Drosophila melanogaster

55 known processes

opa1-like (Dmel_CG8479)

optic atrophy 1-like

(Aliases: CG8479,dOPA1,OPA1,OPA1-like,Opa1-like,Dmel\CG8479,opa1,l(2)s3475,Opa1,dOpa1)

opa1-like biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of mitochondrial fusion GO:0010635 5 0.716
mitochondrion organization GO:0007005 65 0.684
regulation of mitochondrion organization GO:0010821 12 0.604
mitochondrial fission GO:0000266 8 0.581
sperm mitochondrion organization GO:0030382 7 0.379
regulation of mitochondrial fission GO:0090140 7 0.303
transmembrane transport GO:0055085 139 0.299
positive regulation of mitochondrion organization GO:0010822 8 0.277
mitochondrion morphogenesis GO:0070584 8 0.262
mitochondrial fusion GO:0008053 7 0.256
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.251
transcription from rna polymerase ii promoter GO:0006366 368 0.166
small molecule metabolic process GO:0044281 305 0.156
mitotic g2 m transition checkpoint GO:0044818 70 0.140
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.135
regulation of cell death GO:0010941 173 0.130
mitotic dna damage checkpoint GO:0044773 74 0.129
cytoplasmic transport GO:0016482 130 0.125
heterocycle catabolic process GO:0046700 166 0.118
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.107
eye development GO:0001654 323 0.103
g2 dna damage checkpoint GO:0031572 69 0.097
death GO:0016265 284 0.095
mitotic g2 dna damage checkpoint GO:0007095 69 0.092
circulatory system process GO:0003013 37 0.091
single organism intracellular transport GO:1902582 207 0.091
cation transport GO:0006812 110 0.087
regulation of protein depolymerization GO:1901879 27 0.084
compound eye development GO:0048749 307 0.081
protein localization GO:0008104 284 0.080
regulation of anatomical structure morphogenesis GO:0022603 242 0.079
cell death GO:0008219 279 0.074
regulation of nervous system development GO:0051960 248 0.074
heart process GO:0003015 37 0.072
mitotic dna integrity checkpoint GO:0044774 75 0.067
wnt signaling pathway GO:0016055 98 0.067
tube morphogenesis GO:0035239 191 0.065
organelle fission GO:0048285 340 0.064
establishment or maintenance of cell polarity GO:0007163 167 0.064
regulation of protein complex disassembly GO:0043244 29 0.062
negative regulation of protein depolymerization GO:1901880 23 0.062
metal ion transport GO:0030001 74 0.060
cellular protein complex disassembly GO:0043624 35 0.060
ion transport GO:0006811 145 0.059
negative regulation of cytoskeleton organization GO:0051494 30 0.059
heart contraction GO:0060047 26 0.058
camera type eye development GO:0043010 4 0.057
dna damage checkpoint GO:0000077 78 0.057
lipid homeostasis GO:0055088 33 0.056
mitochondrion degradation GO:0000422 8 0.056
cellular amino acid metabolic process GO:0006520 61 0.055
establishment of mitochondrion localization GO:0051654 7 0.055
cation transmembrane transport GO:0098655 88 0.053
regulation of programmed cell death GO:0043067 152 0.052
ethanolamine containing compound metabolic process GO:0042439 4 0.051
negative regulation of cell cycle phase transition GO:1901988 103 0.050
metal ion homeostasis GO:0055065 44 0.047
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.047
er nucleus signaling pathway GO:0006984 9 0.046
organic acid metabolic process GO:0006082 103 0.046
establishment of localization in cell GO:0051649 402 0.044
oxoacid metabolic process GO:0043436 103 0.044
response to abiotic stimulus GO:0009628 341 0.044
regionalization GO:0003002 416 0.044
carboxylic acid metabolic process GO:0019752 92 0.043
central nervous system development GO:0007417 201 0.043
blood circulation GO:0008015 26 0.043
organonitrogen compound metabolic process GO:1901564 318 0.043
single organism behavior GO:0044708 391 0.042
chaeta development GO:0022416 97 0.041
single organism cellular localization GO:1902580 180 0.040
negative regulation of organelle organization GO:0010639 56 0.040
imaginal disc derived wing morphogenesis GO:0007476 337 0.040
regulation of heart rate GO:0002027 11 0.039
mitotic cell cycle checkpoint GO:0007093 88 0.039
dna integrity checkpoint GO:0031570 81 0.039
imaginal disc derived appendage morphogenesis GO:0035114 395 0.039
oxidation reduction process GO:0055114 123 0.038
locomotory behavior GO:0007626 176 0.038
neural retina development GO:0003407 4 0.038
macromolecular complex disassembly GO:0032984 37 0.038
regulation of membrane potential GO:0042391 35 0.038
response to external biotic stimulus GO:0043207 293 0.037
body morphogenesis GO:0010171 2 0.037
retina development in camera type eye GO:0060041 4 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.037
ion transmembrane transport GO:0034220 122 0.037
compound eye morphogenesis GO:0001745 249 0.036
cellular response to sterol depletion GO:0071501 3 0.035
proteolysis GO:0006508 192 0.035
response to temperature stimulus GO:0009266 106 0.035
apoptotic process GO:0006915 159 0.034
cell proliferation GO:0008283 299 0.034
calcium ion transmembrane transport GO:0070588 17 0.033
endoplasmic reticulum organization GO:0007029 13 0.033
positive regulation of phosphorus metabolic process GO:0010562 139 0.033
eye morphogenesis GO:0048592 260 0.033
generation of precursor metabolites and energy GO:0006091 42 0.032
negative regulation of microtubule depolymerization GO:0007026 21 0.032
positive regulation of rna metabolic process GO:0051254 271 0.031
regulation of multicellular organismal development GO:2000026 414 0.031
negative regulation of cell cycle process GO:0010948 109 0.031
positive regulation of organelle organization GO:0010638 65 0.031
negative regulation of response to stimulus GO:0048585 258 0.031
cell migration GO:0016477 238 0.030
positive regulation of macromolecule metabolic process GO:0010604 405 0.030
membrane organization GO:0061024 112 0.030
programmed cell death GO:0012501 257 0.030
negative regulation of cell death GO:0060548 81 0.030
cell aging GO:0007569 2 0.029
single organism membrane organization GO:0044802 93 0.029
macromolecular complex assembly GO:0065003 256 0.029
cell cycle checkpoint GO:0000075 95 0.029
wing disc morphogenesis GO:0007472 344 0.028
positive regulation of cell motility GO:2000147 3 0.028
regulation of intracellular signal transduction GO:1902531 236 0.028
protein complex biogenesis GO:0070271 201 0.028
positive regulation of hydrolase activity GO:0051345 78 0.027
immune system process GO:0002376 347 0.027
regulation of hydrolase activity GO:0051336 97 0.027
positive regulation of cellular component organization GO:0051130 156 0.027
epidermis development GO:0008544 65 0.026
epithelial cell differentiation GO:0030855 322 0.026
response to biotic stimulus GO:0009607 294 0.026
regulation of catalytic activity GO:0050790 185 0.026
lipid metabolic process GO:0006629 121 0.026
phagocytosis GO:0006909 215 0.026
purine ribonucleoside metabolic process GO:0046128 127 0.026
endocytosis GO:0006897 310 0.026
camera type eye morphogenesis GO:0048593 2 0.025
organelle localization GO:0051640 148 0.025
regulation of heart contraction GO:0008016 21 0.025
regulation of cellular amine metabolic process GO:0033238 3 0.025
positive regulation of biosynthetic process GO:0009891 316 0.025
regulation of microtubule based process GO:0032886 49 0.024
aging GO:0007568 143 0.024
response to superoxide GO:0000303 3 0.024
potassium ion transport GO:0006813 20 0.024
cellular protein localization GO:0034613 160 0.024
organelle assembly GO:0070925 198 0.024
synaptic vesicle transport GO:0048489 50 0.024
regulation of cellular component movement GO:0051270 42 0.024
chemical homeostasis GO:0048878 92 0.023
negative regulation of programmed cell death GO:0043069 72 0.023
organic hydroxy compound biosynthetic process GO:1901617 21 0.023
regulation of transport GO:0051049 181 0.023
atp metabolic process GO:0046034 49 0.023
positive regulation of gene expression GO:0010628 290 0.022
regulation of localization GO:0032879 275 0.022
negative regulation of nucleic acid templated transcription GO:1903507 240 0.022
regulation of transmembrane transport GO:0034762 27 0.022
regulation of cell development GO:0060284 215 0.021
negative regulation of apoptotic process GO:0043066 63 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.021
negative regulation of growth GO:0045926 84 0.021
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.020
negative regulation of protein complex disassembly GO:0043242 23 0.020
protein maturation GO:0051604 71 0.020
nucleobase containing compound catabolic process GO:0034655 165 0.020
organic substance transport GO:0071702 257 0.020
alditol phosphate metabolic process GO:0052646 2 0.020
post embryonic appendage morphogenesis GO:0035120 385 0.020
regulation of cell cycle phase transition GO:1901987 130 0.020
positive regulation of response to stimulus GO:0048584 323 0.020
neuronal action potential GO:0019228 10 0.020
nucleoside triphosphate catabolic process GO:0009143 108 0.020
protein depolymerization GO:0051261 31 0.020
cell cycle phase transition GO:0044770 140 0.019
purine containing compound metabolic process GO:0072521 155 0.019
protein complex disassembly GO:0043241 36 0.019
cellular response to dna damage stimulus GO:0006974 223 0.019
phosphatidylcholine metabolic process GO:0046470 3 0.019
monovalent inorganic cation transport GO:0015672 40 0.019
establishment of planar polarity GO:0001736 87 0.019
positive regulation of catalytic activity GO:0043085 118 0.019
positive regulation of catabolic process GO:0009896 105 0.019
nucleus organization GO:0006997 45 0.019
cell cycle arrest GO:0007050 4 0.019
cellular macromolecular complex assembly GO:0034622 153 0.019
retrograde axon cargo transport GO:0008090 9 0.019
cellular amine metabolic process GO:0044106 12 0.018
negative regulation of cellular component organization GO:0051129 108 0.018
regulation of blood circulation GO:1903522 21 0.018
positive regulation of programmed cell death GO:0043068 62 0.018
regulation of molecular function GO:0065009 217 0.018
transmission of nerve impulse GO:0019226 12 0.018
organophosphate metabolic process GO:0019637 195 0.018
homeostatic process GO:0042592 199 0.018
endomembrane system organization GO:0010256 119 0.018
tube development GO:0035295 244 0.018
intracellular signal transduction GO:0035556 300 0.018
cellular macromolecule localization GO:0070727 220 0.018
morphogenesis of an epithelium GO:0002009 276 0.018
embryo development ending in birth or egg hatching GO:0009792 152 0.018
brain development GO:0007420 120 0.018
single organism biosynthetic process GO:0044711 206 0.017
spindle organization GO:0007051 253 0.017
regulation of mitotic cell cycle phase transition GO:1901990 130 0.017
positive regulation of nucleic acid templated transcription GO:1903508 266 0.017
adult locomotory behavior GO:0008344 76 0.017
negative regulation of cell communication GO:0010648 223 0.017
protein processing GO:0016485 68 0.017
meiotic cell cycle GO:0051321 171 0.017
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
nucleotide catabolic process GO:0009166 109 0.017
divalent metal ion transport GO:0070838 26 0.017
cellular catabolic process GO:0044248 372 0.017
wound healing GO:0042060 75 0.017
cellularization GO:0007349 90 0.016
positive regulation of signaling GO:0023056 243 0.016
regulation of phosphate metabolic process GO:0019220 210 0.016
regulation of cell cycle process GO:0010564 181 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.016
mitochondrion localization GO:0051646 17 0.016
negative regulation of mitotic cell cycle GO:0045930 109 0.016
embryonic morphogenesis GO:0048598 206 0.016
positive regulation of developmental process GO:0051094 143 0.016
negative regulation of multicellular organismal process GO:0051241 142 0.016
inorganic cation transmembrane transport GO:0098662 61 0.016
skin development GO:0043588 65 0.016
phosphorylation GO:0016310 294 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
establishment of organelle localization GO:0051656 122 0.015
ameboidal type cell migration GO:0001667 151 0.015
regulation of organelle organization GO:0033043 196 0.015
anion homeostasis GO:0055081 3 0.015
intracellular transport GO:0046907 228 0.015
response to wounding GO:0009611 94 0.015
protein transport GO:0015031 155 0.014
alcohol biosynthetic process GO:0046165 14 0.014
positive regulation of signal transduction GO:0009967 223 0.014
glial cell differentiation GO:0010001 35 0.014
neuron death GO:0070997 27 0.014
appendage morphogenesis GO:0035107 397 0.014
purine nucleoside monophosphate metabolic process GO:0009126 50 0.014
protein ubiquitination GO:0016567 70 0.014
spermatogenesis GO:0007283 200 0.014
aromatic compound catabolic process GO:0019439 166 0.014
localization of cell GO:0051674 257 0.014
nuclear transport GO:0051169 72 0.014
cellular respiration GO:0045333 26 0.014
regulation of developmental pigmentation GO:0048070 24 0.014
regulation of neuron death GO:1901214 26 0.014
adult somatic muscle development GO:0007527 14 0.014
amine metabolic process GO:0009308 12 0.014
spindle assembly GO:0051225 80 0.014
cellular macromolecule catabolic process GO:0044265 136 0.014
response to other organism GO:0051707 293 0.014
protein catabolic process GO:0030163 101 0.013
regulation of execution phase of apoptosis GO:1900117 5 0.013
negative regulation of gene expression GO:0010629 387 0.013
endodermal cell differentiation GO:0035987 3 0.013
multicellular organismal aging GO:0010259 140 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.013
organic acid catabolic process GO:0016054 16 0.013
positive regulation of molecular function GO:0044093 136 0.013
axon cargo transport GO:0008088 29 0.013
response to copper ion GO:0046688 4 0.013
zymogen activation GO:0031638 20 0.013
regulation of retinal cell programmed cell death GO:0046668 18 0.013
actin polymerization or depolymerization GO:0008154 31 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
cellular response to topologically incorrect protein GO:0035967 10 0.013
inositol lipid mediated signaling GO:0048017 4 0.013
establishment of protein localization GO:0045184 163 0.013
ribonucleoside monophosphate metabolic process GO:0009161 51 0.012
regulation of apoptotic process GO:0042981 130 0.012
response to oxygen radical GO:0000305 3 0.012
fatty acid homeostasis GO:0055089 2 0.012
positive regulation of nucleoside metabolic process GO:0045979 47 0.012
regulation of wnt signaling pathway GO:0030111 68 0.012
imaginal disc derived wing hair organization GO:0035317 45 0.012
asymmetric stem cell division GO:0098722 49 0.012
regulation of ion transmembrane transport GO:0034765 27 0.012
regulation of anatomical structure size GO:0090066 163 0.012
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.012
vesicle mediated transport GO:0016192 381 0.012
catabolic process GO:0009056 409 0.012
male gamete generation GO:0048232 201 0.012
pole cell formation GO:0007279 19 0.012
regulation of gtpase activity GO:0043087 44 0.012
positive regulation of cell death GO:0010942 69 0.012
negative regulation of neuron apoptotic process GO:0043524 14 0.012
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
asymmetric protein localization GO:0008105 33 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
protein heterooligomerization GO:0051291 4 0.012
endoderm formation GO:0001706 3 0.012
imaginal disc derived appendage development GO:0048737 399 0.012
regulation of cell cycle GO:0051726 291 0.012
erbb signaling pathway GO:0038127 58 0.011
microtubule depolymerization GO:0007019 25 0.011
cellular component disassembly GO:0022411 46 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
positive regulation of apoptotic process GO:0043065 47 0.011
ncrna metabolic process GO:0034660 43 0.011
regulation of transferase activity GO:0051338 58 0.011
neuroblast proliferation GO:0007405 74 0.011
response to decreased oxygen levels GO:0036293 58 0.011
microtubule based movement GO:0007018 51 0.011
regulation of ion transport GO:0043269 39 0.011
nuclear division GO:0000280 332 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
positive regulation of rna biosynthetic process GO:1902680 266 0.011
energy derivation by oxidation of organic compounds GO:0015980 32 0.011
secretion GO:0046903 109 0.011
epithelial cell development GO:0002064 274 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
negative regulation of epithelial cell proliferation GO:0050680 4 0.011
organophosphate catabolic process GO:0046434 112 0.011
humoral immune response GO:0006959 117 0.011
regulation of microtubule cytoskeleton organization GO:0070507 41 0.011
mitochondrion transport along microtubule GO:0047497 5 0.011
defense response GO:0006952 300 0.011
microtubule polymerization or depolymerization GO:0031109 39 0.011
developmental programmed cell death GO:0010623 138 0.011
purine nucleoside triphosphate catabolic process GO:0009146 108 0.011
cellular amide metabolic process GO:0043603 80 0.011
germ cell migration GO:0008354 43 0.011
regulation of response to oxidative stress GO:1902882 4 0.011
negative regulation of cell proliferation GO:0008285 69 0.010
lipid biosynthetic process GO:0008610 46 0.010
regulation of system process GO:0044057 36 0.010
multicellular organismal signaling GO:0035637 12 0.010
leg disc development GO:0035218 92 0.010
muscle tissue morphogenesis GO:0060415 2 0.010
response to endoplasmic reticulum stress GO:0034976 28 0.010
nuclear dna replication GO:0033260 1 0.010
negative regulation of cell differentiation GO:0045596 143 0.010
purine containing compound biosynthetic process GO:0072522 30 0.010

opa1-like disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.054
disease of cellular proliferation DOID:14566 0 0.054
organ system cancer DOID:0050686 0 0.054
disease of anatomical entity DOID:7 0 0.048
nervous system disease DOID:863 0 0.032
central nervous system disease DOID:331 0 0.020
neurodegenerative disease DOID:1289 0 0.019
muscular disease DOID:0080000 0 0.017
musculoskeletal system disease DOID:17 0 0.017
myopathy DOID:423 0 0.012
heart disease DOID:114 0 0.012
cardiomyopathy DOID:0050700 0 0.012
intrinsic cardiomyopathy DOID:0060036 0 0.012
cardiovascular system disease DOID:1287 0 0.012
muscle tissue disease DOID:66 0 0.012
parkinson s disease DOID:14330 0 0.011
synucleinopathy DOID:0050890 0 0.011