020
Mouse
eye antennal disc development GO:0035214 60 0.020
mitotic dna integrity checkpoint GO:0044774 75 0.020
positive regulation of gene expression GO:0010628 290 0.020
defense response to bacterium GO:0042742 178 0.019
response to biotic stimulus GO:0009607 294 0.019
regulation of neuron apoptotic process GO:0043523 16 0.019
response to bacterium GO:0009617 198 0.019
lipid metabolic process GO:0006629 121 0.019
sphingolipid metabolic process GO:0006665 19 0.019
negative regulation of transcription dna templated GO:0045892 237 0.019
organonitrogen compound metabolic process GO:1901564 318 0.018
cellular response to chemical stimulus GO:0070887 199 0.018
developmental growth GO:0048589 280 0.018
cell motility GO:0048870 251 0.018
immune response GO:0006955 246 0.018
positive regulation of developmental process GO:0051094 143 0.018
membrane lipid metabolic process GO:0006643 22 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
nucleolus organization GO:0007000 4 0.017
secretion GO:0046903 109 0.017
Worm
establishment of localization in cell GO:0051649 402 0.016
Worm
carbohydrate derivative metabolic process GO:1901135 217 0.016
immune system process GO:0002376 347 0.016
multi organism reproductive behavior GO:0044705 121 0.016
response to temperature stimulus GO:0009266 106 0.016
salivary gland development GO:0007431 162 0.016
regulation of meiosis GO:0040020 3 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.016
determination of adult lifespan GO:0008340 137 0.016
regulation of developmental growth GO:0048638 174 0.016
nucleoside monophosphate metabolic process GO:0009123 52 0.015
regulation of nucleotide catabolic process GO:0030811 48 0.015
single organism intracellular transport GO:1902582 207 0.015
positive regulation of signaling GO:0023056 243 0.015
aging GO:0007568 143 0.015
positive regulation of macromolecule metabolic process GO:0010604 405 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
hemopoiesis GO:0030097 46 0.015
decapentaplegic signaling pathway GO:0008101 19 0.014
compound eye morphogenesis GO:0001745 249 0.014
membrane fusion GO:0061025 42 0.014
organelle fission GO:0048285 340 0.014
establishment of protein localization GO:0045184 163 0.014
cytoplasmic transport GO:0016482 130 0.014
carbohydrate metabolic process GO:0005975 82 0.014
cation transport GO:0006812 110 0.014
regulation of innate immune response GO:0045088 71 0.014
inositol lipid mediated signaling GO:0048017 4 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.014
nucleoside phosphate catabolic process GO:1901292 110 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
vesicle organization GO:0016050 44 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.013
cellular lipid metabolic process GO:0044255 83 0.013
nucleoside triphosphate metabolic process GO:0009141 120 0.013
gastrulation involving germ band extension GO:0010004 36 0.013
positive regulation of programmed cell death GO:0043068 62 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
single organism membrane organization GO:0044802 93 0.013
regulation of cellular catabolic process GO:0031329 157 0.013
Mouse
ribonucleoside catabolic process GO:0042454 112 0.013
leucine import GO:0060356 3 0.013
mitotic nuclear division GO:0007067 213 0.012
nephron epithelium development GO:0072009 3 0.012
cell aging GO:0007569 2 0.012
bmp signaling pathway GO:0030509 27 0.012
intracellular transport GO:0046907 228 0.012
cellular catabolic process GO:0044248 372 0.012
Mouse Worm
regulation of apoptotic process GO:0042981 130 0.012
Mouse
glycoprotein biosynthetic process GO:0009101 41 0.012
multicellular organismal homeostasis GO:0048871 41 0.011
organic acid metabolic process GO:0006082 103 0.011
tissue homeostasis GO:0001894 36 0.011
notch signaling pathway GO:0007219 120 0.011
cellular macromolecule catabolic process GO:0044265 136 0.011
Mouse Worm
energy derivation by oxidation of organic compounds GO:0015980 32 0.011
peripheral nervous system development GO:0007422 52 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
regulation of organelle organization GO:0033043 196 0.011
learning or memory GO:0007611 141 0.011
regulation of bmp signaling pathway GO:0030510 23 0.011
macromolecular complex assembly GO:0065003 256 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
nucleotide catabolic process GO:0009166 109 0.011
negative regulation of oskar mrna translation GO:0007319 5 0.011
cardiovascular system development GO:0072358 82 0.010
organophosphate catabolic process GO:0046434 112 0.010
extrinsic apoptotic signaling pathway GO:0097191 1 0.010
regulation of neuron death GO:1901214 26 0.010
nucleobase containing small molecule metabolic process GO:0055086 174 0.010
aromatic compound catabolic process GO:0019439 166 0.010
Mouse Worm
regulation of programmed cell death GO:0043067 152 0.010
Mouse

AIF disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.018
nervous system disease DOID:863 0 0.018
disease of anatomical entity DOID:7 0 0.018
sensory system disease DOID:0050155 0 0.016
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.014
eye disease DOID:5614 0 0.013
eye and adnexa disease DOID:1492 0 0.013