Drosophila melanogaster

150 known processes

Pdf (Dmel_CG6496)

Pigment-dispersing factor

(Aliases: PAP,cPDH,anon-WO0140519.261,CG6496,Dmel\CG6496,pdf,anon-WO0140519.3,Drm-PDF,PDH,PDF,Drm-PDH,BcDNA:RH08487,Drm-pdf)

Pdf biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
circadian rhythm GO:0007623 105 0.996
rhythmic behavior GO:0007622 76 0.987
circadian behavior GO:0048512 76 0.982
rhythmic process GO:0048511 106 0.970
locomotor rhythm GO:0045475 56 0.967
single organism behavior GO:0044708 391 0.941
multi organism behavior GO:0051705 175 0.883
mating behavior GO:0007617 106 0.833
gravitaxis GO:0042332 26 0.810
regulation of behavior GO:0050795 75 0.808
mating GO:0007618 120 0.799
reproductive behavior GO:0019098 122 0.676
locomotory behavior GO:0007626 176 0.639
sleep GO:0030431 49 0.574
multi organism reproductive behavior GO:0044705 121 0.514
multicellular organismal reproductive behavior GO:0033057 110 0.336
entrainment of circadian clock GO:0009649 16 0.316
response to gravity GO:0009629 26 0.315
regulation of circadian rhythm GO:0042752 49 0.277
regulation of circadian sleep wake cycle GO:0042749 25 0.248
purine containing compound biosynthetic process GO:0072522 30 0.247
multi multicellular organism process GO:0044706 123 0.223
neurological system process GO:0050877 358 0.168
regulation of cell proliferation GO:0042127 163 0.160
detection of stimulus GO:0051606 156 0.155
positive regulation of biosynthetic process GO:0009891 316 0.154
purine containing compound metabolic process GO:0072521 155 0.153
sensory perception GO:0007600 196 0.153
regulation of circadian sleep wake cycle sleep GO:0045187 21 0.144
taxis GO:0042330 304 0.141
nucleobase containing small molecule metabolic process GO:0055086 174 0.141
female mating behavior GO:0060180 30 0.134
organonitrogen compound metabolic process GO:1901564 318 0.131
cell proliferation GO:0008283 299 0.126
organophosphate metabolic process GO:0019637 195 0.124
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.123
detection of stimulus involved in sensory perception GO:0050906 92 0.122
response to oxygen containing compound GO:1901700 200 0.115
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.111
inter male aggressive behavior GO:0002121 60 0.105
negative regulation of response to stimulus GO:0048585 258 0.100
anatomical structure homeostasis GO:0060249 97 0.098
negative regulation of cellular biosynthetic process GO:0031327 277 0.097
protein localization GO:0008104 284 0.090
adult behavior GO:0030534 137 0.090
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.090
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.083
positive regulation of macromolecule metabolic process GO:0010604 405 0.083
positive regulation of rna biosynthetic process GO:1902680 266 0.079
positive regulation of cell growth GO:0030307 19 0.078
ribose phosphate metabolic process GO:0019693 145 0.078
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.077
enzyme linked receptor protein signaling pathway GO:0007167 179 0.077
behavioral response to ethanol GO:0048149 49 0.072
response to organic substance GO:0010033 284 0.071
cellular response to chemical stimulus GO:0070887 199 0.069
nucleoside phosphate metabolic process GO:0006753 162 0.068
circadian sleep wake cycle process GO:0022410 24 0.067
aggressive behavior GO:0002118 63 0.067
positive regulation of phosphate metabolic process GO:0045937 139 0.064
organ growth GO:0035265 56 0.059
developmental growth GO:0048589 280 0.059
negative regulation of rna metabolic process GO:0051253 251 0.058
nucleotide metabolic process GO:0009117 161 0.058
regulation of immune system process GO:0002682 176 0.058
positive regulation of signaling GO:0023056 243 0.057
purine ribonucleotide metabolic process GO:0009150 145 0.056
ribonucleotide metabolic process GO:0009259 145 0.055
regulation of cellular component size GO:0032535 98 0.054
response to abiotic stimulus GO:0009628 341 0.053
epithelial tube morphogenesis GO:0060562 88 0.053
transcription from rna polymerase ii promoter GO:0006366 368 0.051
negative regulation of biosynthetic process GO:0009890 277 0.049
regulation of molecular function GO:0065009 217 0.048
positive regulation of signal transduction GO:0009967 223 0.048
regulation of growth GO:0040008 233 0.047
carbohydrate derivative metabolic process GO:1901135 217 0.047
response to temperature stimulus GO:0009266 106 0.045
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.044
positive regulation of gene expression GO:0010628 290 0.044
cellular response to hormone stimulus GO:0032870 44 0.044
positive regulation of nucleic acid templated transcription GO:1903508 266 0.044
regulation of female receptivity GO:0045924 24 0.043
epithelial cell differentiation GO:0030855 322 0.043
cell growth GO:0016049 108 0.042
larval behavior GO:0030537 42 0.042
response to alcohol GO:0097305 95 0.041
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 17 0.040
detection of external stimulus GO:0009581 66 0.040
positive regulation of rna metabolic process GO:0051254 271 0.040
regulation of cell size GO:0008361 63 0.039
macromolecular complex assembly GO:0065003 256 0.039
cellular response to peptide GO:1901653 28 0.039
multicellular organism growth GO:0035264 46 0.038
copulation GO:0007620 26 0.037
eye development GO:0001654 323 0.037
negative regulation of cellular metabolic process GO:0031324 382 0.037
response to organonitrogen compound GO:0010243 75 0.037
positive regulation of response to stimulus GO:0048584 323 0.036
positive regulation of cellular biosynthetic process GO:0031328 316 0.035
entrainment of circadian clock by photoperiod GO:0043153 9 0.035
compound eye development GO:0048749 307 0.035
cellular response to endogenous stimulus GO:0071495 80 0.035
single organism biosynthetic process GO:0044711 206 0.034
dendrite morphogenesis GO:0048813 199 0.034
detection of light stimulus GO:0009583 58 0.033
regulation of camp biosynthetic process GO:0030817 12 0.033
positive regulation of protein metabolic process GO:0051247 128 0.032
epithelial cell development GO:0002064 274 0.032
multicellular organismal aging GO:0010259 140 0.031
eye morphogenesis GO:0048592 260 0.031
neuropeptide signaling pathway GO:0007218 45 0.031
positive regulation of growth GO:0045927 75 0.031
localization of cell GO:0051674 257 0.031
regulation of response to stress GO:0080134 200 0.031
negative regulation of gene expression GO:0010629 387 0.031
growth GO:0040007 359 0.030
camp biosynthetic process GO:0006171 17 0.030
response to radiation GO:0009314 155 0.030
regulation of intracellular signal transduction GO:1902531 236 0.030
circadian sleep wake cycle sleep GO:0050802 23 0.029
developmental maturation GO:0021700 172 0.029
cellular response to organonitrogen compound GO:0071417 36 0.029
positive regulation of cell communication GO:0010647 250 0.029
regulation of epithelial cell differentiation GO:0030856 4 0.029
negative regulation of transcription dna templated GO:0045892 237 0.028
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.028
detection of abiotic stimulus GO:0009582 66 0.028
dendrite development GO:0016358 204 0.028
determination of adult lifespan GO:0008340 137 0.028
regulation of cell cycle GO:0051726 291 0.027
negative regulation of rna biosynthetic process GO:1902679 240 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.026
muscle structure development GO:0061061 224 0.026
tissue morphogenesis GO:0048729 297 0.026
larval feeding behavior GO:0030536 15 0.025
cell death GO:0008219 279 0.025
organonitrogen compound biosynthetic process GO:1901566 117 0.025
regulation of defense response GO:0031347 102 0.025
regulation of cellular protein metabolic process GO:0032268 243 0.025
gland development GO:0048732 191 0.025
feeding behavior GO:0007631 50 0.024
immune response regulating signaling pathway GO:0002764 2 0.024
nucleoside phosphate biosynthetic process GO:1901293 34 0.024
positive regulation of phosphorylation GO:0042327 87 0.024
cellular amino acid metabolic process GO:0006520 61 0.024
death GO:0016265 284 0.024
regulation of phosphate metabolic process GO:0019220 210 0.024
organic substance transport GO:0071702 257 0.023
immune system process GO:0002376 347 0.023
startle response GO:0001964 16 0.023
response to nitrogen compound GO:1901698 90 0.023
negative regulation of nucleic acid templated transcription GO:1903507 240 0.023
response to endogenous stimulus GO:0009719 119 0.023
regulation of protein metabolic process GO:0051246 256 0.023
catechol containing compound metabolic process GO:0009712 10 0.023
small molecule metabolic process GO:0044281 305 0.022
regulation of developmental growth GO:0048638 174 0.022
response to ethanol GO:0045471 59 0.022
response to peptide hormone GO:0043434 29 0.022
ribose phosphate biosynthetic process GO:0046390 28 0.022
regulation of response to external stimulus GO:0032101 115 0.022
response to insulin GO:0032868 29 0.022
cell division GO:0051301 248 0.022
response to heat GO:0009408 63 0.022
circadian sleep wake cycle GO:0042745 28 0.021
positive regulation of intracellular signal transduction GO:1902533 116 0.021
regulation of purine nucleotide metabolic process GO:1900542 62 0.021
male mating behavior GO:0060179 70 0.021
regulation of cell death GO:0010941 173 0.021
cellular protein modification process GO:0006464 438 0.021
insulin receptor signaling pathway GO:0008286 25 0.021
positive regulation of transcription dna templated GO:0045893 266 0.021
limb development GO:0060173 1 0.020
protein complex assembly GO:0006461 200 0.020
chromatin organization GO:0006325 207 0.020
positive regulation of phosphorus metabolic process GO:0010562 139 0.020
cyclic nucleotide biosynthetic process GO:0009190 25 0.020
regulation of organ growth GO:0046620 42 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.020
nitrogen compound transport GO:0071705 85 0.019
histone modification GO:0016570 106 0.019
aging GO:0007568 143 0.019
regionalization GO:0003002 416 0.019
cellular response to organic substance GO:0071310 132 0.019
cellular response to nitrogen compound GO:1901699 51 0.019
homeostatic process GO:0042592 199 0.019
immune response GO:0006955 246 0.019
kidney development GO:0001822 3 0.019
regulation of programmed cell death GO:0043067 152 0.019
positive regulation of developmental process GO:0051094 143 0.019
sensory organ morphogenesis GO:0090596 260 0.019
protein modification process GO:0036211 438 0.019
purine nucleotide metabolic process GO:0006163 146 0.018
organic substance catabolic process GO:1901575 308 0.018
regulation of anatomical structure size GO:0090066 163 0.018
cellular response to abiotic stimulus GO:0071214 58 0.018
regulation of multi organism process GO:0043900 131 0.018
tube development GO:0035295 244 0.018
organelle fission GO:0048285 340 0.018
thermotaxis GO:0043052 16 0.018
tube morphogenesis GO:0035239 191 0.018
appendage morphogenesis GO:0035107 397 0.018
regulation of cellular response to stress GO:0080135 89 0.018
photoperiodism GO:0009648 10 0.018
secretion GO:0046903 109 0.018
chemotaxis GO:0006935 249 0.018
cellular response to radiation GO:0071478 52 0.017
mesenchymal cell differentiation GO:0048762 1 0.017
compound eye photoreceptor cell differentiation GO:0001751 140 0.017
carbohydrate utilization GO:0009758 1 0.017
negative regulation of developmental process GO:0051093 201 0.017
regulation of transcription regulatory region dna binding GO:2000677 3 0.017
organic acid metabolic process GO:0006082 103 0.017
signal transduction by phosphorylation GO:0023014 107 0.017
glycosyl compound metabolic process GO:1901657 127 0.017
positive regulation of multicellular organismal process GO:0051240 143 0.017
regulation of neurogenesis GO:0050767 158 0.017
heart process GO:0003015 37 0.017
cyclic nucleotide metabolic process GO:0009187 28 0.017
compound eye morphogenesis GO:0001745 249 0.017
terminal region determination GO:0007362 25 0.017
positive regulation of cyclic nucleotide metabolic process GO:0030801 9 0.017
response to light stimulus GO:0009416 124 0.017
carboxylic acid metabolic process GO:0019752 92 0.016
photoreceptor cell differentiation GO:0046530 170 0.016
aromatic compound catabolic process GO:0019439 166 0.016
regulation of female receptivity post mating GO:0046008 17 0.016
response to extracellular stimulus GO:0009991 116 0.016
regulation of catalytic activity GO:0050790 185 0.016
sensory perception of sound GO:0007605 56 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.016
regulation of adenylate cyclase activity GO:0045761 12 0.016
connective tissue development GO:0061448 3 0.016
regulation of cell growth GO:0001558 43 0.016
organelle fusion GO:0048284 46 0.015
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.015
regulation of immune response GO:0050776 118 0.015
dna metabolic process GO:0006259 227 0.015
central nervous system development GO:0007417 201 0.015
proteolysis GO:0006508 192 0.015
nucleoside catabolic process GO:0009164 112 0.015
vesicle fusion GO:0006906 19 0.015
olfactory behavior GO:0042048 97 0.015
carbohydrate derivative biosynthetic process GO:1901137 85 0.015
oxoacid metabolic process GO:0043436 103 0.015
apoptotic process GO:0006915 159 0.015
regulation of cell development GO:0060284 215 0.015
aromatic amino acid family metabolic process GO:0009072 3 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
regulation of anatomical structure morphogenesis GO:0022603 242 0.015
positive regulation of cellular component biogenesis GO:0044089 80 0.015
cellular response to dna damage stimulus GO:0006974 223 0.015
regulation of cell morphogenesis GO:0022604 163 0.015
single organism membrane organization GO:0044802 93 0.015
regulation of nucleotide metabolic process GO:0006140 62 0.014
protein complex biogenesis GO:0070271 201 0.014
negative regulation of nucleotide biosynthetic process GO:0030809 3 0.014
neuron projection guidance GO:0097485 241 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
actin filament based process GO:0030029 220 0.014
regulation of cell differentiation GO:0045595 302 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
regulation of dna metabolic process GO:0051052 34 0.014
negative regulation of insulin secretion GO:0046676 1 0.014
intracellular signal transduction GO:0035556 300 0.014
ribonucleoside triphosphate catabolic process GO:0009203 108 0.014
positive regulation of behavior GO:0048520 19 0.014
flight behavior GO:0007629 26 0.014
regulation of localization GO:0032879 275 0.014
regulation of multicellular organism growth GO:0040014 40 0.014
chromosome organization GO:0051276 360 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
mitotic nuclear division GO:0007067 213 0.014
cellular amine metabolic process GO:0044106 12 0.014
molting cycle chitin based cuticle GO:0007591 56 0.014
head development GO:0060322 135 0.014
cell cycle checkpoint GO:0000075 95 0.014
macromolecule catabolic process GO:0009057 161 0.013
regulation of neuron differentiation GO:0045664 103 0.013
response to monosaccharide GO:0034284 4 0.013
establishment of localization in cell GO:0051649 402 0.013
appendage development GO:0048736 401 0.013
positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway GO:0010579 7 0.013
branching morphogenesis of an epithelial tube GO:0048754 45 0.013
cell type specific apoptotic process GO:0097285 38 0.013
purine nucleotide biosynthetic process GO:0006164 29 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.013
programmed cell death GO:0012501 257 0.013
phagocytosis GO:0006909 215 0.013
regulation of multicellular organismal development GO:2000026 414 0.013
exocrine system development GO:0035272 162 0.013
positive regulation of developmental growth GO:0048639 62 0.013
phosphorylation GO:0016310 294 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
cellular response to light stimulus GO:0071482 37 0.013
regulation of apoptotic process GO:0042981 130 0.013
cellular response to ethanol GO:0071361 4 0.013
heterocycle catabolic process GO:0046700 166 0.013
respiratory system development GO:0060541 213 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.013
amine metabolic process GO:0009308 12 0.013
ras protein signal transduction GO:0007265 88 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.013
intracellular receptor signaling pathway GO:0030522 19 0.012
nucleoside phosphate catabolic process GO:1901292 110 0.012
response to other organism GO:0051707 293 0.012
nucleocytoplasmic transport GO:0006913 72 0.012
regulation of catabolic process GO:0009894 170 0.012
response to peptide GO:1901652 29 0.012
regulation of growth rate GO:0040009 3 0.012
response to hormone GO:0009725 45 0.012
regulation of epithelial cell proliferation GO:0050678 4 0.012
nucleoside metabolic process GO:0009116 127 0.012
immune effector process GO:0002252 98 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
purine containing compound catabolic process GO:0072523 112 0.012
negative regulation of cell death GO:0060548 81 0.012
adult locomotory behavior GO:0008344 76 0.012
immune response activating signal transduction GO:0002757 2 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
carbohydrate derivative catabolic process GO:1901136 118 0.012
vesicle mediated transport GO:0016192 381 0.012
cellular response to oxygen containing compound GO:1901701 79 0.012
regulation of gtpase activity GO:0043087 44 0.012
cellular response to peptide hormone stimulus GO:0071375 28 0.012
heart contraction GO:0060047 26 0.011
axon ensheathment GO:0008366 10 0.011
regulation of protein catabolic process GO:0042176 55 0.011
negative regulation of signal transduction GO:0009968 206 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
purine nucleoside triphosphate catabolic process GO:0009146 108 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
regulation of phosphorus metabolic process GO:0051174 210 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
nucleotide biosynthetic process GO:0009165 34 0.011
chromatin modification GO:0016568 147 0.011
positive regulation of dna metabolic process GO:0051054 12 0.011
photoreceptor cell development GO:0042461 96 0.011
limb morphogenesis GO:0035108 1 0.011
positive regulation of defense response GO:0031349 59 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
regulation of phosphorylation GO:0042325 147 0.011
cellular catabolic process GO:0044248 372 0.011
nephron tubule morphogenesis GO:0072078 3 0.011
gliogenesis GO:0042063 80 0.011
camera type eye development GO:0043010 4 0.011
cell maturation GO:0048469 144 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
positive regulation of programmed cell death GO:0043068 62 0.011
xenobiotic catabolic process GO:0042178 1 0.011
response to inorganic substance GO:0010035 44 0.011
positive regulation of immune response GO:0050778 63 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
mesenchymal cell development GO:0014031 1 0.010
organonitrogen compound catabolic process GO:1901565 128 0.010
synaptic transmission GO:0007268 288 0.010
response to oxidative stress GO:0006979 86 0.010
single organism catabolic process GO:0044712 228 0.010
neuronal action potential GO:0019228 10 0.010
regulation of cell cycle process GO:0010564 181 0.010
regulation of protein modification process GO:0031399 112 0.010
positive regulation of nucleotide metabolic process GO:0045981 55 0.010
nephron development GO:0072006 3 0.010
gland morphogenesis GO:0022612 145 0.010
rna splicing via transesterification reactions GO:0000375 73 0.010
hormone metabolic process GO:0042445 33 0.010
membrane fusion GO:0061025 42 0.010

Pdf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
disease of metabolism DOID:0014667 0 0.021
nervous system disease DOID:863 0 0.019
eye and adnexa disease DOID:1492 0 0.012
sensory system disease DOID:0050155 0 0.012
musculoskeletal system disease DOID:17 0 0.011
inherited metabolic disorder DOID:655 0 0.010