Drosophila melanogaster

99 known processes

drosha (Dmel_CG8730)

CG8730 gene product from transcript CG8730-RA

(Aliases: Drosha,Dmel\CG8730,CG8730)

drosha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oocyte fate determination GO:0030716 27 0.941
production of mirnas involved in gene silencing by mirna GO:0035196 10 0.913
dsrna fragmentation GO:0031050 15 0.809
production of small rna involved in gene silencing by rna GO:0070918 15 0.781
dendrite development GO:0016358 204 0.677
germarium derived oocyte differentiation GO:0030706 29 0.635
dendrite morphogenesis GO:0048813 199 0.635
posttranscriptional gene silencing GO:0016441 46 0.632
oocyte differentiation GO:0009994 145 0.543
posttranscriptional gene silencing by rna GO:0035194 45 0.522
nucleosome positioning GO:0016584 3 0.521
chemosensory behavior GO:0007635 106 0.466
protein modification process GO:0036211 438 0.403
regulation of protein metabolic process GO:0051246 256 0.377
gene silencing by mirna GO:0035195 22 0.368
regulation of organelle organization GO:0033043 196 0.364
positive regulation of cellular component organization GO:0051130 156 0.359
regulation of cell cycle GO:0051726 291 0.342
regulation of cellular amino acid metabolic process GO:0006521 0 0.305
positive regulation of gene expression GO:0010628 290 0.300
organelle fission GO:0048285 340 0.296
positive regulation of rna metabolic process GO:0051254 271 0.290
rna processing GO:0006396 147 0.286
germarium derived egg chamber formation GO:0007293 101 0.265
positive regulation of rna biosynthetic process GO:1902680 266 0.258
organelle assembly GO:0070925 198 0.252
epidermal cell differentiation GO:0009913 51 0.245
peptidyl lysine modification GO:0018205 57 0.241
female germ line cyst formation GO:0048135 42 0.234
negative regulation of biosynthetic process GO:0009890 277 0.231
posttranscriptional regulation of gene expression GO:0010608 145 0.230
cellular response to dsrna GO:0071359 15 0.212
axon development GO:0061564 297 0.207
positive regulation of transcription dna templated GO:0045893 266 0.199
regulation of gene expression epigenetic GO:0040029 128 0.194
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.188
response to nitrogen compound GO:1901698 90 0.184
positive regulation of nucleic acid templated transcription GO:1903508 266 0.183
germarium derived oocyte fate determination GO:0007294 26 0.183
macromolecular complex assembly GO:0065003 256 0.179
dna metabolic process GO:0006259 227 0.159
response to dsrna GO:0043331 15 0.152
organonitrogen compound metabolic process GO:1901564 318 0.142
dna repair GO:0006281 54 0.141
ubiquitin dependent protein catabolic process GO:0006511 78 0.136
stem cell proliferation GO:0072089 88 0.135
positive regulation of cellular biosynthetic process GO:0031328 316 0.135
regulation of neuron projection development GO:0010975 69 0.133
embryo development ending in birth or egg hatching GO:0009792 152 0.132
Worm
chromosome segregation GO:0007059 157 0.131
negative regulation of rna metabolic process GO:0051253 251 0.125
gene silencing by rna GO:0031047 57 0.125
stem cell maintenance GO:0019827 67 0.124
mitochondrion organization GO:0007005 65 0.123
regulation of cellular ketone metabolic process GO:0010565 3 0.115
production of sirna involved in rna interference GO:0030422 11 0.111
reproductive system development GO:0061458 74 0.105
regulation of mitotic sister chromatid segregation GO:0033047 28 0.104
cellular macromolecular complex assembly GO:0034622 153 0.101
cellular amino acid metabolic process GO:0006520 61 0.099
cellular amine metabolic process GO:0044106 12 0.098
regulation of neuron differentiation GO:0045664 103 0.098
regulation of cellular protein metabolic process GO:0032268 243 0.098
oocyte development GO:0048599 124 0.097
response to organic cyclic compound GO:0014070 89 0.094
genitalia development GO:0048806 26 0.093
amine metabolic process GO:0009308 12 0.091
cellular response to chemical stimulus GO:0070887 199 0.091
ribonucleoside monophosphate catabolic process GO:0009158 39 0.091
growth GO:0040007 359 0.090
negative regulation of cell differentiation GO:0045596 143 0.086
larval development GO:0002164 104 0.085
cellular macromolecule catabolic process GO:0044265 136 0.083
single organism catabolic process GO:0044712 228 0.082
negative regulation of cell cycle process GO:0010948 109 0.081
mitotic g2 m transition checkpoint GO:0044818 70 0.080
positive regulation of organelle organization GO:0010638 65 0.078
germarium derived female germ line cyst formation GO:0030727 42 0.078
mitotic cell cycle phase transition GO:0044772 138 0.077
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.075
germ line cyst formation GO:0048134 44 0.075
mrna processing GO:0006397 104 0.074
metaphase anaphase transition of cell cycle GO:0044784 28 0.070
transcription from rna polymerase ii promoter GO:0006366 368 0.069
cell cycle checkpoint GO:0000075 95 0.069
ribonucleoprotein complex assembly GO:0022618 23 0.068
regulation of multicellular organismal development GO:2000026 414 0.067
regulation of cellular amine metabolic process GO:0033238 3 0.067
developmental growth GO:0048589 280 0.064
chromosome organization GO:0051276 360 0.063
epithelial cell differentiation GO:0030855 322 0.062
regulation of dendrite development GO:0050773 37 0.061
stem cell development GO:0048864 79 0.060
negative regulation of gene expression GO:0010629 387 0.059
modification dependent macromolecule catabolic process GO:0043632 79 0.059
cellular protein modification process GO:0006464 438 0.058
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.058
epithelial cell migration GO:0010631 148 0.058
head development GO:0060322 135 0.057
ncrna metabolic process GO:0034660 43 0.057
imaginal disc growth GO:0007446 37 0.057
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.056
negative regulation of nucleic acid templated transcription GO:1903507 240 0.056
mitotic dna integrity checkpoint GO:0044774 75 0.056
proteolysis GO:0006508 192 0.054
regulation of cell development GO:0060284 215 0.054
locomotory behavior GO:0007626 176 0.054
positive regulation of developmental growth GO:0048639 62 0.053
segmentation GO:0035282 207 0.053
positive regulation of developmental process GO:0051094 143 0.053
reproductive structure development GO:0048608 74 0.053
neuron projection guidance GO:0097485 241 0.052
sex differentiation GO:0007548 81 0.052
epidermis development GO:0008544 65 0.052
regulation of cell cycle process GO:0010564 181 0.051
regulation of chromosome organization GO:0033044 64 0.051
oocyte construction GO:0007308 112 0.050
negative regulation of intracellular signal transduction GO:1902532 57 0.050
organic acid metabolic process GO:0006082 103 0.048
regulation of response to stress GO:0080134 200 0.048
branching morphogenesis of an epithelial tube GO:0048754 45 0.047
cell division GO:0051301 248 0.047
Worm
multicellular organism growth GO:0035264 46 0.047
nuclear division GO:0000280 332 0.047
positive regulation of biosynthetic process GO:0009891 316 0.046
cellular response to organic substance GO:0071310 132 0.046
axonogenesis GO:0007409 290 0.046
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.046
endocytosis GO:0006897 310 0.045
negative regulation of developmental process GO:0051093 201 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.044
cell type specific apoptotic process GO:0097285 38 0.044
sister chromatid segregation GO:0000819 92 0.044
rna catabolic process GO:0006401 37 0.042
regulation of phosphate metabolic process GO:0019220 210 0.041
negative regulation of protein metabolic process GO:0051248 85 0.040
programmed cell death GO:0012501 257 0.040
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.040
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.040
oxoacid metabolic process GO:0043436 103 0.040
regulation of wnt signaling pathway GO:0030111 68 0.039
cell motility GO:0048870 251 0.038
learning or memory GO:0007611 141 0.038
mrna metabolic process GO:0016071 124 0.038
blastoderm segmentation GO:0007350 159 0.037
negative regulation of phosphorylation GO:0042326 35 0.037
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.036
response to abiotic stimulus GO:0009628 341 0.036
cellular component assembly involved in morphogenesis GO:0010927 151 0.035
nucleosome organization GO:0034728 59 0.035
positive regulation of multicellular organism growth GO:0040018 21 0.035
gene silencing GO:0016458 138 0.035
regulation of phosphorus metabolic process GO:0051174 210 0.034
skin development GO:0043588 65 0.034
regulation of epidermal cell differentiation GO:0045604 3 0.034
muscle structure development GO:0061061 224 0.034
dna integrity checkpoint GO:0031570 81 0.033
cellular catabolic process GO:0044248 372 0.033
targeting of mrna for destruction involved in rna interference GO:0030423 4 0.033
cellular ketone metabolic process GO:0042180 24 0.033
regulation of epithelial cell differentiation GO:0030856 4 0.033
outflow tract morphogenesis GO:0003151 4 0.033
positive regulation of response to stimulus GO:0048584 323 0.032
locomotor rhythm GO:0045475 56 0.032
regulation of cell cycle phase transition GO:1901987 130 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.032
negative regulation of cellular metabolic process GO:0031324 382 0.031
mitotic cell cycle checkpoint GO:0007093 88 0.030
rna phosphodiester bond hydrolysis GO:0090501 17 0.030
Human Worm
single organism behavior GO:0044708 391 0.030
organic substance catabolic process GO:1901575 308 0.030
negative regulation of cellular biosynthetic process GO:0031327 277 0.030
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.030
mitotic sister chromatid segregation GO:0000070 87 0.029
central nervous system development GO:0007417 201 0.029
negative regulation of mitotic cell cycle GO:0045930 109 0.029
covalent chromatin modification GO:0016569 106 0.029
chromatin organization GO:0006325 207 0.029
mushroom body development GO:0016319 70 0.029
regulation of mrna metabolic process GO:1903311 72 0.029
regulation of developmental growth GO:0048638 174 0.029
columnar cuboidal epithelial cell development GO:0002066 249 0.029
small molecule metabolic process GO:0044281 305 0.029
telencephalon development GO:0021537 2 0.028
karyosome formation GO:0030717 22 0.028
positive regulation of transport GO:0051050 92 0.027
positive regulation of macromolecule metabolic process GO:0010604 405 0.027
rna interference GO:0016246 27 0.027
body morphogenesis GO:0010171 2 0.026
regulation of phosphorylation GO:0042325 147 0.026
dna conformation change GO:0071103 105 0.026
oocyte axis specification GO:0007309 108 0.026
response to organic substance GO:0010033 284 0.026
heterocycle catabolic process GO:0046700 166 0.026
cell fate specification GO:0001708 71 0.025
negative regulation of phosphorus metabolic process GO:0010563 45 0.025
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.025
taxis GO:0042330 304 0.025
regulation of multi organism process GO:0043900 131 0.024
regulation of stem cell proliferation GO:0072091 40 0.024
histone h3 k9 acetylation GO:0043970 3 0.024
muscle organ development GO:0007517 127 0.024
enzyme linked receptor protein signaling pathway GO:0007167 179 0.024
carboxylic acid metabolic process GO:0019752 92 0.024
neurological system process GO:0050877 358 0.024
dna damage checkpoint GO:0000077 78 0.023
mitotic nuclear division GO:0007067 213 0.023
eye development GO:0001654 323 0.023
protein complex biogenesis GO:0070271 201 0.023
defense response to other organism GO:0098542 225 0.023
Human
ribonucleoprotein complex subunit organization GO:0071826 28 0.023
cellular response to organic cyclic compound GO:0071407 32 0.023
regulation of multicellular organism growth GO:0040014 40 0.022
neuroblast proliferation GO:0007405 74 0.022
embryonic pattern specification GO:0009880 174 0.021
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.021
chromosome separation GO:0051304 42 0.021
regulation of catabolic process GO:0009894 170 0.020
secretion by cell GO:0032940 101 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.020
negative regulation of multicellular organismal process GO:0051241 142 0.020
development of primary sexual characteristics GO:0045137 50 0.020
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
positive regulation of cell differentiation GO:0045597 64 0.020
macromolecule catabolic process GO:0009057 161 0.020
positive regulation of protein metabolic process GO:0051247 128 0.019
regulation of neurogenesis GO:0050767 158 0.019
maternal specification of dorsal ventral axis oocyte germ line encoded GO:0007311 4 0.019
regulation of cell death GO:0010941 173 0.019
olfactory behavior GO:0042048 97 0.019
hematopoietic progenitor cell differentiation GO:0002244 1 0.019
positive regulation of cellular protein metabolic process GO:0032270 118 0.019
positive regulation of signaling GO:0023056 243 0.018
ncrna processing GO:0034470 30 0.018
positive regulation of cell development GO:0010720 61 0.018
peptidyl amino acid modification GO:0018193 105 0.018
response to oxidative stress GO:0006979 86 0.017
positive regulation of multicellular organismal process GO:0051240 143 0.017
autophagy GO:0006914 108 0.017
organ growth GO:0035265 56 0.017
regionalization GO:0003002 416 0.017
spinal cord development GO:0021510 1 0.017
brain development GO:0007420 120 0.017
mitotic dna damage checkpoint GO:0044773 74 0.017
regulation of protein complex assembly GO:0043254 42 0.017
protein complex assembly GO:0006461 200 0.017
spindle assembly GO:0051225 80 0.017
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.017
regulation of cell differentiation GO:0045595 302 0.017
nuclear transcribed mrna catabolic process GO:0000956 24 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.016
purine nucleoside metabolic process GO:0042278 127 0.016
cellular response to nitrogen compound GO:1901699 51 0.016
mitotic g2 dna damage checkpoint GO:0007095 69 0.016
localization of cell GO:0051674 257 0.016
negative regulation of response to stimulus GO:0048585 258 0.016
protein transport GO:0015031 155 0.016
catabolic process GO:0009056 409 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
protein acylation GO:0043543 42 0.016
regulation of small gtpase mediated signal transduction GO:0051056 93 0.015
cell fate determination GO:0001709 91 0.015
gonad development GO:0008406 50 0.015
mitotic sister chromatid separation GO:0051306 30 0.015
sensory organ morphogenesis GO:0090596 260 0.015
regulation of growth GO:0040008 233 0.015
dorsal ventral pattern formation GO:0009953 133 0.015
regulation of cell proliferation GO:0042127 163 0.015
purine nucleoside catabolic process GO:0006152 112 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.015
positive regulation of neurogenesis GO:0050769 41 0.015
histone h2a ubiquitination GO:0033522 2 0.015
regulation of gene silencing by mirna GO:0060964 8 0.014
ribonucleotide catabolic process GO:0009261 109 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.014
translation GO:0006412 69 0.014
response to hypoxia GO:0001666 53 0.014
negative regulation of cell cycle phase transition GO:1901988 103 0.014
modification dependent protein catabolic process GO:0019941 78 0.014
multi organism behavior GO:0051705 175 0.014
meiotic nuclear division GO:0007126 151 0.014
nucleoside monophosphate catabolic process GO:0009125 39 0.014
dna dependent dna replication GO:0006261 17 0.013
cell cycle phase transition GO:0044770 140 0.013
cellular response to external stimulus GO:0071496 66 0.013
establishment of protein localization GO:0045184 163 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
mrna catabolic process GO:0006402 33 0.013
nucleotide catabolic process GO:0009166 109 0.013
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.013
atp dependent chromatin remodeling GO:0043044 22 0.013
nucleosome mobilization GO:0042766 9 0.013
cognition GO:0050890 141 0.013
regulation of chromatin modification GO:1903308 28 0.013
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.013
regulation of nervous system development GO:0051960 248 0.013
positive regulation of growth GO:0045927 75 0.013
phagocytosis GO:0006909 215 0.013
defense response GO:0006952 300 0.013
Human
regulation of histone modification GO:0031056 20 0.013
chromatin modification GO:0016568 147 0.013
ribosomal large subunit biogenesis GO:0042273 1 0.012
protein dna complex subunit organization GO:0071824 86 0.012
actin polymerization or depolymerization GO:0008154 31 0.012
histone modification GO:0016570 106 0.012
regulation of mitotic cell cycle GO:0007346 190 0.012
regulation of proteasomal protein catabolic process GO:0061136 39 0.012
regulation of programmed cell death GO:0043067 152 0.012
olfactory learning GO:0008355 56 0.012
cell growth GO:0016049 108 0.012
nucleobase containing compound transport GO:0015931 56 0.012
eye morphogenesis GO:0048592 260 0.012
dna alkylation GO:0006305 4 0.012
digestive tract development GO:0048565 149 0.012
rna 3 end processing GO:0031123 45 0.012
histone ubiquitination GO:0016574 4 0.012
dephosphorylation GO:0016311 51 0.011
compound eye development GO:0048749 307 0.011
tube fusion GO:0035146 17 0.011
organophosphate catabolic process GO:0046434 112 0.011
regulation of reproductive process GO:2000241 54 0.011
apoptotic process GO:0006915 159 0.011
negative regulation of nervous system development GO:0051961 92 0.011
regulation of apoptotic process GO:0042981 130 0.011
organic substance transport GO:0071702 257 0.011
response to oxygen containing compound GO:1901700 200 0.011
developmental maturation GO:0021700 172 0.011
single organism biosynthetic process GO:0044711 206 0.011
death GO:0016265 284 0.011
ameboidal type cell migration GO:0001667 151 0.011
negative regulation of cell death GO:0060548 81 0.011
negative regulation of organelle organization GO:0010639 56 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
regulation of sister chromatid segregation GO:0033045 28 0.011
regulation of gene silencing GO:0060968 63 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
mapk cascade GO:0000165 107 0.011
amino acid activation GO:0043038 3 0.011
dendrite guidance GO:0070983 21 0.010
eye photoreceptor cell differentiation GO:0001754 145 0.010
regulation of transcription by chromatin organization GO:0034401 3 0.010
regulation of mrna processing GO:0050684 71 0.010
regulation of localization GO:0032879 275 0.010
phosphorylation GO:0016310 294 0.010
gliogenesis GO:0042063 80 0.010
histone exchange GO:0043486 21 0.010
cellular protein localization GO:0034613 160 0.010
purine nucleoside monophosphate metabolic process GO:0009126 50 0.010
digestive system development GO:0055123 149 0.010

drosha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.066
cancer DOID:162 0 0.027
disease of anatomical entity DOID:7 0 0.026
organ system cancer DOID:0050686 0 0.023