Drosophila melanogaster

16 known processes

APP-BP1 (Dmel_CG7828)

beta-Amyloid precursor protein binding protein 1

(Aliases: Dmel\CG7828,CG7828,anon-WO0140519.225,APPBP1,dAPP-BP1)

APP-BP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.170
regulation of cell death GO:0010941 173 0.139
protein complex biogenesis GO:0070271 201 0.123
homeostatic process GO:0042592 199 0.115
positive regulation of programmed cell death GO:0043068 62 0.114
epithelial cell differentiation GO:0030855 322 0.114
compound eye morphogenesis GO:0001745 249 0.088
transcription from rna polymerase ii promoter GO:0006366 368 0.087
columnar cuboidal epithelial cell development GO:0002066 249 0.087
protein modification by small protein conjugation or removal GO:0070647 106 0.083
oxidation reduction process GO:0055114 123 0.081
positive regulation of cell death GO:0010942 69 0.076
cellular macromolecular complex assembly GO:0034622 153 0.076
cell proliferation GO:0008283 299 0.076
regionalization GO:0003002 416 0.072
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.071
regulation of erbb signaling pathway GO:1901184 42 0.069
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.068
cell death GO:0008219 279 0.067
regulation of cell development GO:0060284 215 0.067
ovarian follicle cell development GO:0030707 248 0.066
positive regulation of macromolecule metabolic process GO:0010604 405 0.066
regulation of apoptotic process GO:0042981 130 0.065
negative regulation of signaling GO:0023057 219 0.061
positive regulation of response to stimulus GO:0048584 323 0.060
vesicle mediated transport GO:0016192 381 0.060
appendage morphogenesis GO:0035107 397 0.060
ribonucleoside triphosphate metabolic process GO:0009199 119 0.057
response to oxidative stress GO:0006979 86 0.055
single organism membrane fusion GO:0044801 42 0.054
regulation of cell cycle GO:0051726 291 0.054
negative regulation of response to stimulus GO:0048585 258 0.053
intracellular transport GO:0046907 228 0.050
programmed cell death GO:0012501 257 0.049
regulation of cell cycle process GO:0010564 181 0.049
organelle assembly GO:0070925 198 0.049
epithelial cell development GO:0002064 274 0.048
proteolysis GO:0006508 192 0.048
atp metabolic process GO:0046034 49 0.048
regulation of mitotic cell cycle GO:0007346 190 0.047
negative regulation of signal transduction GO:0009968 206 0.047
rna processing GO:0006396 147 0.046
positive regulation of apoptotic signaling pathway GO:2001235 4 0.045
negative regulation of nucleic acid templated transcription GO:1903507 240 0.045
rna splicing GO:0008380 83 0.045
protein modification process GO:0036211 438 0.045
eye development GO:0001654 323 0.043
membrane fusion GO:0061025 42 0.042
eye morphogenesis GO:0048592 260 0.042
axonogenesis GO:0007409 290 0.042
endocytosis GO:0006897 310 0.042
intrinsic apoptotic signaling pathway GO:0097193 16 0.041
negative regulation of cell communication GO:0010648 223 0.041
positive regulation of cell communication GO:0010647 250 0.040
skin development GO:0043588 65 0.040
imaginal disc derived appendage development GO:0048737 399 0.038
erbb signaling pathway GO:0038127 58 0.038
ribonucleoside metabolic process GO:0009119 127 0.038
segmentation GO:0035282 207 0.038
cell division GO:0051301 248 0.037
endosomal transport GO:0016197 44 0.037
positive regulation of proteolysis GO:0045862 52 0.037
positive regulation of gene expression GO:0010628 290 0.036
negative regulation of transcription dna templated GO:0045892 237 0.036
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.036
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.035
regulation of catalytic activity GO:0050790 185 0.035
membrane organization GO:0061024 112 0.034
purine ribonucleoside metabolic process GO:0046128 127 0.034
positive regulation of endopeptidase activity GO:0010950 26 0.034
appendage development GO:0048736 401 0.034
enzyme linked receptor protein signaling pathway GO:0007167 179 0.034
glycosyl compound metabolic process GO:1901657 127 0.033
regulation of cell differentiation GO:0045595 302 0.033
response to radiation GO:0009314 155 0.032
epidermal growth factor receptor signaling pathway GO:0007173 58 0.032
regulation of cell cycle phase transition GO:1901987 130 0.032
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.031
negative regulation of cell death GO:0060548 81 0.030
response to external biotic stimulus GO:0043207 293 0.030
defense response to other organism GO:0098542 225 0.030
regulation of wnt signaling pathway GO:0030111 68 0.030
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.029
morphogenesis of a polarized epithelium GO:0001738 93 0.029
chromosome segregation GO:0007059 157 0.029
neuron projection guidance GO:0097485 241 0.028
cell motility GO:0048870 251 0.028
nucleoside phosphate metabolic process GO:0006753 162 0.028
positive regulation of transcription dna templated GO:0045893 266 0.027
negative regulation of developmental process GO:0051093 201 0.027
purine ribonucleoside catabolic process GO:0046130 112 0.027
regulation of response to stress GO:0080134 200 0.027
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.027
tissue morphogenesis GO:0048729 297 0.026
macromolecular complex assembly GO:0065003 256 0.026
regulation of cellular component size GO:0032535 98 0.026
developmental maturation GO:0021700 172 0.026
positive regulation of signal transduction GO:0009967 223 0.026
nucleoside monophosphate metabolic process GO:0009123 52 0.026
protein ubiquitination GO:0016567 70 0.026
apoptotic process GO:0006915 159 0.026
purine nucleoside monophosphate metabolic process GO:0009126 50 0.026
dna metabolic process GO:0006259 227 0.026
organelle fusion GO:0048284 46 0.026
activation of cysteine type endopeptidase activity GO:0097202 17 0.026
cellular amino acid metabolic process GO:0006520 61 0.025
regulation of growth GO:0040008 233 0.025
intracellular signal transduction GO:0035556 300 0.025
oocyte axis specification GO:0007309 108 0.025
phagocytosis GO:0006909 215 0.025
organonitrogen compound metabolic process GO:1901564 318 0.025
compound eye development GO:0048749 307 0.025
single organism membrane organization GO:0044802 93 0.024
establishment or maintenance of cell polarity GO:0007163 167 0.024
oocyte differentiation GO:0009994 145 0.024
purine containing compound metabolic process GO:0072521 155 0.024
wing disc morphogenesis GO:0007472 344 0.024
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.024
chemotaxis GO:0006935 249 0.024
regulation of molecular function GO:0065009 217 0.023
anatomical structure homeostasis GO:0060249 97 0.023
regulation of phosphate metabolic process GO:0019220 210 0.023
establishment of organelle localization GO:0051656 122 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.023
cellular component assembly involved in morphogenesis GO:0010927 151 0.023
rna splicing via transesterification reactions GO:0000375 73 0.023
regulation of nervous system development GO:0051960 248 0.023
morphogenesis of an epithelium GO:0002009 276 0.023
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.023
nucleoside triphosphate metabolic process GO:0009141 120 0.022
positive regulation of protein metabolic process GO:0051247 128 0.022
purine ribonucleotide metabolic process GO:0009150 145 0.022
regulation of cellular protein metabolic process GO:0032268 243 0.022
cytoplasmic transport GO:0016482 130 0.021
meiotic nuclear division GO:0007126 151 0.021
mrna processing GO:0006397 104 0.021
cell maturation GO:0048469 144 0.021
purine nucleoside catabolic process GO:0006152 112 0.021
cellular response to radiation GO:0071478 52 0.021
neuron remodeling GO:0016322 29 0.021
sensory organ morphogenesis GO:0090596 260 0.021
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.020
cellular protein modification process GO:0006464 438 0.020
regulation of multicellular organismal development GO:2000026 414 0.020
mrna metabolic process GO:0016071 124 0.020
establishment of localization in cell GO:0051649 402 0.020
regulation of programmed cell death GO:0043067 152 0.020
positive regulation of rna metabolic process GO:0051254 271 0.020
purine nucleoside metabolic process GO:0042278 127 0.020
imaginal disc derived appendage morphogenesis GO:0035114 395 0.020
nucleobase containing small molecule metabolic process GO:0055086 174 0.020
cell cycle phase transition GO:0044770 140 0.019
regulation of intracellular signal transduction GO:1902531 236 0.019
protein modification by small protein conjugation GO:0032446 79 0.019
epidermis development GO:0008544 65 0.019
nuclear division GO:0000280 332 0.019
cellular macromolecule catabolic process GO:0044265 136 0.019
growth GO:0040007 359 0.018
carbohydrate derivative catabolic process GO:1901136 118 0.018
phosphorylation GO:0016310 294 0.018
regulation of mitotic cell cycle phase transition GO:1901990 130 0.018
positive regulation of signaling GO:0023056 243 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.018
regulation of proteolysis GO:0030162 87 0.018
regulation of cell proliferation GO:0042127 163 0.018
cellular nitrogen compound catabolic process GO:0044270 165 0.018
protein complex assembly GO:0006461 200 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
male gamete generation GO:0048232 201 0.017
cellular protein complex assembly GO:0043623 71 0.017
regulation of phosphorus metabolic process GO:0051174 210 0.017
protein localization GO:0008104 284 0.017
imaginal disc derived wing morphogenesis GO:0007476 337 0.017
regulation of organelle organization GO:0033043 196 0.017
single organism intracellular transport GO:1902582 207 0.016
response to oxygen containing compound GO:1901700 200 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.016
response to extracellular stimulus GO:0009991 116 0.016
regulation of protein metabolic process GO:0051246 256 0.016
response to abiotic stimulus GO:0009628 341 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.016
positive regulation of rna biosynthetic process GO:1902680 266 0.016
negative regulation of programmed cell death GO:0043069 72 0.016
regulation of anatomical structure size GO:0090066 163 0.016
dendrite morphogenesis GO:0048813 199 0.016
eye photoreceptor cell differentiation GO:0001754 145 0.016
positive regulation of nucleic acid templated transcription GO:1903508 266 0.016
regulation of transport GO:0051049 181 0.016
embryonic axis specification GO:0000578 107 0.016
regulation of immune response GO:0050776 118 0.016
regulation of defense response GO:0031347 102 0.016
response to light stimulus GO:0009416 124 0.016
organophosphate metabolic process GO:0019637 195 0.015
cellular homeostasis GO:0019725 80 0.015
axon guidance GO:0007411 233 0.015
germarium derived egg chamber formation GO:0007293 101 0.015
organelle fission GO:0048285 340 0.015
neural precursor cell proliferation GO:0061351 75 0.015
instar larval development GO:0002168 55 0.015
sex differentiation GO:0007548 81 0.015
response to inorganic substance GO:0010035 44 0.015
purine nucleoside monophosphate catabolic process GO:0009128 38 0.015
positive regulation of apoptotic process GO:0043065 47 0.015
reproductive structure development GO:0048608 74 0.015
negative regulation of rna metabolic process GO:0051253 251 0.014
positive regulation of peptidase activity GO:0010952 29 0.014
photoreceptor cell differentiation GO:0046530 170 0.014
neuron maturation GO:0042551 31 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
negative regulation of cell proliferation GO:0008285 69 0.014
regulation of multi organism process GO:0043900 131 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
protein maturation GO:0051604 71 0.014
response to ionizing radiation GO:0010212 32 0.014
stem cell division GO:0017145 69 0.014
wnt signaling pathway GO:0016055 98 0.013
ribonucleotide catabolic process GO:0009261 109 0.013
neuromuscular junction development GO:0007528 149 0.013
cell growth GO:0016049 108 0.013
positive regulation of biosynthetic process GO:0009891 316 0.013
mitotic dna damage checkpoint GO:0044773 74 0.013
nucleoside catabolic process GO:0009164 112 0.013
positive regulation of wnt signaling pathway GO:0030177 25 0.013
organophosphate catabolic process GO:0046434 112 0.013
cell cycle arrest GO:0007050 4 0.013
negative regulation of erbb signaling pathway GO:1901185 29 0.013
organelle localization GO:0051640 148 0.013
body morphogenesis GO:0010171 2 0.013
positive regulation of cellular biosynthetic process GO:0031328 316 0.013
cellular catabolic process GO:0044248 372 0.013
larval development GO:0002164 104 0.013
regulation of innate immune response GO:0045088 71 0.013
positive regulation of molecular function GO:0044093 136 0.013
mitotic cell cycle phase transition GO:0044772 138 0.013
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.012
ribonucleoside monophosphate metabolic process GO:0009161 51 0.012
oocyte construction GO:0007308 112 0.012
nucleotide catabolic process GO:0009166 109 0.012
regulation of peptidase activity GO:0052547 39 0.012
transmembrane transport GO:0055085 139 0.012
synaptic vesicle localization GO:0097479 53 0.012
female meiotic division GO:0007143 70 0.012
anterior posterior axis specification GO:0009948 109 0.012
development of primary sexual characteristics GO:0045137 50 0.012
immune system process GO:0002376 347 0.012
developmental growth GO:0048589 280 0.012
centrosome organization GO:0051297 163 0.012
gonad development GO:0008406 50 0.012
extracellular matrix assembly GO:0085029 13 0.012
posttranscriptional regulation of gene expression GO:0010608 145 0.012
cellular response to oxidative stress GO:0034599 28 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
small gtpase mediated signal transduction GO:0007264 88 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
anterior posterior pattern specification GO:0009952 136 0.011
g2 dna damage checkpoint GO:0031572 69 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
regulation of cellular component biogenesis GO:0044087 201 0.011
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.011
mrna splicing via spliceosome GO:0000398 73 0.011
cellular respiration GO:0045333 26 0.011
ion transmembrane transport GO:0034220 122 0.011
imaginal disc derived leg segmentation GO:0036011 26 0.011
cytoplasm organization GO:0007028 64 0.011
axon development GO:0061564 297 0.011
centrosome duplication GO:0051298 121 0.011
energy derivation by oxidation of organic compounds GO:0015980 32 0.011
ribonucleoside monophosphate catabolic process GO:0009158 39 0.011
response to other organism GO:0051707 293 0.011
organic substance catabolic process GO:1901575 308 0.011
stem cell proliferation GO:0072089 88 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.011
vesicle organization GO:0016050 44 0.011
asymmetric protein localization GO:0008105 33 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.010
post embryonic appendage morphogenesis GO:0035120 385 0.010
actin filament based process GO:0030029 220 0.010
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.010
protein phosphorylation GO:0006468 169 0.010
regulation of cysteine type endopeptidase activity GO:2000116 27 0.010

APP-BP1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.046
cancer DOID:162 0 0.034
disease of cellular proliferation DOID:14566 0 0.034
organ system cancer DOID:0050686 0 0.015
nervous system disease DOID:863 0 0.015