Drosophila melanogaster

49 known processes

LKR (Dmel_CG7144)

lysine ketoglutarate reductase

(Aliases: CG7144,dLKR,BEST:CK02318,Dmel\CG7144,CK02318,SDH,anon-WO0149856.1)

LKR biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
g protein coupled receptor signaling pathway GO:0007186 136 0.125
response to organic substance GO:0010033 284 0.095
organic substance transport GO:0071702 257 0.065
negative regulation of gene expression GO:0010629 387 0.056
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.053
cellular protein modification process GO:0006464 438 0.051
transmembrane transport GO:0055085 139 0.050
negative regulation of cellular metabolic process GO:0031324 382 0.049
embryonic development via the syncytial blastoderm GO:0001700 148 0.049
regionalization GO:0003002 416 0.047
response to abiotic stimulus GO:0009628 341 0.045
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.042
immune system process GO:0002376 347 0.040
single organism behavior GO:0044708 391 0.040
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.040
single organism biosynthetic process GO:0044711 206 0.039
negative regulation of biosynthetic process GO:0009890 277 0.037
organonitrogen compound metabolic process GO:1901564 318 0.037
dorsal ventral pattern formation GO:0009953 133 0.036
l amino acid import GO:0043092 2 0.036
adult behavior GO:0030534 137 0.036
negative regulation of cellular biosynthetic process GO:0031327 277 0.035
small molecule metabolic process GO:0044281 305 0.034
epithelial cell differentiation GO:0030855 322 0.034
transcription from rna polymerase ii promoter GO:0006366 368 0.033
forebrain development GO:0030900 2 0.032
negative regulation of rna metabolic process GO:0051253 251 0.032
immune response GO:0006955 246 0.032
response to oxygen containing compound GO:1901700 200 0.032
imaginal disc derived appendage morphogenesis GO:0035114 395 0.032
organelle fission GO:0048285 340 0.032
wing disc morphogenesis GO:0007472 344 0.031
multicellular organismal reproductive behavior GO:0033057 110 0.031
appendage development GO:0048736 401 0.029
protein modification process GO:0036211 438 0.029
multi organism reproductive behavior GO:0044705 121 0.029
mating GO:0007618 120 0.028
ion transmembrane transport GO:0034220 122 0.028
nitrogen compound transport GO:0071705 85 0.027
reproductive behavior GO:0019098 122 0.027
establishment of localization in cell GO:0051649 402 0.027
response to organic cyclic compound GO:0014070 89 0.027
embryo development ending in birth or egg hatching GO:0009792 152 0.026
localization of cell GO:0051674 257 0.026
cell death GO:0008219 279 0.026
ion transport GO:0006811 145 0.026
macromolecular complex assembly GO:0065003 256 0.026
appendage morphogenesis GO:0035107 397 0.026
positive regulation of response to stimulus GO:0048584 323 0.026
vesicle mediated transport GO:0016192 381 0.026
regulation of cell death GO:0010941 173 0.025
multi organism behavior GO:0051705 175 0.025
compound eye development GO:0048749 307 0.025
regulation of protein metabolic process GO:0051246 256 0.025
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.025
chromosome organization GO:0051276 360 0.025
cellular amino acid metabolic process GO:0006520 61 0.025
imaginal disc derived appendage development GO:0048737 399 0.024
nucleoside phosphate metabolic process GO:0006753 162 0.024
cell cell signaling involved in cell fate commitment GO:0045168 210 0.024
imaginal disc derived wing morphogenesis GO:0007476 337 0.024
neuropeptide signaling pathway GO:0007218 45 0.024
protein complex biogenesis GO:0070271 201 0.024
cell motility GO:0048870 251 0.024
developmental growth GO:0048589 280 0.023
innate immune response GO:0045087 144 0.023
negative regulation of nucleic acid templated transcription GO:1903507 240 0.023
negative regulation of transcription dna templated GO:0045892 237 0.023
oxoacid metabolic process GO:0043436 103 0.023
post embryonic appendage morphogenesis GO:0035120 385 0.023
intracellular transport GO:0046907 228 0.023
regulation of intracellular signal transduction GO:1902531 236 0.023
positive regulation of signaling GO:0023056 243 0.023
nuclear division GO:0000280 332 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.023
positive regulation of macromolecule metabolic process GO:0010604 405 0.023
death GO:0016265 284 0.022
endocytosis GO:0006897 310 0.022
meiotic nuclear division GO:0007126 151 0.022
negative regulation of rna biosynthetic process GO:1902679 240 0.022
central nervous system development GO:0007417 201 0.022
positive regulation of biosynthetic process GO:0009891 316 0.021
phosphorylation GO:0016310 294 0.021
growth GO:0040007 359 0.021
regulation of anatomical structure morphogenesis GO:0022603 242 0.021
phagocytosis GO:0006909 215 0.021
positive regulation of cell communication GO:0010647 250 0.021
imaginal disc pattern formation GO:0007447 91 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
cell migration GO:0016477 238 0.020
positive regulation of cellular biosynthetic process GO:0031328 316 0.020
wing disc pattern formation GO:0035222 66 0.020
response to radiation GO:0009314 155 0.020
intracellular signal transduction GO:0035556 300 0.020
eye development GO:0001654 323 0.020
regulation of localization GO:0032879 275 0.020
organophosphate metabolic process GO:0019637 195 0.019
morphogenesis of an epithelium GO:0002009 276 0.019
protein localization GO:0008104 284 0.019
negative regulation of multicellular organismal process GO:0051241 142 0.019
positive regulation of transcription dna templated GO:0045893 266 0.019
epithelial cell development GO:0002064 274 0.019
lateral inhibition GO:0046331 206 0.019
regulation of programmed cell death GO:0043067 152 0.019
cellular response to dna damage stimulus GO:0006974 223 0.019
protein complex assembly GO:0006461 200 0.018
programmed cell death GO:0012501 257 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.018
multi multicellular organism process GO:0044706 123 0.018
defense response GO:0006952 300 0.018
positive regulation of signal transduction GO:0009967 223 0.018
response to light stimulus GO:0009416 124 0.018
single organism intracellular transport GO:1902582 207 0.018
body morphogenesis GO:0010171 2 0.018
mating behavior GO:0007617 106 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
catabolic process GO:0009056 409 0.018
chaeta development GO:0022416 97 0.018
positive regulation of nucleic acid templated transcription GO:1903508 266 0.018
nucleotide metabolic process GO:0009117 161 0.018
male mating behavior GO:0060179 70 0.018
positive regulation of rna biosynthetic process GO:1902680 266 0.018
locomotory behavior GO:0007626 176 0.017
positive regulation of gene expression GO:0010628 290 0.017
regulation of response to stress GO:0080134 200 0.017
compound eye morphogenesis GO:0001745 249 0.017
regulation of phosphorus metabolic process GO:0051174 210 0.017
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.017
response to endogenous stimulus GO:0009719 119 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
organonitrogen compound biosynthetic process GO:1901566 117 0.016
male gamete generation GO:0048232 201 0.016
negative regulation of signaling GO:0023057 219 0.016
amine metabolic process GO:0009308 12 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
homeostatic process GO:0042592 199 0.016
cellular response to organic substance GO:0071310 132 0.016
gland development GO:0048732 191 0.016
positive regulation of rna metabolic process GO:0051254 271 0.016
regulation of cell cycle GO:0051726 291 0.016
ameboidal type cell migration GO:0001667 151 0.016
salivary gland morphogenesis GO:0007435 145 0.016
meiotic cell cycle GO:0051321 171 0.016
determination of adult lifespan GO:0008340 137 0.016
cell growth GO:0016049 108 0.015
regulation of apoptotic process GO:0042981 130 0.015
protein phosphorylation GO:0006468 169 0.015
carboxylic acid metabolic process GO:0019752 92 0.015
response to nitrogen compound GO:1901698 90 0.015
spermatogenesis GO:0007283 200 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.015
brain development GO:0007420 120 0.015
ovarian follicle cell development GO:0030707 248 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
regulation of cellular component size GO:0032535 98 0.014
muscle structure development GO:0061061 224 0.014
response to monosaccharide GO:0034284 4 0.014
spindle organization GO:0007051 253 0.014
carbohydrate metabolic process GO:0005975 82 0.014
humoral immune response GO:0006959 117 0.014
taxis GO:0042330 304 0.014
anion transport GO:0006820 41 0.014
actin cytoskeleton organization GO:0030036 206 0.014
exocrine system development GO:0035272 162 0.014
muscle organ development GO:0007517 127 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
head development GO:0060322 135 0.014
actin filament based process GO:0030029 220 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
sensory perception of pain GO:0019233 4 0.014
regulation of gene expression epigenetic GO:0040029 128 0.013
response to wounding GO:0009611 94 0.013
response to lipopolysaccharide GO:0032496 4 0.013
organic acid metabolic process GO:0006082 103 0.013
positive regulation of developmental process GO:0051094 143 0.013
secretion GO:0046903 109 0.013
rna processing GO:0006396 147 0.013
tissue morphogenesis GO:0048729 297 0.013
protein transport GO:0015031 155 0.013
response to hexose GO:0009746 3 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
posttranscriptional regulation of gene expression GO:0010608 145 0.013
cell adhesion GO:0007155 136 0.013
regulation of molecular function GO:0065009 217 0.013
sensory organ morphogenesis GO:0090596 260 0.013
negative regulation of cell communication GO:0010648 223 0.013
regulation of cell differentiation GO:0045595 302 0.013
mrna processing GO:0006397 104 0.013
segmentation GO:0035282 207 0.013
cellular macromolecular complex assembly GO:0034622 153 0.013
biological adhesion GO:0022610 138 0.013
response to oxygen levels GO:0070482 59 0.012
chemotaxis GO:0006935 249 0.012
monocarboxylic acid transport GO:0015718 3 0.012
developmental programmed cell death GO:0010623 138 0.012
negative regulation of response to stimulus GO:0048585 258 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.012
regulation of catalytic activity GO:0050790 185 0.012
cellular amine metabolic process GO:0044106 12 0.012
synaptic transmission GO:0007268 288 0.012
mrna metabolic process GO:0016071 124 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
response to biotic stimulus GO:0009607 294 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
embryonic morphogenesis GO:0048598 206 0.012
dendrite morphogenesis GO:0048813 199 0.012
respiratory system development GO:0060541 213 0.012
mitochondrion organization GO:0007005 65 0.012
phenol containing compound metabolic process GO:0018958 57 0.012
response to alcohol GO:0097305 95 0.012
purine containing compound metabolic process GO:0072521 155 0.012
response to organonitrogen compound GO:0010243 75 0.012
chromatin organization GO:0006325 207 0.012
organic substance catabolic process GO:1901575 308 0.012
secretion by cell GO:0032940 101 0.012
positive regulation of cell migration GO:0030335 2 0.012
macromolecule catabolic process GO:0009057 161 0.012
phosphate ion transport GO:0006817 4 0.012
regulation of transport GO:0051049 181 0.012
axon guidance GO:0007411 233 0.012
single organism cellular localization GO:1902580 180 0.012
multicellular organismal aging GO:0010259 140 0.012
organelle localization GO:0051640 148 0.012
regulation of immune response GO:0050776 118 0.012
organic hydroxy compound metabolic process GO:1901615 83 0.012
response to glucose GO:0009749 2 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
cellular macromolecule localization GO:0070727 220 0.011
establishment of protein localization GO:0045184 163 0.011
regulation of cell shape GO:0008360 113 0.011
axonogenesis GO:0007409 290 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
wound healing GO:0042060 75 0.011
sodium dependent phosphate transport GO:0044341 2 0.011
telencephalon development GO:0021537 2 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
tube development GO:0035295 244 0.011
camera type eye development GO:0043010 4 0.011
tube morphogenesis GO:0035239 191 0.011
mitotic nuclear division GO:0007067 213 0.011
salivary gland development GO:0007431 162 0.011
eye morphogenesis GO:0048592 260 0.011
regulation of anatomical structure size GO:0090066 163 0.011
embryonic pattern specification GO:0009880 174 0.011
single organism carbohydrate metabolic process GO:0044723 72 0.011
positive regulation of transport GO:0051050 92 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
negative regulation of cell death GO:0060548 81 0.011
adult locomotory behavior GO:0008344 76 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
negative regulation of developmental process GO:0051093 201 0.011
digestive system development GO:0055123 149 0.011
mapk cascade GO:0000165 107 0.011
cation transmembrane transport GO:0098655 88 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
morphogenesis of embryonic epithelium GO:0016331 94 0.011
response to starvation GO:0042594 97 0.010
digestive tract development GO:0048565 149 0.010
regulation of behavior GO:0050795 75 0.010
regulation of cell cycle process GO:0010564 181 0.010
regulation of cellular localization GO:0060341 136 0.010
regulation of immune system process GO:0002682 176 0.010
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
neuron projection guidance GO:0097485 241 0.010
developmental maturation GO:0021700 172 0.010
male meiosis GO:0007140 52 0.010
tissue migration GO:0090130 155 0.010
cellular response to biotic stimulus GO:0071216 4 0.010
regulation of phosphorylation GO:0042325 147 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
regulation of protein modification process GO:0031399 112 0.010
wnt signaling pathway GO:0016055 98 0.010

LKR disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.018
disease of metabolism DOID:0014667 0 0.016
inherited metabolic disorder DOID:655 0 0.012
nervous system disease DOID:863 0 0.011