Drosophila melanogaster

95 known processes

Pcl (Dmel_CG5109)

Polycomblike

(Aliases: Dmel\CG5109,CG5109,pcl,l(2)s1859,PCL)

Pcl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription dna templated GO:0045892 237 0.999
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.999
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.999
negative regulation of nucleic acid templated transcription GO:1903507 240 0.998
negative regulation of cellular biosynthetic process GO:0031327 277 0.997
gene silencing GO:0016458 138 0.988
imaginal disc derived appendage development GO:0048737 399 0.979
negative regulation of gene expression GO:0010629 387 0.976
imaginal disc derived appendage morphogenesis GO:0035114 395 0.958
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.949
Mouse
wing disc morphogenesis GO:0007472 344 0.943
appendage morphogenesis GO:0035107 397 0.936
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.935
regionalization GO:0003002 416 0.902
Mouse
negative regulation of rna biosynthetic process GO:1902679 240 0.900
negative regulation of biosynthetic process GO:0009890 277 0.896
negative regulation of rna metabolic process GO:0051253 251 0.891
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.881
imaginal disc derived wing morphogenesis GO:0007476 337 0.881
negative regulation of cellular metabolic process GO:0031324 382 0.852
defense response to fungus GO:0050832 48 0.845
chromatin silencing GO:0006342 76 0.692
imaginal disc derived leg morphogenesis GO:0007480 80 0.690
regulation of gene expression epigenetic GO:0040029 128 0.666
trunk segmentation GO:0035290 8 0.658
response to fungus GO:0009620 50 0.647
chromatin organization GO:0006325 207 0.619
appendage development GO:0048736 401 0.608
leg disc development GO:0035218 92 0.600
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.598
Mouse
chromatin modification GO:0016568 147 0.583
specification of segmental identity trunk GO:0035292 7 0.533
segmentation GO:0035282 207 0.532
Mouse
covalent chromatin modification GO:0016569 106 0.526
Human Mouse
imaginal disc pattern formation GO:0007447 91 0.457
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.447
Mouse
tissue morphogenesis GO:0048729 297 0.406
segment specification GO:0007379 33 0.403
Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.364
chromatin mediated maintenance of transcription GO:0048096 7 0.347
transcription from rna polymerase ii promoter GO:0006366 368 0.329
Mouse
neuroblast differentiation GO:0014016 29 0.323
positive regulation of rna metabolic process GO:0051254 271 0.303
Mouse
ectodermal placode morphogenesis GO:0071697 4 0.284
regulation of cell shape GO:0008360 113 0.263
regulation of dna templated transcription elongation GO:0032784 17 0.257
regulation of response to gamma radiation GO:2001228 4 0.252
positive regulation of macromolecule metabolic process GO:0010604 405 0.176
Human Mouse
enzyme linked receptor protein signaling pathway GO:0007167 179 0.174
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.174
protein modification process GO:0036211 438 0.172
Human Mouse
epithelial cell differentiation GO:0030855 322 0.166
wnt signaling pathway GO:0016055 98 0.161
nephron development GO:0072006 3 0.157
negative regulation of gene expression epigenetic GO:0045814 77 0.145
chemosensory behavior GO:0007635 106 0.129
embryonic morphogenesis GO:0048598 206 0.122
carbohydrate derivative metabolic process GO:1901135 217 0.120
histone modification GO:0016570 106 0.118
Human Mouse
histone lysine methylation GO:0034968 32 0.117
Human Mouse
leg disc morphogenesis GO:0007478 80 0.117
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.108
chromosome organization GO:0051276 360 0.107
eye antennal disc development GO:0035214 60 0.107
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.103
Mouse
reproductive structure development GO:0048608 74 0.102
peptidyl lysine modification GO:0018205 57 0.096
histone h3 k4 methylation GO:0051568 16 0.095
sex differentiation GO:0007548 81 0.094
organelle fission GO:0048285 340 0.093
vesicle mediated transport GO:0016192 381 0.084
regulation of molecular function GO:0065009 217 0.082
salivary gland cell autophagic cell death GO:0035071 83 0.081
methylation GO:0032259 47 0.079
Human Mouse
morphogenesis of an epithelium GO:0002009 276 0.079
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.079
compound eye development GO:0048749 307 0.078
tissue death GO:0016271 102 0.074
regulation of multicellular organism growth GO:0040014 40 0.073
positive regulation of phosphorus metabolic process GO:0010562 139 0.072
spermatogenesis GO:0007283 200 0.068
dendrite development GO:0016358 204 0.068
ectodermal placode development GO:0071696 4 0.066
positive regulation of nucleic acid templated transcription GO:1903508 266 0.064
Mouse
sex determination GO:0007530 18 0.064
phagocytosis GO:0006909 215 0.062
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.061
positive regulation of biosynthetic process GO:0009891 316 0.060
Mouse
sensory perception GO:0007600 196 0.057
apposition of dorsal and ventral imaginal disc derived wing surfaces GO:0007475 15 0.054
germarium derived female germ line cyst encapsulation GO:0030708 8 0.053
body morphogenesis GO:0010171 2 0.052
regulation of phosphorus metabolic process GO:0051174 210 0.051
embryonic pattern specification GO:0009880 174 0.050
neurological system process GO:0050877 358 0.047
imaginal disc derived wing vein specification GO:0007474 48 0.047
circadian behavior GO:0048512 76 0.046
ectodermal placode formation GO:0060788 4 0.046
histone methylation GO:0016571 40 0.045
Human Mouse
endocytosis GO:0006897 310 0.045
dendrite morphogenesis GO:0048813 199 0.045
salivary gland histolysis GO:0035070 88 0.044
nucleosome positioning GO:0016584 3 0.043
reproductive system development GO:0061458 74 0.043
germ line cyst encapsulation GO:0048138 8 0.043
eye photoreceptor cell differentiation GO:0001754 145 0.042
regulation of chromosome organization GO:0033044 64 0.042
Human Mouse
protein dna complex subunit organization GO:0071824 86 0.042
cellular protein modification process GO:0006464 438 0.041
Human Mouse
wing disc pattern formation GO:0035222 66 0.040
regulation of meiosis GO:0040020 3 0.039
male gamete generation GO:0048232 201 0.038
single organism behavior GO:0044708 391 0.036
stem cell development GO:0048864 79 0.036
Mouse
mesodermal cell fate specification GO:0007501 2 0.035
central nervous system development GO:0007417 201 0.035
response to ecdysone GO:0035075 34 0.034
carbohydrate metabolic process GO:0005975 82 0.034
protein alkylation GO:0008213 43 0.033
Human Mouse
organonitrogen compound metabolic process GO:1901564 318 0.033
histone ubiquitination GO:0016574 4 0.032
nephron epithelium development GO:0072009 3 0.032
secretion GO:0046903 109 0.032
chromatin remodeling GO:0006338 72 0.031
regulation of phosphate metabolic process GO:0019220 210 0.031
dorsal ventral pattern formation GO:0009953 133 0.031
protein acetylation GO:0006473 39 0.030
positive regulation of cell communication GO:0010647 250 0.029
wing disc dorsal ventral pattern formation GO:0048190 47 0.029
response to ketone GO:1901654 34 0.029
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.029
intestinal epithelial structure maintenance GO:0060729 3 0.029
secretion by cell GO:0032940 101 0.028
regulation of chromatin silencing GO:0031935 36 0.028
single organism carbohydrate metabolic process GO:0044723 72 0.028
protein methylation GO:0006479 43 0.027
Human Mouse
neuron recognition GO:0008038 101 0.027
neuroblast fate determination GO:0007400 12 0.027
regulation of catalytic activity GO:0050790 185 0.027
macromolecule methylation GO:0043414 45 0.027
Human Mouse
mating behavior GO:0007617 106 0.027
response to sterol GO:0036314 34 0.026
hindbrain development GO:0030902 2 0.026
organophosphate metabolic process GO:0019637 195 0.026
positive regulation of signaling GO:0023056 243 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.025
Mouse
female germ line cyst encapsulation GO:0048139 8 0.025
negative regulation of cell communication GO:0010648 223 0.024
maintenance of gastrointestinal epithelium GO:0030277 3 0.024
limb morphogenesis GO:0035108 1 0.024
response to biotic stimulus GO:0009607 294 0.023
eye development GO:0001654 323 0.023
wound healing spreading of epidermal cells GO:0035313 1 0.023
regulation of histone modification GO:0031056 20 0.022
Human Mouse
gastrulation GO:0007369 70 0.022
regulation of protein metabolic process GO:0051246 256 0.022
Human Mouse
synaptic target recognition GO:0008039 45 0.022
compound eye photoreceptor cell differentiation GO:0001751 140 0.022
histone acetylation GO:0016573 38 0.022
brain development GO:0007420 120 0.022
developmental programmed cell death GO:0010623 138 0.022
nucleosome organization GO:0034728 59 0.022
dna damage checkpoint GO:0000077 78 0.022
anterior posterior pattern specification GO:0009952 136 0.021
compound eye morphogenesis GO:0001745 249 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.021
Mouse
autophagic cell death GO:0048102 83 0.020
gonad development GO:0008406 50 0.020
signal transduction by phosphorylation GO:0023014 107 0.020
regulation of protein modification process GO:0031399 112 0.020
Human Mouse
negative regulation of signal transduction GO:0009968 206 0.019
multi organism reproductive behavior GO:0044705 121 0.019
paracrine signaling GO:0038001 7 0.019
gene silencing by rna GO:0031047 57 0.019
glycoprotein metabolic process GO:0009100 41 0.019
columnar cuboidal epithelial cell development GO:0002066 249 0.019
meiotic cell cycle GO:0051321 171 0.019
blastoderm segmentation GO:0007350 159 0.019
programmed cell death GO:0012501 257 0.019
skin development GO:0043588 65 0.018
regulation of epithelial cell differentiation GO:0030856 4 0.018
dna integrity checkpoint GO:0031570 81 0.018
neuroblast fate commitment GO:0014017 19 0.018
response to external biotic stimulus GO:0043207 293 0.017
muscle structure development GO:0061061 224 0.017
positive regulation of response to stimulus GO:0048584 323 0.017
epithelial tube morphogenesis GO:0060562 88 0.016
locomotory behavior GO:0007626 176 0.016
development of primary sexual characteristics GO:0045137 50 0.016
cardioblast cell fate commitment GO:0042684 14 0.016
cellular response to endogenous stimulus GO:0071495 80 0.016
open tracheal system development GO:0007424 204 0.016
convergent extension GO:0060026 2 0.015
homeostatic process GO:0042592 199 0.015
small molecule metabolic process GO:0044281 305 0.015
transmembrane transport GO:0055085 139 0.015
carbohydrate derivative biosynthetic process GO:1901137 85 0.015
response to superoxide GO:0000303 3 0.015
positive regulation of cellular protein metabolic process GO:0032270 118 0.015
Human Mouse
regulation of cell cycle GO:0051726 291 0.015
cell recognition GO:0008037 102 0.015
positive regulation of gene expression GO:0010628 290 0.015
Mouse
neuroblast development GO:0014019 13 0.014
positive regulation of catalytic activity GO:0043085 118 0.014
gland development GO:0048732 191 0.014
nuclear division GO:0000280 332 0.014
ecdysone mediated induction of salivary gland cell autophagic cell death GO:0035072 12 0.014
purine ribonucleotide catabolic process GO:0009154 109 0.014
mating GO:0007618 120 0.014
olfactory behavior GO:0042048 97 0.014
internal protein amino acid acetylation GO:0006475 38 0.014
ion transport GO:0006811 145 0.013
ovarian follicle cell stalk formation GO:0030713 17 0.013
sensory organ morphogenesis GO:0090596 260 0.013
optic placode formation GO:0001743 4 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
mapk cascade GO:0000165 107 0.013
dna alkylation GO:0006305 4 0.013
regulation of decapentaplegic signaling pathway GO:0090097 8 0.013
morphogenesis of follicular epithelium GO:0016333 36 0.013
hematopoietic or lymphoid organ development GO:0048534 57 0.013
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
fertilization GO:0009566 26 0.012
organelle assembly GO:0070925 198 0.012
embryonic organ development GO:0048568 50 0.012
negative regulation of response to gamma radiation GO:2001229 4 0.012
tube morphogenesis GO:0035239 191 0.012
regulation of tube size GO:0035150 46 0.012
renal tubule development GO:0061326 64 0.012
pigmentation GO:0043473 75 0.012
long chain fatty acid metabolic process GO:0001676 3 0.012
defense response GO:0006952 300 0.012
anterior head development GO:0097065 3 0.012
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.012
regulation of organelle organization GO:0033043 196 0.011
Human Mouse
interspecies interaction between organisms GO:0044419 16 0.011
positive regulation of rna biosynthetic process GO:1902680 266 0.011
Mouse
ribonucleotide catabolic process GO:0009261 109 0.011
protein glycosylation GO:0006486 32 0.011
histolysis GO:0007559 102 0.011
negative regulation of response to stimulus GO:0048585 258 0.011
wound healing GO:0042060 75 0.011
positive regulation of gene expression epigenetic GO:0045815 16 0.011
protein dna complex assembly GO:0065004 63 0.011
larval development GO:0002164 104 0.011
multicellular organism growth GO:0035264 46 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
positive regulation of cellular biosynthetic process GO:0031328 316 0.011
Mouse
tube development GO:0035295 244 0.011
mitotic nuclear division GO:0007067 213 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
camera type eye morphogenesis GO:0048593 2 0.011
kidney development GO:0001822 3 0.011
response to organic substance GO:0010033 284 0.011
myofibril assembly GO:0030239 36 0.010
imaginal disc derived female genitalia development GO:0007486 6 0.010
positive regulation of transcription dna templated GO:0045893 266 0.010
Mouse
negative regulation of cellular protein metabolic process GO:0032269 85 0.010
Mouse

Pcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024
organ system cancer DOID:0050686 0 0.024
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011