Drosophila melanogaster

109 known processes

tio (Dmel_CG12630)

tiptop

(Aliases: Tio,Dmel\CG12630,CG12630)

tio biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
compound eye development GO:0048749 307 0.345
body morphogenesis GO:0010171 2 0.306
imaginal disc derived appendage development GO:0048737 399 0.305
Fly
regionalization GO:0003002 416 0.263
growth GO:0040007 359 0.260
transcription from rna polymerase ii promoter GO:0006366 368 0.246
glial cell migration GO:0008347 31 0.211
epithelial cell differentiation GO:0030855 322 0.202
axis specification GO:0009798 167 0.200
tissue morphogenesis GO:0048729 297 0.191
vesicle mediated transport GO:0016192 381 0.185
epithelial cell development GO:0002064 274 0.181
neurological system process GO:0050877 358 0.176
Mouse
negative regulation of rna metabolic process GO:0051253 251 0.171
positive regulation of cellular biosynthetic process GO:0031328 316 0.171
developmental induction GO:0031128 3 0.161
positive regulation of rna metabolic process GO:0051254 271 0.159
appendage morphogenesis GO:0035107 397 0.156
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.151
morphogenesis of an epithelium GO:0002009 276 0.149
eye development GO:0001654 323 0.143
positive regulation of biosynthetic process GO:0009891 316 0.140
regulation of cell development GO:0060284 215 0.139
sensory organ morphogenesis GO:0090596 260 0.137
Mouse
photoreceptor cell differentiation GO:0046530 170 0.132
male gamete generation GO:0048232 201 0.130
negative regulation of cellular biosynthetic process GO:0031327 277 0.130
establishment of localization in cell GO:0051649 402 0.127
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.125
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.125
post embryonic appendage morphogenesis GO:0035120 385 0.124
Fly
eye morphogenesis GO:0048592 260 0.124
positive regulation of gene expression GO:0010628 290 0.122
negative regulation of transcription dna templated GO:0045892 237 0.122
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.121
compound eye morphogenesis GO:0001745 249 0.120
negative regulation of gene expression GO:0010629 387 0.120
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.115
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.115
head development GO:0060322 135 0.111
regulation of multicellular organismal development GO:2000026 414 0.111
developmental growth GO:0048589 280 0.107
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.106
camera type eye development GO:0043010 4 0.104
positive regulation of transcription dna templated GO:0045893 266 0.103
establishment or maintenance of cell polarity GO:0007163 167 0.103
camera type eye morphogenesis GO:0048593 2 0.103
cellular macromolecule localization GO:0070727 220 0.099
positive regulation of macromolecule metabolic process GO:0010604 405 0.097
positive regulation of rna biosynthetic process GO:1902680 266 0.097
gland development GO:0048732 191 0.095
negative regulation of cell differentiation GO:0045596 143 0.094
forebrain development GO:0030900 2 0.093
intracellular transport GO:0046907 228 0.092
single organism intracellular transport GO:1902582 207 0.092
cytoplasmic transport GO:0016482 130 0.091
retina development in camera type eye GO:0060041 4 0.091
protein localization GO:0008104 284 0.091
muscle cell differentiation GO:0042692 103 0.089
Mouse
appendage development GO:0048736 401 0.089
Fly
eye antennal disc development GO:0035214 60 0.089
Fly
columnar cuboidal epithelial cell development GO:0002066 249 0.089
anterior posterior pattern specification GO:0009952 136 0.085
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 266 0.083
negative regulation of cellular metabolic process GO:0031324 382 0.082
neural retina development GO:0003407 4 0.077
regulation of cell differentiation GO:0045595 302 0.077
Mouse
synaptic transmission GO:0007268 288 0.077
syncytium formation GO:0006949 43 0.076
stem cell proliferation GO:0072089 88 0.075
single organism behavior GO:0044708 391 0.073
myoblast fusion GO:0007520 43 0.071
gliogenesis GO:0042063 80 0.070
chorion containing eggshell formation GO:0007304 105 0.068
negative regulation of developmental process GO:0051093 201 0.068
negative regulation of nucleic acid templated transcription GO:1903507 240 0.068
cell motility GO:0048870 251 0.065
regulation of anatomical structure morphogenesis GO:0022603 242 0.064
neural precursor cell proliferation GO:0061351 75 0.063
wnt signaling pathway GO:0016055 98 0.063
Fly
dorsal appendage formation GO:0046843 47 0.062
brain development GO:0007420 120 0.062
cellular component assembly involved in morphogenesis GO:0010927 151 0.061
proteolysis GO:0006508 192 0.061
cell cycle phase transition GO:0044770 140 0.060
endocytosis GO:0006897 310 0.059
phagocytosis GO:0006909 215 0.058
cell migration GO:0016477 238 0.058
embryo development ending in birth or egg hatching GO:0009792 152 0.058
Mouse Fly
dendrite morphogenesis GO:0048813 199 0.057
negative regulation of rna biosynthetic process GO:1902679 240 0.057
segmentation GO:0035282 207 0.057
eye photoreceptor cell differentiation GO:0001754 145 0.056
cell proliferation GO:0008283 299 0.056
eggshell chorion assembly GO:0007306 66 0.055
telencephalon development GO:0021537 2 0.054
smoothened signaling pathway GO:0007224 49 0.053
circadian behavior GO:0048512 76 0.052
cell type specific apoptotic process GO:0097285 38 0.052
negative regulation of cell communication GO:0010648 223 0.052
taxis GO:0042330 304 0.052
regulation of cellular component biogenesis GO:0044087 201 0.051
cell cell signaling involved in cell fate commitment GO:0045168 210 0.050
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.050
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.050
neuron projection guidance GO:0097485 241 0.048
salivary gland development GO:0007431 162 0.047
negative regulation of multicellular organismal process GO:0051241 142 0.047
negative regulation of response to stimulus GO:0048585 258 0.047
single organism cellular localization GO:1902580 180 0.046
kidney development GO:0001822 3 0.046
Mouse
respiratory system development GO:0060541 213 0.046
Mouse
regulation of neural precursor cell proliferation GO:2000177 35 0.045
compound eye photoreceptor cell differentiation GO:0001751 140 0.045
organic substance transport GO:0071702 257 0.045
intracellular protein transport GO:0006886 104 0.044
spermatogenesis GO:0007283 200 0.044
ectodermal placode morphogenesis GO:0071697 4 0.044
nucleobase containing small molecule metabolic process GO:0055086 174 0.044
establishment of protein localization GO:0045184 163 0.043
cell maturation GO:0048469 144 0.042
apoptotic process GO:0006915 159 0.042
programmed cell death GO:0012501 257 0.041
regulation of cell proliferation GO:0042127 163 0.040
ectodermal placode formation GO:0060788 4 0.040
dorsal ventral pattern formation GO:0009953 133 0.040
Fly
regulation of localization GO:0032879 275 0.040
embryonic morphogenesis GO:0048598 206 0.039
Mouse Fly
proximal distal pattern formation GO:0009954 15 0.038
Fly
regulation of multi organism process GO:0043900 131 0.038
stem cell maintenance GO:0019827 67 0.037
imaginal disc derived appendage morphogenesis GO:0035114 395 0.037
Fly
localization of cell GO:0051674 257 0.037
imaginal disc derived wing morphogenesis GO:0007476 337 0.037
Fly
myotube differentiation GO:0014902 46 0.037
stem cell development GO:0048864 79 0.037
mushroom body development GO:0016319 70 0.036
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.036
negative regulation of nervous system development GO:0051961 92 0.036
axon development GO:0061564 297 0.035
protein targeting GO:0006605 64 0.035
larval development GO:0002164 104 0.034
protein transport GO:0015031 155 0.034
rhythmic process GO:0048511 106 0.034
central nervous system development GO:0007417 201 0.033
oocyte construction GO:0007308 112 0.033
embryonic pattern specification GO:0009880 174 0.033
cellular catabolic process GO:0044248 372 0.033
negative regulation of signal transduction GO:0009968 206 0.033
negative regulation of biosynthetic process GO:0009890 277 0.033
ovarian follicle cell development GO:0030707 248 0.033
response to alcohol GO:0097305 95 0.033
rhythmic behavior GO:0007622 76 0.033
regulation of neurogenesis GO:0050767 158 0.033
muscle structure development GO:0061061 224 0.032
Mouse
organonitrogen compound metabolic process GO:1901564 318 0.032
response to wounding GO:0009611 94 0.032
enzyme linked receptor protein signaling pathway GO:0007167 179 0.032
response to lipopolysaccharide GO:0032496 4 0.031
protein targeting to nucleus GO:0044744 51 0.031
wing disc morphogenesis GO:0007472 344 0.031
Fly
regulation of nervous system development GO:0051960 248 0.030
negative regulation of cell development GO:0010721 62 0.030
peripheral nervous system development GO:0007422 52 0.030
dendrite development GO:0016358 204 0.030
embryonic axis specification GO:0000578 107 0.029
regulation of stem cell proliferation GO:0072091 40 0.029
regulation of cell cycle process GO:0010564 181 0.029
intracellular signal transduction GO:0035556 300 0.029
protein import GO:0017038 55 0.028
ectodermal placode development GO:0071696 4 0.028
morphogenesis of a polarized epithelium GO:0001738 93 0.027
wound healing GO:0042060 75 0.027
response to organic substance GO:0010033 284 0.027
adult behavior GO:0030534 137 0.027
ocellus development GO:0008056 4 0.027
small molecule metabolic process GO:0044281 305 0.027
positive regulation of signal transduction GO:0009967 223 0.026
axonogenesis GO:0007409 290 0.026
protein localization to organelle GO:0033365 82 0.026
rna localization GO:0006403 115 0.026
stem cell differentiation GO:0048863 117 0.026
photoreceptor cell fate commitment GO:0046552 41 0.025
tripartite regional subdivision GO:0007351 103 0.025
chemotaxis GO:0006935 249 0.025
regulation of cell cycle GO:0051726 291 0.025
regulation of wnt signaling pathway GO:0030111 68 0.025
regulation of embryonic pattern specification GO:1902875 27 0.024
gland morphogenesis GO:0022612 145 0.024
carbohydrate derivative metabolic process GO:1901135 217 0.024
regulation of neuron differentiation GO:0045664 103 0.024
single organism nuclear import GO:1902593 51 0.024
cellular protein localization GO:0034613 160 0.024
establishment of ommatidial planar polarity GO:0042067 49 0.024
anterior posterior axis specification GO:0009948 109 0.024
entrainment of circadian clock GO:0009649 16 0.024
developmental maturation GO:0021700 172 0.024
spermatid differentiation GO:0048515 114 0.024
regulation of developmental growth GO:0048638 174 0.024
aromatic compound catabolic process GO:0019439 166 0.023
ribose phosphate metabolic process GO:0019693 145 0.023
positive regulation of cell communication GO:0010647 250 0.023
leg disc development GO:0035218 92 0.023
Fly
chromosome organization GO:0051276 360 0.023
response to ethanol GO:0045471 59 0.023
death GO:0016265 284 0.023
phosphorylation GO:0016310 294 0.022
catabolic process GO:0009056 409 0.022
ameboidal type cell migration GO:0001667 151 0.022
positive regulation of signaling GO:0023056 243 0.022
organelle localization GO:0051640 148 0.022
circadian rhythm GO:0007623 105 0.022
regulation of intracellular signal transduction GO:1902531 236 0.022
response to oxygen containing compound GO:1901700 200 0.022
lateral inhibition GO:0046331 206 0.022
sensory perception of mechanical stimulus GO:0050954 72 0.022
Mouse
nuclear import GO:0051170 51 0.022
negative regulation of signaling GO:0023057 219 0.022
cellular response to chemical stimulus GO:0070887 199 0.021
connective tissue development GO:0061448 3 0.021
nuclear transport GO:0051169 72 0.021
nephron tubule development GO:0072080 3 0.021
establishment of planar polarity GO:0001736 87 0.021
negative regulation of wnt signaling pathway GO:0030178 28 0.021
memory GO:0007613 94 0.021
sperm individualization GO:0007291 48 0.021
pigmentation GO:0043473 75 0.020
positive regulation of response to stimulus GO:0048584 323 0.020
regulation of catabolic process GO:0009894 170 0.020
establishment of tissue polarity GO:0007164 87 0.020
apoptotic process involved in development GO:1902742 20 0.020
regulation of organelle organization GO:0033043 196 0.020
cell death GO:0008219 279 0.020
imaginal disc derived wing vein specification GO:0007474 48 0.020
response to organophosphorus GO:0046683 2 0.019
establishment of protein localization to organelle GO:0072594 62 0.019
syncytium formation by plasma membrane fusion GO:0000768 43 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
nucleoside phosphate metabolic process GO:0006753 162 0.019
organophosphate metabolic process GO:0019637 195 0.019
exocrine system development GO:0035272 162 0.019
regulation of molecular function GO:0065009 217 0.019
peptide metabolic process GO:0006518 80 0.019
embryonic organ development GO:0048568 50 0.019
Mouse
response to other organism GO:0051707 293 0.019
developmental programmed cell death GO:0010623 138 0.018
optic placode formation GO:0001743 4 0.018
regulation of protein metabolic process GO:0051246 256 0.018
limb development GO:0060173 1 0.018
ribonucleoside triphosphate metabolic process GO:0009199 119 0.018
ras protein signal transduction GO:0007265 88 0.018
cellular protein modification process GO:0006464 438 0.018
ribonucleoside metabolic process GO:0009119 127 0.018
positive regulation of developmental process GO:0051094 143 0.018
Mouse
response to biotic stimulus GO:0009607 294 0.018
regulation of growth GO:0040008 233 0.018
organic substance catabolic process GO:1901575 308 0.018
protein modification process GO:0036211 438 0.017
oocyte development GO:0048599 124 0.017
oocyte axis specification GO:0007309 108 0.017
regulation of epithelial cell differentiation GO:0030856 4 0.017
regulation of transport GO:0051049 181 0.017
single organism catabolic process GO:0044712 228 0.017
macromolecule catabolic process GO:0009057 161 0.017
organic cyclic compound catabolic process GO:1901361 168 0.017
axon guidance GO:0007411 233 0.016
neuron fate commitment GO:0048663 50 0.016
nucleotide metabolic process GO:0009117 161 0.016
neuroblast differentiation GO:0014016 29 0.016
organelle assembly GO:0070925 198 0.016
nucleoside triphosphate metabolic process GO:0009141 120 0.016
cell fate specification involved in pattern specification GO:0060573 8 0.016
nucleoside metabolic process GO:0009116 127 0.016
eggshell formation GO:0030703 105 0.016
retina morphogenesis in camera type eye GO:0060042 2 0.016
purine ribonucleotide metabolic process GO:0009150 145 0.016
cellular amine metabolic process GO:0044106 12 0.015
optic lobe placode formation GO:0001744 4 0.015
regulation of embryonic development GO:0045995 68 0.015
defense response to other organism GO:0098542 225 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.015
carbohydrate derivative catabolic process GO:1901136 118 0.015
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.015
nucleocytoplasmic transport GO:0006913 72 0.015
spermatid development GO:0007286 98 0.015
regulation of reproductive process GO:2000241 54 0.015
mesoderm development GO:0007498 78 0.015
organonitrogen compound catabolic process GO:1901565 128 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
oocyte differentiation GO:0009994 145 0.015
adult locomotory behavior GO:0008344 76 0.015
oocyte anterior posterior axis specification GO:0007314 72 0.015
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.015
extrinsic apoptotic signaling pathway GO:0097191 1 0.015
maternal determination of anterior posterior axis embryo GO:0008358 74 0.015
bolwig s organ development GO:0055034 8 0.014
blood circulation GO:0008015 26 0.014
response to bacterium GO:0009617 198 0.014
homeostatic process GO:0042592 199 0.014
salivary gland histolysis GO:0035070 88 0.014
purine ribonucleoside catabolic process GO:0046130 112 0.014
purine nucleotide catabolic process GO:0006195 109 0.014
histolysis GO:0007559 102 0.014
regulation of proteolysis GO:0030162 87 0.014
covalent chromatin modification GO:0016569 106 0.014
antennal development GO:0007469 25 0.014
response to hexose GO:0009746 3 0.014
hematopoietic progenitor cell differentiation GO:0002244 1 0.014
ribonucleotide catabolic process GO:0009261 109 0.014
regulation of phosphorus metabolic process GO:0051174 210 0.014
anterior posterior axis specification embryo GO:0008595 103 0.014
ribonucleoside catabolic process GO:0042454 112 0.014
regulation of cell morphogenesis GO:0022604 163 0.014
establishment of organelle localization GO:0051656 122 0.014
response to endogenous stimulus GO:0009719 119 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
kidney morphogenesis GO:0060993 3 0.013
Mouse
tissue death GO:0016271 102 0.013
nucleoside catabolic process GO:0009164 112 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
regulation of insulin like growth factor receptor signaling pathway GO:0043567 3 0.013
locomotory behavior GO:0007626 176 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.013
negative regulation of developmental growth GO:0048640 64 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
nephron development GO:0072006 3 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
multicellular organismal reproductive behavior GO:0033057 110 0.013
antimicrobial humoral response GO:0019730 99 0.013
response to external biotic stimulus GO:0043207 293 0.013
learning or memory GO:0007611 141 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
cell fate specification GO:0001708 71 0.013
defense response to bacterium GO:0042742 178 0.013
purine nucleotide metabolic process GO:0006163 146 0.013
reproductive system development GO:0061458 74 0.013
organelle fission GO:0048285 340 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.012
autophagic cell death GO:0048102 83 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
equator specification GO:0045317 4 0.012
nephron epithelium development GO:0072009 3 0.012
gonad development GO:0008406 50 0.012
nephron morphogenesis GO:0072028 3 0.012
cell adhesion GO:0007155 136 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
blastoderm segmentation GO:0007350 159 0.012
macromolecular complex assembly GO:0065003 256 0.012
single organism biosynthetic process GO:0044711 206 0.012
regeneration GO:0031099 16 0.012
chromatin modification GO:0016568 147 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
purine containing compound catabolic process GO:0072523 112 0.012
cellular response to organic substance GO:0071310 132 0.012
cellularization GO:0007349 90 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
heterocycle catabolic process GO:0046700 166 0.012
leg disc morphogenesis GO:0007478 80 0.012
endodermal cell differentiation GO:0035987 3 0.012
protein dna complex assembly GO:0065004 63 0.012
cellular amino acid metabolic process GO:0006520 61 0.012
oxoacid metabolic process GO:0043436 103 0.012
positive regulation of molecular function GO:0044093 136 0.012
positive regulation of cell migration GO:0030335 2 0.012
cellular protein catabolic process GO:0044257 83 0.012
nephron tubule morphogenesis GO:0072078 3 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
negative regulation of epithelial cell proliferation GO:0050680 4 0.011
response to nutrient levels GO:0031667 114 0.011
multi organism reproductive behavior GO:0044705 121 0.011
hindbrain development GO:0030902 2 0.011
cytoplasm organization GO:0007028 64 0.011
carboxylic acid metabolic process GO:0019752 92 0.011
cardiovascular system development GO:0072358 82 0.011
notch signaling pathway GO:0007219 120 0.011
optic lobe placode development GO:0001748 10 0.011
proteasomal protein catabolic process GO:0010498 59 0.011
outflow tract morphogenesis GO:0003151 4 0.011
sensory neuron axon guidance GO:0097374 2 0.011
positive regulation of cell motility GO:2000147 3 0.011
spinal cord development GO:0021510 1 0.011
salivary gland cell autophagic cell death GO:0035071 83 0.011
multi organism behavior GO:0051705 175 0.011
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.011
regulation of hydrolase activity GO:0051336 97 0.011
regulation of pole plasm oskar mrna localization GO:0007317 27 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
multicellular organism growth GO:0035264 46 0.011
protein phosphorylation GO:0006468 169 0.011
response to gravity GO:0009629 26 0.011
dorsal ventral axis specification GO:0009950 66 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
limb morphogenesis GO:0035108 1 0.011
adult walking behavior GO:0007628 9 0.011
r7 cell differentiation GO:0045466 43 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
positive regulation of catabolic process GO:0009896 105 0.011
tube development GO:0035295 244 0.011
actin cytoskeleton organization GO:0030036 206 0.010
synaptic transmission gabaergic GO:0051932 1 0.010
protein import into nucleus translocation GO:0000060 6 0.010
male meiosis GO:0007140 52 0.010
regulation of oocyte development GO:0060281 27 0.010
regulation of immune system process GO:0002682 176 0.010
mitotic spindle organization GO:0007052 220 0.010
multi multicellular organism process GO:0044706 123 0.010
regulation of cellular catabolic process GO:0031329 157 0.010
regulation of cellular component size GO:0032535 98 0.010
photoreceptor cell development GO:0042461 96 0.010
response to abiotic stimulus GO:0009628 341 0.010
developmental pigmentation GO:0048066 68 0.010
carbohydrate metabolic process GO:0005975 82 0.010
regulation of epithelial cell proliferation GO:0050678 4 0.010
circulatory system development GO:0072359 82 0.010
pyridine nucleotide metabolic process GO:0019362 2 0.010
neuron neuron synaptic transmission GO:0007270 14 0.010
amine metabolic process GO:0009308 12 0.010
cranial nerve development GO:0021545 1 0.010

tio disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
physical disorder DOID:0080015 0 0.021
congenital nervous system abnormality DOID:2490 0 0.021
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.014
eye disease DOID:5614 0 0.014