Drosophila melanogaster

71 known processes

Su(var)2-HP2 (Dmel_CG12864)

CG12864 gene product from transcript CG12864-RB

(Aliases: Dmel\CG12864,SU(VAR)2-HP2,CG12864,HP2)

Su(var)2-HP2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome organization GO:0051276 360 0.993
chromatin silencing GO:0006342 76 0.988
negative regulation of gene expression epigenetic GO:0045814 77 0.951
chromatin organization GO:0006325 207 0.925
regulation of gene expression epigenetic GO:0040029 128 0.893
gene silencing GO:0016458 138 0.890
heterochromatin organization GO:0070828 25 0.863
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.855
negative regulation of gene expression GO:0010629 387 0.680
chromatin modification GO:0016568 147 0.680
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.651
negative regulation of cellular biosynthetic process GO:0031327 277 0.647
dna metabolic process GO:0006259 227 0.622
negative regulation of biosynthetic process GO:0009890 277 0.590
negative regulation of rna biosynthetic process GO:1902679 240 0.571
cellular response to dna damage stimulus GO:0006974 223 0.509
negative regulation of transcription dna templated GO:0045892 237 0.449
negative regulation of cellular metabolic process GO:0031324 382 0.436
meiotic cell cycle GO:0051321 171 0.433
organelle fission GO:0048285 340 0.411
cell cycle checkpoint GO:0000075 95 0.392
chromatin assembly GO:0031497 48 0.389
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.375
telomere maintenance GO:0000723 21 0.359
regulation of organelle organization GO:0033043 196 0.330
regulation of chromosome organization GO:0033044 64 0.324
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.314
dna packaging GO:0006323 91 0.310
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.301
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.298
dna replication GO:0006260 48 0.297
sister chromatid segregation GO:0000819 92 0.295
dna conformation change GO:0071103 105 0.287
dna damage checkpoint GO:0000077 78 0.283
chromosome segregation GO:0007059 157 0.280
covalent chromatin modification GO:0016569 106 0.277
negative regulation of nucleic acid templated transcription GO:1903507 240 0.253
chromatin assembly or disassembly GO:0006333 52 0.252
nuclear division GO:0000280 332 0.237
nucleosome mobilization GO:0042766 9 0.226
negative regulation of rna metabolic process GO:0051253 251 0.223
mitotic dna damage checkpoint GO:0044773 74 0.221
peptidyl lysine methylation GO:0018022 16 0.204
dna repair GO:0006281 54 0.203
nucleosome organization GO:0034728 59 0.202
catabolic process GO:0009056 409 0.172
cellular protein modification process GO:0006464 438 0.166
centrosome organization GO:0051297 163 0.155
positive regulation of gene expression GO:0010628 290 0.142
small molecule metabolic process GO:0044281 305 0.139
regulation of chromatin silencing GO:0031935 36 0.136
histone modification GO:0016570 106 0.135
meiotic cell cycle process GO:1903046 132 0.134
positive regulation of rna metabolic process GO:0051254 271 0.128
meiotic chromosome segregation GO:0045132 59 0.125
cellular catabolic process GO:0044248 372 0.121
small rna loading onto risc GO:0070922 6 0.119
dosage compensation GO:0007549 16 0.117
aromatic compound catabolic process GO:0019439 166 0.116
organic substance catabolic process GO:1901575 308 0.114
g2 dna damage checkpoint GO:0031572 69 0.107
nucleobase containing compound catabolic process GO:0034655 165 0.103
posttranscriptional gene silencing by rna GO:0035194 45 0.100
chromatin remodeling GO:0006338 72 0.099
organophosphate metabolic process GO:0019637 195 0.098
microtubule organizing center organization GO:0031023 168 0.098
posttranscriptional gene silencing GO:0016441 46 0.096
regulation of transcription by chromatin organization GO:0034401 3 0.094
double strand break repair GO:0006302 26 0.090
neuron projection guidance GO:0097485 241 0.090
regulation of mitotic cell cycle GO:0007346 190 0.089
protein modification process GO:0036211 438 0.085
regulation of dna metabolic process GO:0051052 34 0.085
purine ribonucleoside metabolic process GO:0046128 127 0.082
negative regulation of mitotic cell cycle GO:0045930 109 0.082
regulation of cellular amine metabolic process GO:0033238 3 0.082
nucleoside triphosphate catabolic process GO:0009143 108 0.080
meiotic nuclear division GO:0007126 151 0.080
histone h4 k20 methylation GO:0034770 4 0.079
purine nucleotide catabolic process GO:0006195 109 0.077
mitotic g2 dna damage checkpoint GO:0007095 69 0.076
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.075
mitotic cell cycle phase transition GO:0044772 138 0.073
purine nucleoside metabolic process GO:0042278 127 0.073
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.073
negative regulation of cell cycle GO:0045786 116 0.072
single organism catabolic process GO:0044712 228 0.071
sister chromatid cohesion GO:0007062 18 0.070
regulation of cell cycle process GO:0010564 181 0.069
organonitrogen compound metabolic process GO:1901564 318 0.068
mitotic g2 m transition checkpoint GO:0044818 70 0.068
purine ribonucleotide catabolic process GO:0009154 109 0.066
regionalization GO:0003002 416 0.065
positive regulation of cellular catabolic process GO:0031331 95 0.065
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.064
cellular macromolecule catabolic process GO:0044265 136 0.063
nucleoside catabolic process GO:0009164 112 0.063
embryo development ending in birth or egg hatching GO:0009792 152 0.063
telomere organization GO:0032200 21 0.063
cellular ketone metabolic process GO:0042180 24 0.063
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.063
purine ribonucleoside catabolic process GO:0046130 112 0.062
ribonucleoside catabolic process GO:0042454 112 0.062
telomere capping GO:0016233 11 0.061
transcription from rna polymerase ii promoter GO:0006366 368 0.061
regulation of cell cycle GO:0051726 291 0.059
nucleoside triphosphate metabolic process GO:0009141 120 0.059
ribonucleoside monophosphate catabolic process GO:0009158 39 0.059
purine nucleoside catabolic process GO:0006152 112 0.058
centrosome duplication GO:0051298 121 0.058
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.057
axonogenesis GO:0007409 290 0.057
ribose phosphate metabolic process GO:0019693 145 0.057
signal transduction in response to dna damage GO:0042770 3 0.054
cell cycle phase transition GO:0044770 140 0.053
dna methylation GO:0006306 4 0.052
mitotic sister chromatid segregation GO:0000070 87 0.052
gene silencing by rna GO:0031047 57 0.052
protein dna complex subunit organization GO:0071824 86 0.052
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.052
mitotic cell cycle checkpoint GO:0007093 88 0.051
heterocycle catabolic process GO:0046700 166 0.051
positive regulation of transcription dna templated GO:0045893 266 0.051
regulation of mitotic cell cycle phase transition GO:1901990 130 0.050
positive regulation of rna biosynthetic process GO:1902680 266 0.050
modification dependent macromolecule catabolic process GO:0043632 79 0.049
peptidyl lysine trimethylation GO:0018023 6 0.049
production of sirna involved in rna interference GO:0030422 11 0.049
methylation GO:0032259 47 0.049
dna integrity checkpoint GO:0031570 81 0.048
glycosyl compound metabolic process GO:1901657 127 0.048
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.048
regulation of catabolic process GO:0009894 170 0.048
negative regulation of organelle organization GO:0010639 56 0.047
regulation of cellular catabolic process GO:0031329 157 0.045
cellular nitrogen compound catabolic process GO:0044270 165 0.045
mitotic cell cycle embryonic GO:0045448 38 0.044
negative regulation of cell cycle phase transition GO:1901988 103 0.044
response to organic cyclic compound GO:0014070 89 0.044
macromolecular complex assembly GO:0065003 256 0.043
nucleotide catabolic process GO:0009166 109 0.043
taxis GO:0042330 304 0.042
male courtship behavior veined wing generated song production GO:0045433 20 0.042
organophosphate catabolic process GO:0046434 112 0.041
dsrna fragmentation GO:0031050 15 0.041
regulation of cellular ketone metabolic process GO:0010565 3 0.041
histone lysine methylation GO:0034968 32 0.041
organic cyclic compound catabolic process GO:1901361 168 0.040
purine nucleoside triphosphate metabolic process GO:0009144 119 0.039
production of small rna involved in gene silencing by rna GO:0070918 15 0.038
cellular response to ketone GO:1901655 17 0.037
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.036
centrosome cycle GO:0007098 137 0.036
regulation of cellular protein metabolic process GO:0032268 243 0.036
single organism biosynthetic process GO:0044711 206 0.035
carbohydrate derivative catabolic process GO:1901136 118 0.035
positive regulation of macromolecule metabolic process GO:0010604 405 0.035
ribonucleotide catabolic process GO:0009261 109 0.035
atp dependent chromatin remodeling GO:0043044 22 0.035
cell cycle dna replication GO:0044786 23 0.034
ubiquitin dependent protein catabolic process GO:0006511 78 0.033
ribonucleotide metabolic process GO:0009259 145 0.033
rna interference GO:0016246 27 0.032
protein catabolic process GO:0030163 101 0.032
localization of cell GO:0051674 257 0.032
nucleosome positioning GO:0016584 3 0.031
ribonucleoside metabolic process GO:0009119 127 0.030
purine containing compound catabolic process GO:0072523 112 0.030
appendage morphogenesis GO:0035107 397 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
chromatin maintenance GO:0070827 2 0.030
positive regulation of catabolic process GO:0009896 105 0.030
dna methylation or demethylation GO:0044728 4 0.030
cellular protein catabolic process GO:0044257 83 0.029
positive regulation of cellular protein metabolic process GO:0032270 118 0.029
dendrite morphogenesis GO:0048813 199 0.029
dorsal ventral pattern formation GO:0009953 133 0.029
purine containing compound metabolic process GO:0072521 155 0.029
protein complex biogenesis GO:0070271 201 0.029
purine ribonucleotide metabolic process GO:0009150 145 0.029
regulation of proteasomal protein catabolic process GO:0061136 39 0.029
ribonucleoside triphosphate metabolic process GO:0009199 119 0.028
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.028
nucleoside phosphate catabolic process GO:1901292 110 0.028
positive regulation of biosynthetic process GO:0009891 316 0.028
positive regulation of organelle organization GO:0010638 65 0.028
regulation of chromatin organization GO:1902275 32 0.027
purine nucleoside monophosphate metabolic process GO:0009126 50 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.027
chemotaxis GO:0006935 249 0.027
negative regulation of cell cycle process GO:0010948 109 0.027
posttranscriptional regulation of gene expression GO:0010608 145 0.027
nucleotide metabolic process GO:0009117 161 0.027
purine nucleotide metabolic process GO:0006163 146 0.027
histone methylation GO:0016571 40 0.026
regulation of cellular protein catabolic process GO:1903362 44 0.026
axon guidance GO:0007411 233 0.026
modification dependent protein catabolic process GO:0019941 78 0.026
positive regulation of nucleic acid templated transcription GO:1903508 266 0.026
peptidyl lysine modification GO:0018205 57 0.026
homeostatic process GO:0042592 199 0.026
regulation of localization GO:0032879 275 0.026
dendrite development GO:0016358 204 0.026
glycosyl compound catabolic process GO:1901658 112 0.026
appendage development GO:0048736 401 0.026
chromosome separation GO:0051304 42 0.026
ribonucleoside triphosphate catabolic process GO:0009203 108 0.025
olfactory learning GO:0008355 56 0.025
neurological system process GO:0050877 358 0.025
nucleobase containing small molecule metabolic process GO:0055086 174 0.025
wing disc morphogenesis GO:0007472 344 0.024
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.024
regulation of response to dna damage stimulus GO:2001020 23 0.024
response to sterol GO:0036314 34 0.024
tissue morphogenesis GO:0048729 297 0.024
anatomical structure homeostasis GO:0060249 97 0.024
axon development GO:0061564 297 0.024
nucleoside monophosphate metabolic process GO:0009123 52 0.024
regulation of gene silencing GO:0060968 63 0.024
reproductive structure development GO:0048608 74 0.024
embryonic development via the syncytial blastoderm GO:0001700 148 0.023
cellular response to dsrna GO:0071359 15 0.023
cellular response to chemical stimulus GO:0070887 199 0.023
mitotic chromosome condensation GO:0007076 22 0.023
organonitrogen compound catabolic process GO:1901565 128 0.023
histone acetylation GO:0016573 38 0.022
gland development GO:0048732 191 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.022
developmental growth GO:0048589 280 0.022
regulation of neuron differentiation GO:0045664 103 0.022
negative regulation of cellular component organization GO:0051129 108 0.022
protein modification by small protein conjugation or removal GO:0070647 106 0.022
imaginal disc derived appendage development GO:0048737 399 0.022
dosage compensation by hyperactivation of x chromosome GO:0009047 7 0.021
positive regulation of cellular amine metabolic process GO:0033240 0 0.021
reproductive system development GO:0061458 74 0.021
cellular macromolecular complex assembly GO:0034622 153 0.021
forebrain development GO:0030900 2 0.020
regulation of chromatin modification GO:1903308 28 0.020
regulation of nuclear division GO:0051783 58 0.020
nucleoside metabolic process GO:0009116 127 0.020
peptidyl amino acid modification GO:0018193 105 0.020
nucleoside phosphate metabolic process GO:0006753 162 0.020
single organism intracellular transport GO:1902582 207 0.020
negative regulation of cell division GO:0051782 17 0.019
dna dependent dna replication GO:0006261 17 0.019
regulation of protein metabolic process GO:0051246 256 0.019
peptidyl lysine dimethylation GO:0018027 3 0.019
response to organic substance GO:0010033 284 0.019
atp metabolic process GO:0046034 49 0.019
positive regulation of cellular biosynthetic process GO:0031328 316 0.019
gliogenesis GO:0042063 80 0.019
protein complex assembly GO:0006461 200 0.019
purine nucleoside triphosphate catabolic process GO:0009146 108 0.019
histone h3 k4 methylation GO:0051568 16 0.018
cell death GO:0008219 279 0.018
positive regulation of apoptotic signaling pathway GO:2001235 4 0.018
negative regulation of signal transduction GO:0009968 206 0.018
response to ionizing radiation GO:0010212 32 0.018
ribonucleoside monophosphate metabolic process GO:0009161 51 0.018
protein alkylation GO:0008213 43 0.018
regulation of cellular response to stress GO:0080135 89 0.018
cellular response to organic cyclic compound GO:0071407 32 0.017
regulation of mitotic sister chromatid segregation GO:0033047 28 0.017
intracellular transport GO:0046907 228 0.017
protein modification by small protein conjugation GO:0032446 79 0.017
negative regulation of chromosome organization GO:2001251 19 0.017
mitotic nuclear division GO:0007067 213 0.017
regulation of catalytic activity GO:0050790 185 0.016
negative regulation of cell differentiation GO:0045596 143 0.016
response to dsrna GO:0043331 15 0.016
nuclear body organization GO:0030575 6 0.016
regulation of neurogenesis GO:0050767 158 0.016
response to nitrogen compound GO:1901698 90 0.016
regulation of protein catabolic process GO:0042176 55 0.015
camera type eye development GO:0043010 4 0.015
carbohydrate derivative metabolic process GO:1901135 217 0.015
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.015
limb morphogenesis GO:0035108 1 0.015
cellular response to oxygen levels GO:0071453 30 0.015
body morphogenesis GO:0010171 2 0.015
male meiosis chromosome segregation GO:0007060 10 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
histone exchange GO:0043486 21 0.014
cell aging GO:0007569 2 0.014
targeting of mrna for destruction involved in rna interference GO:0030423 4 0.014
mitotic dna integrity checkpoint GO:0044774 75 0.014
histone h3 k27 methylation GO:0070734 6 0.014
regulation of photoreceptor cell differentiation GO:0046532 34 0.014
organic substance transport GO:0071702 257 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
mitotic sister chromatid separation GO:0051306 30 0.014
protein acetylation GO:0006473 39 0.014
single organism cellular localization GO:1902580 180 0.013
innate immune response GO:0045087 144 0.013
macromolecule methylation GO:0043414 45 0.013
regulation of wnt signaling pathway GO:0030111 68 0.013
sex differentiation GO:0007548 81 0.013
proteasomal protein catabolic process GO:0010498 59 0.013
wnt signaling pathway GO:0016055 98 0.013
protein dna complex assembly GO:0065004 63 0.013
response to ketone GO:1901654 34 0.013
regulation of cell differentiation GO:0045595 302 0.013
regulation of behavior GO:0050795 75 0.012
regulation of cell cycle phase transition GO:1901987 130 0.012
positive regulation of neurogenesis GO:0050769 41 0.012
nucleoside monophosphate catabolic process GO:0009125 39 0.012
oxoacid metabolic process GO:0043436 103 0.012
response to bacterium GO:0009617 198 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
growth GO:0040007 359 0.012
regulation of defense response to virus by host GO:0050691 10 0.012
response to ecdysone GO:0035075 34 0.012
proteolysis GO:0006508 192 0.011
atp catabolic process GO:0006200 38 0.011
embryonic hemopoiesis GO:0035162 26 0.011
positive regulation of chromatin silencing GO:0031937 16 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.011
wound healing GO:0042060 75 0.011
establishment of localization in cell GO:0051649 402 0.011
response to oxygen containing compound GO:1901700 200 0.011
regulation of gtp catabolic process GO:0033124 44 0.011
replication fork processing GO:0031297 0 0.011
karyosome formation GO:0030717 22 0.011
apoptotic signaling pathway GO:0097190 27 0.011
dna modification GO:0006304 5 0.011
regulation of dna replication GO:0006275 13 0.011
negative regulation of neurogenesis GO:0050768 53 0.010
post embryonic appendage morphogenesis GO:0035120 385 0.010
development of primary sexual characteristics GO:0045137 50 0.010
positive regulation of cell development GO:0010720 61 0.010
positive regulation of phosphate metabolic process GO:0045937 139 0.010
cellular component maintenance GO:0043954 23 0.010
negative regulation of multicellular organismal process GO:0051241 142 0.010
positive regulation of nucleoside metabolic process GO:0045979 47 0.010

Su(var)2-HP2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.038
disease of cellular proliferation DOID:14566 0 0.038
organ system cancer DOID:0050686 0 0.038
disease of anatomical entity DOID:7 0 0.017