Drosophila melanogaster

154 known processes

mus309 (Dmel_CG6920)

mutagen-sensitive 309

(Aliases: mus 309,blm,Dmblm,DmKu70,CG6920,Dmel\CG6920,Blm,MUS309,Ku70,DmBlm,RecQ,mus309/DmBLM,DmBLM)

mus309 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via nonhomologous end joining GO:0006303 5 0.869
non recombinational repair GO:0000726 7 0.819
double strand break repair GO:0006302 26 0.727
mitotic g2 m transition checkpoint GO:0044818 70 0.688
Human
double strand break repair via synthesis dependent strand annealing GO:0045003 6 0.649
g2 dna damage checkpoint GO:0031572 69 0.593
Human
cell division GO:0051301 248 0.575
Human
nucleobase containing compound catabolic process GO:0034655 165 0.514
negative regulation of cell cycle GO:0045786 116 0.437
Human
negative regulation of cell cycle phase transition GO:1901988 103 0.435
Human
dna synthesis involved in dna repair GO:0000731 5 0.359
mitotic g2 dna damage checkpoint GO:0007095 69 0.322
Human
negative regulation of cell cycle g2 m phase transition GO:1902750 8 0.289
negative regulation of cell cycle process GO:0010948 109 0.273
Human
mitotic dna damage checkpoint GO:0044773 74 0.271
Human
dna integrity checkpoint GO:0031570 81 0.257
Human Worm
meiosis i GO:0007127 59 0.241
regulation of cell cycle phase transition GO:1901987 130 0.237
Human
negative regulation of mitotic cell cycle GO:0045930 109 0.235
Human
meiotic cell cycle process GO:1903046 132 0.221
dna repair GO:0006281 54 0.207
double strand break repair via homologous recombination GO:0000724 13 0.191
meiotic chromosome segregation GO:0045132 59 0.189
Worm
mitotic dna integrity checkpoint GO:0044774 75 0.176
Human
dna recombination GO:0006310 32 0.174
organic cyclic compound catabolic process GO:1901361 168 0.172
cellular catabolic process GO:0044248 372 0.171
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.169
response to abiotic stimulus GO:0009628 341 0.167
Human Worm
cellular response to dna damage stimulus GO:0006974 223 0.159
female meiotic division GO:0007143 70 0.159
death GO:0016265 284 0.157
Mouse Worm
catabolic process GO:0009056 409 0.151
dna double strand break processing GO:0000729 3 0.150
Human
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 8 0.145
regulation of dna repair GO:0006282 5 0.143
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.138
aromatic compound catabolic process GO:0019439 166 0.134
regulation of cell differentiation GO:0045595 302 0.133
positive regulation of macromolecule metabolic process GO:0010604 405 0.133
Human
negative regulation of cellular biosynthetic process GO:0031327 277 0.132
cell cycle phase transition GO:0044770 140 0.126
Human
cellular nitrogen compound catabolic process GO:0044270 165 0.124
dna damage checkpoint GO:0000077 78 0.119
Human Worm
regulation of cell cycle GO:0051726 291 0.110
Human
regulation of multicellular organismal development GO:2000026 414 0.110
positive regulation of transcription dna templated GO:0045893 266 0.106
Human
regulation of cellular protein metabolic process GO:0032268 243 0.106
Human
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.102
Human
reciprocal dna recombination GO:0035825 19 0.099
mrna metabolic process GO:0016071 124 0.099
mrna processing GO:0006397 104 0.096
response to organic substance GO:0010033 284 0.095
Human
macromolecule catabolic process GO:0009057 161 0.093
Human
mitotic recombination GO:0006312 2 0.089
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.088
Human
regulation of cell cycle process GO:0010564 181 0.086
Human
response to ionizing radiation GO:0010212 32 0.086
Human Worm
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.085
Human
nuclear transcribed mrna catabolic process GO:0000956 24 0.084
positive regulation of rna biosynthetic process GO:1902680 266 0.083
Human
mitotic cell cycle checkpoint GO:0007093 88 0.082
Human
small molecule metabolic process GO:0044281 305 0.080
positive regulation of rna metabolic process GO:0051254 271 0.078
Human
regulation of protein metabolic process GO:0051246 256 0.078
Human
asymmetric cell division GO:0008356 37 0.077
response to alkaloid GO:0043279 26 0.075
Human
translesion synthesis GO:0019985 2 0.072
cell cycle checkpoint GO:0000075 95 0.072
Human Worm
telomere maintenance via recombination GO:0000722 1 0.071
response to radiation GO:0009314 155 0.069
Human Worm
regulation of mitotic cell cycle phase transition GO:1901990 130 0.068
Human
positive regulation of biosynthetic process GO:0009891 316 0.068
Human
regulation of mitotic cell cycle GO:0007346 190 0.068
Human
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.068
nucleotide excision repair GO:0006289 8 0.067
recombinational repair GO:0000725 13 0.067
regulation of double strand break repair GO:2000779 3 0.064
chromosome segregation GO:0007059 157 0.064
Worm
postreplication repair GO:0006301 2 0.064
rna processing GO:0006396 147 0.064
regulation of embryonic development GO:0045995 68 0.063
rna catabolic process GO:0006401 37 0.062
mitotic cell cycle phase transition GO:0044772 138 0.060
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.059
organelle fission GO:0048285 340 0.059
protein modification process GO:0036211 438 0.058
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.055
protein complex assembly GO:0006461 200 0.055
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.055
positive regulation of cellular biosynthetic process GO:0031328 316 0.055
Human
positive regulation of catabolic process GO:0009896 105 0.055
cellular response to abiotic stimulus GO:0071214 58 0.055
Human
cellular protein modification process GO:0006464 438 0.054
Human
female meiosis chromosome segregation GO:0016321 33 0.053
retina development in camera type eye GO:0060041 4 0.053
organic substance catabolic process GO:1901575 308 0.053
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.052
Human
programmed cell death GO:0012501 257 0.051
Mouse Worm
positive regulation of nucleic acid templated transcription GO:1903508 266 0.050
Human
nucleobase containing small molecule metabolic process GO:0055086 174 0.049
macromolecular complex assembly GO:0065003 256 0.049
Human
regulation of cell development GO:0060284 215 0.048
mrna catabolic process GO:0006402 33 0.048
response to monosaccharide GO:0034284 4 0.046
single organism biosynthetic process GO:0044711 206 0.045
regulation of nervous system development GO:0051960 248 0.044
transmembrane transport GO:0055085 139 0.044
purine nucleoside metabolic process GO:0042278 127 0.043
organonitrogen compound metabolic process GO:1901564 318 0.043
positive regulation of nervous system development GO:0051962 69 0.043
organophosphate metabolic process GO:0019637 195 0.043
anatomical structure homeostasis GO:0060249 97 0.042
Mouse
negative regulation of cellular metabolic process GO:0031324 382 0.042
maintenance of location GO:0051235 73 0.042
ribonucleoside monophosphate catabolic process GO:0009158 39 0.041
telomere organization GO:0032200 21 0.041
Mouse
homeostatic process GO:0042592 199 0.041
Mouse
camera type eye development GO:0043010 4 0.040
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.040
g2 m transition of mitotic cell cycle GO:0000086 19 0.040
purine containing compound catabolic process GO:0072523 112 0.040
ribonucleoside triphosphate metabolic process GO:0009199 119 0.039
carboxylic acid metabolic process GO:0019752 92 0.039
posttranscriptional regulation of gene expression GO:0010608 145 0.039
humoral immune response GO:0006959 117 0.038
heterocycle catabolic process GO:0046700 166 0.038
positive regulation of cellular catabolic process GO:0031331 95 0.037
retrograde axon cargo transport GO:0008090 9 0.037
protein phosphorylation GO:0006468 169 0.036
Human
response to anesthetic GO:0072347 9 0.036
dorsal ventral pattern formation GO:0009953 133 0.036
negative regulation of biosynthetic process GO:0009890 277 0.036
chromosome organization GO:0051276 360 0.035
Mouse Worm
long term memory GO:0007616 62 0.035
cell cycle g2 m phase transition GO:0044839 22 0.034
positive regulation of developmental process GO:0051094 143 0.034
positive regulation of cell communication GO:0010647 250 0.034
positive regulation of multicellular organismal process GO:0051240 143 0.033
organic acid metabolic process GO:0006082 103 0.033
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.033
purine ribonucleoside metabolic process GO:0046128 127 0.033
negative regulation of gene expression GO:0010629 387 0.033
regulation of meiosis GO:0040020 3 0.033
mrna 3 end processing GO:0031124 28 0.033
ribose phosphate metabolic process GO:0019693 145 0.032
apoptotic process GO:0006915 159 0.032
Mouse Worm
negative regulation of response to stimulus GO:0048585 258 0.032
positive regulation of endopeptidase activity GO:0010950 26 0.032
oxoacid metabolic process GO:0043436 103 0.032
endocytosis GO:0006897 310 0.031
molting cycle chitin based cuticle GO:0007591 56 0.031
cell proliferation GO:0008283 299 0.031
Mouse
positive regulation of signaling GO:0023056 243 0.031
regulation of transport GO:0051049 181 0.031
positive regulation of response to stimulus GO:0048584 323 0.031
ion transport GO:0006811 145 0.030
regulation of neurogenesis GO:0050767 158 0.030
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.030
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.030
kidney morphogenesis GO:0060993 3 0.029
nucleoside metabolic process GO:0009116 127 0.029
negative regulation of cell division GO:0051782 17 0.029
Human
response to caffeine GO:0031000 12 0.028
regionalization GO:0003002 416 0.028
response to drug GO:0042493 17 0.028
sensory organ morphogenesis GO:0090596 260 0.028
reciprocal meiotic recombination GO:0007131 19 0.028
lipid storage GO:0019915 38 0.027
ribonucleoside catabolic process GO:0042454 112 0.027
dna biosynthetic process GO:0071897 24 0.027
phosphorylation GO:0016310 294 0.027
Human
regulation of dna recombination GO:0000018 4 0.026
Human Mouse
signal transduction in response to dna damage GO:0042770 3 0.026
epithelial cell development GO:0002064 274 0.026
carbohydrate derivative metabolic process GO:1901135 217 0.026
telomere maintenance GO:0000723 21 0.026
Mouse
positive regulation of signal transduction GO:0009967 223 0.026
meiotic cell cycle GO:0051321 171 0.026
cellular response to radiation GO:0071478 52 0.026
Human
regulation of cell death GO:0010941 173 0.026
Mouse Worm
negative regulation of signal transduction GO:0009968 206 0.026
regulation of intracellular signal transduction GO:1902531 236 0.026
regulation of cell division GO:0051302 72 0.025
Human
vesicle mediated transport GO:0016192 381 0.025
mitotic cell cycle embryonic GO:0045448 38 0.025
cell death GO:0008219 279 0.025
Mouse Worm
cellular amino acid metabolic process GO:0006520 61 0.025
regulation of cellular response to stress GO:0080135 89 0.025
cellular response to chemical stimulus GO:0070887 199 0.025
Human
negative regulation of cell communication GO:0010648 223 0.025
cellular macromolecule catabolic process GO:0044265 136 0.024
Human
regulation of epithelial cell differentiation GO:0030856 4 0.024
organonitrogen compound catabolic process GO:1901565 128 0.024
metal ion transport GO:0030001 74 0.023
cellular macromolecular complex assembly GO:0034622 153 0.023
meiotic nuclear division GO:0007126 151 0.023
digestive tract development GO:0048565 149 0.023
purine nucleotide metabolic process GO:0006163 146 0.022
regulation of localization GO:0032879 275 0.022
purine containing compound metabolic process GO:0072521 155 0.022
immune system process GO:0002376 347 0.022
Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.022
male gamete generation GO:0048232 201 0.021
dorsal ventral axis specification GO:0009950 66 0.021
atp metabolic process GO:0046034 49 0.021
compound eye morphogenesis GO:0001745 249 0.021
body morphogenesis GO:0010171 2 0.021
embryo development ending in birth or egg hatching GO:0009792 152 0.021
positive regulation of catalytic activity GO:0043085 118 0.021
regulation of catalytic activity GO:0050790 185 0.021
Human
regulation of cellular catabolic process GO:0031329 157 0.021
rna localization GO:0006403 115 0.020
nucleoside phosphate metabolic process GO:0006753 162 0.020
dna geometric change GO:0032392 16 0.020
regulation of organelle organization GO:0033043 196 0.020
cellular amine metabolic process GO:0044106 12 0.020
positive regulation of epithelial cell differentiation GO:0030858 1 0.020
negative regulation of multicellular organismal process GO:0051241 142 0.020
regulation of peptidase activity GO:0052547 39 0.020
positive regulation of intracellular signal transduction GO:1902533 116 0.020
regulation of multi organism process GO:0043900 131 0.020
gastrulation GO:0007369 70 0.019
positive regulation of cell differentiation GO:0045597 64 0.019
positive regulation of protein metabolic process GO:0051247 128 0.019
regulation of mrna metabolic process GO:1903311 72 0.019
cytokinesis GO:0000910 90 0.019
male meiosis chromosome segregation GO:0007060 10 0.019
response to oxygen containing compound GO:1901700 200 0.019
Human
positive regulation of gene expression GO:0010628 290 0.019
Human
regulation of hydrolase activity GO:0051336 97 0.019
stress activated mapk cascade GO:0051403 52 0.018
negative regulation of cell differentiation GO:0045596 143 0.018
secretion GO:0046903 109 0.018
response to other organism GO:0051707 293 0.018
purine nucleoside catabolic process GO:0006152 112 0.018
eye development GO:0001654 323 0.018
germarium derived oocyte fate determination GO:0007294 26 0.018
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.018
regulation of cellular amine metabolic process GO:0033238 3 0.018
spermatogenesis GO:0007283 200 0.017
cellular response to ionizing radiation GO:0071479 15 0.017
Human
synaptic transmission GO:0007268 288 0.017
lipid localization GO:0010876 54 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.017
regulation of organ morphogenesis GO:2000027 78 0.017
regulation of nuclear division GO:0051783 58 0.017
positive regulation of cell size GO:0045793 21 0.017
positive regulation of apoptotic process GO:0043065 47 0.016
catechol containing compound biosynthetic process GO:0009713 3 0.016
mrna splicing via spliceosome GO:0000398 73 0.016
posttranscriptional gene silencing by rna GO:0035194 45 0.016
mitotic dna replication checkpoint GO:0033314 5 0.016
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.016
negative regulation of cell proliferation GO:0008285 69 0.016
rna 3 end processing GO:0031123 45 0.016
actin filament based process GO:0030029 220 0.016
ribonucleoside triphosphate catabolic process GO:0009203 108 0.016
protein localization GO:0008104 284 0.016
organophosphate catabolic process GO:0046434 112 0.016
response to organonitrogen compound GO:0010243 75 0.016
Human
positive regulation of neurogenesis GO:0050769 41 0.016
amine metabolic process GO:0009308 12 0.016
regulation of synaptic transmission GO:0050804 69 0.016
negative regulation of signaling GO:0023057 219 0.016
carbohydrate metabolic process GO:0005975 82 0.016
regulation of cysteine type endopeptidase activity GO:2000116 27 0.015
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.015
ion transmembrane transport GO:0034220 122 0.015
purine ribonucleoside catabolic process GO:0046130 112 0.015
glycosyl compound metabolic process GO:1901657 127 0.015
regulation of phosphorus metabolic process GO:0051174 210 0.015
Human
establishment of localization in cell GO:0051649 402 0.015
organelle assembly GO:0070925 198 0.015
positive regulation of proteolysis GO:0045862 52 0.015
regulation of mrna catabolic process GO:0061013 5 0.015
negative regulation of translation GO:0017148 28 0.015
positive regulation of peptidase activity GO:0010952 29 0.015
alternative mrna splicing via spliceosome GO:0000380 60 0.015
regulation of mrna processing GO:0050684 71 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
anion transmembrane transport GO:0098656 26 0.014
alpha amino acid metabolic process GO:1901605 20 0.014
regulation of anatomical structure size GO:0090066 163 0.014
regulation of autophagy GO:0010506 62 0.014
cell aging GO:0007569 2 0.014
organic substance transport GO:0071702 257 0.014
negative regulation of nervous system development GO:0051961 92 0.014
oocyte fate determination GO:0030716 27 0.014
nuclear division GO:0000280 332 0.014
regulation of response to dna damage stimulus GO:2001020 23 0.014
regulation of apoptotic process GO:0042981 130 0.014
Mouse Worm
enzyme linked receptor protein signaling pathway GO:0007167 179 0.014
regulation of response to biotic stimulus GO:0002831 63 0.013
intracellular mrna localization GO:0008298 66 0.013
cellular response to mechanical stimulus GO:0071260 2 0.013
jnk cascade GO:0007254 50 0.013
regulation of pole plasm oskar mrna localization GO:0007317 27 0.013
single organism carbohydrate metabolic process GO:0044723 72 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
regulation of cell maturation GO:1903429 27 0.013
cellular response to gamma radiation GO:0071480 10 0.013
forebrain development GO:0030900 2 0.013
negative regulation of developmental growth GO:0048640 64 0.013
antimicrobial humoral response GO:0019730 99 0.013
regulation of g2 m transition of mitotic cell cycle GO:0010389 15 0.013
purine nucleoside monophosphate catabolic process GO:0009128 38 0.013
regulation of endopeptidase activity GO:0052548 36 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
dna metabolic process GO:0006259 227 0.013
regulation of cell proliferation GO:0042127 163 0.012
Mouse
regulation of stress activated mapk cascade GO:0032872 41 0.012
single organism behavior GO:0044708 391 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
nitrogen compound transport GO:0071705 85 0.012
response to oxidative stress GO:0006979 86 0.012
developmental growth GO:0048589 280 0.012
regulation of protein complex assembly GO:0043254 42 0.012
response to nitrogen compound GO:1901698 90 0.012
Human
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
protein catabolic process GO:0030163 101 0.012
regulation of oocyte development GO:0060281 27 0.012
regulation of rna splicing GO:0043484 69 0.012
regulation of catabolic process GO:0009894 170 0.012
regulation of nf kappab import into nucleus GO:0042345 1 0.012
response to ethanol GO:0045471 59 0.012
male meiosis cytokinesis GO:0007112 26 0.012
cellular homeostasis GO:0019725 80 0.012
regulation of phosphorylation GO:0042325 147 0.011
Human
production of molecular mediator of immune response GO:0002440 46 0.011
primary amino compound metabolic process GO:1901160 2 0.011
cellular response to organic substance GO:0071310 132 0.011
Human
regulation of protein modification process GO:0031399 112 0.011
Human
purine ribonucleotide metabolic process GO:0009150 145 0.011
regulation of cellular component size GO:0032535 98 0.011
rna splicing GO:0008380 83 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
negative regulation of developmental process GO:0051093 201 0.011
regulation of jnk cascade GO:0046328 40 0.011
positive regulation of molecular function GO:0044093 136 0.011
learning or memory GO:0007611 141 0.011
epithelial cell differentiation GO:0030855 322 0.011
nucleotide metabolic process GO:0009117 161 0.011
autophagy GO:0006914 108 0.011
appendage morphogenesis GO:0035107 397 0.011
cellular protein complex assembly GO:0043623 71 0.011
wnt signaling pathway GO:0016055 98 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
negative regulation of rna biosynthetic process GO:1902679 240 0.011
response to paraquat GO:1901562 4 0.011
response to light stimulus GO:0009416 124 0.011
dorsal closure GO:0007391 79 0.011
response to decreased oxygen levels GO:0036293 58 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
mesenchymal cell development GO:0014031 1 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.011
regulation of cellular component biogenesis GO:0044087 201 0.011
negative regulation of growth GO:0045926 84 0.011
cellular macromolecule localization GO:0070727 220 0.011
regulation of molecular function GO:0065009 217 0.011
Human Mouse
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.010
cation transport GO:0006812 110 0.010
anterior posterior axis specification GO:0009948 109 0.010
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.010
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.010
regulation of photoreceptor cell differentiation GO:0046532 34 0.010
cell motility GO:0048870 251 0.010
regulation of ion transport GO:0043269 39 0.010
polarity specification of dorsal ventral axis GO:0009951 6 0.010
actin cytoskeleton organization GO:0030036 206 0.010
regulation of mrna 3 end processing GO:0031440 7 0.010
stress activated protein kinase signaling cascade GO:0031098 55 0.010
response to hypoxia GO:0001666 53 0.010
response to external biotic stimulus GO:0043207 293 0.010
positive regulation of hydrolase activity GO:0051345 78 0.010
carbohydrate derivative biosynthetic process GO:1901137 85 0.010
negative regulation of meiotic cell cycle GO:0051447 2 0.010
cuticle development GO:0042335 86 0.010

mus309 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.046
cancer DOID:162 0 0.046
thoracic cancer DOID:5093 0 0.041
organ system cancer DOID:0050686 0 0.041
disease of anatomical entity DOID:7 0 0.016
breast cancer DOID:1612 0 0.015
bone disease DOID:0080001 0 0.013
connective tissue disease DOID:65 0 0.013
musculoskeletal system disease DOID:17 0 0.013
male reproductive organ cancer DOID:3856 0 0.011
reproductive organ cancer DOID:193 0 0.011