Drosophila melanogaster

2 known processes

hrg (Dmel_CG9854)

hiiragi

(Aliases: PAP,Pap,l(2)k07619,l(2)07619,Dmel\CG9854,CG9854)

hrg biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.923
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.780
regulation of intracellular signal transduction GO:1902531 236 0.512
dendrite development GO:0016358 204 0.449
negative regulation of rna metabolic process GO:0051253 251 0.407
phosphorylation GO:0016310 294 0.309
intracellular signal transduction GO:0035556 300 0.283
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.265
transcription from rna polymerase ii promoter GO:0006366 368 0.258
positive regulation of cell communication GO:0010647 250 0.251
positive regulation of macromolecule metabolic process GO:0010604 405 0.240
protein modification process GO:0036211 438 0.222
positive regulation of signal transduction GO:0009967 223 0.215
regulation of cellular protein metabolic process GO:0032268 243 0.212
locomotory behavior GO:0007626 176 0.208
regulation of cell death GO:0010941 173 0.197
mrna metabolic process GO:0016071 124 0.196
negative regulation of transcription dna templated GO:0045892 237 0.189
positive regulation of rna biosynthetic process GO:1902680 266 0.181
cellular protein modification process GO:0006464 438 0.181
positive regulation of signaling GO:0023056 243 0.171
positive regulation of response to stimulus GO:0048584 323 0.155
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.155
negative regulation of gene expression GO:0010629 387 0.153
regulation of multicellular organismal development GO:2000026 414 0.151
Worm
notch signaling pathway GO:0007219 120 0.151
death GO:0016265 284 0.149
Worm
positive regulation of protein metabolic process GO:0051247 128 0.149
positive regulation of developmental process GO:0051094 143 0.146
cell death GO:0008219 279 0.141
Worm
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.141
positive regulation of intracellular signal transduction GO:1902533 116 0.133
regulation of notch signaling pathway GO:0008593 100 0.132
negative regulation of nucleic acid templated transcription GO:1903507 240 0.129
negative regulation of cellular biosynthetic process GO:0031327 277 0.122
central nervous system development GO:0007417 201 0.119
regulation of multi organism process GO:0043900 131 0.115
positive regulation of phosphorus metabolic process GO:0010562 139 0.111
negative regulation of developmental process GO:0051093 201 0.111
Worm
regulation of protein metabolic process GO:0051246 256 0.109
negative regulation of response to stimulus GO:0048585 258 0.108
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.108
protein phosphorylation GO:0006468 169 0.106
head development GO:0060322 135 0.105
anterior posterior axis specification GO:0009948 109 0.101
regulation of dendrite morphogenesis GO:0048814 28 0.099
negative regulation of rna biosynthetic process GO:1902679 240 0.099
positive regulation of phosphate metabolic process GO:0045937 139 0.099
rna processing GO:0006396 147 0.099
Human
cell migration GO:0016477 238 0.098
regulation of response to stress GO:0080134 200 0.096
organelle fission GO:0048285 340 0.096
localization of cell GO:0051674 257 0.094
nuclear division GO:0000280 332 0.091
heterocycle catabolic process GO:0046700 166 0.086
cell cell signaling involved in cell fate commitment GO:0045168 210 0.085
positive regulation of biosynthetic process GO:0009891 316 0.084
anterior posterior pattern specification GO:0009952 136 0.083
regulation of phosphorus metabolic process GO:0051174 210 0.082
developmental maturation GO:0021700 172 0.081
protein modification by small protein removal GO:0070646 28 0.081
positive regulation of transcription dna templated GO:0045893 266 0.078
dorsal ventral pattern formation GO:0009953 133 0.078
regulation of phosphate metabolic process GO:0019220 210 0.078
cellular response to endogenous stimulus GO:0071495 80 0.077
cardiocyte differentiation GO:0035051 29 0.075
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.075
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.074
embryonic development via the syncytial blastoderm GO:0001700 148 0.073
programmed cell death GO:0012501 257 0.071
Worm
spermatid differentiation GO:0048515 114 0.071
regulation of ras protein signal transduction GO:0046578 93 0.070
immune system process GO:0002376 347 0.070
segmentation GO:0035282 207 0.069
negative regulation of cell cycle GO:0045786 116 0.068
negative regulation of cell communication GO:0010648 223 0.068
guanosine containing compound catabolic process GO:1901069 74 0.068
cellular catabolic process GO:0044248 372 0.067
blastoderm segmentation GO:0007350 159 0.065
cytoplasmic transport GO:0016482 130 0.065
regulation of mitotic cell cycle GO:0007346 190 0.065
regulation of gene expression epigenetic GO:0040029 128 0.064
immune effector process GO:0002252 98 0.064
gland development GO:0048732 191 0.063
positive regulation of cellular biosynthetic process GO:0031328 316 0.062
regulation of cell differentiation GO:0045595 302 0.062
positive regulation of cellular amine metabolic process GO:0033240 0 0.060
regulation of nervous system development GO:0051960 248 0.060
macromolecular complex assembly GO:0065003 256 0.060
positive regulation of nucleic acid templated transcription GO:1903508 266 0.059
ras protein signal transduction GO:0007265 88 0.058
positive regulation of cellular protein metabolic process GO:0032270 118 0.057
cell motility GO:0048870 251 0.057
cellular macromolecule catabolic process GO:0044265 136 0.056
larval development GO:0002164 104 0.056
Worm
negative regulation of signaling GO:0023057 219 0.056
defense response to other organism GO:0098542 225 0.056
body morphogenesis GO:0010171 2 0.055
Worm
response to abiotic stimulus GO:0009628 341 0.054
regulation of dendrite development GO:0050773 37 0.053
cell division GO:0051301 248 0.053
organic substance catabolic process GO:1901575 308 0.052
cellular nitrogen compound catabolic process GO:0044270 165 0.052
male gamete generation GO:0048232 201 0.052
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.051
regulation of organ morphogenesis GO:2000027 78 0.051
regulation of programmed cell death GO:0043067 152 0.051
regulation of cellular ketone metabolic process GO:0010565 3 0.051
small molecule metabolic process GO:0044281 305 0.050
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.050
semaphorin plexin signaling pathway GO:0071526 4 0.050
organonitrogen compound metabolic process GO:1901564 318 0.049
catabolic process GO:0009056 409 0.049
mapk cascade GO:0000165 107 0.048
salivary gland morphogenesis GO:0007435 145 0.047
epithelial cell development GO:0002064 274 0.047
negative regulation of multicellular organismal process GO:0051241 142 0.047
Worm
cellular protein complex assembly GO:0043623 71 0.047
eye development GO:0001654 323 0.047
positive regulation of rna metabolic process GO:0051254 271 0.046
exocrine system development GO:0035272 162 0.045
positive regulation of gene expression GO:0010628 290 0.044
regulation of organelle organization GO:0033043 196 0.044
urogenital system development GO:0001655 72 0.044
gliogenesis GO:0042063 80 0.044
regulation of embryonic development GO:0045995 68 0.043
microtubule polymerization or depolymerization GO:0031109 39 0.043
regulation of glial cell differentiation GO:0045685 1 0.042
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.042
macromolecule catabolic process GO:0009057 161 0.042
mitotic nuclear division GO:0007067 213 0.042
enzyme linked receptor protein signaling pathway GO:0007167 179 0.042
nucleobase containing small molecule metabolic process GO:0055086 174 0.041
spindle organization GO:0007051 253 0.040
spermatogenesis GO:0007283 200 0.040
gtp catabolic process GO:0006184 72 0.039
cellular response to growth factor stimulus GO:0071363 30 0.039
imaginal disc derived leg segmentation GO:0036011 26 0.039
regulation of cell cycle GO:0051726 291 0.039
jak stat cascade GO:0007259 49 0.039
gtp metabolic process GO:0046039 72 0.039
negative regulation of cell death GO:0060548 81 0.039
regulation of immune system process GO:0002682 176 0.039
cranial nerve development GO:0021545 1 0.039
cellular response to organic substance GO:0071310 132 0.039
telencephalon development GO:0021537 2 0.038
regulation of gene silencing GO:0060968 63 0.038
mrna processing GO:0006397 104 0.038
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.037
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.037
mesenchymal cell differentiation GO:0048762 1 0.037
negative regulation of cellular metabolic process GO:0031324 382 0.037
apoptotic process GO:0006915 159 0.037
Worm
carbohydrate derivative catabolic process GO:1901136 118 0.037
digestive system development GO:0055123 149 0.037
cellular protein localization GO:0034613 160 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.036
protein complex biogenesis GO:0070271 201 0.036
negative regulation of cell differentiation GO:0045596 143 0.035
rrna processing GO:0006364 3 0.035
embryo development ending in birth or egg hatching GO:0009792 152 0.035
Worm
positive regulation of cell projection organization GO:0031346 29 0.035
kidney development GO:0001822 3 0.034
peptidyl tyrosine phosphorylation GO:0018108 24 0.034
somatic stem cell maintenance GO:0035019 14 0.034
positive regulation of phosphorylation GO:0042327 87 0.034
nucleotide metabolic process GO:0009117 161 0.034
organic cyclic compound catabolic process GO:1901361 168 0.034
small gtpase mediated signal transduction GO:0007264 88 0.034
response to growth factor GO:0070848 31 0.033
positive regulation of cellular component organization GO:0051130 156 0.033
immune system development GO:0002520 57 0.032
regulation of cell cycle process GO:0010564 181 0.032
regulation of mrna processing GO:0050684 71 0.032
regulation of gtpase activity GO:0043087 44 0.032
tissue morphogenesis GO:0048729 297 0.032
intracellular protein transport GO:0006886 104 0.032
morphogenesis of embryonic epithelium GO:0016331 94 0.032
chromosome organization GO:0051276 360 0.031
protein complex assembly GO:0006461 200 0.031
axon development GO:0061564 297 0.031
regulation of cellular amino acid metabolic process GO:0006521 0 0.031
nucleoside phosphate metabolic process GO:0006753 162 0.031
vesicle mediated transport GO:0016192 381 0.031
cell proliferation GO:0008283 299 0.031
regulation of molecular function GO:0065009 217 0.030
embryonic pattern specification GO:0009880 174 0.030
posttranscriptional regulation of gene expression GO:0010608 145 0.030
imaginal disc derived wing morphogenesis GO:0007476 337 0.030
cellular response to chemical stimulus GO:0070887 199 0.029
peptidyl tyrosine modification GO:0018212 24 0.029
defense response GO:0006952 300 0.028
protein localization GO:0008104 284 0.028
embryonic morphogenesis GO:0048598 206 0.028
lateral inhibition GO:0046331 206 0.028
compound eye morphogenesis GO:0001745 249 0.027
regulation of synapse assembly GO:0051963 94 0.027
posttranscriptional gene silencing GO:0016441 46 0.027
positive regulation of mapk cascade GO:0043410 63 0.027
response to external biotic stimulus GO:0043207 293 0.027
stem cell differentiation GO:0048863 117 0.026
erk1 and erk2 cascade GO:0070371 39 0.026
glycosyl compound metabolic process GO:1901657 127 0.026
purine nucleoside metabolic process GO:0042278 127 0.026
cellular ketone metabolic process GO:0042180 24 0.026
regulation of cell development GO:0060284 215 0.026
signal release GO:0023061 49 0.026
regulation of small gtpase mediated signal transduction GO:0051056 93 0.025
rna splicing via transesterification reactions GO:0000375 73 0.025
positive regulation of protein phosphorylation GO:0001934 34 0.025
single organism cellular localization GO:1902580 180 0.025
imaginal disc pattern formation GO:0007447 91 0.024
regulation of apoptotic process GO:0042981 130 0.024
wing disc pattern formation GO:0035222 66 0.024
regulation of protein phosphorylation GO:0001932 64 0.024
forebrain development GO:0030900 2 0.023
nerve development GO:0021675 6 0.023
regionalization GO:0003002 416 0.023
kidney morphogenesis GO:0060993 3 0.023
cardiovascular system development GO:0072358 82 0.023
endocytosis GO:0006897 310 0.023
organelle localization GO:0051640 148 0.023
negative regulation of signal transduction GO:0009968 206 0.023
intracellular transport GO:0046907 228 0.022
regulation of mrna metabolic process GO:1903311 72 0.022
centrosome organization GO:0051297 163 0.022
purine nucleoside catabolic process GO:0006152 112 0.022
regulation of gliogenesis GO:0014013 11 0.022
positive regulation of ras protein signal transduction GO:0046579 43 0.022
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.022
nephron development GO:0072006 3 0.022
regulation of epithelial cell proliferation GO:0050678 4 0.022
organophosphate metabolic process GO:0019637 195 0.022
guanosine containing compound metabolic process GO:1901068 74 0.021
post embryonic hemopoiesis GO:0035166 17 0.021
dendrite morphogenesis GO:0048813 199 0.021
protein transport GO:0015031 155 0.021
anterior posterior axis specification embryo GO:0008595 103 0.021
protein polymerization GO:0051258 42 0.021
axonogenesis GO:0007409 290 0.021
regulation of neuron differentiation GO:0045664 103 0.020
cell cycle phase transition GO:0044770 140 0.020
single organism intracellular transport GO:1902582 207 0.020
positive regulation of protein modification process GO:0031401 58 0.020
compound eye development GO:0048749 307 0.020
negative regulation of cellular response to growth factor stimulus GO:0090288 6 0.020
signal transduction in response to dna damage GO:0042770 3 0.020
mesenchymal cell development GO:0014031 1 0.020
mrna splicing via spliceosome GO:0000398 73 0.020
biological adhesion GO:0022610 138 0.019
single organism behavior GO:0044708 391 0.019
signal transduction by phosphorylation GO:0023014 107 0.019
organonitrogen compound catabolic process GO:1901565 128 0.019
regulation of developmental growth GO:0048638 174 0.019
regulation of stem cell differentiation GO:2000736 14 0.019
cellular response to peptide hormone stimulus GO:0071375 28 0.019
gastrulation GO:0007369 70 0.019
oxoacid metabolic process GO:0043436 103 0.018
positive regulation of growth GO:0045927 75 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.018
glycosyl compound catabolic process GO:1901658 112 0.018
ribonucleoside triphosphate metabolic process GO:0009199 119 0.018
cellular macromolecule localization GO:0070727 220 0.018
regulation of cellular amine metabolic process GO:0033238 3 0.018
rubidium ion transport GO:0035826 1 0.018
positive regulation of small gtpase mediated signal transduction GO:0051057 43 0.018
regulation of protein catabolic process GO:0042176 55 0.018
negative regulation of biosynthetic process GO:0009890 277 0.018
response to biotic stimulus GO:0009607 294 0.018
stem cell maintenance GO:0019827 67 0.017
sister chromatid segregation GO:0000819 92 0.017
regulation of cell division GO:0051302 72 0.017
purine containing compound metabolic process GO:0072521 155 0.017
establishment of protein localization GO:0045184 163 0.017
imaginal disc derived leg morphogenesis GO:0007480 80 0.017
nucleoside triphosphate catabolic process GO:0009143 108 0.017
homeostatic process GO:0042592 199 0.017
positive regulation of cell cycle process GO:0090068 28 0.017
positive regulation of multicellular organismal process GO:0051240 143 0.017
regulation of epithelial cell differentiation GO:0030856 4 0.017
tube morphogenesis GO:0035239 191 0.017
chromosome condensation GO:0030261 41 0.016
imaginal disc derived appendage morphogenesis GO:0035114 395 0.016
aromatic compound catabolic process GO:0019439 166 0.016
nucleoside phosphate catabolic process GO:1901292 110 0.016
stem cell development GO:0048864 79 0.016
axis specification GO:0009798 167 0.016
regulation of mapk cascade GO:0043408 92 0.016
mitotic spindle organization GO:0007052 220 0.016
regulation of erk1 and erk2 cascade GO:0070372 39 0.016
positive regulation of cell death GO:0010942 69 0.016
epithelial cell differentiation GO:0030855 322 0.016
maternal determination of anterior posterior axis embryo GO:0008358 74 0.016
post embryonic appendage morphogenesis GO:0035120 385 0.016
cytokinesis GO:0000910 90 0.016
defense response to gram negative bacterium GO:0050829 94 0.016
response to organic substance GO:0010033 284 0.016
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.016
regulation of localization GO:0032879 275 0.016
regulation of phosphorylation GO:0042325 147 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
regulation of neurogenesis GO:0050767 158 0.016
regulation of organ formation GO:0003156 3 0.016
epithelial cell migration GO:0010631 148 0.015
regulation of nuclear division GO:0051783 58 0.015
gland morphogenesis GO:0022612 145 0.015
purine containing compound catabolic process GO:0072523 112 0.015
positive regulation of programmed cell death GO:0043068 62 0.015
mitotic cell cycle phase transition GO:0044772 138 0.015
ribonucleoprotein complex biogenesis GO:0022613 31 0.015
nucleobase containing compound catabolic process GO:0034655 165 0.015
salivary gland development GO:0007431 162 0.015
hindbrain development GO:0030902 2 0.015
vesicle targeting to from or within golgi GO:0048199 1 0.015
positive regulation of apoptotic process GO:0043065 47 0.015
muscle structure development GO:0061061 224 0.015
kidney epithelium development GO:0072073 3 0.015
renal system development GO:0072001 72 0.015
wing disc dorsal ventral pattern formation GO:0048190 47 0.015
ubiquitin dependent protein catabolic process GO:0006511 78 0.015
positive regulation of organelle organization GO:0010638 65 0.015
renal tubule development GO:0061326 64 0.015
digestive tract morphogenesis GO:0048546 127 0.015
gene silencing by mirna GO:0035195 22 0.014
brain development GO:0007420 120 0.014
regulation of protein modification process GO:0031399 112 0.014
positive regulation of molecular function GO:0044093 136 0.014
sensory organ morphogenesis GO:0090596 260 0.014
neural precursor cell proliferation GO:0061351 75 0.014
digestive tract development GO:0048565 149 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.014
response to bacterium GO:0009617 198 0.014
phagocytosis GO:0006909 215 0.014
positive regulation of catabolic process GO:0009896 105 0.014
gene silencing by rna GO:0031047 57 0.014
cellular protein complex disassembly GO:0043624 35 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
positive regulation of proteolysis GO:0045862 52 0.014
positive regulation of exocytosis GO:0045921 4 0.014
cell cycle checkpoint GO:0000075 95 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
single organism membrane organization GO:0044802 93 0.014
regulation of synapse structure and activity GO:0050803 128 0.014
neuronal stem cell maintenance GO:0097150 4 0.014
response to extracellular stimulus GO:0009991 116 0.014
regulation of hydrolase activity GO:0051336 97 0.014
amine metabolic process GO:0009308 12 0.014
larval behavior GO:0030537 42 0.014
positive regulation of stem cell differentiation GO:2000738 3 0.014
regulation of immune response GO:0050776 118 0.014
negative regulation of apoptotic process GO:0043066 63 0.013
histone modification GO:0016570 106 0.013
single organism catabolic process GO:0044712 228 0.013
positive regulation of notch signaling pathway GO:0045747 34 0.013
regulation of cell maturation GO:1903429 27 0.013
maintenance of location GO:0051235 73 0.013
morphogenesis of an epithelium GO:0002009 276 0.013
endosomal transport GO:0016197 44 0.013
nucleoside metabolic process GO:0009116 127 0.013
protein modification by small protein conjugation or removal GO:0070647 106 0.013
leg disc morphogenesis GO:0007478 80 0.013
organic acid metabolic process GO:0006082 103 0.013
cellular response to dna damage stimulus GO:0006974 223 0.013
neurological system process GO:0050877 358 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
protein targeting to nucleus GO:0044744 51 0.013
imaginal disc derived leg joint morphogenesis GO:0016348 15 0.013
production of molecular mediator of immune response GO:0002440 46 0.013
positive regulation of jun kinase activity GO:0043507 4 0.012
positive regulation of cytoskeleton organization GO:0051495 21 0.012
regulation of cellular catabolic process GO:0031329 157 0.012
establishment of localization in cell GO:0051649 402 0.012
embryonic hemopoiesis GO:0035162 26 0.012
stem cell proliferation GO:0072089 88 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
regulation of cellular response to growth factor stimulus GO:0090287 13 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
anatomical structure homeostasis GO:0060249 97 0.012
negative regulation of phosphate metabolic process GO:0045936 45 0.012
columnar cuboidal epithelial cell development GO:0002066 249 0.012
cellular homeostasis GO:0019725 80 0.012
regulation of protein polymerization GO:0032271 28 0.012
regulation of hemocyte proliferation GO:0035206 37 0.012
eye morphogenesis GO:0048592 260 0.012
endomembrane system organization GO:0010256 119 0.012
negative regulation of response to external stimulus GO:0032102 22 0.012
antimicrobial humoral response GO:0019730 99 0.012
cell maturation GO:0048469 144 0.012
regulation of nucleotide catabolic process GO:0030811 48 0.011
cell adhesion GO:0007155 136 0.011
organophosphate catabolic process GO:0046434 112 0.011
mushroom body development GO:0016319 70 0.011
establishment of organelle localization GO:0051656 122 0.011
peptidyl amino acid modification GO:0018193 105 0.011
reproductive behavior GO:0019098 122 0.011
dna metabolic process GO:0006259 227 0.011
nucleotide catabolic process GO:0009166 109 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
regulation of secretion GO:0051046 44 0.011
intracellular protein transmembrane transport GO:0065002 4 0.011
carbohydrate metabolic process GO:0005975 82 0.011
regulation of heart morphogenesis GO:2000826 3 0.011
regulation of reproductive process GO:2000241 54 0.011
regulation of cell proliferation GO:0042127 163 0.011
positive regulation of protein complex assembly GO:0031334 22 0.011
glial cell proliferation GO:0014009 13 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
phosphatidylinositol mediated signaling GO:0048015 4 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.011
regulation of cytoskeleton organization GO:0051493 89 0.011
adipose tissue development GO:0060612 2 0.011
organic substance transport GO:0071702 257 0.010
actin cytoskeleton reorganization GO:0031532 22 0.010
regulation of cellular response to stress GO:0080135 89 0.010
regulation of binding GO:0051098 16 0.010
outflow tract morphogenesis GO:0003151 4 0.010
nuclear transport GO:0051169 72 0.010
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.010
dna integrity checkpoint GO:0031570 81 0.010
muscle cell differentiation GO:0042692 103 0.010

hrg disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.078
cancer DOID:162 0 0.051
disease of cellular proliferation DOID:14566 0 0.051
organ system cancer DOID:0050686 0 0.015
nervous system disease DOID:863 0 0.012